Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells

(2018) Rui Cao et al.   CANCER LETTERS

NRF2 addiction in cancer cells

(2018) Hiroshi Kitamura et al.   CANCER SCIENCE

Sulforaphene Enhances The Efficacy of Photodynamic Therapy In Anaplastic Thyroid Cancer Through Ras/RAF/MEK/ERK Pathway Suppression

(2018) Saswata Chatterjee et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

(2017) Sebastien Antoni et al.   EUROPEAN UROLOGY

EAU Guidelines on Non–Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016

(2017) Marko Babjuk et al.   EUROPEAN UROLOGY

Tp53 and its potential therapeutic role as a target in bladder cancer

(2017) Chiara Ciccarese et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

(2017) Saowanee Jeayeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

(2017) Zihang Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Cancer

(2017) İlhan Gecit et al.   JOURNAL OF MEMBRANE BIOLOGY

Unlocking bladder cancer

(2017) Chris Berdik   NATURE

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model

(2017) H Kitamura et al.   ONCOGENE

Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells

(2017) Sul-Gi Park et al.   Pharmacological Reports

Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop

(2017) Rui Cao et al.   Journal of Cancer

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting p38MAPK/NFκB Pathway in H9c2 Cardiac Cells

(2017) Runmin Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production

(2016) Kartini Iskandar et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Role of JNK Signalling in Responses to Oxidative DNA Damage

(2016) Zeeshan Shaukat et al.   CURRENT DRUG TARGETS

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

(2016) Shang-Jyh Kao et al.   ENVIRONMENTAL TOXICOLOGY

Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes

(2016) Jakub Dobruch et al.   EUROPEAN UROLOGY

Second Line Chemotherapy for Advanced and Metastatic Urothelial Carcinoma: Vinflunine and Beyond—A Comprehensive Review of the Current Literature

(2016) Christoph Oing et al.   JOURNAL OF UROLOGY

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways

(2016) Fengsen Duan et al.   PLoS One

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma

(2015) Y. Shi et al.   ANNALS OF ONCOLOGY

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism

(2015) Dionysios V. Chartoumpekis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise

(2015) J. Kim et al.   CLINICAL CANCER RESEARCH

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells

(2015) BIAO ZHENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeted therapies in bladder cancer: an overview of in vivo research

(2015) Kim E. M. van Kessel et al.   Nature Reviews Urology

Reactive Oxygen and Nitrogen Species

(2015) Dereck Salisbury et al.   NURSING RESEARCH

Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis

(2014) G. P. Nagaraju et al.   CARCINOGENESIS

Novel signaling axis for ROS generation during K-Ras-induced cellular transformation

(2014) M-T Park et al.   CELL DEATH AND DIFFERENTIATION

Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer

(2014) Lidija Milkovic et al.   CURRENT PHARMACEUTICAL DESIGN

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

(2014) Jacob M. Kaufman et al.   Journal of Thoracic Oncology

Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression

(2014) BING ZHAO et al.   ONCOLOGY REPORTS

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

(2013) Ju Mei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Compound K Induces Apoptosis of Bladder Cancer T24 Cells Via Reactive Oxygen Species-Mediated p38 MAPK Pathway

(2013) Han Wang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

(2013) Ramón Rodrigo et al.   DISEASE MARKERS

Screening for bladder cancer with urinary tumor markers in chemical workers with exposure to aromatic amines

(2013) Beate Pesch et al.   INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

Loss of SPARC in bladder cancer enhances carcinogenesis and progression

(2013) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant CpG Islands' Hypermethylation of ABCB1 in Mesenchymal Stem Cells of Patients with Steroid-associated Osteonecrosis

(2013) Z. Sun et al.   JOURNAL OF RHEUMATOLOGY

Apoptosis Induction of Human Bladder Cancer Cells by Sanguinarine through Reactive Oxygen Species-Mediated Up-Regulation of Early Growth Response Gene-1

(2013) Min Ho Han et al.   PLoS One

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Up-regulation of BLT2 is critical for the survival of bladder cancer cells

(2011) Ji-Min Seo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells

(2010) Shambhunath Choudhary et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the erk pathway in selective induction of human urinary bladder cancer j82 cell death

(2010) Shambhunath Choudhary et al.   MOLECULAR CARCINOGENESIS

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction

(2009) Shambhunath Choudhary et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mitochondrial Cytochrome B Gene Mutation Promotes Tumor Growth in Bladder Cancer

(2008) S. Dasgupta et al.   CANCER RESEARCH

Altered redox status accompanies progression to metastatic human bladder cancer

(2008) N HEMPEL et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE