Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

(2020) Andrew D. Krystal et al.   NATURE MEDICINE

Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression

(2019) Hanneke Geugies et al.   BRAIN

Dissociable Neural Responses to Monetary and Social Gain and Loss in Women With Major Depressive Disorder

(2019) Anjali Sankar et al.   Frontiers in Behavioral Neuroscience

Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies

(2018) Hanna Keren et al.   AMERICAN JOURNAL OF PSYCHIATRY

T88. Reduced Neural Response to Reward in Major Depression Disorder Using a fMRI Reinforcement Learning Task

(2018) Alexandra Antonesei et al.   BIOLOGICAL PSYCHIATRY

Neuroscience of apathy and anhedonia: a transdiagnostic approach

(2018) Masud Husain et al.   NATURE REVIEWS NEUROSCIENCE

Impaired reward prediction error encoding and striatal-midbrain connectivity in depression

(2018) Poornima Kumar et al.   NEUROPSYCHOPHARMACOLOGY

Individuals with more severe depression fail to sustain nucleus accumbens activity to preferred music over time

(2018) Lisanne M. Jenkins et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development

(2018) Andrew D. Krystal et al.   NATURE REVIEWS DRUG DISCOVERY

Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation

(2018) J. Paul Hamilton et al.   Translational Psychiatry

Effort-Based Reinforcement Processing and Functional Connectivity Underlying Amotivation in Medicated Patients with Depression and Schizophrenia

(2017) Il Ho Park et al.   JOURNAL OF NEUROSCIENCE

Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder

(2017) Liang Gong et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Patients with major depressive disorder exhibit reduced reward size coding in the striatum

(2017) Masahiro Takamura et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hyper-responsivity to losses in the anterior insula during economic choice scales with depression severity

(2017) J. B. Engelmann et al.   PSYCHOLOGICAL MEDICINE

Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder

(2017) Wen-Hua Liu et al.   Social Cognitive and Affective Neuroscience

Association of Neural and Emotional Impacts of Reward Prediction Errors With Major Depression

(2017) Robb B. Rutledge et al.   JAMA Psychiatry

Anticipation-related brain connectivity in bipolar and unipolar depression: a graph theory approach

(2016) Anna Manelis et al.   BRAIN

Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder

(2016) Hannah Carl et al.   JOURNAL OF AFFECTIVE DISORDERS

Neural signals of ‘intensity’ but not ‘wanting’ or ‘liking’ of rewards may be trait markers for depression

(2016) Ciara McCabe   JOURNAL OF PSYCHOPHARMACOLOGY

Mapping inflammation onto mood: Inflammatory mediators of anhedonia

(2016) Walter Swardfager et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Assessing anhedonia in depression: Potentials and pitfalls

(2016) Sakina J. Rizvi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder

(2016) Xin-hua Yang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms

(2016) Masaya Misaki et al.   Scientific Reports

Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder

(2016) C B Young et al.   Translational Psychiatry

Moderation of the Relationship Between Reward Expectancy and Prediction Error-Related Ventral Striatal Reactivity by Anhedonia in Unmedicated Major Depressive Disorder: Findings From the EMBARC Study

(2015) Tsafrir Greenberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample

(2015) Argyris Stringaris et al.   AMERICAN JOURNAL OF PSYCHIATRY

Failure of hippocampal deactivation during loss events in treatment-resistant depression

(2015) Blair A. Johnston et al.   BRAIN

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

(2015) Alexis E. Whitton et al.   CURRENT OPINION IN PSYCHIATRY

Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects

(2015) Coraline D Metzger et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism

(2015) Arielle R. Baskin-Sommers et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Perceived life stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression

(2015) Poornima Kumar et al.   JOURNAL OF AFFECTIVE DISORDERS

Reduced striatal activation in females with major depression during the processing of affective stimuli

(2015) Megan E. Connolly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Neural networks involved in adolescent reward processing: An activation likelihood estimation meta-analysis of functional neuroimaging studies

(2015) Merav H. Silverman et al.   NEUROIMAGE

Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia

(2015) Nuria Segarra et al.   NEUROPSYCHOPHARMACOLOGY

Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

(2015) Theodore D Satterthwaite et al.   NEUROPSYCHOPHARMACOLOGY

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

(2015) Ronny Redlich et al.   NEUROPSYCHOPHARMACOLOGY

Neural reward processing in individuals remitted from major depression

(2015) B. Ubl et al.   PSYCHOLOGICAL MEDICINE

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

Altered neural reward and loss processing and prediction error signalling in depression

(2015) Bettina Ubl et al.   Social Cognitive and Affective Neuroscience

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model

(2014) Diego A. Pizzagalli   Annual Review of Clinical Psychology

Neural response to reward anticipation in those with depression with and without panic disorder

(2014) Stephanie M. Gorka et al.   JOURNAL OF AFFECTIVE DISORDERS

Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults

(2014) Jordan F. Karp et al.   JOURNAL OF CLINICAL PSYCHIATRY

Reward dysfunction in major depression: Multimodal neuroimaging evidence for refining the melancholic phenotype

(2014) Dan Foti et al.   NEUROIMAGE

Evaluation of Opioid Modulation in Major Depressive Disorder

(2014) Elliot Ehrich et al.   NEUROPSYCHOPHARMACOLOGY

Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders

(2014) Claudia Hägele et al.   PSYCHOPHARMACOLOGY

Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression

(2013) Henry W Chase et al.   BIPOLAR DISORDERS

Neuroscience of affect: brain mechanisms of pleasure and displeasure

(2013) Kent C Berridge et al.   CURRENT OPINION IN NEUROBIOLOGY

An fMRI study of reward circuitry in patients with minimal or extensive history of major depression

(2013) Geoffrey B. C. Hall et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies

(2013) Wei-Na Zhang et al.   JOURNAL OF AFFECTIVE DISORDERS

Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss

(2013) Crystal Edler Schiller et al.   JOURNAL OF AFFECTIVE DISORDERS

Blunted reward responsiveness in remitted depression

(2013) Pia Pechtel et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?

(2013) Spilios V Argyropoulos et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies

(2013) Guillaume Sescousse et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

Reduced Reward Learning Predicts Outcome in Major Depressive Disorder

(2012) Elske Vrieze et al.   BIOLOGICAL PSYCHIATRY

Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States

(2012) Ronald C. Kessler et al.   INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH

Modulation of Frontostriatal Interaction Aligns with Reduced Primary Reward Processing under Serotonergic Drugs

(2012) B. Abler et al.   JOURNAL OF NEUROSCIENCE

Anhedonia Predicts Poorer Recovery Among Youth With Selective Serotonin Reuptake Inhibitor Treatment–Resistant Depression

(2012) Dana L. McMakin et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The Behavioral Pharmacology of Effort-related Choice Behavior: Dopamine, Adenosine and Beyond

(2012) John D Salamone et al.   JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR

The factor structure of major depression symptoms: A test of four competing models using the Patient Health Questionnaire-9

(2012) Jon D. Elhai et al.   PSYCHIATRY RESEARCH

‘The risks of playing it safe’: a prospective longitudinal study of response to reward in the adolescent offspring of depressed parents

(2012) A. Rawal et al.   PSYCHOLOGICAL MEDICINE

Ventral Striatum Response During Reward and Punishment Reversal Learning in Unmedicated Major Depressive Disorder

(2011) Oliver J. Robinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Rapid Habituation of Ventral Striatal Response to Reward Receipt in Postpartum Depression

(2011) Eydie L. Moses-Kolko et al.   BIOLOGICAL PSYCHIATRY

Expected value and prediction error abnormalities in depression and schizophrenia

(2011) Victoria B. Gradin et al.   BRAIN

Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes

(2011) Gabriel S. Dichter et al.   JOURNAL OF AFFECTIVE DISORDERS

Surprise Signals in Anterior Cingulate Cortex: Neuronal Encoding of Unsigned Reward Prediction Errors Driving Adjustment in Behavior

(2011) B. Y. Hayden et al.   JOURNAL OF NEUROSCIENCE

Neurobiology of Decision Making in Depressed Adolescents: A Functional Magnetic Resonance Imaging Study

(2011) Mujeeb U. Shad et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Understanding dopamine and reinforcement learning: The dopamine reward prediction error hypothesis

(2011) P. W. Glimcher   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards

(2011) Moria J. Smoski et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

“I won, but I'm not getting my hopes up”: Depression moderates the relationship of outcomes and reward anticipation

(2011) Thomas M. Olino et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms

(2011) R. Uher et al.   PSYCHOLOGICAL MEDICINE

Value, pleasure and choice in the ventral prefrontal cortex

(2011) Fabian Grabenhorst et al.   TRENDS IN COGNITIVE SCIENCES

The neurobiology of anhedonia and other reward-related deficits

(2011) Andre Der-Avakian et al.   TRENDS IN NEUROSCIENCES

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Reward and Punishment Processing in Depression

(2010) Neir Eshel et al.   BIOLOGICAL PSYCHIATRY

A Pooled MADRS/IDS Cross-Correlation Analysis

(2010) Frederick W. Reimherr et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Individuals With Major Depressive Disorder

(2009) Diego A. Pizzagalli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Dopamine modulates effort-based decision making in rats.

(2009) Mark E. Bardgett et al.   BEHAVIORAL NEUROSCIENCE

The Effects of Psychotherapy on Neural Responses to Rewards in Major Depression

(2009) Gabriel S. Dichter et al.   BIOLOGICAL PSYCHIATRY

Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment

(2009) Ciara McCabe et al.   BIOLOGICAL PSYCHIATRY

Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study

(2009) Jonathan Price et al.   BRITISH JOURNAL OF PSYCHIATRY

Immaturities in Reward Processing and Its Influence on Inhibitory Control in Adolescence

(2009) C.F. Geier et al.   CEREBRAL CORTEX

fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder

(2009) Moria J. Smoski et al.   JOURNAL OF AFFECTIVE DISORDERS

The Reward Circuit: Linking Primate Anatomy and Human Imaging

(2009) Suzanne N Haber et al.   NEUROPSYCHOPHARMACOLOGY

Brain activation to favorite music in healthy controls and depressed patients

(2009) Elizabeth A. Osuch et al.   NEUROREPORT

Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia

(2009) Michael T. Treadway et al.   PLoS One

Neural representation of reward in recovered depressed patients

(2009) Ciara McCabe et al.   PSYCHOPHARMACOLOGY

Anhedonia in schizophrenia and major depression: state or trait?

(2009) Lorenzo Pelizza et al.   Annals of General Psychiatry

Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder

(2008) Erika E. Forbes et al.   AMERICAN JOURNAL OF PSYCHIATRY

Abnormal temporal difference reward-learning signals in major depression

(2008) P. Kumar et al.   BRAIN

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Choice, uncertainty and value in prefrontal and cingulate cortex

(2008) Matthew F S Rushworth et al.   NATURE NEUROSCIENCE

Neural substrates of reward magnitude, probability, and risk during a wheel of fortune decision-making task

(2008) B SMITH et al.   NEUROIMAGE

Affective neuroscience of pleasure: reward in humans and animals

(2008) Kent C. Berridge et al.   PSYCHOPHARMACOLOGY

Neural Responses to Monetary Incentives in Major Depression

(2007) Brian Knutson et al.   BIOLOGICAL PSYCHIATRY