Programmed cell death and clearance of cell corpses in Caenorhabditis elegans

The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage

(2015) J. Wang et al.   DEVELOPMENT

PtdIns(4,5)P2and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance

(2015) Shiya Cheng et al.   JOURNAL OF CELL BIOLOGY

EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

(2015) Brent Neumann et al.   NATURE

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells

(2015) Hengwen Yang et al.   Nature Communications

Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

(2015) Zao Li et al.   PLoS Genetics

A Defective Meiotic Outcome of a Failure in Homologous Pairing and Synapsis Is Masked by Meiotic Quality Control

(2015) Frank Mei et al.   PLoS One

Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans

(2014) L J Neukomm et al.   CELL DEATH AND DIFFERENTIATION

The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms

(2014) M. Gurling et al.   DEVELOPMENT

Asymmetric Neuroblast Divisions Producing Apoptotic Cells Require the Cytohesin GRP-1 in Caenorhabditis elegans

(2014) Jerome Teuliere et al.   GENETICS

The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans

(2014) Meng Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway

(2014) Akihisa Nakagawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Translational Regulators GCN-1 and ABCF-3 Act Together to Promote Apoptosis in C. elegans

(2014) Takashi Hirose et al.   PLoS Genetics

LIN-3/EGF Promotes the Programmed Cell Death of Specific Cells in Caenorhabditis elegans by Transcriptional Activation of the Pro-apoptotic Gene egl-1

(2014) Hang-Shiang Jiang et al.   PLoS Genetics

Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance inC. elegans

(2013) Shiya Cheng et al.   Autophagy

A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis

(2013) Xiao Ge et al.   CELL RESEARCH

Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans

(2013) Q. Shen et al.   DEVELOPMENT

Mechanistic insights into CED-4-mediated activation of CED-3

(2013) W. Huang et al.   GENES & DEVELOPMENT

Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans

(2013) Ayaka Sasaki et al.   MOLECULAR BIOLOGY OF THE CELL

An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways

(2013) Takashi Hirose et al.   NATURE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma

(2013) M. Chiorazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in Caenorhabditis elegans

(2013) Didi Chen et al.   PLoS Genetics

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans

(2013) Daniel P. Denning et al.   PLoS Genetics

MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells

(2012) Jing Xu et al.   CELL RESEARCH

Programmed Cell Death: A New Way Worms Get Rid of Unwanted Cells

(2012) Jody Rosenblatt   CURRENT BIOLOGY

C. elegans Secreted Lipid-Binding Protein NRF-5 Mediates PS Appearance on Phagocytes for Cell Corpse Engulfment

(2012) Yan Zhang et al.   CURRENT BIOLOGY

CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells

(2012) James Mapes et al.   CURRENT BIOLOGY

Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance

(2012) J. Huang et al.   DEVELOPMENT

Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment

(2012) Y. Kang et al.   GENES & DEVELOPMENT

Apoptotic regulators promote cytokinetic midbody degradation inC. elegans

(2012) Yongping Chai et al.   JOURNAL OF CELL BIOLOGY

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

(2012) Daniel P. Denning et al.   NATURE

C. elegans EIF-3.K Promotes Programmed Cell Death through CED-3 Caspase

(2012) Chun-Yi Huang et al.   PLoS One

Control of Nonapoptotic Developmental Cell Death in Caenorhabditis elegans by a Polyglutamine-Repeat Protein

(2012) E. S. Blum et al.   SCIENCE

Two PI 3-Kinases and One PI 3-Phosphatase Together Establish the Cyclic Waves of Phagosomal PtdIns(3)P Critical for the Degradation of Apoptotic Cells

(2012) Nan Lu et al.   PLOS BIOLOGY

Integrin α PAT-2/CDC-42 Signaling Is Required for Muscle-Mediated Clearance of Apoptotic Cells in Caenorhabditis elegans

(2012) Hsiao-Han Hsieh et al.   PLoS Genetics

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

The Arf GAP CNT-2 Regulates the Apoptotic Fate in C. elegans Asymmetric Neuroblast Divisions

(2011) Aakanksha Singhvi et al.   CURRENT BIOLOGY

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans

(2011) L. J. Neukomm et al.   DEVELOPMENT

The Chromodomain Protein MRG-1 Facilitates SC-Independent Homologous Pairing during Meiosis in Caenorhabditis elegans

(2011) Carolyn R. Dombecki et al.   DEVELOPMENTAL CELL

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

(2011) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

A Conserved Role for SNX9-Family Members in the Regulation of Phagosome Maturation during Engulfment of Apoptotic Cells

(2011) Johann Almendinger et al.   PLoS One

SPK-1, an SR protein kinase, inhibits programmed cell death inCaenorhabditis elegans

(2011) Brendan D. Galvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4

(2010) Shiqian Qi et al.   CELL

Cell death specification inC. elegans

(2010) Erin Peden et al.   CELL CYCLE

Engulfment of Apoptotic Cells in C. elegans Is Mediated by Integrin α/SRC Signaling

(2010) Tsung-Yuan Hsu et al.   CURRENT BIOLOGY

Non-apoptotic cell death in Caenorhabditis elegans

(2010) Manolis Vlachos et al.   DEVELOPMENTAL DYNAMICS

ccz-1 mediates the digestion of apoptotic corpses in C. elegans

(2010) C. Nieto et al.   JOURNAL OF CELL SCIENCE

Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling

(2010) Nan Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

(2010) Lukas J. Neukomm et al.   NATURE CELL BIOLOGY

Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

(2010) Xiaochen Wang et al.   NATURE CELL BIOLOGY

Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans

(2010) T. Hirose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation

(2010) P. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

(2010) A. Nakagawa et al.   SCIENCE

Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling

(2010) D. Chen et al.   SCIENCE

The Wnt Pathway Controls Cell Death Engulfment, Spindle Orientation, and Migration through CED-10/Rac

(2010) Juan Cabello et al.   PLOS BIOLOGY

Genetic Control of Programmed Cell Death During Animal Development

(2009) Barbara Conradt   Annual Review of Genetics

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

(2009) X Geng et al.   CELL DEATH AND DIFFERENTIATION

C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5

(2009) W. Li et al.   DEVELOPMENT

Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery To Promote Apoptosis in Caenorhabditis elegans

(2009) Q. Shen et al.   MOLECULAR AND CELLULAR BIOLOGY

Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

(2009) Michael E Hurwitz et al.   PLOS BIOLOGY

Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells

(2009) Wei Zou et al.   PLoS Genetics

Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis

(2009) Mei Yang et al.   PLoS Genetics

C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells

(2008) Q. Lu et al.   DEVELOPMENT

C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis

(2008) S. Greiss et al.   GENES & DEVELOPMENT

The small GTPase Rab2 functions in the removal of apoptotic cells inCaenorhabditis elegans

(2008) Paolo M. Mangahas et al.   JOURNAL OF CELL BIOLOGY

SNX9 - a prelude to vesicle release

(2008) R. Lundmark et al.   JOURNAL OF CELL SCIENCE

Lysosome Biogenesis Mediated by vps-18 Affects Apoptotic Cell Degradation in Caenorhabditis elegans

(2008) Hui Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent of ced-9

(2008) David G. Breckenridge et al.   MOLECULAR CELL

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

(2008) Xin Geng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

Phagocytic Receptor CED-1 Initiates a Signaling Pathway for Degrading Engulfed Apoptotic Cells

(2008) Xiaomeng Yu et al.   PLOS BIOLOGY

Control of Apoptosis by Asymmetric Cell Division

(2008) Julia Hatzold et al.   PLOS BIOLOGY