A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current

Formation of Spatially Discordant Alternans Due to Fluctuations and Diffusion of Calcium

(2014) Daisuke Sato et al.   PLoS One

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

(2014) Jiqing Guo et al.   PLoS One

Ranolazine for Congenital and Acquired Late I Na -Linked Arrhythmias

(2013) Jonathan D. Moreno et al.   CIRCULATION RESEARCH

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

(2013) Serge Sicouri et al.   HEART RHYTHM

Dynamics of the late Na+ current during cardiac action potential and its contribution to afterdepolarizations

(2013) Balazs Horvath et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac fibrosis and arrhythmogenesis: The road to repair is paved with perils

(2013) Thao P. Nguyen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Late Sodium Current Is an Intrinsic Regulator of Cardiac Repolarization—A Quantitative Assessment

(2012) Y. Song et al.   HEART RHYTHM

Arrhythmogenic consequences of myofibroblast–myocyte coupling

(2011) Thao P. Nguyen et al.   CARDIOVASCULAR RESEARCH

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

The Role of Fibroblasts in Complex Fractionated Electrograms During Persistent/Permanent Atrial Fibrillation

(2011) Takashi Ashihara et al.   CIRCULATION RESEARCH

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

(2011) J. D. Moreno et al.   Science Translational Medicine

Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes

(2009) Dawn M. Pedrotty et al.   CARDIOVASCULAR RESEARCH

Cardiac Ion Channels

(2009) Augustus O. Grant   Circulation-Arrhythmia and Electrophysiology

An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes

(2008) Yejia Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Electrotonic Myofibroblast-to-Myocyte Coupling Increases Propensity to Reentrant Arrhythmias in Two-Dimensional Cardiac Monolayers

(2008) Sharon Zlochiver et al.   BIOPHYSICAL JOURNAL