Article
Plant Sciences
Elaine da Silva Siqueira, Virginia Marcia Concato, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Idessania Nazareth Costa, Waldiceu Aparecido Verri Junior, Wander Rogerio Pavanelli, Carolina Panis, Mario Sergio Mantovani, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa
Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.
Article
Oncology
Md Gulam Musawwir Khan, Nadia Boufaied, Mehdi Yeganeh, Rajani Kandhi, Stephanie Petkiewicz, Ankur Sharma, Akihiko Yoshimura, Gerardo Ferbeyre, David P. Labbe, Sheela Ramanathan, Subburaj Ilangumaran
Summary: The SOCS1 protein protects liver cells from becoming cancerous and its deficiency increases susceptibility to liver cancer. CDKN1A is a protein that can protect against liver cancer but under certain circumstances, it can promote cancer growth. Our findings show that SOCS1 suppresses the expression of CDKN1A, preventing liver cells from withstanding the stress associated with cancer growth. This pathway could be targeted for therapeutic strategies in SOCS1-deficient liver cancers.
Article
Cell & Tissue Engineering
Mito Kanatsu-Shinohara, Honda Naoki, Takashi Tanaka, Misako Tatehana, Takako Kikkawa, Noriko Osumi, Takashi Shinohara
Summary: The Trp53 tumor suppressor gene, in conjunction with Cdkn1a, limits genetic diversity in germline transmission patterns. Trp53 or Cdkn1a deficiency results in the production of transgenic offspring in a random pattern with increased genetic diversity.
Article
Oncology
Xun Wu, Yi-Shing Lisa Cheng, Mathew Matthen, Angela Yoon, Gary K. Schwartz, Shashi Bala, Alison M. Taylor, Fatemeh Momen-Heravi
Summary: miR-34a directly targets MET and acts as a tumor suppressor in HNSCC by inhibiting HNSCC cell proliferation. Administration of LNA-miR-34a reduces HNSCC cell proliferation and tumor burden, suppresses immunosuppressive effects in the tumor microenvironment, and increases the frequency of Th1 cells and CD8 naive T cells in HNSCC patient samples.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sari Assaf, Dan Vodo, Kiril Malovitski, Janan Mohamad, Shir Bergson, Yarden Feller, Liron Malki, Ofer Sarig, Eli Sprecher
Summary: Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous blistering disease caused by autoantibodies against desmoglein (DSG)3. ST18 overexpression and DSG3 down-regulation are associated with PV. Moreover, DSG3 down-regulation enhances p53 function. These findings provide potential molecular targets for PV treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Michael R. Murphy, Anthony Ramadei, Ahmet Doymaz, Sophia Varriano, Devorah M. Natelson, Amy Yu, Sera Aktas, Marie Mazzeo, Michael Mazzeo, George Zakusilo, Frida E. Kleiman
Summary: Alternative polyadenylation (APA) is a mechanism for dynamic changes in gene expression. In this study, we identified a DDR-activated APA event in CDKN1A gene, which leads to the production of a lncRNA called SPUD. SPUD regulates p21 expression post-transcriptionally through its interaction with p21 translational regulators. This finding highlights the importance of lncRNAs in DDR progression and cell-cycle.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
N. Akhter, S. A. Dar, S. Haque, M. Wahid, A. Jawed, S. Akhtar, R. A. Alharbi, A. A. A. Sindi, A. Alruwetei, H. M. Zubair Choudhry, A. Ahmad
Summary: Individuals with SNPs in p21, p53, and CCND1 genes were found to be more susceptible to developing breast cancer. The study highlights the importance of combining analysis of low-penetrance mutant alleles to accurately assess their association with breast cancer risk. Future research on gene-environment interactions in different populations may further confirm these findings.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michele Mannelli, Bianca Bartoloni, Giulia Cantini, Elena Nencioni, Francesca Magherini, Michaela Luconi, Alessandra Modesti, Tania Gamberi, Tania Fiaschi
Summary: Cachexia worsens the quality of life and treatment outcomes of oncologic patients. The secretome from colon carcinoma CT26 induces cachectic features in adipocytes, leading to metabolic alterations. The STAT3 signaling cascade is responsible for these changes in lactate dehydrogenase and adiponectin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Giorgia Giordani, Valeria Cavaliere, Giuseppe Gargiulo, Giovanna Lattanzi, Davide Andrenacci
Summary: The transposon theory of aging suggests that the activation of transposable elements (TEs) in somatic tissues leads to a shortened lifespan. Studies have found that regulation of TEs changes during aging, with a decrease in middle-aged adults and reactivation in older individuals, indicating dynamic regulation of TEs throughout the lifespan.
Review
Genetics & Heredity
Mohsen Rashid, Leila Rostami Zadeh, Behzad Baradaran, Ommoleila Molavi, Zeinab Ghesmati, Mehdi Sabzichi, Fatemeh Ramezani
Summary: Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays a crucial role in cancer progression, functioning differently in cells depending on oxygen levels. Targeting HIF-1 alpha and its downstream signaling molecules is a potential strategy for modulating cancer development and progression. Inhibitors of HIF-1 alpha and agents that suppress mTOR, PI3k/Akt, and MAPK pathways could be effective in cancer treatment.
Article
Chemistry, Multidisciplinary
Huan Tan, Gustavo Castro, Jike Lyu, Pablo Loza-Alvarez, Florencio Sanchez, Josep Fontcuberta, Ignasi Fina
Summary: This study takes advantage of the built-in asymmetry at ferroelectric/electrode interfaces to achieve polarization reversal under illumination, and demonstrates the ability to optically control the resistance states in a ferroelectric capacitor.
MATERIALS HORIZONS
(2022)
Article
Biochemistry & Molecular Biology
Enjiang Chen, Enliang Li, Hao Liu, Yue Zhou, Liang Wen, Jianxin Wang, Yi Wang, Longyun Ye, Tingbo Liang
Summary: The study demonstrates that miR-26b enhances the sensitivity of HCC cells to doxorubicin, providing a potential therapeutic pathway involving the modulation of de-ubiquitination of p53 and regulation of autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Amer Ali Abd El-Hafeez, Nina Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy, Pranavi Chamarthi, Navin Rajapakse, Soumita Das, Kathryn E. Luker, Tapas K. Hazra, Gary D. Luker, Pradipta Ghosh
Summary: Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs via one of the two competing pathways, i.e., non-homologous end-joining (NHEJ) or homologous recombination (HR). We show that cell fate after DSBs hinges on GIV/Girdin, a guanine nucleotide-exchange modulator of heterotrimeric Gi alpha center dot beta gamma protein. GIV suppresses HR by binding and sequestering BRCA1, a key coordinator of multiple steps within the HR pathway, away from DSBs; it does so using a C-terminal motif that binds BRCA1's BRCT-modules via both phospho-dependent and -independent mechanisms. Using another non-overlapping C-terminal motif GIV binds and activates Gi and enhances the freeGb gamma -> PI-3-kinase -> Akt pathway, which promotes survival and is known to suppress HR, favor NHEJ. Absence of GIV, or loss of either of its C-terminal motifs enhanced cell death upon genotoxic stress. Because GIV selectively binds other BRCT-containing proteins suggests that G-proteins may fine-tune sensing, repair, and survival after diverse types of DNA damage.
Review
Biology
Julian M. Rozenberg, Svetlana Zvereva, Aleksandra Dalina, Igor Blatov, Ilya Zubarev, Daniil Luppov, Alexander Bessmertnyi, Alexander Romanishin, Lamak Alsoulaiman, Vadim Kumeiko, Alexander Kagansky, Gerry Melino, Carlo Ganini, Nikolai A. Barlev
Summary: During oncogenesis, cells undergo unrestricted proliferation, altering tissue homeostasis and possibly due to dysregulation of p53 family proteins p63 and p73. While p63 and p73 can compensate for loss of p53 in some cases, their overlap with p53 functions is strongest in regulating p53-dependent gene expression. Surprisingly, p73 is rarely lost or mutated in cancers, with its inactive isoforms often overexpressed and promoting cancer growth by repressing cell death mediated by p73.
Article
Nanoscience & Nanotechnology
Yufen Han, Jiaqian Li, Xiaojin Zhang, Fan Xia, Yu Dai
Summary: Poly(N-isopropylacrylamide)-anchored gold nanoparticles were prepared through host-guest interaction, allowing reversible regulation of catalytic activity by controlling temperature and light irradiation.
Article
Biochemistry & Molecular Biology
Furqan Sami, Xing Lu, Swetha Parvathaneni, Rabindra Roy, Ronald K. Gary, Sudha Sharma
BIOCHEMICAL JOURNAL
(2015)
Article
Biochemical Research Methods
Derek A. Jensen, Ronald K. Gary
JOURNAL OF CHROMATOGRAPHY A
(2015)
Article
Biotechnology & Applied Microbiology
Furqan Sami, Ronald K. Gary, Yayin Fang, Sudha Sharma
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2016)
Article
Biology
Ata Ur Rahman Mohammed Abdul, Bhagya De Silva, Ronald K. Gary
Article
Biochemistry & Molecular Biology
Swapna R. Mudireddy, Ataur Rahman Mohammed Abdul, Priyatham Gorjala, Ronald K. Gary
Review
Clinical Neurology
Jeffrey L. Cummings, Sarah J. Banks, Ronald K. Gary, Jefferson W. Kinney, Joseph M. Lombardo, Ryan R. Walsh, Kate Zhong
Article
Multidisciplinary Sciences
Mary G. Johlfs, Priyatham Gorjala, Yasuyo Urasaki, Thuc T. Le, Ronald R. Fiscus
Article
Biochemical Research Methods
Rebecca C. Lim, Bhagya De Silva, Ji Hye Park, Vernon F. Hodge, Ronald K. Gary
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Bhagya De Silva, Ronald K. Gary
Article
Oncology
Ranjana Mitra, Thuc T. Le, Priyatham Gorjala, Oscar B. Goodman
Article
Endocrinology & Metabolism
Janica C. Wong, Van Vo, Priyatham Gorjala, Ronald R. Fiscus
DIABETES & VASCULAR DISEASE RESEARCH
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Priyatham Gorjala, Ataur-Rahman Mohammedabdul, Ronald K. Gary