Article
Nutrition & Dietetics
Anthony A. Xu, Luke K. Kennedy, Kristi Hoffman, Donna L. White, Fasiha Kanwal, Hashem B. El-Serag, Joseph F. Petrosino, Li Jiao
Summary: This study investigated the impact of dietary fatty acid intake on gut microbiota composition and structure. The results showed that different types of fatty acid intake were associated with significant differences in the β diversity of gut bacteria. Specific bacteria such as Sutterella, Tyzzerella, and Fusobacterium were found to have a significant correlation with fatty acid intake.
Article
Immunology
Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana
Summary: The composition of early-life gut microbial communities in nursery-reared rhesus macaques is influenced by age, birth year, and vaccination status. The study identified a positive correlation between certain microbial species, such as Sutterella and Rodentibacter, and vaccine-elicited antibody responses. Metagenomic analysis revealed metabolic pathways associated with improved antibody responses following HIV vaccination. The findings suggest a bidirectional relationship between the microbiota and vaccines, highlighting the importance of understanding this interplay in developing more effective vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Caijun Zhao, Xiaoyu Hu, Min Qiu, Lijuan Bao, Keyi Wu, Xiangyue Meng, Yihong Zhao, Lianjun Feng, Shiyu Duan, Yuhong He, Naisheng Zhang, Yunhe Fu
Summary: This study demonstrates that gut microbiota disturbance caused by metabolic abnormalities of gut microbiota is associated with the occurrence and development of mastitis. The underlying mechanism of how gut dysbiosis leads to mastitis pathogenesis remains unclear. Additionally, the regulation of commensal bacteria and gut metabolism may provide a potential strategy for mastitis intervention.
Editorial Material
Microbiology
Nicolas Benech, Nathalie Rolhion, Harry Sokol
Summary: This study demonstrates a new mechanism by which bacteria can control intestinal motility and vagal neuronal activation through tryptophan catabolites acting on the TrpA1 receptor of enteroendocrine cells.
CELL HOST & MICROBE
(2021)
Review
Food Science & Technology
Zongxin Ling, Xia Liu, Yiwen Cheng, Xiumei Yan, Shaochang Wu
Summary: The altered assembly, structure and dynamics of the gut microbiota actively participate in the aging process, affecting healthy aging and age-associated diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Taichi A. Suzuki, J. Liam Fitzstevens, Victor T. Schmidt, Hagay Enav, Kelsey E. Huus, Mirabeau Mbong Ngwese, Anne Griesshammer, Anne Pfleiderer, Bayode R. Adegbite, Jeannot F. Zinsou, Meral Esen, Thirumalaisamy P. Velavan, Ayola A. Adegnika, Le Huu Song, Timothy D. Spector, Amanda L. Muehlbauer, Nina Marchi, Hyena Kang, Lisa Maier, Ran Blekhman, Laure Segurel, GwangPyo Ko, Nicholas D. Youngblut, Peter Kremsner, Ruth E. Ley
Summary: The gut microbiomes of human populations worldwide have common core microbial species. However, within a species, certain strains show population specificity. This study suggests that humans and their gut microbes have experienced parallel evolutionary history, and specific microbial strains may play a crucial role in microbiome-mediated disease phenotypes.
Editorial Material
Medicine, Research & Experimental
Anusha Jayaraman, Sven Pettersson
Summary: Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease. The gut-muscle axis hypothesis suggests that communication between the gut microbiota and muscular system regulates muscular function and may be disrupted in muscular disorders. Unhealthy microbiota profiles caused by excessive sugar and lipid-rich processed food consumption can be reversed by personalized dietary changes, which not only alter the microbiota composition but also reset the production of beneficial microbial metabolites associated with prolonged health span. Recent studies highlight the potential of microbiota-informed dietary interventions in genetically linked muscle disorders like DMD.
EMBO MOLECULAR MEDICINE
(2023)
Review
Microbiology
Ganggang Chen, Fenglei Shi, Wei Yin, Yao Guo, Anru Liu, Jiacheng Shuai, Jinhao Sun
Summary: Alcohol use disorder (AUD) disrupts the gut barrier and alters gut microbiota composition, leading to impaired brain function and worsening mental status of patients. This review explores the potential mechanisms by which alcohol affects gut and brain function through the gut microbiota and discusses the regulation of neurotransmitter release. Fecal microbiota transplantation could be a potential intervention for alcohol addiction.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Bingqian Zhou, Xiaoqi Pang, Jingyi Wu, Tianyu Liu, Bangmao Wang, Hailong Cao
Summary: The COVID-19 epidemic is a global health threat with gastrointestinal symptoms being common manifestations. Alterations in the gut microbiota are associated with COVID-19 progression and severity, as well as post-COVID-19 syndrome. Therapeutic strategies such as diet, probiotics/prebiotics, herb, and fecal microbiota transplantation have shown positive effects. Understanding the connections between gut microbiota and COVID-19 could provide new insights for COVID-19 management in the future.
Review
Medicine, Research & Experimental
Nidhi Singh, Veer Singh, Sachchida Nand Rai, Vishal Mishra, Emanuel Vamanu, Mohan P. Singh
Summary: The central nervous system plays an essential role in regulating the physiological condition of the human body. Gut microbes can affect brain function by releasing neuroactive metabolites, and they also play a role in neurological diseases. The microbiota-gut-brain axis serves as a communication pathway between the gut and brain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Microbiology
Gael Urait Varela-Trinidad, Carolina Dominguez-Diaz, Karla Solorzano-Castanedo, Liliana Iniguez-Gutierrez, Teresita De Jesus Hernandez-Flores, Mary Fafutis-Morris
Summary: The gut microbiota, consisting of billions of microorganisms in the gastrointestinal tract, plays a significant role in the host's immunity and nutrient absorption. It interacts not only with the gut but also with other extraintestinal organs. Dysbiosis of the gut microbiota is a critical factor in the pathogenesis of various diseases. Probiotics can intervene in maintaining the balance of the gut microbiota, thereby promoting individual health.
Review
Pharmacology & Pharmacy
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler
Summary: Colorectal cancer is a complex condition caused by a combination of environmental, genetic, and epigenetic factors, with disruptions in gut microbiota structure associated with various intestinal diseases, including cancer. Bacteria can induce cellular transformation and promote tumor progression through mechanisms such as biofilm formation and genotoxin secretion. The gut microbiota is also involved in drug metabolism, radiotherapy responses, and targeted immunotherapy, with therapy efficacy varying based on the composition of the host's gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ecology
Alan Emanuel Silva Cerqueira, Tobin J. Hammer, Nancy A. Moran, Weyder Cristiano Santana, Maria Catarina Megumi Kasuya, Cynthia Canedo da Silva
Summary: A study on Brazilian stingless bees revealed that they lack common bacterial symbionts Snodgrassella and Gilliamella found in other social corbiculate bees, instead harboring more environmental bacteria and bee-specific Starmerella yeasts. This indicates ecological shifts or acquisition of new symbionts as functional replacements in the stingless bees.
Article
Chemistry, Applied
Shanlong Tang, Yuxia Chen, Fuli Deng, Xiaowei Yan, Ruqing Zhong, Qingshi Meng, Lei Liu, Yong Zhao, Sheng Zhang, Liang Chen, Hongfu Zhang
Summary: XOS enhances gut barrier and modulates gut immunity by optimizing gut microbiota and their metabolites, with effects including suppressing pro-inflammatory cytokines, increasing beneficial microbes, and altering biological processes in gut cells.
CARBOHYDRATE POLYMERS
(2022)
Review
Immunology
Kazuma Yagi, Nobuhiro Asai, Gary B. Huffnagle, Nicholas W. Lukacs, Wendy Fonseca
Summary: Several environmental factors can impact the development of early-life microbiota, which in turn affects the occurrence of respiratory tract infections and diseases. The role of gut and lung microbiota in airway diseases, particularly in the context of respiratory syncytial virus (RSV) infection, is of increasing interest.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mingjuan Luo, Mengyang Tang, Feng Jiang, Yizhen Jia, Robert Kien Howe Chin, Wei Liang, Hu Cheng
Summary: ICP is associated with an increased risk of preeclampsia, cesarean section, and preterm birth, while treatment with UDCA can reduce the rate of preterm birth.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2021)
Article
Endocrinology & Metabolism
Y. Li, L. Jin, J. Yan, Y. Huang, H. Zhang, R. Zhang, C. Hu
Summary: The study found that serum TSK levels were lower in obese subjects compared to controls, but in obese individuals, TSK was positively correlated with BMI, visceral fat area, and deterioration of glucose metabolism. A genetic locus (rs11236956) was identified to be associated with TSK levels and metabolic traits in obese subjects and the total population.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Hanrui Yin, Feixiang Yuan, Fuxin Jiao, Yuguo Niu, Xiaoxue Jiang, Jiali Deng, Yajie Guo, Shanghai Chen, Qiwei Zhai, Cheng Hu, Yiming Li, Feifan Guo
Summary: Intermittent leucine deprivation (ILD) leads to long-lasting improvements in insulin sensitivity by increasing hepatic GCN2 expression and reducing DNA methylation, and also improves insulin sensitivity in insulin-resistant mice.
Article
Endocrinology & Metabolism
Wei Liu, Chao Sun, Ying Yan, Hongchao Cao, Zhoumin Niu, Siyi Shen, Shengnan Liu, Yuting Wu, Yan Li, Lijian Hui, Yuying Li, Lin Zhao, Cheng Hu, Qiurong Ding, Jingjing Jiang, Hao Ying
Summary: This study uncovers the effects of hepatic p38 activation on systemic metabolism and provides new insights into the pathogenesis of nonalcoholic fatty liver disease.
Article
Biochemistry & Molecular Biology
Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng, Jiqiu Wang, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma
Summary: This study discovered that local hyperthermia therapy promotes the activation of beige fat and offers a promising strategy against obesity via the HSF1-A2B1 transcriptional axis.
Article
Endocrinology & Metabolism
Jie Xu, Li Jin, Jie Chen, Rong Zhang, Hong Zhang, Yangyang Li, Danfeng Peng, Yunjuan Gu, Michael B. Wheeler, Cheng Hu
Summary: This study aimed to investigate the genetic effects of key genes involved in IAPP processing and degradation pathway on T2DM risk and metabolic traits in Chinese population. The results showed that common variants in these genes were significantly associated with T2DM and related traits. Additionally, there was a significant interaction between SLC30A8 and IAPP in patients with T2DM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Xiangnan Fang, Li Jin, Mengyang Tang, Wenqian Lu, Siyu Lai, Rong Zhang, Hong Zhang, Feng Jiang, Mingjuan Luo, Cheng Hu
Summary: This study examined the association between single-nucleotide polymorphisms (SNPs) confirmed for diabetes and obesity and the risk of gestational diabetes mellitus (GDM) by constructing a genetic risk score (GRS). The results showed that SNPs in the MTNR1B and CDKAL1 genes were strongly associated with GDM risk. The GRS based on SNPs associated with GDM, as well as those associated with obesity/waist-to-hip ratio (WHR)/body mass index (BMI), were also found to be positively associated with GDM risk. Overall, the findings suggest that GDM may share a common genetic background with type 2 diabetes and obesity, and SNPs associated with insulin secretion defects play a vital role in the development of GDM.
Article
Endocrinology & Metabolism
Mayina Kahaer, Bei Zhang, Wujin Chen, Meiting Liang, Yi He, Miao Chen, Rui Li, Tingting Tian, Cheng Hu, Yuping Sun
Summary: The TyG index was found to have a stronger association with HUA and better predictive ability compared to obesity indices, especially in males and females. The study also revealed that the TyG index had a higher AUC value in males, while the visceral obesity index CMI showed the highest AUC value in females.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jie Xu, Li Jin, Yi Sun, Rong Zhang, Xianghui Chen, Ranran Zhou, Yunjuan Gu, Cheng Hu
Summary: The study revealed a significant association between serum 12(S)-HETE and diabetic kidney disease (DKD) and disease severity, suggesting its potential use as a biomarker for early diagnosis of DKD.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Medicine, General & Internal
Mingjuan Luo, Jingyi Guo, Wenqian Lu, Xiangnan Fang, Rong Zhang, Mengyang Tang, Qiong Luo, Wei Liang, Xiangtian Yu, Cheng Hu
Summary: Gestational diabetes mellitus (GDM) is a common complication of pregnancy with adverse effects on both pregnant women and newborns. This study confirmed triglyceride and total cholesterol as independent risk factors for adverse pregnancy outcomes in GDM patients. Several key metabolites were identified as potential biomarkers for adverse pregnancy outcomes, shedding new light on the pathology of GDM.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ningning Bai, Xuhong Lu, Li Jin, Miriayi Alimujiang, Jingyuan Ma, Fan Hu, Yuejie Xu, Jingjing Sun, Jun Xu, Rong Zhang, Junfeng Han, Cheng Hu, Ying Yang
Summary: CLSTN3 gene is routinely expressed in human white adipose tissue (WAT), predominantly enriched in the adipocyte fraction. The variant rs7296261 in the CLSTN3 locus is associated with a high risk of obesity, and its risk allele is linked to an increase in CLSTN3 expression in human WAT. Overexpression of CLSTN3 in inguinal WAT of mice results in dysfunctional expansion, liver steatosis, and systemic metabolic deficiency.
MOLECULAR METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Shiyun Wang, Zixuan Deng, Hong Zhang, Rong Zhang, Dandan Yan, Xiaojiao Zheng, Weiping Jia, Cheng Hu
Summary: Hp genotype affects the association between DDAH 1 rs233109 and diabetic macroangiopathy in Chinese patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing Yan, Yuemei Zhang, Hairong Yu, Yicen Zong, Daixi Wang, Jiangfei Zheng, Li Jin, Xiangtian Yu, Caizhi Liu, Yi Zhang, Feng Jiang, Rong Zhang, Xiangnan Fang, Ting Xu, Mingyu Li, Jianzhong Di, Yan Lu, Xinran Ma, Jian Zhang, Weiping Jia, Cheng Hu
Summary: This study reveals that GPSM1 is genetically associated with T2D and obesity. The authors demonstrate that myeloid GPSM1 promotes metabolic inflammation and accelerates T2D and obesity development. They also identify a small molecule compound that inhibits GPSM1 function, potentially making it a candidate for metabolic therapy.
NATURE COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Mingwei Guo, Jing Yao, Jin Li, Jun Zhang, Dongmei Wang, Hui Zuo, Yi Zhang, Bo Xu, Yinzhao Zhong, Fei Shen, Jian Lu, Shuzhe Ding, Cheng Hu, Lingyan Xu, Junjie Xiao, Xinran Ma
Summary: This study aims to investigate the changes of Fndc5/irisin in skeletal muscles during aging and whether irisin administration could improve age-associated sarcopenia and metabolic dysfunction. The results showed that the expression levels of irisin and its precursor Fndc5 were reduced in aging skeletal muscles. Furthermore, administration of recombinant irisin protein improved sarcopenia and relieved age-associated metabolic diseases. This study revealed the importance of irisin in muscle physiology and energy homeostasis during aging and suggested a potential therapeutic strategy against age-associated metabolic diseases through irisin administration.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Medicine, General & Internal
Wenqian Lu, Cheng Hu
Summary: This review summarizes recent studies on biomolecules associated with GDM and postpartum diabetes, focusing on their predictive value in screening and diagnosis.
CHINESE MEDICAL JOURNAL
(2022)
