Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Do glia drive synaptic and cognitive impairment in disease?

(2015) Won-Suk Chung et al.   NATURE NEUROSCIENCE

Prospects for genetically modified non-human primate models, including the common marmoset

(2015) Erika Sasaki   NEUROSCIENCE RESEARCH

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Heat shock response and homeostatic plasticity

(2015) Shanker Karunanithi et al.   Frontiers in Cellular Neuroscience

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Electrochemical Immunosensors for Effective Evaluation of Amyloid-Beta Modulators on Oligomeric and Fibrillar Aggregation Processes

(2014) Anthony J. Veloso et al.   ANALYTICAL CHEMISTRY

Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death

(2014) Sudhish Sharma et al.   CELL STRESS & CHAPERONES

Basal and stress-inducible expression of HSPA6 in human keratinocytes is regulated by negative and positive promoter regions

(2014) Vincent P. Ramirez et al.   CELL STRESS & CHAPERONES

Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins

(2014) Rayees U. H. Mattoo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS)

(2014) Lindsay Poppe et al.   EXPERIMENTAL NEUROLOGY

Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2

(2014) Longhe Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of apoptosis by heat shock proteins

(2014) Donna Kennedy et al.   IUBMB LIFE

Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress

(2014) Sam Khalouei et al.   JOURNAL OF NEUROCHEMISTRY

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Biological Activity of sym-Triazines with Acetylcholine-like Substitutions as Multitarget Modulators of Alzheimer’s Disease

(2013) Anthony J. Veloso et al.   ACS Chemical Neuroscience

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

Rodent models of amyotrophic lateral sclerosis

(2013) Philip McGoldrick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Moving forward in clinical trials for ALS: motor neurons lead the way please

(2013) Barış Genç et al.   DRUG DISCOVERY TODAY

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease

(2013) Bong-Suk Choi et al.   NEUROCHEMICAL RESEARCH

The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

(2013) D. Jantas et al.   NEUROTOXICITY RESEARCH

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

(2013) Bernadett Kalmar et al.   PHARMACOLOGY & THERAPEUTICS

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

sym-Triazines for Directed Multitarget Modulation of Cholinesterases and Amyloid-β in Alzheimer’s Disease

(2012) Anthony J. Veloso et al.   ACS Chemical Neuroscience

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines

(2012) Shivaprasad H. Venkatesha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

(2012) John Labbadia et al.   BRAIN

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease

(2012) Bert A. ’t Hart et al.   DRUG DISCOVERY TODAY

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis

(2012) Petra Dunkel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents

(2011) Kwong-Fai Wong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B′, in differentiated human neuronal cells

(2010) Ari M. Chow et al.   CELL STRESS & CHAPERONES

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

(2010) Daniel Paris et al.   Journal of Neuroinflammation

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future

(2010) Anthony E Lang   NATURE MEDICINE

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated fromCelastrus regelii

(2009) D. H. Kim et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Surface expression of Hsp70B’ in response to proteasome inhibition in human colon cells

(2008) Emily J. Noonan et al.   CELL STRESS & CHAPERONES

Hsp70B′ and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection☆

(2008) E NOONAN et al.   EXPERIMENTAL CELL RESEARCH

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

(2008) Bernadett Kalmar et al.   JOURNAL OF NEUROCHEMISTRY

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY