Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research
Authors
Keywords
iPS cells, Differentiation, Neurodegeneration, Alzheimer’s disease, Dopaminergic neurons, Cholinergic neurons, Astrocytes
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 19, Pages 3693-3709
Publisher
Springer Nature
Online
2016-05-06
DOI
10.1007/s00018-016-2265-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Hypoxia Induces Pluripotency in Primordial Germ Cells by HIF1α Stabilization and Oct4 Deregulation
- (2015) Pilar López-Iglesias et al. ANTIOXIDANTS & REDOX SIGNALING
- Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns
- (2015) Kenneth K.B. Tan et al. BIOMATERIALS
- Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
- (2015) Skarphedinn Halldorsson et al. BIOSENSORS & BIOELECTRONICS
- Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1 and TNF-
- (2015) E. Hennessy et al. JOURNAL OF NEUROSCIENCE
- Current advances in the generation of human iPS cells: implications in cell-based regenerative medicine
- (2015) Ana Revilla et al. Journal of Tissue Engineering and Regenerative Medicine
- Dopaminergic differentiation of schizophrenia hiPSCs
- (2015) B J Hartley et al. MOLECULAR PSYCHIATRY
- Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors
- (2015) Staffan Holmqvist et al. Stem Cell Research
- Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization
- (2015) Marta M. Silva et al. Stem Cells Translational Medicine
- Extracellular matrix: A dynamic microenvironment for stem cell niche
- (2014) Francesca Gattazzo et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency
- (2014) Julie Mathieu et al. Cell Stem Cell
- Efficient Differentiation of Human Embryonic Stem Cells Toward Dopaminergic Neurons Using Recombinant LMX1A Factor
- (2014) Ali Fathi et al. MOLECULAR BIOTECHNOLOGY
- Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death
- (2014) Lishu Duan et al. Molecular Neurodegeneration
- Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
- (2014) K Brennand et al. MOLECULAR PSYCHIATRY
- Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons
- (2014) Elizabeth M. Hartfield et al. PLoS One
- STAT3 but Not STAT1 Is Required for Astrocyte Differentiation
- (2014) Seulgi Hong et al. PLoS One
- Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes
- (2014) Cláudia Correia et al. Stem Cell Reviews and Reports
- “Footprint-Free” Human Induced Pluripotent Stem Cell-Derived Astrocytes for In Vivo Cell-Based Therapy
- (2014) Elisabetta Mormone et al. STEM CELLS AND DEVELOPMENT
- Primary Culture of Mouse Dopaminergic Neurons
- (2014) Florence Gaven et al. Jove-Journal of Visualized Experiments
- Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits
- (2013) Yan Liu et al. NATURE BIOTECHNOLOGY
- Feeder-Free Generation and Long-Term Culture of Human Induced Pluripotent Stem Cells Using Pericellular Matrix of Decidua Derived Mesenchymal Cells
- (2013) Hayato Fukusumi et al. PLoS One
- Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling
- (2013) Peter Reinhardt et al. PLoS One
- Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
- (2013) A. Serio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling
- (2013) Lucy A. Crompton et al. Stem Cell Research
- Repression of Zeb1 and Hypoxia Cause Sequential Mesenchymal-to-Epithelial Transition and Induction of Aid, Oct4, and Dnmt1, Leading to Immortalization and Multipotential Reprogramming of Fibroblasts in Spheres
- (2013) Yongqing Liu et al. STEM CELLS
- Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions
- (2013) Atossa Shaltouki et al. STEM CELLS
- Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings
- (2013) Meredith N. Braskie et al. TRENDS IN COGNITIVE SCIENCES
- Dissecting the diversity of midbrain dopamine neurons
- (2013) Jochen Roeper TRENDS IN NEUROSCIENCES
- Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes
- (2013) Laurent Roybon et al. Cell Reports
- Efficient neuronal differentiation and maturation of human pluripotent stem cells encapsulated in 3D microfibrous scaffolds
- (2012) Hong Fang Lu et al. BIOMATERIALS
- Moving Beyond Tyrosine Hydroxylase to Define Dopaminergic Neurons for Use in Cell Replacement Therapies for Parkinson’s Disease
- (2012) Robert B. White et al. CNS & Neurological Disorders-Drug Targets
- Duration of Shh signaling contributes to mDA neuron diversity
- (2012) Lindsay Hayes et al. DEVELOPMENTAL BIOLOGY
- Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment
- (2012) Yosif M. Ganat et al. JOURNAL OF CLINICAL INVESTIGATION
- Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease
- (2012) Lezanne Ooi et al. JOURNAL OF NEURAL TRANSMISSION
- Genomic Analysis of Reactive Astrogliosis
- (2012) J. L. Zamanian et al. JOURNAL OF NEUROSCIENCE
- Comparison of several attachment methods for human iPS, embryonic and adipose-derived stem cells for tissue engineering
- (2012) Mai T. Lam et al. Journal of Tissue Engineering and Regenerative Medicine
- Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
- (2012) Mason A. Israel et al. NATURE
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
- (2012) N. Egawa et al. Science Translational Medicine
- Are you or aren’t you? Challenges associated with physiologically identifying dopamine neurons
- (2012) Mark A. Ungless et al. TRENDS IN NEUROSCIENCES
- Clinicopathological correlates of behavioral and psychological symptoms of dementia
- (2011) Manuel F. Casanova et al. ACTA NEUROPATHOLOGICA
- Extracellular matrix and perineuronal nets in CNS repair
- (2011) Jessica C.F. Kwok et al. Developmental Neurobiology
- Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
- (2011) Aude Carreau et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- Specification of transplantable astroglial subtypes from human pluripotent stem cells
- (2011) Robert Krencik et al. NATURE BIOTECHNOLOGY
- Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
- (2011) Amanda M Haidet-Phillips et al. NATURE BIOTECHNOLOGY
- Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels
- (2011) Jérôme Lecoq et al. NATURE MEDICINE
- Chemically defined conditions for human iPSC derivation and culture
- (2011) Guokai Chen et al. NATURE METHODS
- Radial Glia: Progenitor, Pathway, and Partner
- (2011) Mari Sild et al. NEUROSCIENTIST
- Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders
- (2011) I. Petit et al. Stem Cell Research
- The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells
- (2011) Christopher J. Bissonnette et al. STEM CELLS
- Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Functional Astrocytes
- (2011) Luni Emdad et al. STEM CELLS AND DEVELOPMENT
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix
- (2010) Andreas Faissner et al. BRAIN RESEARCH REVIEWS
- Role of BMPs in controlling the spatial and temporal origin of GFAP astrocytes in the embryonic spinal cord
- (2010) Eric Agius et al. DEVELOPMENTAL BIOLOGY
- Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice
- (2010) Yongjie Yang et al. GLIA
- GSK3 signalling in neural development
- (2010) Eun-Mi Hur et al. NATURE REVIEWS NEUROSCIENCE
- Translational prospects for human induced pluripotent stem cells
- (2010) Marie Csete Regenerative Medicine
- Developmental and neurochemical features of cholinergic neurons in the murine cerebral cortex
- (2009) Silvia Consonni et al. BMC NEUROSCIENCE
- Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells
- (2009) X.-J. Li et al. DEVELOPMENT
- Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins
- (2009) M. J. Cooke et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
- (2009) Mats Nilbratt et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1
- (2009) Yongjie Yang et al. NEURON
- Spatiotemporally separableShhdomains in the midbrain define distinct dopaminergic progenitor pools
- (2009) Milan Joksimovic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Embryonic Stem Cells with GFP Knocked into the Dopamine Transporter Yield Purified Dopamine Neuronsin vitroand from Knock-in Mice
- (2009) Wenbo Zhou et al. STEM CELLS
- Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
- (2008) Maria C.N. Marchetto et al. Cell Stem Cell
- Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
- (2008) Elliott J Mufson et al. Expert Review of Neurotherapeutics
- A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
- (2008) J. D. Cahoy et al. JOURNAL OF NEUROSCIENCE
- Specification of CNS glia from neural stem cells in the embryonic neuroepithelium
- (2007) N. Kessaris et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started