期刊
CELL BIOLOGY INTERNATIONAL
卷 40, 期 7, 页码 796-802出版社
WILEY-BLACKWELL
DOI: 10.1002/cbin.10618
关键词
aging; cell function; endothelial implications
类别
资金
- Brazilian Federal Government Funding Agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [AUX-PRODOC-106/2005]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- CAPES
Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study compared parameters from non-stimulated neutrophils, obtained from young (18-30 years old [y.o.]) and elderly (65-80 y.o.) human volunteers. Measured as an inflammatory marker, plasmatic concentration of hs-CRP was found higher in elderly individuals. Non-stimulated neutrophil production of ROS and NO was, respectively, 38 and 29% higher for the aged group. From the adhesion molecules evaluated, only CD11b expression was elevated in neutrophils from the aged group, whereas no differences were found for CD11a, CD18, or CD62. A 69% higher non-stimulated in vitro neutrophil/endothelial cell adhesion was observed for neutrophils isolated from elderly donors. Our results suggest that with aging, neutrophils may be constitutively producing more reactive species in closer proximity to endothelial cells of vessel walls, which may both contribute to vascular damage and reflect a neutrophil intracellular disrupted redox balance, altering neutrophil function in aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据