The baculovirus expression vector system: A commercial manufacturing platform for viral vaccines and gene therapy vectors

Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency loss

(2014) Kathleen M Holtz et al.   BMC BIOTECHNOLOGY

Impact of Influenza B Lineage-Level Mismatch Between Trivalent Seasonal Influenza Vaccines and Circulating Viruses, 1999–2012

(2014) Terho Heikkinen et al.   CLINICAL INFECTIOUS DISEASES

Severe acute respiratory syndrome vs. the Middle East respiratory syndrome

(2014) David S. Hui et al.   CURRENT OPINION IN PULMONARY MEDICINE

Current advancements and potential strategies in the development of MERS-CoV vaccines

(2014) Naru Zhang et al.   Expert Review of Vaccines

Current status of haemophilia gene therapy

(2014) K. H. High et al.   HAEMOPHILIA

Full-Length Dystrophin Reconstitution with Adeno-Associated Viral Vectors

(2014) William Lostal et al.   HUMAN GENE THERAPY

Vaccine Allergy

(2014) Jean-Christoph Caubet et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Thirty years of baculovirus-insect cell protein expression: from dark horse to mainstream technology

(2014) M. M. van Oers et al.   JOURNAL OF GENERAL VIROLOGY

Mechanism of a Decrease in Potency for the Recombinant Influenza A Virus Hemagglutinin H3 Antigen During Storage

(2014) John M. Hickey et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of a Novel Rhabdovirus in Spodoptera frugiperda Cell Lines

(2014) H. Ma et al.   JOURNAL OF VIROLOGY

Chikungunya at the Door — Déjà Vu All Over Again?

(2014) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Enhanced Production of Chikungunya Virus-Like Particles Using a High-pH Adapted Spodoptera frugiperda Insect Cell Line

(2014) James M. Wagner et al.   PLoS One

A Vaccine of L2 Epitope Repeats Fused with a Modified IgG1 Fc Induced Cross-Neutralizing Antibodies and Protective Immunity against Divergent Human Papillomavirus Types

(2014) Xue Chen et al.   PLoS One

Estimating the Ebola epidemic

(2014) K. Kupferschmidt   SCIENCE

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Development of a recombinant toxin fragment vaccine for Clostridium difficile infection

(2014) Jerzy Karczewski et al.   VACCINE

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside

(2014) Valerie Ferreira et al.   Frontiers in Immunology

Traditional and New Influenza Vaccines

(2013) S.-S. Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

Recombinant Trivalent Influenza Vaccine (Flublok®): A Review of Its Use in the Prevention of Seasonal Influenza in Adults

(2013) Lily P. H. Yang   DRUGS

New developments in the use of gene therapy to treat Duchenne muscular dystrophy

(2013) Susan Jarmin et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Baculovirus vector as an avian influenza vaccine: Hemagglutinin expression and presentation augment the vaccine immunogenicity

(2013) Chi-Yuan Chen et al.   JOURNAL OF BIOTECHNOLOGY

Easy expression of the C-terminal heavy chain domain of botulinum neurotoxin serotype A as a vaccine candidate using a bi-cistronic baculovirus system

(2013) Oliver B. Villaflores et al.   JOURNAL OF VIROLOGICAL METHODS

Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

(2013) A. Marzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge

(2013) Guangliang Liu et al.   VACCINE

Assembly and immunogenicity of coronavirus-like particles carrying infectious bronchitis virus M and S proteins

(2013) Genmei Liu et al.   VACCINE

Chikungunya virus-like particles are more immunogenic in a lethal AG129 mouse model compared to glycoprotein E1 or E2 subunits

(2013) Stefan W. Metz et al.   VACCINE

Evaluation of safety and immunogenicity of recombinant influenza hemagglutinin (H5/Indonesia/05/2005) formulated with and without a stable oil-in-water emulsion containing glucopyranosyl-lipid A (SE+GLA) adjuvant

(2013) John J. Treanor et al.   VACCINE

Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

(2013) Gale E. Smith et al.   VACCINE

Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response

(2013) Michael Maynard-Smith et al.   VACCINE

Global alert to avian influenza virus infection: From H5N1 to H7N9

(2013) Yong Poovorawan et al.   Pathogens and Global Health

Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

(2013) Stefan W. Metz et al.   PLoS Neglected Tropical Diseases

Safety profile of recombinant adeno-associated viral vectors: focus on alipogene tiparvovec (Glybera®)

(2013) Florence Salmon et al.   Expert Review of Clinical Pharmacology

Development of the Vault Particle as a Platform Technology

(2012) Leonard H. Rome et al.   ACS Nano

Vaccine process technology

(2012) Jessica O. Josefsberg et al.   BIOTECHNOLOGY AND BIOENGINEERING

A designer hyper interleukin 11 (H11) is a biologically active cytokine

(2012) Hanna Dams-Kozlowska et al.   BMC BIOTECHNOLOGY

Adeno-associated virus (AAV) gene therapy for neurological disease

(2012) Marc S. Weinberg et al.   NEUROPHARMACOLOGY

SweetBac: A New Approach for the Production of Mammalianised Glycoproteins in Insect Cells

(2012) Dieter Palmberger et al.   PLoS One

Recombinant protein vaccines produced in insect cells

(2012) Manon M.J. Cox   VACCINE

Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines

(2012) Daesub Song et al.   VIRUS GENES

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Insect cell technology is a versatile and robust vaccine manufacturing platform

(2011) Jimmy A Mena et al.   Expert Review of Vaccines

Rapid Immune Responses to a Botulinum Neurotoxin Hc Subunit Vaccine throughIn VivoTargeting to Antigen-Presenting Cells

(2011) David M. White et al.   INFECTION AND IMMUNITY

A fast track influenza virus vaccine produced in insect cells

(2011) Manon M.J. Cox et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Opportunities and challenges for the baculovirus expression system

(2011) Monique M. van Oers   JOURNAL OF INVERTEBRATE PATHOLOGY

Arbovirus vaccines; opportunities for the baculovirus-insect cell expression system

(2011) Stefan W. Metz et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

H5N1 Virus-Like Particle Vaccine Elicits Cross-Reactive Neutralizing Antibodies That Preferentially Bind to the Oligomeric Form of Influenza Virus Hemagglutinin in Humans

(2011) S. Khurana et al.   JOURNAL OF VIROLOGY

Identification of Sequence Variants in Genetic Disease-Causing Genes Using Targeted Next-Generation Sequencing

(2011) Xiaoming Wei et al.   PLoS One

Pandemic Novel 2009 H1N1 Influenza: What Have We Learned?

(2011) Philip LaRussa   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

(2011) Ye V. Liu et al.   VACCINE

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy adults 50–64 years of age☆

(2011) R. Baxter et al.   VACCINE

Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: A randomized, placebo-controlled trial

(2011) John J. Treanor et al.   VACCINE

N-Glycosylation engineering of lepidopteran insect cells by the introduction of the  1,4-N-acetylglucosaminyltransferase III gene

(2010) T. Okada et al.   GLYCOBIOLOGY

Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

(2010) Michel Deschuyteneer et al.   Human vaccines & immunotherapeutics

Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice

(2010) Baojing Lu et al.   IMMUNOLOGY

Improving adeno-associated vector yield in high density insect cell cultures

(2010) Jimmy A. Mena et al.   JOURNAL OF GENE MEDICINE

Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

(2010) Timothy K MacLachlan et al.   MOLECULAR THERAPY

Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957

(2010) Claudia Pappas et al.   PLoS One

Production of recombinant proteins by microbes and higher organisms

(2009) Arnold L. Demain et al.   BIOTECHNOLOGY ADVANCES

Producing Recombinant Adeno-Associated Virus in Foster Cells: Overcoming Production Limitations Using a Baculovirus–Insect Cell Expression Strategy

(2009) Tamas Virag et al.   HUMAN GENE THERAPY

A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

(2009) Richard H Smith et al.   MOLECULAR THERAPY

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Comparative immunogenicity of recombinant influenza hemagglutinin (rHA) and trivalent inactivated vaccine (TIV) among persons ≥65 years old

(2009) W.A. Keitel et al.   VACCINE

Gypsy endogenous retrovirus maintains potential infectivity in several species of Drosophilids

(2008) Jose V Llorens et al.   BMC EVOLUTIONARY BIOLOGY

Toward exascale production of recombinant adeno-associated virus for gene transfer applications

(2008) S Cecchini et al.   GENE THERAPY

Immune Responses of Healthy Subjects to a Single Dose of Intramuscular Inactivated Influenza A/Vietnam/1203/2004 (H5N1) Vaccine after Priming with an Antigenic Variant

(2008) Nega Ali Goji et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Adeno-associated Virus Transduction and Integration

(2008) Brian R Schultz et al.   MOLECULAR THERAPY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic Cells

(2008) Bingke Bai et al.   PLoS One

Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses

(2007) Bingke Bai et al.   MOLECULAR IMMUNOLOGY