Article
Biotechnology & Applied Microbiology
Paul Mcmullin, Darian Emmett, Andrew Gibbons, Kelly Clingo, Preston Higbee, Andrew Sykes, David T. Fullwood, Ulrike H. Mitchell, Anton E. Bowden
Summary: This study utilized an optical motion capture system and a new marker set to non-invasively measure the dynamic, 3D in vivo segmental kinematics of the lower spine in a laboratory setting. The results were consistent with previous studies and identified motion coupling paradigms in the lumbar spinal segments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Jiajun Huang, Weike Zeng, Ming Li, Ziying Cheng, Junshen Huang, Changchun Liang, Yuxi Li, Lin Huang
Summary: Percutaneous cement discoplasty (PCD) can enhance the stability of the lumbar spine in flexion-extension and lateral bending, providing effective treatment for low back pain. Fractures and sliding of bone cement after PCD may lead to nerve compression.
FRONTIERS IN SURGERY
(2022)
Article
Biology
Dacheng Sang, Cheng-Fei Du, Bingxuan Wu, Xin-Yi Cai, Wei Cui, Chen-Xi Yuchi, Tianhua Rong, Hongpeng Sang, Baoge Liu
Summary: This study investigated the effect of cervical disc degeneration (CDD) on the motion path of the instantaneous center of rotation (ICR) in the cervical spine. The results showed that CDD significantly affected the ICR motion paths, with shifts in the degenerated and adjacent segments. The changes observed in adjacent segments may represent compensatory mechanisms to maintain cervical spine balance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rafael Menezes-Reis, Carlos E. Garrido Salmon, Gustavo P. Bonugli, Debora Mazoroski, Leonor G. Savarese, Carlos Fernando P. S. Herrero, Helton L. A. Defino, Marcello Henrique Nogueira-Barbosa
Summary: The study found that a decrease in lumbar lordosis is associated with dehydration of the intervertebral disc nucleus pulposus, while low values of sacral slope, pelvic tilt, pelvic incidence, thoracic kyphosis, and spinosacral angle are related to a decrease in T2 relaxation times of the annulus fibrosus. Overall, spinopelvic parameters show a discrete association with lumbar disc composition and water content.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Environmental Sciences
Tomasz Kuligowski
Summary: This study aimed to analyze the prevalence of lumbar segmental instability (LSI) in young patients with different types of lumbar disc herniation (LDH). The results showed that individuals with more severe disc damage were more likely to have LSI. Additionally, females were more prone to this pathology. The different types of LDH did not significantly affect the prevalence of LSI in young individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Pedro Berjano, Francesco Langella, Luca Ventriglia, Domenico Compagnone, Paolo Barletta, David Huber, Francesca Mangili, Ginevra Licandro, Fabio Galbusera, Andrea Cina, Tito Bassani, Claudio Lamartina, Laura Scaramuzzo, Roberto Bassani, Marco Brayda-Bruno, Jorge Hugo Villafane, Lorenzo Monti, Laura Azzimonti
Summary: The study aimed to predict good to excellent early clinical outcomes using a machine learning approach based on demographic and HRQOL scores. Evaluations showed that the machine learning models provided high performance in predicting early clinical results, with significant sensitivity and specificity.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marco Foreman, Krisna Maddy, Aashay Patel, Akshay Reddy, Meredith Costello, Brandon Lucke-Wold
Summary: Clinicians have historically managed and treated lower back pain, but now face the challenge of differentiating between lumbar spine pathology and lumbosacral plexopathy. This review provides insights into the anatomy and clinical assessment of both pathologies, as well as highlighting diagnostic tools to aid in accurate diagnosis and treatment. Additionally, emerging treatment options for these conditions, including regenerative nerve therapies, are discussed.
Article
Clinical Neurology
Nicolas Serratrice, Antoine Gennari, Sung-Joo Yuh, Yann Sabah, Amandine Gavotto, Philippe Paquis
Summary: This study revealed that an increase in segmental lordosis is associated with a satisfactory functional outcome following a single-level lumbar disc prosthesis or a hybrid construct. The findings suggest that gain in segmental lordosis may serve as a significant positive predictor factor for patient outcome.
WORLD NEUROSURGERY
(2021)
Article
Orthopedics
Ofir Uri, Liad Alfandari, Yoram Folman, Amit Keren, William Smith, Inbar Paz, Eyal Behrbalk
Summary: This study compared the incidence of acute disc herniation following mini-open and minimally invasive decompression of lumbar spinal stenosis. The results showed that the incidence of postoperative disc herniation was significantly lower in the minimally invasive group compared to the mini-open group.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Luis Becker, Lukas Schoennagel, Tim Victor Mihalache, Henryk Haffer, Friederike Schoemig, Hendrik Schmidt, Matthias Pumberger
Summary: Patients with LSTV exhibit reduced range of motion in the transitional segment and significantly increased motion distribution to the cranial adjacent segment in flexion-extension radiographs. These findings may explain the higher rates of degeneration within the segment.
Article
Multidisciplinary Sciences
Amparo Vanaclocha, Vicente Vanaclocha, Carlos M. Atienza, Pablo Jorda-Gomez, Cristina Diaz-Jimenez, Jose A. Garcia-Lorente, Nieves Saiz-Sapena, Leyre Vanaclocha
Summary: A new artificial disc replacement device (ADDISC) has been developed to mimic the biomechanical properties of a healthy intervertebral disc, providing excellent durability and shock absorption, as demonstrated through finite element analysis and experimental testing.
Review
Clinical Neurology
Lei Feng, Yanfang Luo, Shangxing Wu, Weihao Yang, Wei LI, Jing Tian
Summary: This study compared the effectiveness of repeat discectomy (RD) and spinal fusion (SF) in the treatment of recurrent lumbar disc herniation (RLDH). The results showed that SF had better outcomes in terms of pain scores, disability index, and incidence of complications compared to RD.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Ralph Laeubli, Robin Brugger, Tatiana Pirvu, Sven Hoppe, Dominik Sieron, Karol Szyluk, Christoph E. Albers, Andreas Christe
Summary: This study found that the presence of disproportionate motion segments in the lower spine may lead to a significantly higher risk for disc herniation in patients undergoing discectomy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Masatsugu Tsukamoto, Tadatsugu Morimoto, Takaomi Kobayashi, Kazuki Muranaka, Tomohito Yoshihara, Kazumasa Maeda, Motoki Sonohata, Yuichi Kasai, Koji Otani, Masaaki Mawatari
Summary: This study evaluates the relationships between traction spur, Modic changes (MCs), and vacuum phenomenon (VP) and radiographic measurements in the lumbar spine. The results show a significant association between traction spur and translational motion, as well as between VP and vertical motion. These findings are important for identifying lumbar intervertebral instability.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Pendar Soltanmohammadi, Amir Tavakoli, G. Daniel G. Langohr, George S. Athwal, Ryan Willing
Summary: The study compared the effects of solid and hollow stems on healthy, osteopenic, and osteoporotic bones using finite element models, finding that hollow-stemmed implants outperformed solid-stemmed ones in reducing cortical bone stress and improving bone remodeling.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Zhenming Zhang, Chaochao Zhou, Zhitao Rao, Timothy Foster, Hany Bedair, Guoan Li
Summary: The study found that during flexion, the changes in medial and lateral contact point heights were within 2.5 mm, while the changes in medial and lateral condyle heights measured using different axes ranged from 3.0 mm to 8.9 mm. The height changes measured by the contact points and the iso-height axis (IHA) were similar and significantly smaller than those measured using the trans-epicondyle axis (TEA) and geometric center axis (GCA).
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Review
Orthopedics
Chaochao Zhou, Yun Peng, Shuai An, Hany Bedair, Guoan Li
Summary: This study reviewed recent evidences on the kinematics of bicruciate retaining total knee arthroplasty (TKA), showing differences in internal rotation, external rotation, and position in BCR TKAs compared to native knees. The study also found that native knee kinematics were not fully restored after BCR TKA during various knee activities, suggesting the need for further investigations into whether contemporary BCR TKAs can fully restore native knee kinematics.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Heidi M. Godoy, Michael Rotenberg, Guido LaPorta, Ryan Willing
Summary: The study found that fusion of the subtalar and talonavicular joints can increase joint stiffness, but does not significantly affect fracture patterns statistically. Testing revealed that under low-speed loading, ankle joints were prone to dislocation injuries rather than specific bone fractures.
JOURNAL OF FOOT & ANKLE SURGERY
(2021)
Article
Orthopedics
Thiago Vivacqua, Samira Vakili, Ryan Willing, Gilbert Moatshe, Ryan Degen, Alan M. Getgood
Summary: This study compares the effects of a modified anatomic technique and the original anatomic reconstruction in improving varus and external rotatory laxity after knee injury. The results show that both techniques can restore varus laxity, but the modified technique has a better effect on end-range external rotation.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biophysics
Guoan Li, Chaochao Zhou, Zhenming Zhang, Timothy Foster, Hany Bedair
Summary: This study investigated the factors associated with axial rotations of the femur using physiological and morphological measurement methods. The results showed that the femur externally rotates at low flexion angles and has minimal rotation at higher flexion angles. The morphological method measured larger posterior translations of the lateral condyle, indicating a medial pivoting rotation, while the physiological method measured larger contact distances on the medial condyle, indicating a lateral pivoting rotation.
JOURNAL OF BIOMECHANICS
(2022)
Article
Orthopedics
Melissa M. Simonik, James Pitarresi, Ryan Willing
Summary: This computational study analyzed the effects of common beam parameters on medial column arthrodesis. The results showed that increasing implant stiffness, threaded portion length, and using a solid beam significantly increased medial column stiffness. Simultaneously increasing all three factors further improved bone stiffness while reducing stress, strain, and implant forces.
JOURNAL OF FOOT & ANKLE SURGERY
(2022)
Article
Orthopedics
Emma Donnelly, Samira Vakili, Alan Getgood, Ryan Willing, Ryan M. Degen
Summary: This study evaluated the effects of capsulotomy and repair on torque, stiffness, and femoral head displacement after hip arthroscopy. The results showed that capsulotomies significantly reduced torque and stiffness, while repairs failed to fully restore them. However, there were no significant joint translations to corroborate concerns of microinstability.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biophysics
Guoan Li, Chaochao Zhou, Jia Yu, Sophia Li, Timothy Foster, Hany Bedair
Summary: Through analyzing the in vivo tibiofemoral articulations, we investigated the mechanisms of tibial rotations. The results showed that the articular contact distance on femoral condyles was larger than that on tibial surfaces, and the axial tibial rotations due to articulations on femoral condyles were significantly larger than those on tibial surfaces until 60 deg of flexion. Minimal additional axial tibial rotations were observed beyond 60 deg of flexion. This study provides new insights into the understanding of mechanisms of axial tibial rotations and potential improvements for knee surgeries.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Orthopedics
H. D'Sa, R. Willing, T. Murray, K. Rowan, R. Grewal, G. King, P. Daneshvar
Summary: This study evaluated the reliability of the Tolat classification for sigmoid notch characterization. The results showed that the classification had fair to moderate agreement, and using an axial view of the distal radius for classification may not accurately reflect the anatomy of the entire notch.
JOURNAL OF WRIST SURGERY
(2023)
Article
Engineering, Biomedical
Jia Yu, Yulian Xia, Chaochao Zhou, Tsungyuan Tsai, Sophia Li, Timothy Foster, Hany Bedair, Guoan Li
Summary: This study aimed to develop and validate a new concept of flexion axis by calculating points on femoral condyles that maintain constant heights during knee flexion. The results showed that these points form a medial-lateral flexion axis called the iso-height axis (IHA). The IHA exhibited minimal changes in proximal-distal translations and varus-valgus rotations along the flexion path, suggesting interesting clinical implications for knee surgeries.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Sydney Hitchon, William Anderson, Jaques S. Milner, Gregory Hong, Todor Ivanov, Ryan Willing, David Holdsworth
Summary: This study compared the mechanical behaviors of titanium cylindrical gyroid structures with different porosities. Both experimental and simulation results showed consistent relationships between porosity and apparent modulus of elasticity. Calibration of the fatigue strength coefficient improved the prediction accuracy of fatigue life, but discrepancies between prediction and experiment remained, which could be attributed to difficulties in defining failure and minor differences in porosities.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Mathematical & Computational Biology
Jun Liu, Zhenhua Yan, Chaochao Zhou, Liren Shao, Yuanyuan Han, Yusheng Song
Summary: Medical image segmentation of the liver is crucial for clinical diagnosis and liver cancer evaluation. In this study, a Multi-scale Feature Extraction and Enhancement U-Net (mfeeU-Net) incorporating Res2Net blocks, Squeeze-and-Excitation (SE) blocks, and Edge Attention (EA) blocks was proposed for automatic liver segmentation from CT images. Experimental results showed that mfeeU-Net can compete with and outperform recently proposed convolutional neural networks, effectively addressing challenges such as discontinuous liver regions and fuzzy boundaries.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Orthopedics
Chaofan Han, Chaochao Zhou, Hanwen Zhang, Peng Yin, Runsheng Guo, Wei Wang, Yiqi Zhang, Thomas Cha, Guoan Li, Yong Hai
Summary: This study used biomechanical finite element modeling based on three-dimensional reconstruction to determine the specific bone mineral density (BMD) of each vertebral body in adolescent idiopathic scoliosis (AIS) patients. The overall BMD of patients with AIS was found to gradually decrease from the top to the bottom of the spine. These findings provide valuable insights for surgical planning and biomechanical analysis in the context of scoliosis treatment using finite element models.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Allan R. Sekeitto, Jance G. McGale, Liam A. Montgomery, Edward M. Vasarhelyi, Ryan Willing, Brent A. Lanting
Summary: The thickness of the polyethylene insert in posterior-stabilized total knee arthroplasty affects the engagement of the post-cam mechanism, and understuffing and overstuffing have different effects on joint mechanics. Subtle changes in the polyethylene insert thickness alter the kinematics of the post-cam mechanism.
