Journal
CELL BIOLOGY INTERNATIONAL
Volume 40, Issue 7, Pages 796-802Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbin.10618
Keywords
aging; cell function; endothelial implications
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Funding
- Brazilian Federal Government Funding Agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [AUX-PRODOC-106/2005]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- CAPES
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Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study compared parameters from non-stimulated neutrophils, obtained from young (18-30 years old [y.o.]) and elderly (65-80 y.o.) human volunteers. Measured as an inflammatory marker, plasmatic concentration of hs-CRP was found higher in elderly individuals. Non-stimulated neutrophil production of ROS and NO was, respectively, 38 and 29% higher for the aged group. From the adhesion molecules evaluated, only CD11b expression was elevated in neutrophils from the aged group, whereas no differences were found for CD11a, CD18, or CD62. A 69% higher non-stimulated in vitro neutrophil/endothelial cell adhesion was observed for neutrophils isolated from elderly donors. Our results suggest that with aging, neutrophils may be constitutively producing more reactive species in closer proximity to endothelial cells of vessel walls, which may both contribute to vascular damage and reflect a neutrophil intracellular disrupted redox balance, altering neutrophil function in aging.
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