Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

(2011) Guozhu Chen et al.   BMC CANCER

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

(2011) Srikumar M. Raja et al.   CANCER BIOLOGY & THERAPY

Celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression

(2011) Yoonseo Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules

(2011) Haeng Ran Seo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways

(2011) Jorn Markus Schattenberg et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways

(2011) Haibo Mou et al.   TOXICOLOGY IN VITRO

Celastrol Attenuates Hypertension-Induced Inflammation and Oxidative Stress in Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1

(2010) X. Yu et al.   AMERICAN JOURNAL OF HYPERTENSION

End of life in cancer patients: drugs or words?

(2010) E. Aitini et al.   ANNALS OF ONCOLOGY

RNA polymerase – An important molecular target of triptolide in cancer cells

(2010) Jingxuan Pan   CANCER LETTERS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Explaining Marginal Benefits to Patients, When "Marginal" Means Additional but Not Necessarily Small

(2010) T. J. Smith et al.   CLINICAL CANCER RESEARCH

Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells

(2010) Hee-Sun Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway

(2010) Kim   INTERNATIONAL JOURNAL OF ONCOLOGY

Male infertility in cancer patients: Review of the literature

(2010) Gert R Dohle   INTERNATIONAL JOURNAL OF UROLOGY

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters

(2009) Ke Hao et al.   BMC CANCER

Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation

(2009) Feng Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

(2009) J.J.E.M. Kitzen et al.   EUROPEAN JOURNAL OF CANCER

Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated fromCelastrus regelii

(2009) D. H. Kim et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

(2009) Dae Yong Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

(2009) Zhipeng Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Tripchlorolide protects neuronal cells from microglia-mediated β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

(2009) Xiao-Dong Pan et al.   GLIA

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma

(2009) Ling Xiao Liu et al.   HEPATOLOGY

Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine Receptors

(2009) Sara M. Johnson et al.   JOURNAL OF SURGICAL RESEARCH

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics

(2009) Kwong-Fai Wong et al.   PROTEIN AND PEPTIDE LETTERS

Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: Pathogenesis and therapeutic implications

(2009) Kwong L Chan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia

(2008) Xiao-dong Pan et al.   BIOCHEMICAL PHARMACOLOGY

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

(2008) B. Z. Carter et al.   BLOOD

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

(5R)-5-hydroxytriptolide inhibits the immune response of human peripheral blood mononuclear cells

(2008) Ru Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Therapeutic effect of tripterine on adjuvant arthritis in rats

(2008) Hong Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

BCR/ABL, DNA damage and DNA repair: Implications for new treatment concepts

(2008) Tomasz Skorski   LEUKEMIA & LYMPHOMA

IMMUNOCHEMICAL CHARACTERIZATION OF THE FUNCTIONAL CONSTITUENTS OFTRIPTERYGIUM WILFORDIICONTRIBUTING TO ITS ANTI-INFLAMMATORY PROPERTY

(2007) Kwong-Fai Wong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY