Article
Chemistry, Multidisciplinary
Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang
Summary: Selective photoredox reactions allow direct alkylation of unprotected myo-inositol at C4, offering a possibility for selective C-H alkylations without the need for multi-step protection-deprotection strategies.
CHEMICAL COMMUNICATIONS
(2022)
Article
Orthopedics
Katie J. Sikes, Anna McConnell, Natalie Serkova, Brian Cole, David Frisbie
Summary: The study aimed to investigate the potential role of glucose metabolism in the development of tendinopathy, revealing dysregulated metabolites such as creatinine, D-chiro-inositol, and lipids following tendon injury. These findings suggest novel pathways for manipulation to enhance preventative and therapeutic strategies for tendon-related injuries.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Fisheries
Wenxiao Cui, Aijun Ma, Ardavan Farhadi, Hafiz Sohaib Ahmed Saqib, Simin Liu, Huiying Chen, Hongyu Ma
Summary: This review paper provides a detailed explanation of the molecular and physiological mechanisms by which myo-inositol improves physiological functions in aquatic animals. It highlights the gaps in our understanding of the physiological functions regulated by myo-inositol and offers valuable information for the aquaculture industry.
Review
Microbiology
Alec Banner, Helen S. Toogood, Nigel S. Scrutton
Summary: The research highlights the current progress in consolidated bioprocessing approach where microorganisms are engineered to convert waste lignocellulose into fuels and chemicals. Challenges include the complexity of enzymatic degradation process and the localization of cellulolytic enzymes. Future prospects involve utilizing biofoundry approach and high throughput design methods to address existing bottlenecks and enhance microbial cellulolytic capabilities to commercially viable levels.
Article
Biochemistry & Molecular Biology
Mirela Ivancic Santek, Marina Grubisic, Maja Galic Perecinec, Suncica Beluhan, Bozidar Santek
Summary: High production costs of microbial lipids can be reduced by using available and cheap lignocellulosic biomass. This study found that C:N ratios below 25 stimulated fungus growth, while ratios above 50 led to lipid accumulation. Among the inhibitors from lignocellulosic biomass, phenolics were found to be the most toxic.
PROCESS BIOCHEMISTRY
(2021)
Article
Energy & Fuels
Cong Du, Yimin Li, Ruijuan Xiang, Ying He, Hao Sun, Huanan Wang, Wenjie Yuan
Summary: This study improved the microbial strain K. marxianus 1727 through adaptive laboratory evolution, resulting in enhanced inhibitor resistance, thermotolerance, and utilization of multiple carbon sources for more efficient bioethanol production from lignocellulosic biomass.
Article
Green & Sustainable Science & Technology
Chunyun Qu, Kaiqun Dai, Hongxin Fu, Jufang Wang
Summary: The study found that ArgR(1864) is a negative regulator for chaperonin synthesis in Thermoanaerobacterium aotearoense SCUT27. Knocking out argR(1864) resulted in a mutant with enhanced antioxidant capacity, better growth and metabolic product generation abilities, as well as advantages in ethanol production.
Article
Plant Sciences
Naveen Sharma, Bhavya Shree, Paramjit Khurana
Summary: In this study, it was found that L-myo-inositol phosphate synthase (MIPS) regulates chlorophyll content and photosynthesis efficiency via the ethylene signaling pathway. Overexpression of TaMIPS-A in Arabidopsis enhanced photosynthetic potential under heat stress. Supplementation of ethylene precursor ACC or ethylene signaling inhibitor AgNO3 to TaMIPS-A overexpression Arabidopsis transgenics indicated that MIPS regulates photosynthetic efficiency and chlorophyll content via the ethylene signaling pathway, both under normal and thermal stress conditions.
Article
Food Science & Technology
Sara Arefhosseini, Neda Roshanravan, Samira Asghari, Helda Tutunchi, Mehrangiz Ebrahimi-Mameghani
Summary: This study investigated the effects of MI supplementation on inflammatory gene expression, serum hs-CRP, WBC-derived inflammatory biomarkers, body composition, and liver function in obese patients with NAFLD. The results showed that MI supplementation led to a significant reduction in TNF-alpha mRNA expression and a greater decrease in fat mass and increase in fat-free mass compared to the placebo group. However, no significant differences were observed in other WBC-derived inflammatory markers and serum hs-CRP.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Corri D. Hamilton, Olivia R. Steidl, April M. MacIntyre, Connor G. Hendrich, Caitilyn Allen
Summary: The soilborne pathogen Ralstonia solanacearum infects host roots and colonizes xylem vessels, utilizing different carbon sources at low cell density (LCD) and high cell density (HCD) stages to adapt to the nutritional environments of plant roots and xylem sap, thereby influencing its growth and infection in plants.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Plant Sciences
Cheng-Hsun Li, Yun-Cheng Tu, Meng-Fang Wen, Hsing-Jung Tien, Hungchen Emilie Yen
Summary: Ice plants develop salt tolerance through morphological, physiological, biochemical, and molecular changes. Supplying myo-inositol promotes the expression of key genes and improves salt tolerance in ice plants.
FUNCTIONAL PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hualiang Feng, Yimin Li, Cong Du, Wenjie Yuan
Summary: Aeration strategy was proposed to enhance microbial tolerance to inhibitors derived from lignocellulosic biomass pretreatment, improving biofuel fermentation efficiency. High aeration rate resulted in decreased fermentation time and residual xylose, accompanied by increased product yields.
PROCESS BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Mohamed Ali Abdel-Rahman, Saad El-Din Hassan, Amr Fouda, Ahmed A. Radwan, Mohammed G. Barghoth, Salha G. Desouky
Summary: The study identified a newly isolated Bacillus coagulans strain Azu-10 capable of efficiently producing lactic acid from xylose under optimal fermentation conditions, even in the presence of various lignocellulose-derived inhibitors. The strain exhibited high biomass and lactic acid production in the presence of furanic inhibitors, carboxylic acids, and phenolic compounds at different concentrations.
FERMENTATION-BASEL
(2021)
Article
Agricultural Engineering
Zhijia Liu, Mohammad Radi, Elsayed T. T. Mohamed, Adam M. Feist, Giuliano Dragone, Solange I. Mussatto
Summary: The use of adaptive laboratory evolution in hydrolysate-based medium improved the tolerance of Rhodosporidium toruloides to inhibitors in lignocellulosic biomass hydrolysate, resulting in enhanced lipid accumulation and carotenoid production compared to the wild-type strain. Whole genome sequencing revealed that the wild-type strain naturally contained tolerance-related genes that facilitated evolution in biomass-derived inhibitors.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Yichao Ge, Yihan Ma, Meilu Zhao, Jihua Wei, Xiaodan Wu, Zunjing Zhang, Han Yang, Houxing Lei, Bin Wu
Summary: In this study, a new tool called BFFP was developed for reliable identification of active candidate nodes from crude extracts, and several new compounds were successfully isolated from a marine-derived fungus. Some of these compounds exhibited strong inhibitory activity, highlighting their potential therapeutic value in cancer and inflammation treatment. Furthermore, literature-based QSAR analysis provided insights into the structural features associated with inhibitory activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agricultural Engineering
Lei Qin, Li Liu, Wen-Chao Li, Jia-Qing Zhu, Bing-Zhi Li, Ying-Jin Yuan
BIORESOURCE TECHNOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Lei Qin, Wen-Chao Li, Li Liu, Jia-Qing Zhu, Xia Li, Bing-Zhi Li, Ying-Jin Yuan
BIOTECHNOLOGY FOR BIOFUELS
(2016)
Article
Biotechnology & Applied Microbiology
D. Zhu, R. Li, F. Liu, H. Xu, B. Li, Y. Yuan, P. E. J. Saris, M. Qiao
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Fei-Fei Li, Ying Zhao, Bing-Zhi Li, Jian-Jun Qiao, Guang-Rong Zhao
MICROBIAL CELL FACTORIES
(2016)
Article
Microbiology
Meng-Long Hu, Jian Zha, Lin-Wei He, Ya-Jin Lv, Ming-Hua Shen, Cheng Zhong, Bing-Zhi Li, Ying-Jin Yuan
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Ming-Hua Shen, Hao Song, Bing-Zhi Li, Ying-Jin Yuan
BIOTECHNOLOGY LETTERS
(2015)
Article
Agricultural Engineering
Zhi-Min Zhao, Xianzhi Meng, Brent Scheidemantle, Yunqiao Pu, Zhi-Hua Liu, Bing-Zhi Li, Charles E. Wyman, Charles M. Cai, Arthur J. Ragauskas
Summary: This study fully evaluated the bioconversion performance of CELF lignin for the first time and found that it outperforms other technical lignins in terms of carboxylic acid OH content, molecular weight, and linkages. Rhodococcus opacus PD630 cell count and lipid yield were significantly improved with CELF lignin compared to ethanol organosolv lignin and kraft lignin. Principal component analysis indicated that more carboxylic acid groups and lower molecular weight contributed to the enhanced bioconversion performance of CELF lignin.
BIORESOURCE TECHNOLOGY
(2022)
Review
Microbiology
Yong-Shui Tan, Ren-Kuan Zhang, Zhi-Hua Liu, Bing-Zhi Li, Ying-Jin Yuan
Summary: Adaptation is an important strategy for enhancing stress tolerance in microbial cell factories. This paper reviews the effects of adaptation on microbial substrate utilization capacity and environmental stress tolerance, and discusses the mechanisms involved in enhancing microbial adaptive capacity.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Kai Chen, Zi-Jing He, Zhi-Hua Liu, Arthur J. Ragauskas, Bing-Zhi Li, Ying-Jin Yuan
Summary: This review summarizes the modification technologies of lignin-based activated carbon (LAC) and discusses its potential in advanced applications. The changes in porosity and surface chemistry of LAC are thoroughly discussed. The results highlight the importance of modification technologies in altering the properties and defining the functionalities of LAC, making it a promising porous carbon material.
Review
Biotechnology & Applied Microbiology
Zhi-Hua Liu, Bing-Zhi Li, Joshua S. Yuan, Ying-Jin Yuan
Summary: Lignin, as the largest renewable aromatic resource, shows potential for sustainable production of chemicals, fuels, and materials. The review presents biological lignin conversion routes (BLCRs) that offer opportunities for lignin valorization through biological funneling and aromatic bioconversion pathways, enabling a lignocellulose-based bioeconomy.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haiyan Wang, Ai-Ping Pang, Bingzhi Li, Liujie Huo, Fu-Gen Wu, Fengming Lin
Summary: This study investigates the role of intracellular sugar transporters in cellulase production by lignocellulose-degrading fungi. The expression of sugar transporter genes mfs, gst, and lac1 was upregulated in Trichoderma reesei cultivated on lactose. Deletion of these transporters inhibited cellulase production, cell growth, and sporulation, indicating their supportive role in cellulase production on lactose. The study also identifies the localization of MFS and LAC1 in the cytoplasm and endoplasmic reticulum, respectively, representing the first discovery of intracellular sugar transporters involved in cellulase biosynthesis in lactose culture. The absence of the lac1 gene had a significant impact on cellulase production, particularly at the early stage.
Review
Biotechnology & Applied Microbiology
Hai-Na Lan, Ruo-Ying Liu, Zhi-Hua Liu, Xia Li, Bing-Zhi Li, Ying-Jin Yuan
Summary: This review examines a novel valorization route for lignin to high-value natural products, particularly flavonoids, through microbial bioconversion. It summarizes the biodegradation of lignin and identifies aromatic monomers as important precursors for flavonoid synthesis. The biosynthesis pathways of flavonoids in plants and strains are compared and the key branch points and important intermediates in these pathways are discussed. The most significant enzyme reactions in the biosynthesis of flavonoids, such as Claisen condensation, cyclization, and hydroxylation, are also demonstrated. Current challenges and potential future strategies for transforming lignin into flavonoids are addressed.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Chenglong Zhang, Wang Chen, Tianyu Dong, Ying Wang, Mingdong Yao, Wenhai Xiao, Bingzhi Li
Summary: This study overcame the catalysis compartmentalization between two key exogenous enzymes by altering their subcellular localization, resulting in increased taxadiene yield. The highest reported titer of taxadiene biosynthesis in eukaryotic microbes was achieved.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Haiyan Wang, Ai-Ping Pang, Wei Wang, Bingzhi Li, Chengcheng Li, Fu-Gen Wu, Fengming Lin
Summary: This study identified intracellular sugar transporters (mfs, gst, and lac1) that facilitate cellulase production and are distributed in the ER. These transporters had low sugar transporting ability, suggesting they may be involved in cellular sugar utilization rather than uptake. Lac1 was found to be essential for cellulase production and biomass formation by affecting protein processing in the ER and lipid biosynthesis. It appears to regulate cellulase production post-transcriptionally, independent of known regulation pathways.
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Tao Shi, Li Xu, Ya-Nan Wang, Shi-Chang Liu, Zhi-Hua Liu, Guang-Jiu Zhao, Bing-Zhi Li, Ying-Jin Yuan
Summary: By using a one-step ethylenediamine pretreatment strategy, the PL intensity of lignin can be significantly enhanced, and various properties such as multiple emission peaks and red-shift fluorescence emission can be achieved. This approach provides a novel route for the utilization of lignin in the field of organic fluorescence materials.