HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer

Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial

(2015) Yoshinari Maeda et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE

(2015) Keita Saito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

(2015) Ling Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heat shock protein vaccines against glioblastoma: from bench to bedside

(2015) Leonel Ampie et al.   JOURNAL OF NEURO-ONCOLOGY

Dendritic-Tumor Fusion Cells Derived Heat Shock Protein70-Peptide Complex Has Enhanced Immunogenicity

(2015) Yunfei Zhang et al.   PLoS One

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis

(2015) Zhongbin Deng et al.   Nature Communications

The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells

(2015) Donatella Malanga et al.   Oncotarget

Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice

(2014) R. G. Newman et al.   BLOOD

Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells

(2014) Tsutomu Tanaka et al.   CANCER SCIENCE

Enhancement of Tumor-Specific T Cell-Mediated Immunity in Dendritic Cell-Based Vaccines by Mycobacterium tuberculosis Heat Shock Protein X

(2014) I. D. Jung et al.   JOURNAL OF IMMUNOLOGY

Functions of Heat Shock Proteins in Pathways of the Innate and Adaptive Immune System

(2014) Robert Julian Binder   JOURNAL OF IMMUNOLOGY

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

(2013) Hongliang Fang et al.   Cellular & Molecular Immunology

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

(2013) E. Lam et al.   JOURNAL OF VIROLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural characterization of a eukaryotic chaperone—the ribosome-associated complex

(2012) Christoph Leidig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient induction of a Her2-specific anti-tumor response by dendritic cells pulsed with a Hsp70L1–Her2341–456 fusion protein

(2011) Qiang Fu et al.   Cellular & Molecular Immunology

Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response

(2011) Hongliang Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies

(2011) Sabine Tischer et al.   Journal of Translational Medicine

The Chaperone Network Connected to Human Ribosome-Associated Complex

(2011) H. Jaiswal et al.   MOLECULAR AND CELLULAR BIOLOGY

Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells

(2011) T. Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

(2011) Sudesh Pawaria et al.   Nature Communications

Re-Examination of CD91 Function in GRP94 (Glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-Presentation

(2010) A. R. Jockheck-Clark et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Endogenous Heat Shock Protein 90 of Dendritic Cells in Antigen Cross-Presentation

(2010) T. Ichiyanagi et al.   JOURNAL OF IMMUNOLOGY

Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Delivers Heat Shock Protein 60-Fused Antigen into the MHC Class I Presentation Pathway

(2010) J. Xie et al.   JOURNAL OF IMMUNOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-Term Protection Against Human Papillomavirus E7-Positive Tumor by a Single Vaccination of Adeno-Associated Virus Vectors Encoding a Fusion Protein of Inactivated E7 of Human Papillomavirus 16/18 and Heat Shock Protein 70

(2009) Liqiao Zhou et al.   HUMAN GENE THERAPY

A Heat Shock Protein 70-Based Vaccine with Enhanced Immunogenicity for Clinical Use

(2009) Jianlin Gong et al.   JOURNAL OF IMMUNOLOGY

T Cell Activation by Heat Shock Protein 70 Vaccine Requires TLR Signaling and Scavenger Receptor Expressed by Endothelial Cells-1

(2009) J. Gong et al.   JOURNAL OF IMMUNOLOGY

Phase III Comparison of Vitespen, an Autologous Tumor-Derived Heat Shock Protein gp96 Peptide Complex Vaccine, With Physician's Choice of Treatment for Stage IV Melanoma: The C-100-21 Study Group

(2008) Alessandro Testori et al.   JOURNAL OF CLINICAL ONCOLOGY

Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity

(2008) Barbara Valentinis et al.   JOURNAL OF LEUKOCYTE BIOLOGY