Article
Biotechnology & Applied Microbiology
Ming Lei, Kangcheng Zhao, Wenbin Hua, Kun Wang, Shuai Li, Xinghuo Wu, Cao Yang
Summary: The study demonstrated that overexpression of c-Jun has a positive effect on the treatment of intervertebral disc degeneration, inhibiting the inflammatory response in vivo and potentially delaying the degeneration of the intervertebral disc.
Article
Biochemistry & Molecular Biology
Tianxiao Sun, Haihua Li, Yan Zhang, Guixin Xiong, Yuerun Liang, Fang Lu, Rong Zheng, Qi Zou, Jiejie Hao
Summary: In this study, it was found that DGM could inhibit TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. Furthermore, DGM treatment improved lung function, reduced lung inflammation and fibrosis, and decreased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Sarah S. McCarthy, Michele Karolak, Leif Oxburgh
Summary: Expansion of interstitial cells in adult kidney is a hallmark of chronic disease, while their proliferation during fetal development is necessary for organ formation. Inactivation of TGF beta/Smad response in mouse interstitial cell lineage leads to overproliferation of interstitial cells regionally in the kidney medulla. Smad4 loss primarily reduces TGF beta signaling in the interstitium, while increasing Wnt/beta-catenin signaling.
Article
Oncology
Hsin-Yi Chen, Shu-Jou Chan, Xinxin Liu, An-Chi Wei, Ru-In Jian, Kuan-Wei Huang, Yaw-Dong Lang, Jou-Ho Shih, Chun-Chieh Liao, Chiu-Lin Luan, Yu-Tung Kao, Shang-Yin Chiang, Pei-Wen Hsiao, Yuh-Shan Jou, Yunching Chen, Ruey-Hwa Chen
Summary: This study identifies the lncRNA Smyca as an oncogene that promotes poor prognosis in multiple cancer types. Smyca enhances tumor metabolic reprogramming, migration, invasion, cancer stemness, metastasis, and chemoresistance by potentiating TGF-beta/Smad signaling and c-Myc-mediated transcription. Targeting Smyca prevents metastasis and overcomes chemoresistance.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Immunology
Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song, Lihua Lai, Meng Xia, Jianhua Zhang, Qingqing Wang
Summary: The decreased expression of Fbxw7 is significantly related to the severity of pulmonary fibrosis in IPF patients. Fbxw7 is a key inhibitory factor for the development and progression of pulmonary fibrosis. Fbxw7 suppresses the expression of TGF-beta in profibrotic macrophages by interacting with and degrading C-Jun.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shu Yang, Hongying Zhang, Hua Yang, Jin Zhang, Jiao Wang, Ting Luo, Yangfu Jiang, Hui Hua
Summary: This study reveals that SEPHS1 is a positive regulator of SMAD proteins in hepatocellular carcinoma (HCC) and its expression is up-regulated in HCC cells. Knockdown of SEPHS1 inhibits the migration and invasion of HCC cells, as well as suppresses the stimulation by TGF-beta. Overexpression of SEPHS1 promotes cell invasion in HCC, which is correlated with poor prognosis for HCC patients.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoshuang Wang, Mei Feng, Tengfei Xiao, Baosen Guo, Danyang Liu, Chenglong Liu, Jinpeng Pei, Qiaofeng Liu, Yi Xiao, Rina Rosin-Arbesfeld, Ying Shi, Yang Zhou, Mengxuan Yang, Yu-Xiong Feng, Yizhou Jiang, Zhimin Shao, Ker Yu, Di Zhu
Summary: The expression of BCL9 and BCL9L is correlated with malignancy in TNBC patient tumors, and they promote tumor cell growth, migration, and metastasis. Inhibition of BCL9/BCL9L and TGF-beta suppresses Treg activity, while TGF-beta signaling increases tumor infiltration of cytotoxic CD8 (+) T cells. Inhibiting BCL9/BCL9L synergizes with PD-1/L1 antibodies to inhibit tumor growth.
Article
Multidisciplinary Sciences
Xin Li, Qiu-Ling Fan, Tian-Kui Ma, Cong Liu, Hang Shi, Yuan-Yuan Sun, Yue Wang, Dong-Xue Ding, Ao Tang, Yu Qin, Qi Yang, Hong Ding, Hang-Yu Li, Wei-Neng Fu
Summary: This study found that the downregulation of MYCT1 expression is associated with diabetic kidney disease and MYCT1 overexpression may have therapeutic benefits for the treatment of this disease.
Article
Endocrinology & Metabolism
Pengfei Zhu, Zhijiao Song, Xingyu Bi, Yiliang Miao, Xueqing Wu
Summary: PRR11 plays an important role in early pregnancy loss by promoting cell proliferation, migration, and angiogenesis. It is correlated with EGR1 and the TGF-beta/Smad signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
Zhenzong Tan, Wang Huang, Peng Yu
Summary: ARID2 is downregulated in colon cancer, and its overexpression suppresses cell proliferation, invasion, migration, and EMT in colon cancer by inactivating the TGF-ss 1/Smad pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Cell Biology
Lih-Fhung Hiew, Chi-Him Poon, Heng-Ze You, Lee-Wei Lim
Summary: Research on TGF-beta/Smad signaling has shown its significance in neurogenesis and its potential impact on neuropsychiatric disorders. The relationship between TGF-beta/Smad signaling and neurogenesis in response to stressors suggests a role in stress response regulation and behavioral outcomes of mood disorders. Modifications to these signaling pathways have been found to have diverse effects on neurogenesis, highlighting the complexity of the interactions involved.
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Article
Medicine, Research & Experimental
Alex Boye
Summary: Early detection of cancer is crucial for cancer management and limited survival. Understanding cancer biology and key factors in cancer progression plays a significant role in cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Shanzhong Yang, Yong-Jig Cho, Lin Jin, Guandou Yuan, Arunima Datta, Phillip Buckhaults, Pran K. Datta
Article
Oncology
Guandou Yuan, Bixiang Zhang, Shanzhong Yang, Lin Jin, Arunima Datta, Sejong Bae, Xiaoping Chen, Pran K. Datta
Review
Medicine, General & Internal
Trung Vu, Lin Jin, Pran K. Datta
JOURNAL OF CLINICAL MEDICINE
(2016)
Article
Cell & Tissue Engineering
Lin Jin, Chenbei Chang, Kevin M. Pawlik, Arunima Datta, Larry M. Johnson, Trung Vu, Joseph L. Napoli, Pran K. Datta
Article
Cell Biology
Lin Jin, Pran K. Datta
Article
Multidisciplinary Sciences
Lin Jin, Yunjia Chen, David K. Crossman, Arunima Datta, Trung Vu, James A. Mobley, Malay Kumar Basu, Mariangela Scarduzio, Hengbin Wang, Chenbei Chang, Pran K. Datta
NATURE COMMUNICATIONS
(2020)
Article
Gastroenterology & Hepatology
Trung Vu, Arunima Datta, Carolyn Banister, Lin Jin, Guandou Yuan, Temesgen Samuel, Sejong Bae, Isam-Eldin Eltoum, Upender Manne, Bixiang Zhang, Robert S. Welner, Kasturi Mitra, Phillip Buckhaults, Pran K. Datta
Summary: The study revealed that STRAP plays a crucial role in Apc mutation/deletion-induced intestinal tumorigenesis through a novel feed-forward regulatory axis involving STRAP/MEK-ERK/Wnt-beta-catenin/STRAP. This indicates a potential therapeutic target for colorectal cancer associated with Apc gene mutations.
Article
Biochemistry & Molecular Biology
Ritesh K. Srivastava, Purushotham Guroji, Lin Jin, M. Shahid Mukhtar, Mohammad Athar
Summary: Aberrant activation of multiple complex signaling pathways, including BET and mTORC1/2, plays a crucial role in the pathogenesis of RMS. Inhibition of BRD4 and mTORC1/2 showed synergistic effects in suppressing RMS growth and enhancing therapeutic efficacy. The bromodomain inhibitor RVX-208 effectively blocked BRD4 occupancy on its target promoters, leading to decreased activation of downstream signaling mechanisms. Furthermore, the combined treatment induced necroptosis-mediated cell death, providing a potential therapeutic intervention for drug-resistant RMS.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Lin Jin, Trung Vu, Guandou Yuan, Pran K. Datta
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
