Article
Respiratory System
Jonathan Thorsen, Jakob Stokholm, Morten Arendt Rasmussen, Michael Roggenbuck-Wedemeyer, Nadja H. Vissing, Martin S. Mortensen, Asker D. Brejnrod, Louise Fleming, Andrew Bush, Graham Roberts, Florian Singer, Urs Frey, Gunilla Hedlin, Bjorn Nordlund, Clare S. Murray, Mahmoud Abdel-Aziz, Simone Hashimoto, Wim van Aalderen, Anke H. Maitland-van der Zee, Dominick Shaw, Stephen J. Fowler, Ana Sousa, Peter J. Sterk, Kian Fan Chung, Ian M. Adcock, Ratko Djukanovic, Charles Auffray, Aruna T. Bansal, Scott Wagers, Bo Chawes, Klaus Bonnelykke, Soren Johannes Sorensen, Hans Bisgaard
Summary: There is a major unmet need for improving the care of children and adolescents with severe asthma and wheeze. Identifying factors contributing to disease severity, such as the airway microbiota, may lead to improved diagnostics, biomarkers, or therapies. In this study, the oropharyngeal airway microbiota of children and adolescents with severe and mild/moderate asthma/wheeze were compared. The results showed a modest difference in the microbiota between children with severe and mild/moderate asthma/wheeze across all age groups, and a strong association between the microbiota and age. However, the microbiota may not be a strong enough biomarker for targeted intervention.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Allergy
Sergio Souza da Cunha, Gillian Santorelli, Neil Pearce, John Wright, Sam Oddie, Emily Petherick, Lucy Pembrey
Summary: The study of 12,476 children showed an association between prenatal exposure to antibiotics and postnatal exposure to antibiotics with an increased risk of asthma in children, especially in those exposed postnatally where the risk of asthma increased with the number of prescriptions. The effect was lower among children with mothers of Pakistani ethnicity, and the interaction between prenatal and postnatal exposures was inconclusive. The population attributable risk of postnatal exposure for asthma was 4.6%.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Critical Care Medicine
Jonathan Thorsen, Jakob Stokholm, Morten Arendt Rasmussen, Martin Steen Mortensen, Asker Daniel Brejnrod, Mathis Hjelmso, Shiraz Shah, Bo Chawes, Klaus Bonnelykke, Soren Johannes Sorensen, Hans Bisgaard
Summary: The richness of airway microbiota is associated with episode duration during acute episodes of asthma-like symptoms, and it can modify the effect of azithromycin treatment in preschool children with recurrent asthma-like symptoms.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Rong Li, Qi Guo, Jian Zhao, Wenhui Kang, Ruoyu Lu, Zichong Long, Lili Huang, Yiting Chen, Anda Zhao, Jinhong Wu, Yong Yin, Shenghui Li
Summary: Genetic research has shown a causal relationship between gut microbiota and asthma, including its three phenotypes. Specific genera of gut microbiota were found to be positively or negatively associated with the risk of asthma. These findings contribute to our understanding of the role of gut microbiota in the pathology of asthma and have potential implications for asthma prevention and diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Snehal N. Chaudhari, Megan D. McCurry, A. Sloan Devlin
Summary: This review article discusses how uncovering phenotypes linked to the human microbiome progresses from correlative studies to studies in germ-free animals and fecal microbiota transplants, and, finally, to identification of strains and molecules.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Microbiology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: Our study found that despite heavy and sustained antibiotic pressure, microbial communities within the same patient remained more similar to each other than to those from other patients. We identified 6 taxa within the pre-treatment microbiota that predicted the extent of antibiotic-induced perturbations. Our results suggest that specific species in the pre-treatment microbiota play a key role in determining personalized microbiota responses to antibiotics in humans, which could lead to precision interventions to prevent antibiotic-induced dysbiosis and its adverse clinical consequences.
Article
Medicine, Research & Experimental
Wanzhong Liao, Wei Liu, Yu Yan, Liang Li, Jianjun Tong, Yanping Huang, Shuwei Guo, Weizhe Jiang, Shujie Fu
Summary: In a mouse model of ovalbumin-induced allergic asthma, treatment with Hylocereus undatus flower (HUF) significantly reduced the key features of allergic asthma, including elevated respiratory rate, inflammatory cell accumulation, airway inflammation, and the expression of pro-inflammatory molecules. HUF also improved the disrupted gut microbiota composition in asthmatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nutrition & Dietetics
Jinli Huang, Juan Zhang, Xingzhi Wang, Zenghui Jin, Panpan Zhang, Hui Su, Xin Sun
Summary: This review provides an overview of the clinical features of allergic rhinitis (AR) and allergic asthma (AA), as well as the potential role of probiotics in the prevention and treatment of these diseases. The study found that an imbalance in gut microbiota may contribute to the development of allergic diseases, and probiotics can modulate immune responses to improve inflammation and enhance host defense.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Sara K. Di Simone, Ina Rudloff, Claudia A. Nold-Petry, Samuel C. Forster, Marcel F. Nold
Summary: Interactions between the developing microbiome and maturing immune system in early life play a critical role in establishing a beneficial homeostasis for both the host and commensals. The lung is home to a diverse community of microbes, which can be associated with health, as well as local or systemic diseases. This article discusses how the colonization and changes in the microbial community during early life correlate with immune development, health, and disease from infancy to adulthood. The authors also highlight the advances in microbiology, immunology, and computational biology that enable the investigation of the functional relevance of interactions between the respiratory microbiome and the host immune system, potentially leading to microbiome-based therapeutics.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Alexandru Cosmin Pantazi, Cristina Maria Mihai, Adriana Luminita Balasa, Tatiana Chisnoiu, Ancuta Lupu, Corina Elena Frecus, Larisia Mihai, Adina Ungureanu, Mustafa Ali Kassim Kassim, Antonio Andrusca, Maria Nicolae, Viviana Cuzic, Vasile Valeriu Lupu, Simona Claudia Cambrea
Summary: The intestinal microbiota is a diverse and complex microecosystem that stabilizes by the age of three and plays a crucial role in human health, particularly in early childhood. Dysbiosis has been linked to the development of allergic diseases, such as atopic dermatitis, asthma, and food allergies. Next-generation sequencing methods have improved our understanding of the relationship between dysbiosis and allergic diseases. This review paper aims to synthesize the current knowledge on the development of the intestinal microbiota, its long-term impact on health, and the connection between dysbiosis and allergic diseases, as well as interventions for prevention and treatment.
Article
Critical Care Medicine
Mahmoud I. Abdel-Aziz, Jonathan Thorsen, Simone Hashimoto, Susanne J. H. Vijverberg, Anne H. Neerincx, Paul Brinkman, Wim van Aalderen, Jakob Stokholm, Morten Arendt Rasmussen, Michael Roggenbuck-Wedemeyer, Nadja H. Vissing, Martin Steen Mortensen, Asker Daniel Brejnrod, Louise J. Fleming, Clare S. Murray, Stephen J. Fowler, Urs Frey, Andrew Bush, Florian Singer, Gunilla Hedlin, Bjorn Nordlund, Dominick E. Shaw, Kian Fan Chung, Ian M. Adcock, Ratko Djukanovic, Charles Auffray, Aruna T. Bansal, Ana R. Sousa, Scott S. Wagers, Bo Lund Chawes, Klaus Bonnelykke, Soren Johannes Sorensen, Aletta D. Kraneveld, Peter J. Sterk, Graham Roberts, Hans Bisgaard, Anke H. Maitland-van der Zee
Summary: By analyzing the oropharyngeal microbiota of children with asthma or wheezing, four distinct clusters with unique clinical characteristics were identified, and the enrichment scores of transcriptomic pathways associated with exacerbation risk and airway remodeling varied among these clusters.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Plamen Bokov, Donies Jallouli-Masmoudi, Flore Amat, Veronique Houdouin, Christophe Delclaux
Summary: The study found that parameters related to small airway dysfunction are linked to asthma probability, but are unable to differentiate wheezing phenotypes. Lung function parameters obtained from impulse oscillometry and asthma probability belong to independent dimensions of the wheezing disease.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Respiratory System
Lei Wu, Chencong Shen, Yuanling Chen, Xin Yang, Xiaofei Luo, Chengcheng Hang, Lingling Yan, Xuefeng Xu
Summary: This study suggests that alterations in lower airway microbiota may be strongly associated with the development of wheezing and wheezing recurrence later in life. The study also found significant differences in microbial composition details between PW children and the control group. The results also showed that wheezing history, gender, and caesarean section have a greater impact on the composition of airway microbiota.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Hanshu Yuan, Zhongmao Liu, Jinhong Dong, Leonard B. Bacharier, Daniel Jackson, David Mauger, Homer Boushey, Mario Castro, Juliana Durack, Yvonne J. Huang, Robert F. Lemanske Jr, Gregory A. Storch, George M. Weinstock, Kristine Wylie, Ronina Covar, Anne M. Fitzpatrick, Wanda Phipatanakul, Rachel G. Robison, Avraham Beigelman, Yanjiao Zhou
Summary: This study suggests that the upper airway mycobiome is associated with asthma control and may be used for predicting asthma exacerbation.
Article
Pharmacology & Pharmacy
Jun Zheng, Qian Wu, Liang Zhang, Ya Zou, Meifen Wang, Li He, Sheng Guo
Summary: This study found that Qingfei oral liquid (QF) has a significant anti-inflammatory effect on airway inflammation in asthmatic mice and can regulate the balance of respiratory microbiota. QF may reduce airway inflammation by downregulating the MAPK and Nod-like receptor signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Carolina Iturriaga, Maria Francisca Bustos, Catalina Le Roy, Rocio Rodriguez, Lorena Cifuentes, Sergio Silva-Valenzuela, Cristian Vera-Kellet, Francisca Cristi, Guillermo Perez-Mateluna, Carolina Cabalin, Rodrigo Hoyos-Bachiloglu, Carlos A. Camargo, Arturo Borzutzky
Summary: This study evaluated the association of obesity with atopic dermatitis (AD) in children from Chile. The study found that children with AD had similar rates of obesity as healthy controls, but showed sex-specific associations of abdominal obesity and AD.
PEDIATRIC DERMATOLOGY
(2023)
Article
Emergency Medicine
Margaret E. Samuels-Kalow, Jingya Gao, Krislyn M. Boggs, Carlos A. Camargo Jr, Kori S. Zachrison
Summary: The study found significant regionalization of pediatric emergency care. Although there was no significant variation in regionalization based on insurance status, there were differences in network density and transfer rates. Further research is needed to understand the factors influencing transfer decisions and how these patterns may vary by state.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Christopher L. Bennett, Krislyn M. Boggs, Margaret E. Samuels-Kalow, Monica Saxena, Melissa Pasao, Ali S. Raja, Carlos A. Camargo Jr
Summary: This study examines the gender differences in first authorship and characteristics in the Society for Academic Emergency Medicine (SAEM) Annual Meeting abstracts and resulting manuscript publications. It found that a minority of abstracts and publications had female first authors, and abstracts with female first authors took longer to achieve manuscript publication. Moreover, a significant proportion of female first author abstracts resulted in male first author publications.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Gregory A. Peters, Rebecca E. Cash, Scott A. Goldberg, Alexander J. Ordoobadi, Carlos A. Camargo Jr
Summary: The study aimed to analyze the characteristics of EMS activations for asthma/COPD exacerbations in the US, including demographics, clinical features, and EMS response. A large nationwide sample from 2018 to 2019 was used, and the data showed that 5% of 9-1-1 activations were for asthma/COPD exacerbation. Most patients were adults, with a higher proportion of females in adult patients and males in pediatric patients. The majority of activations occurred in urban settings, and advanced life support units managed most cases. Inhaled bronchodilators and systemic corticosteroid therapy were commonly administered to patients.
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ruby H. N. Nguyen, Emily A. Knapp, Xiuhong Li, Carlos A. Camargo, Elisabeth Conradt, Whitney Cowell, Karen J. Derefinko, Amy J. Elliott, Alexander M. Friedman, Gurjit K. Khurana Hershey, Julie A. Hofheimer, Barry M. Lester, Cindy T. McEvoy, Jenae M. Neiderhiser, Emily Oken, Steven J. Ondersma, Sheela Sathyanarayana, Meagan E. Stabler, Annemarie Stroustrup, Irene Tung, Monica McGrath
Summary: This study analyzed cross-sectional data from 21,905 pregnancies enrolled in the ECHO program in the United States. The study identified characteristics associated with opioid use during pregnancy, including race, pregnancy period, parity, tobacco use, illegal drug use, and maternal depression.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Immunology
Tadao Ooka, Zhaozhong Zhu, Liming Liang, Juan C. Celedon, Brennan Harmon, Andrea Hahn, Eugene P. Rhee, Robert J. Freishtat, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Through integrated genetics-metabolomics analysis, genetically driven metabolites associated with asthma development and genetic loci associated with both these metabolites and asthma susceptibility were identified in this high-risk population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Makiko Nanishi, Aruna Chandran, Xiuhong Li, Joseph B. Stanford, Akram N. Alshawabkeh, Judy L. Aschner, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, James E. Gern, Tina Hartert, Julie Herbstman, Gurjit K. Khurana Hershey, Alison E. Hipwell, Margaret R. Karagas, Catherine J. Karr, Leslie D. Leve, Augusto A. Litonjua, Cindy T. McEvoy, Rachel L. Miller, Emily Oken, T. Michael O'Shea, Nigel Paneth, Scott T. Weiss, Robert O. Wright, Rosalind J. Wright, Kecia N. Carroll, Xueying Zhang, Qi Zhao, Edward Zoratti, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Based on large-scale cohort data, this study found that infants hospitalized with bronchiolitis are at a higher risk for developing asthma. There is quantitative heterogeneity in different racial and ethnic groups.
Letter
Emergency Medicine
Krislyn M. Boggs, Rebecca E. Cash, Dorsey Glew, Piroz Bahar, Kohei Hasegawa, Ali S. Raja, Carlos A. Camargo Jr
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Pediatrics
Aruna Chandran, Mohamad Burjak, Joshua Petimar, Ghassan Hamra, Melissa M. Melough, Anne L. Dunlop, Brittney M. Snyder, Augusto A. Litonjua, Tina Hartert, James Gern, Akram N. Alshawabkeh, Judy Aschner, Carlos A. Camargo, Dana Dabelea, Cristiane S. Duarte, Assiamira Ferrara, Jody M. Ganiban, Frank Gilliland, Diane R. Gold, Monique Hedderson, Julie B. Herbstman, Christine Hockett, Margaret R. Karagas, Jean M. Kerver, Kathleen A. Lee-Sarwar, Barry Lester, Cindy T. McEvoy, Zhongzheng Niu, Joseph B. Stanford, Rosalind Wright, Emily Zimmerman, Shohreh Farzan, Zhumin Zhang, Emily Knapp
Summary: This study aimed to evaluate the association between the Healthy, Hunger-Free Kids Act (HHFKA) and youth body mass index (BMI). The results showed that the implementation of HHFKA was associated with a significant decrease in BMIz among school-aged youths in the US. The findings suggest that interventions in school meal programs represent a key opportunity to combat the childhood obesity epidemic.
Article
Geriatrics & Gerontology
Jeffrey M. Caterino, Julie A. Stephens, Randell Wexler, Carlos A. Camargo, Katherine M. Hunold, Lai Wei, David Hains, Lauren T. Southerland, Jason J. Bischof, Andrew Schwaderer
Summary: The study found that there were no significant differences in urinary antimicrobial peptide (AMPs) levels between older and younger adults, but older adults had lower levels of a specific AMP, hBD-2. This finding has implications for the potential use of urinary AMPs as diagnostic markers and will facilitate further exploration into the role of innate immunity in urinary tract infection susceptibility in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
Carolina Cabalin, Guillermo Perez-Mateluna, Carolina Iturriaga, Carlos A. Camargo, Arturo Borzutzky
Summary: This study investigated the effects of oral cholecalciferol supplementation on vitamin D receptor (vdr), Cathelicidin Antimicrobial Peptide (camp/LL-37), and Thymic Stromal Lymphopoietin (tslp) in children with atopic dermatitis (AD). The results showed that oral vitamin D3 supplementation improved serum 25-hydroxyvitamin D levels, AD severity, and increased the expression of vdr and camp in lesional skin of children with AD, providing mechanistic clues for its effects.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Meeting Abstract
Allergy
Zhaozhong Zhu, Robert Freishtat, Brennan Harmon, Andrea Hahn, Stephen Teach, Marcos Perez-Losada, Kohei Hasegawa, Carlos Camargo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Anjali J. Kaimal, Margaret E. Samuels-Kalow, Krislyn M. Boggs, Maeve F. Swanton, Carlos A. Camargo Jr
Summary: This study examined out-of-hospital deliveries and high-risk complications treated by EMS clinicians in the U.S. Most out-of-hospital deliveries involved patients between the ages of 20-34 and occurred on weekdays. There were disparities in the level of care and access to definitive care based on maternal and community factors.
PREHOSPITAL EMERGENCY CARE
(2023)
