Editorial Material
Cell Biology
Gregory M. Chen, Jan Joseph Melenhorst, Kai Tan
Summary: CAR T cell therapies targeting CD19 and CD22 have shown success in treating B cell cancers, but not in non-B cell cancers. The interaction between CAR T cells and normal B cells may play a crucial role in determining clinical CAR T cell responses.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden, R. Neal Smith, Ivy A. Rosales, Robert B. Colvin, Sarah Chute, Lynn D. Cornell, Sandra M. Herrmann, Riley Fadden, Ryan J. Sullivan, Nancy J. Yang, Sara Barmettler, Sophia Wells, Shruti Gupta, Alexandra-Chloe Villani, Kerry L. Reynolds, Jocelyn Farmer
Summary: Non-invasive biomarkers such as elevated sIL-2R level and flow cytometric markers of B and T cell dysregulation may aid in the diagnosis of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biology
Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang
Summary: The study utilized single-cell RNA sequencing to analyze the tumor immune microenvironment of ccRCC patients and found an increase in CD8(+) T cells and macrophages in tumor-infiltrated immune cells, as well as identified a proliferation subpopulation associated with the progression of ccRCC. Utilizing gene expression analysis, the study also demonstrated the ability to predict clinical outcomes and pathological diseases based on subcluster assignment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Li Huang, Xuedi Zhang, Junyu Fan, Xiaolei Liu, Shuhua Luo, Dianqing Cao, Youtan Liu, Zhengyuan Xia, Hanhui Zhong, Cuiping Chen, Liangqing Zhang, Zhifeng Liu, Jing Tang
Summary: This study found that EGFR can affect the activation and apoptosis of CD4+ T cells by promoting Glut1 transportation, leading to immune dysfunction in sepsis. The levels of EGFR and Glut1 expression and the activation levels of CD4+ T cells were significantly higher in sepsis patients compared to healthy individuals.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Oncology
Marit M. Melssen, Natasha D. Sheybani, Katie M. Leick, Craig L. Slingluff Jr
Summary: Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to intervene on these targets can be developed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Wenbin Zhou, Muxin Yu, Hong Pan, Wen Qiu, Hui Wang, Mengjia Qian, Nan Che, Kai Zhang, Xinrui Mao, Li Li, Ruoxi Wang, Hui Xie, Lijun Ling, Yi Zhao, Xiaoan Liu, Cong Wang, Qiang Ding, Shui Wang
Summary: Microwave ablation (MWA) has shown a high complete ablation rate for early-stage breast cancer and induced a shift in the Th1/Th2 balance towards Th1, along with stimulating antitumor immune response. This suggests that MWA may not only be a promising local therapy for breast cancer but also trigger antitumor immunity, offering new avenues for treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Shujuan Zhou, Fanyan Meng, Shiyao Du, Hanqing Qian, Naiqing Ding, Huizi Sha, Mei Zhu, Xiaoxiao Yu, Lifeng Wang, Baorui Liu, Jia Wei
Summary: The study introduced a novel bifunctional agent, iRGD-anti-CD3, to enhance T cell infiltration, activation, and cytotoxicity against target cancer cells. The modification significantly inhibited tumor growth and prolonged survival in xenograft mouse models, with additional improvement seen when combined with PD-1 blockade. Mechanistic studies revealed the potential of iRGD-anti-CD3 in promoting T cell extravasation through a transport pathway called vesiculovacuolar organelles in the endothelial cytoplasm.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Fisheries
Wei Liang, Kunming Li, Qian Zhang, Kang Li, Kete Ai, Jiansong Zhang, Xinying Jiao, Jiaqi Li, Xiumei Wei, Jialong Yang
Summary: This study investigates the role of interleukin-2 inducible T cell kinase (ITK) in the adaptive immune response of Nile tilapia and its regulation of T-cell activation. The results show that ITK plays a critical role in regulating T-cell activation in Nile tilapia and is involved in the lymphocyte-mediated adaptive immunity of fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michel Y. Braun
Summary: T cells, particularly T lymphocytes of the immune system, exhibit characteristics of proliferation and mobility in tissues and organs, requiring metabolic plasticity to fulfill their immune function. This review focuses on the various mechanisms that allow T cells to adapt their metabolism to different real-life circumstances, such as exiting quiescence, differentiating into effector cells, and participating in immune memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jane C. Stinchcombe, Yukako Asano, Christopher J. G. Kaufman, Kristin Bohlig, Christopher J. Peddie, Lucy M. Collinson, Andre Nadler, Gillian M. Griffiths
Summary: Cytotoxic T lymphocytes (CTLs) kill virus-infected and cancer cells through T cell receptor (TCR) recognition. Activation of TCR triggers the production of diacylglycerol (DAG) and shedding of activated TCRs into DAG-enriched ectosomes at the immune synapse, rather than internalization through endocytosis. The budding ectosomes are then endocytosed by target cells, terminating TCR signaling and disconnecting CTLs from target cells for serial killing. Ectocytosis therefore limits TCR signaling.
Article
Oncology
Nikos Kourtis, Qingqing Wang, Bei Wang, Erin Oswald, Christina Adler, Samvitha Cherravuru, Evangelia Malahias, Lance Zhang, Jacquelynn Golubov, Qiaozhi Wei, Samantha Lemus, Min Ni, Yueming Ding, Yi Wei, Gurinder S. Atwal, Gavin Thurston, Lynn E. Macdonald, Andrew J. Murphy, Ankur Dhanik, Matthew A. Sleeman, Scott S. Tykodi, Dimitris Skokos
Summary: This study maps the chromatin landscape of immune cells in patients with early-stage clear cell renal cell carcinoma (ccRCC) and identifies the association between NF-kappa B and dysfunction in CD8(+) T cells. Importantly, it provides a valuable resource for understanding the functional states and regulatory dynamics of immune cells in ccRCC.
Article
Immunology
Zhongxue Feng, Min Li, Aijia Ma, Luping Huang, Lingmiao Kong, Yan Kang, Zhenling Wang, Fei Xiao, Wei Zhang
Summary: Intermedin (IMD) protects immune cells from sepsis by repairing vascular endothelial junctions and inhibiting macrophage infiltration. IMD affects immune cell development, differentiation, and response to infection. It promotes T and B cell proliferation and differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Critical Care Medicine
Ya Wang, Anthony S. McLean
Summary: This article is one of the reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022, providing the latest information in the field. Other selected articles can be found online.
Article
Oncology
Sean Hammond, Anna Olsson-Brown, Joshua Gardner, Paul Thomson, Serat-E Ali, Carol Jolly, Dan Carr, Lorenzo Ressel, Munir Pirmohamed, Dean Naisbitt
Summary: This study presented a case of a patient who developed immune-related adverse reactions after receiving ICI treatment, with experimental confirmation of the potential interactions between ICIs and other medications. It underscores the importance of considering all concomitant medications in patients receiving ICIs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Juan Estrada, Jinghui Zhan, Petia Mitchell, Jonathan Werner, Pedro J. Beltran, Jason DeVoss, Jing Qing, Keegan S. Cooke
Summary: In a mouse tumor model, combination treatment with OncoVEX(mGM-CSF) and checkpoint inhibitors led to increased tumor growth inhibition, reduced lung metastases, and prolonged animal survival. OncoVEX(mGM-CSF) induced both neoantigen-specific and tumor antigen-specific T-cell responses. These findings suggest that the combination of T-VEC and checkpoint inhibition may be effective in treating patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Clinical Neurology
Chunyan Li, Timothy G. White, Kevin A. Shah, Wayne Chaung, Keren Powell, Ping Wang, Henry H. Woo, Raj K. Narayan
Summary: This study demonstrates that percutaneous electrical stimulation of the infraorbital branch of the trigeminal nerve (pTNS) can increase brain CGRP concentrations in a dose-dependent manner, producing controllable cerebral vasodilation. This vasodilatory response appears to be independent of the pressor response induced by pTNS, and can be maintained even after transection of the spinal cord or specific nerve administration.
Review
Immunology
William Royster, Ping Wang, Monowar Aziz
Summary: Siglec-G plays an important immunoregulatory role in B-1a cells and myeloid cells, contributing to the potential therapeutic approach in treating sepsis. A clear understanding of Siglec-G is crucial in developing novel therapeutics for sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nimisha Mathur, Syed F. Mehdi, Manasa Anipindi, Monowar Aziz, Sawleha A. Khan, Hema Kondakindi, Barbara Lowell, Ping Wang, Jesse Roth
Summary: Sepsis triggers widespread inflammation, illness, and death, leading to intensive research on causes and treatments. Ghrelin, an endogenous peptide with anti-inflammatory properties, stimulates growth hormone release and appetite while also inhibiting pro-inflammatory forces, showing promising results in preclinical animal models and potentially benefiting sepsis patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chuyi Tan, Bridgette Reilly, Alok Jha, Atsushi Murao, Yongchan Lee, Max Brenner, Monowar Aziz, Ping Wang
Summary: This study suggests that eCIRP is actively released from viable macrophages through GSDMD pores. Inhibition of GSDMD can reduce the release of eCIRP and potentially inhibit eCIRP-mediated inflammation in sepsis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Surgery
Sara Siskind, William Royster, Max Brenner, Ping Wang
Summary: Inhibiting the extracellular cold-inducible RNA-binding protein/triggering receptor expressed on myeloid cells-1 pathway with M3 attenuates acute kidney injury, indicating that M3 could be a potential therapeutic agent for treating acute kidney injury.
Article
Biochemistry & Molecular Biology
Satoshi Takizawa, Yongchan Lee, Asha Jacob, Monowar Aziz, Ping Wang
Summary: This study found that eCIRP induces trogocytosis of neutrophils during inflammation, and the trogocytosed neutrophils exhibit an exaggerated pro-inflammatory phenotype.
MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Colleen P. Nofi, Ping Wang, Monowar Aziz
Summary: This article focuses on a subgroup of endogenous molecules, known as chromatin-associated molecular patterns (CAMPs), which can be detected as foreign and trigger immune signaling pathways. The release of CAMPs from cells, their mechanism of action and downstream immune signaling pathways, as well as targeted therapeutic approaches to mitigate inflammation and tissue injury, are reviewed.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Kensuke Murata, Atsushi Murao, Monowar Aziz, Ping Wang
Summary: Neutrophil heterogeneity in sepsis is a significant factor, and the extracellular cold-inducible RNA-binding protein (eCIRP) regulates neutrophil phenotype and function through TLR4. This study found that eCIRP can induce CD112 expression in neutrophils, promoting Th1 differentiation in sepsis.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Cassie Shu Zhu, Xiaoling Qiang, Weiqiang Chen, Jianhua Li, Xiqian Lan, Huan Yang, Jonathan Gong, Lance Becker, Ping Wang, Kevin J. Tracey, Haichao Wang
Summary: The expression and secretion of procathepsin-L (pCTS-L) induced by serum amyloid A (SAA) contributes to its late and systemic accumulation in sepsis. Inhibition of pCTS-L interaction may be a potential antibody-based strategy to prevent dysregulated immune responses mediated by late-acting cytokines.
Article
Neurosciences
Archna Sharma, Ezgi Sari, Yongchan Lee, Shivani Patel, Max Brenner, Philippe Marambaud, Ping Wang
Summary: Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have been implicated in neurogenerative diseases. The current study investigates how eCIRP regulates the signaling pathways involved in calcium and calpain, and uncovers a novel mechanism involving Ca2+ release from ER stores in an IL-6R alpha/PLC/IP3-dependent manner.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Surgery
Molly Kobritz, Colleen Nofi, Maria Sfakianos, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151 has the potential to therapeutically reduce acute intestinal injury in sepsis.
Article
Medicine, Research & Experimental
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Summary: Extracellular cold-inducible RNA-binding protein (eCIRP) is a key factor in the severity and mortality of sepsis, which induces the formation of antigen-presenting aged neutrophils (APANs) through CD4+ T cell activation, Th1 polarization, and IFN-gamma-mediated hyper-NETosis. APANs exacerbate acute lung injury (ALI) and worsen the survival of septic animals. These findings highlight the role of eCIRP and APANs in sepsis pathogenesis and potential therapeutic targets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Physiology
Zhijian Hu, Fangming Zhang, Max Brenner, Asha Jacob, Ping Wang
Summary: Renal ischemia-reperfusion (RIR)-induced acute kidney injury (AKI) is a common renal disorder with high morbidity and mortality. STING is a signaling pathway that mediates inflammation and injury through cytosolic DNA activation. eCIRP, a damage-associated molecular pattern, activates STING and worsens hemorrhagic shock. H151, a small molecule, inhibits eCIRP-induced STING activation in vitro and protects against RIR-induced AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. F. Coppa, Monowar Aziz, Ping Wang
Summary: This study investigates the potential of a synthetic miRNA called PS-OMe miR130 in inhibiting eCIRP-mediated inflammation and acute lung injury in sepsis. The results show that PS-OMe miR130 has a strong binding affinity to eCIRP, decreases inflammatory proteins, and improves survival in a murine model of sepsis. This synthetic miRNA, with enhanced stability and protection from nuclease activity, holds promise as a novel therapeutic approach.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Mian Zhou, Monowar Aziz, Hao-Ting Yen, Gaifeng Ma, Atsushi Murao, Ping Wang
Summary: In this study, we identified a novel mechanism by which eCIRP impairs macrophage bacterial phagocytosis in sepsis. Increased eCIRP levels were associated with decreased bacterial clearance in infected mice. eCIRP inhibited actin remodeling in macrophages through the formation of a STAT3-beta PIX complex, resulting in phagocytic dysfunction. Inhibition of STAT3 rescued the macrophage phagocytic dysfunction induced by eCIRP.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)