Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Roozbeh Akhavanfar, Seyyed-Ghavam Shafagh, Behnood Mohammadpour, Yalda Farahmand, Mohammad Hassan Lotfalizadeh, Keihan Kookli, Ali Adili, Goli Siri, Seyed Mahmoud Eshagh Hosseini
Summary: Gastric cancer is a prevalent malignancy worldwide, with poor prognosis and management despite therapeutic advances. The Wnt/beta-catenin pathway is an important target for gastric cancer treatment. Non-coding RNAs play crucial roles in gene regulation and are involved in signaling pathways such as Wnt/beta-catenin. Understanding the role of these regulatory molecules in gastric cancer development may lead to the identification of potential therapeutic targets.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Hongqi Wang, Peng Zhang
Summary: The study revealed that CASC15 is highly expressed in OS patients and cell lines, promoting cell proliferation and migration while affecting the cell cycle through the activation of the Wnt/beta-catenin pathway. Overexpression of CASC15 in OS cells led to increased metastasis both in vivo and in vitro, with a direct impact on the Wnt pathway and subsequent epithelial-mesenchymal transition.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Immunology
Yating Wen, Fangzhen Luo, Lanhua Zhao, Shengmei Su, Wenbo Lei, Yi Liu, Keliang Shi, Zhongyu Li
Summary: During Ct infection, upregulating FGD5-AS1 affects DNA replication and apoptosis of host cells through the Wnt/beta-catenin pathway, indicating the involvement of lncRNAs in the interaction between Ct and hosts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Pin Lv, Yuan Xue
Summary: The study identified the expression level of LINC01638 in papillary thyroid carcinoma (PTC) and its role in PTC progression. It was found that LINC01638 regulates PTC progression by inhibiting the Wnt/beta-catenin pathway and activating Axin2.
Review
Medicine, Research & Experimental
Madineh Mazarei, Venus Shahabi Rabori, Nazila Ghasemi, Mehrnaz Salehi, Najmeh Rayatpisheh, Negin Jahangiri, Mohammadreza Saberiyan
Summary: Scientific advancements have contributed to a reduction in cancer-related fatalities, and lncRNA serves as an innovative therapeutic approach in gene expression regulation. MALAT1, a significant lncRNA, is associated with several human disorders and studying its functional roles in cancer metastasis and its interactions with cellular signaling pathways has promising implications for cancer treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biology
Hao Lyu, Jiahui Zhang, Qian Wei, Yuan Huang, Rui Zhang, Shuai Xiao, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Summary: This study identified 45 prognostic genes significantly associated with the overall survival of pancreatic adenocarcinoma (PAAD) patients and constructed a prognostic model based on six autophagy- and Wnt/beta-catenin-related lncRNAs. It provides a basis for understanding the pathogenesis of PAAD and reveals a potential prognostic indicator.
Review
Neurosciences
Ali Ghasemi, Zohreh Qaffaripour, Mehdi Tourani, Kiarash Saleki, Nasim Rahmani-Kukia, Seyyed Hossein Khatami, Mortaza Taheri-Anganeh
Summary: Long non-coding RNAs (lncRNAs) play important roles in cell biology despite their inability to code proteins. They have been found to be dysregulated in various disorders, including Alzheimer's disease (AD). By modulating signaling pathways, particularly the Wnt/β-catenin pathway, lncRNAs can exacerbate or improve AD. This article discusses the mechanisms by which lncRNAs alter Wnt/β-catenin signaling and highlights its potential as a new aspect for diagnosing and treating AD.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Jie Xu, Xiaoyan Deng, Xiangmei Wu, Huifang Zhu, Yinghua Zhu, Jie Liu, Qian Chen, Chengfu Yuan, Geli Liu, Changdong Wang
Summary: This study found that gastric cancer may cause bone damage prior to bone metastasis, possibly through cilia-dependent activation of the Wnt/beta-catenin signaling pathway as indicated by clinical evidence and mouse model experiments.
Article
Pathology
Zhenyou Feng, Huiming Ding, Zhiwei Peng, Kongwang Hu
Summary: This study investigated the relationship between KDM6A expression and patient prognosis, as well as the role of KDM6A in GC development. Immunohistochemical analysis of 107 GC patients' tumors revealed that reduced KDM6A expression was associated with shorter survival time. In vitro tests showed that KDM6A gene suppression inhibited GC cell proliferation, migration, and invasion, while high KDM6A expression promoted these processes. The study also found that KDM6A down-regulation affected the expression of various proteins involved in Wnt/beta-catenin signaling and EMT, and blocking this pathway reversed the aggressive behavior of low KDM6A-expressing GC cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Hashem O. Alsaab
Summary: Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal cell characteristics, allowing metastatic cells to migrate and invade. Recent studies have shown a connection between the EMT process and Wnt/ll-catenin signaling in cancer. Upregulation of the Wnt/ll-catenin pathway leads to EMT, while non-coding RNAs, including miRNAs and lncRNAs, are involved in regulating this pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Liang Ma, Wenyue Yan, Xingwei Sun, Ping Chen
Summary: The study demonstrates that VPS9D1-AS1 is significantly upregulated in esophageal squamous cell carcinoma (ESCC), correlating with poor prognosis in patients. VPS9D1-AS1 can promote tumor progression and may serve as a potential biomarker for ESCC diagnosis.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
