Balance Between Rapid Delayed Rectifier K + Current and Late Na + Current on Ventricular Repolarization

Changes in cellular Ca 2+ and Na + regulation during the progression towards heart failure in the guinea pig

(2019) H.‐Y. Ke et al.   JOURNAL OF PHYSIOLOGY-LONDON

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy

(2019) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes

(2019) Bence Hegyi et al.   Circulation-Arrhythmia and Electrophysiology

Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and β adrenergic stimulation

(2019) Bence Hegyi et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Mexiletine Shortens the QT Interval in Patients With Potassium Channel–Mediated Type 2 Long QT Syndrome

(2019) J. Martijn Bos et al.   Circulation-Arrhythmia and Electrophysiology

A microtranslatome coordinately regulates sodium and potassium currents in the human heart

(2019) Catherine A Eichel et al.   eLife

Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control ExcitabilityNovelty and Significance

(2018) Daniela Ponce-Balbuena et al.   CIRCULATION RESEARCH

Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes

(2018) Bence Hegyi et al.   Circulation-Arrhythmia and Electrophysiology

Complex electrophysiological remodeling in postinfarction ischemic heart failure

(2018) Bence Hegyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback

(2018) Stefano Morotti et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII

(2018) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The QUIDAM study: Hydroquinidine therapy for the management of Brugada syndrome patients at high arrhythmic risk

(2017) Antoine Andorin et al.   HEART RHYTHM

Ca 2+ -activated Cl − current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization

(2017) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular Pathophysiology of Congenital Long QT Syndrome

(2017) M. S. Bohnen et al.   PHYSIOLOGICAL REVIEWS

Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin

(2016) Dmytro Kornyeyev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

(2016) Dmitry O. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ranolazine for Congenital Long-QT Syndrome Type III

(2016) Ehud Chorin et al.   Circulation-Arrhythmia and Electrophysiology

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

(2016) Pei-Chi Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rabbit models as tools for preclinical cardiac electrophysiological safety testing: Importance of repolarization reserve

(2016) István Baczkó et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes

(2015) Balázs Horváth et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In VivoCLINICAL PERSPECTIVE

(2015) Patric Glynn et al.   CIRCULATION

IKrImpact on Repolarization and Its Variability Assessed by Dynamic Clamp

(2015) Claudia Altomare et al.   Circulation-Arrhythmia and Electrophysiology

Synchronous Systolic Subcellular Ca2+-Elevations Underlie Ventricular Arrhythmia in Drug-Induced Long QT Type 2

(2015) Jong J. Kim et al.   Circulation-Arrhythmia and Electrophysiology

Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

(2015) Luiz Belardinelli et al.   HEART RHYTHM

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current

(2015) Pei-Chi Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chemistry, Physiology, and Pharmacology of β.-Adrenergic Mechanisms in the Heart. Why are .β-Blocker Antiarrhythmics Superior?

(2015) A. Szentmiklosi et al.   CURRENT PHARMACEUTICAL DESIGN

Asynchronous activation of calcium and potassium currents by isoproterenol in canine ventricular myocytes

(2014) Ferenc Ruzsnavszky et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Contribution of ion currents to beat-to-beat variability of action potential duration in canine ventricular myocytes

(2014) Norbert Szentandrássy et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Selectivity Problems with Drugs Acting on Cardiac Na+ and Ca2+ Channels

(2013) Bence Hegyi et al.   CURRENT MEDICINAL CHEMISTRY

β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

(2013) Yuanfang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dynamics of the late Na+ current during cardiac action potential and its contribution to afterdepolarizations

(2013) Balazs Horvath et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of action potential configuration and the contribution of Ca2+and K+currents to isoprenaline-induced changes in canine ventricular cells

(2012) N Szentandrássy et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Late Na+ Current - Origin and Pathophysiological Relevance

(2012) Antonio Zaza et al.   CARDIOVASCULAR DRUGS AND THERAPY

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After β-Adrenergic Stimulation

(2012) Daniel M. Johnson et al.   CIRCULATION RESEARCH

Tetrodotoxin blocks L-type Ca2+ channels in canine ventricular cardiomyocytes

(2012) Bence Hegyi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of I Kr Inhibition on Ventricular Repolarization

(2011) Lin Wu et al.   CIRCULATION

Suppression of Re-Entrant and Multifocal Ventricular Fibrillation by the Late Sodium Current Blocker Ranolazine

(2011) Norishige Morita et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-Term Follow-Up of Patients With Short QT Syndrome

(2011) Carla Giustetto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations

(2010) László Bárándi et al.   BASIC RESEARCH IN CARDIOLOGY

Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart

(2009) J. A. Wasserstrom et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences

(2008) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The QT syndromes: long and short

(2008) Hiroshi Morita et al.   LANCET