Article
Geriatrics & Gerontology
Caterina Trevisan, Marianna Noale, Claudio Barbiellini Amidei, Eliana Ferroni, Cristina Basso, Ugo Fedeli, Giovannella Baggio, Stefania Maggi, Giuseppe Sergi
Summary: Frailty is strongly associated with infection-related hospitalizations in older men and women, and previous exposure to endogenous estrogens among women modifies this relationship.
Article
Geriatrics & Gerontology
Hui Shi, Mei-Ling Ge, Birong Dong, Qian-Li Xue
Summary: Higher Framingham CVD risk score was associated with a greater risk of incident frailty among Chinese older adults in this study. However, this association was no longer significant after adjusting for chronological age.
Article
Immunology
Ting Liu, Yu Liu, Chen-xi Liu, Yong-mei Jiang
Summary: This study investigates the role of CXCL13 in the pathogenesis of inflammatory bowel disease (IBD) using clinical specimens and animal models. The findings show that CXCL13 concentration is significantly higher in IBD patients and correlates with inflammatory markers. In mice models, CXCL13 deficiency leads to a milder form of the disease. The study suggests that CXCL13 plays a critical role in the pathogenesis of IBD and may be a potential target for adjunctive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Harald Krenzlin, Dragan Jankovic, Christoph Alberter, Darius Kalasauskas, Christiane Westphalen, Florian Ringel, Naureen Keric
Summary: This study evaluated the impact of age and frailty on surgical outcomes and overall survival in elderly patients with glioblastoma. Frailty, as determined by screening tests, was found to be associated with shorter overall survival and higher numbers of surgical complications independent of patient age, tumor size, or localization.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Breno S. Diniz, Maria Fernanda Lima-Costa, Sergio Viana Peixoto, Joselia O. A. Firmo, Karen C. L. Torres, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, James Grady, George A. Kuchel, Erico Castro-Costa
Summary: Cognitive frailty is a common condition among older adults and is associated with a higher risk of mortality. Our study found that individuals with cognitive frailty had significantly higher levels of serum IL-6 and an increased risk of mortality.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Cell Biology
Camilla S. L. Tuttle, Suzanne W. M. Luesken, Mariette E. C. Waaijer, Andrea B. Maier
Summary: This systematic review provides an overview of the evidence on senescent cells in age-related disease pathologies in humans, as well as the markers currently used to detect senescence levels. The study found that senescence plays an important role in disease pathologies in different organ systems and age-related diseases, particularly in the heart and respiratory systems. The expression levels of senescence markers also vary in different diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Medicine, General & Internal
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos
Summary: This study identified regression-based biological age clocks for the retina and explored their applications in Age-Related Macular Degeneration (AMD). The clocks showed good separation among AMD samples of different severity scores and demonstrated consistent age reprograming features in cultured cells. Additionally, potential targets mechanistically linked to AMD and aging were discovered. These clocks have potential applications in monitoring AMD and in vitro screens.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Roya Ostovar, Filip Schroeter, Ralf-Uwe Kuehnel, Martin Hartrumpf, Johannes Maximilian Albes
Summary: Age has an impact on perioperative mortality, but it is not a predictor of frailty. This study found that elderly patients undergoing mitral valve surgery with pre-existing renal failure had a significantly higher risk of mortality, postoperative renal failure, dialysis requirement, and possibly the development of pleural and pericardial effusions. Additionally, frequent critical illnesses such as myopathy and neuropathy, along with a decrease in BMI, were observed in the oldest age group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Julia W. Wu, Amber Yaqub, Yuan Ma, Wouter Koudstaal, Albert Hofman, M. Arfan Ikram, Mohsen Ghanbari, Jaap Goudsmit
Summary: The study demonstrates that accelerated biological age is a predictor of major age-related morbidity, including dementia, among healthy elderly individuals. Additionally, microRNAs were found to be significantly associated with age, with top differentially expressed microRNAs based on biological age having a higher significance level, suggesting that biological age captures aspects of aging signals at the epigenetic level.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Augusto Bleve, Francesca Motta, Barbara Durante, Chiara Pandolfo, Carlo Selmi, Antonio Sica
Summary: The immune system plays a crucial role in maintaining tissue homeostasis and defending against pathogens and cancer cells. However, the aging process leads to a decline in immune function, resulting in compromised immune responses and unresolved inflammation. This contributes to a subclinical syndrome of homeostatic frailty in the elderly, making them more susceptible to immune debilitation and chronic low-grade inflammation, which in turn increase the risk of chronic and degenerative diseases. This review focuses on the age-dependent changes in myeloid populations and their impact on frailty and diseases in the elderly.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Richard Ivell, Kee Heng, Katie Severn, Leen Antonio, Gyorgy Bartfai, Felipe F. F. Casanueva, Ilpo T. T. Huhtaniemi, Aleksander Giwercman, Mario Maggi, Daryl B. B. O'Connor, Terence W. W. O'Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick C. W. Wu, Ravinder Anand-Ivell
Summary: This study aimed to determine the ability of INSL3 to predict hypogonadism and age-related morbidity. The results showed that INSL3 is associated with both primary and secondary hypogonadism and is also related to various health problems such as reduced sexual function, decreased bone mineral density, hypertension, cardiovascular disease, cancer, and diabetes. In addition, INSL3 may play a role in promoting healthy bone metabolism. Assessing INSL3 in men may provide important insights into the development of diseases in the elderly.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Amy L. Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S. El-Sayed Moustafa, Max Tomlinson, Ruth C. E. Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J. Steves, Massimo Mangino, Jordana T. Bell, Chloe C. Y. Wong, Timothy J. Vyse, Kerrin S. Small, Carlos Isales
Summary: Our study demonstrates that age acquired XCI-skew captures changes to the haematopoietic stem cell population and has clinical potential as a unique biomarker of chronic disease risk.
Article
Geriatrics & Gerontology
D. Angioni, W. H. Lu, S. Sourdet, T. Macaron, C. Takeda, S. Guyonnet, J. F. Mangin, Y. Rolland, P. de Souto Barreto, B. Vellas
Summary: This study aimed to compare the biological and neuroimaging profile of different types of frailty in community-dwelling older adults. The results suggest that age-related frailty and disease-related frailty may have different levels of severity on a biological level. Further research is needed to identify biomarkers that can distinguish these classifications of frailty.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Multidisciplinary Sciences
Maiko Maruyama-Inoue, Tatsuya Inoue, Shaheeda Mohamed, Yoko Kitajima, Shoko Ikeda, Arisa Ito, Kazuaki Kadonosono
Summary: This study aimed to report the incidence of elevated intraocular pressure (IOP) after anti-vascular endothelial growth factor (VEGF) intravitreal injections in Japanese patients with age-related macular degeneration (AMD). The study found that a history of glaucoma, treatment modality, and total number of injections were significantly associated with elevated IOP, which is considered a late complication of intravitreal injections in AMD patients.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Liv Tybjaerg Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt, Borge Gronne Nordestgaard
Summary: The study showed that elevated plasma apolipoprotein A1 and HDL cholesterol, as well as lower LDL cholesterol, are associated with increased risk of AMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Magdalena Koziczak-Holbro, Dean F. Rigel, Berengere Dumotier, David A. Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bosch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moise Azria, Robin A. Fairhurst, Steven J. Charlton, Brian P. Richardson, Estelle Lach-Trifilieff, David J. Glass, Thomas Ullrich, Shinji Hatakeyama
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Cell Biology
Jason D. Roh, Ryan Hobson, Vinita Chaudhari, Pablo Quintero, Ashish Yeri, Mark Benson, Chunyang Xiao, Daniel Zlotoff, Vassilios Bezzerides, Nicholas Houstis, Colin Platt, Federico Damilano, Brian R. Lindman, Sammy Elmariah, Michael Biersmith, Se-Jin Lee, Christine E. Seidman, Jonathan G. Seidman, Robert E. Gerszten, Estelle Lach-Trifilieff, David J. Glass, Anthony Rosenzweig
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Giselle A. Joseph, Sharon X. Wang, Cody E. Jacobs, Weihua Zhou, Garrett C. Kimble, Herman W. Tse, John K. Eash, Tea Shavlakadze, David J. Glass
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Perrine Castets, Nathalie Rion, Marine Theodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guerard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Ruediger Rudolf, David J. Glass, Markus A. Ruegg
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Samuel M. Cadena, Yunyu Zhang, Jian Fang, Sophie Brachat, Pia Kuss, Elisa Giorgetti, Louis S. Stodieck, Michaela Kneissel, David J. Glass
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Paola Sebastiani, Stefano Monti, Melody Morris, Anastasia Gurinovich, Tanaka Toshiko, Stacy L. Andersen, Benjamin Sweigar, Luigi Ferrucci, Lori L. Jennings, David J. Glass, Thomas T. Perls
Article
Cell Biology
Tea Shavlakadze, Melody Morris, Jian Fang, Sharon X. Wang, Jiang Zhu, Weihua Zhou, Herman W. Tse, Ricardo Mondragon-Gonzalez, Guglielmo Roma, David J. Glass
Article
Cell Biology
Ajeet Pratap Singh, Maria X. Sosa, Jian Fang, Shiva Kumar Shanmukhappa, Alexis Hubaud, Caroline H. Fawcett, Gregory J. Molind, Tingwei Tsai, Paola Capodieci, Kristie Wetzel, Ellen Sanchez, Guangliang Wang, Matthew Coble, Wenlong Tang, Samuel M. Cadena, Mark C. Fishman, David J. Glass
Article
Cell Biology
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi
Article
Cell Biology
Paola Sebastiani, Anthony Federico, Melody Morris, Anastasia Gurinovich, Toshiko Tanaka, Kevin B. Chandler, Stacy L. Andersen, Gerald Denis, Katherine Costello, Luigi Ferrucci, Lori Jennings, David J. Glass, Stefano Monti, Thomas T. Perls
Summary: Using samples from the New England Centenarian Study, researchers characterized the serum proteome of centenarians, their offspring, and age-matched controls. They identified protein signatures associated with longer survival in centenarians and younger individuals and found similarities in aging markers between centenarians and short-lived cohorts. The study provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms to prolong health and support longevity.
Article
Geriatrics & Gerontology
Anastasia Gurinovich, Zeyuan Song, William Zhang, Anthony Federico, Stefano Monti, Stacy L. Andersen, Lori L. Jennings, David J. Glass, Nir Barzilai, Sofiya Millman, Thomas T. Perls, Paola Sebastiani
Summary: The study conducted a genome-wide association study and proteomic analysis on centenarians and controls, identifying genetic variants and protein signatures associated with longevity. The findings suggest that these features could be potential targets for discovering healthy-aging interventions.
Article
Biology
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rueegg
Summary: Muscle size is regulated by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which controls protein synthesis and breakdown. Paradoxically, while mTORC1 activity is necessary for muscle hypertrophy, its constant activation promotes protein breakdown through the UPS. This study highlights the importance of mTORC1-mediated PKB/Akt inhibition and the role of the UPS in muscle atrophy and proteome integrity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael D. Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Kyoko Watanabe, Anthony Marketta, Michael Van Meter, Stefan Semrau, Julie Horowitz, Jing Tang, Jack A. Kosmicki, Veera M. Rajagopal, Yuxin Zou, Yariv Houvras, Arkopravo Ghosh, Christopher Gillies, Joelle Mbatchou, Ryan R. White, Niek Verweij, Jonas Bovijn, Neelroop N. Parikshak, Michelle G. LeBlanc, Marcus Jones, David J. Glass, Luca A. Lotta, Michael N. Cantor, Gurinder S. Atwal, Adam E. Locke, Manuel A. R. Ferreira, Raquel Deering, Charles Paulding, Alan R. Shuldiner, Gavin Thurston, Adolfo A. Ferrando, Will Salerno, Jeffrey G. Reid, John D. Overton, Jonathan Marchini, Hyun M. Kang, Aris Baras, Goncalo R. Abecasis, Eric Jorgenson
Summary: Clonal haematopoiesis, associated with ageing and adverse health outcomes, involves the expansion of certain blood cell lineages. This study identified novel germline genetic variations influencing predisposition to clonal haematopoiesis using exome sequence data from over 600,000 individuals. The study also found associations between clonal haematopoiesis and severe COVID-19 outcomes, cardiovascular disease, and malignancy.
Article
Biochemistry & Molecular Biology
Megan McAleavy, Qian Zhang, Peter J. Ehmann, Jianing Xu, Matthew F. Wipperman, Dharani Ajithdoss, Li Pan, Matthew Wakai, Raphael Simonson, Abhilash Gadi, Adelekan Oyejide, Sara C. Hamon, Anita Boyapati, Lori G. Morton, Tea Shavlakadze, Christos A. Kyratsous, David J. Glass
Summary: Patients with elevated activin A, activin B, and FLRG at hospital admission are associated with severe outcomes of COVID-19. Inhibition of activin A signaling may be beneficial in treating COVID-19 patients with ARDS.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Correction
Medicine, Research & Experimental
Hui-Hua Li, Monte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass, Cam Patterson
JOURNAL OF CLINICAL INVESTIGATION
(2022)
