Article
Cell & Tissue Engineering
Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu, Shaoyi Zheng
Summary: Preservation of donor hearts with hypoxic CdM derived from BMSCs can improve post-transplant graft function by reducing apoptosis and inflammation. The cardioprotective effects were demonstrated by shorter time to spontaneous contraction, better left ventricular function, lower histopathological scores, higher ejection fraction, and fractional shortening.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Sevil Korkmaz-Icoez, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamas Radovits, Alex Ali Sayour, Mihaly Ruppert, Gabor Veres, Matthias Karck, Gabor Szabo
Summary: The study demonstrates that the use of CM from bone marrow MSCs can protect vascular grafts in BD rats, alleviating endothelial dysfunction caused by IR injury and reducing levels of inflammation and apoptosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Sevil Korkmaz-Icoez, Xiaoxin Sun, Shiliang Li, Paige Brlecic, Sivakkanan Loganathan, Mihaly Ruppert, Alex Ali Sayour, Tamas Radovits, Matthias Karck, Gabor Szabo
Summary: The study revealed that adding conditioned medium from mesenchymal stem cells can protect vascular grafts from ischemia/reperfusion injury in aged rats, alleviating endothelial dysfunction.
Article
Physiology
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray-Gundersen, Hirofumi Tanaka, Sophie Lalande
Summary: Ischemic preconditioning and intermittent hypoxia can attenuate the reduction in brachial artery endothelial function caused by ischemia-reperfusion injury in young healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh, Nahid Aboutaleb
Summary: This study demonstrated that hAM-MSCs-CM has cardioprotective effects against MI/R injury by modulating autophagy through the mTOR/ULK1 pathway, improving cardiac function and reducing fibrosis. These findings suggest that hAM-MSCs-CM may be a promising candidate for attenuating MI/R injury in the future, although further investigations are needed.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cell Biology
Tingting Zhang, Yanyan Wang, Qin Xia, Zhiyi Tu, Jiajun Sun, Qi Jing, Pei Chen, Xuan Zhao
Summary: Cerebral ischemia/reperfusion (I/R) injury results in increased apoptosis of microglial cells and neurons, with propofol protecting the brain against I/R injury by downregulating Cx43.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irina A. Mandel, Yuriy K. Podoksenov, Sergey L. Mikheev, Irina V. Suhodolo, Yulia S. Svirko, Vladimir M. Shipulin, Anastasia V. Ivanova, Andrey G. Yavorovskiy, Andrey I. Yaroshetskiy
Summary: Hypoxic-hyperoxic preconditioning (HHP) may reduce endothelial damage and improve postoperative outcome in cardiac surgery with cardiopulmonary bypass. The HHP group had a lower frequency of postoperative complications compared to the control group. Endothelial damage markers were predictive of postoperative complications.
Article
Cell Biology
Bo Sun, Xianhui Meng, Yumin Li, Yanlong Li, Rui Liu, Zhongdang Xiao
Summary: In this study, we demonstrated that conditioning medium derived from human cord blood mesenchymal stem cells (CBMSC-CM) improved immune response efficiency and reduced cellular senescence in aged mice. CBMSC-CM administration resulted in a decrease in NK and regulatory T-cell populations in peripheral blood, an increase in naive T-cell number, and restoration of the ratio of naive to memory T-cells in CD4(+) T-cell population. Additionally, CBMSC-CM treatment reduced the number of senescent T-cells in kidney tissues and attenuated hydrogen peroxide triggered T-cell response and oxidative stress induced cellular senescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Physiology
Sten Stray-Gundersen, Sahar D. Massoudian, Frank Wojan, Hirofumi Tanaka, Sophie Lalande
Summary: This study demonstrates that systemic hypoxic preconditioning can attenuate the reduction in brachial artery flow-mediated dilation induced by an ischemia-reperfusion injury in older adults. This is particularly important for older adults who are at greater risk for ischemic events.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Vitale Miceli, Alessandro Bertani, Cinzia Maria Chinnici, Matteo Bulati, Mariangela Pampalone, Giandomenico Amico, Claudia Carcione, Eva Schmelzer, Jorg C. Gerlach, Pier Giulio Conaldi
Summary: The study showed that the conditioned medium of human amnion-derived MSCs can alleviate the effects of lung IRI by improving the efficacy of EVLP, preserving the viability of alveolar epithelial cells and delaying apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kongwei Guo, Yanxing Shang, Zhao Wang, Yu Li, Jinliang Chen, Baofeng Zhu, Dongmei Zhang, Jianrong Chen
Summary: BRG1 plays a key role in apoptosis and oxidative damage, but its role in the pathophysiology of ischemic stroke is unclear. We found that BRG1 expression was increased during cerebral ischemia and reperfusion, particularly in activated microglia. Modulating BRG1 expression levels significantly affected microglial activation and the expression of antioxidant and pro-oxidant proteins after ischemic stroke. Our findings suggest that BRG1 protects against brain ischemia/reperfusion injury by reducing oxidative damage through the KEAP1-NRF2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Tzu-Lin Lee, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Summary: The study demonstrates that ADSC-CM significantly reduces injury and fibrosis in I/R-treated hearts and H/R-treated cardiomyocytes, while decreasing expression of related proteins and promoting cell survival through the miR-221/222/p38/NF-kappa B pathway.
Article
Cell & Tissue Engineering
Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ryo Kanai, Satoshi Maeda, Shinya Takahashi, Masataka Nagao, Takao Masaki
Summary: Ex vivo-expanded, hypoxia-preconditioned SF-MSCs show promising potential as a cell therapy to prevent renal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yujie Zhang, Mingxin Wu, Wubin Dai, Min Chen, Zhaoyang Guo, Xin Wang, Di Tan, Kui Shi, Longjian Xue, Sheng Liu, Yifeng Lei
JOURNAL OF NANOBIOTECHNOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Xin Wang, Zhekun Shi, Fandong Meng, Yan Zhao, Zhongshuai Wu, Yifeng Lei, Longjian Xue
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Quan Liu, Fandong Meng, Xin Wang, Baisong Yang, Di Tan, Qian Li, Zhekun Shi, Kui Shi, Wenhui Chen, Sheng Liu, Yifeng Lei, Longjian Xue
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Qian Li, Lijun Li, Kui Shi, Baisong Yang, Xin Wang, Zhekun Shi, Di Tan, Fandong Meng, Quan Liu, Shiqi Hu, Yifeng Lei, Sheng Liu, Longjian Xue
Article
Multidisciplinary Sciences
Guicai Li, Tiantian Zheng, Linliang Wu, Qi Han, Yifeng Lei, Longjian Xue, Luzhong Zhang, Xiaosong Gu, Yumin Yang
Summary: This study constructed a bionic microenvironment-inspired scaffold integrated with anisotropic micro-nanocomposite topographies and IKVAV peptide, showing effective induction of orientation growth of Schwann cells and up-regulation of genes and proteins relevant to myelination. Three main signal pathways were proposed, revealing the synergistic effects of anisotropic micro-nanocomposite topographies and biological cues on neuroregeneration. This study provides an important strategy for developing functional artificial nerve implants.
Article
Biochemistry & Molecular Biology
Jingwen Li, Mingxin Wu, Wenhui Chen, Haiyang Liu, Di Tan, Shengnan Shen, Yifeng Lei, Longjian Xue
Summary: Inspired by plant structures, a multiple compartmentalized capsular structure for controlled drug delivery was successfully designed and manufactured using bioprinting technology. This structure allows customized drug release with sustained release for about 410 minutes, offering possibilities for personalized medicine.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Chemistry, Physical
Haiyang Liu, Yan Wang, Zhekun Shi, Di Tan, Xichen Yang, Lingheng Xiong, Gang Li, Yifeng Lei, Longjian Xue
Summary: A fast self-assembly method of photonic crystals with tunable structural colors is introduced. By infiltrating composite hydrogels into the gaps of silica nanoparticles, a structural color hydrogel that can quickly respond to different stimuli is obtained. With the addition of carbon nanotubes, the composite PC hydrogel can also output an electronic signal together with optical color changes.
Article
Materials Science, Biomaterials
Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo, Yifeng Lei
Summary: This study developed a personalized microneedle patch system for the treatment of hypertrophic scars (HS). The patches were made from dissolving gelatin and starch and loaded with losartan. The results showed that these patches effectively inhibited HS formation, reducing fibrosis and collagen deposition. This research opens up a new approach for personalized management and treatment of skin diseases.
BIOMATERIALS SCIENCE
(2023)
Review
Materials Science, Biomaterials
Yan Wang, You Wu, Yifeng Lei
Summary: Blood glucose monitoring is crucial for diabetics. Microneedle-based technology has gained attention for glucose sensing. This review summarizes the use of microneedles for glucose collection and analysis. It discusses different principles of biofluid extraction using microneedles, such as external negative pressure and iontophoresis. It also highlights the integration of microneedles with various analysis approaches, like Raman methods and electrochemical sensing, and explores future development prospects.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Multidisciplinary
Jinhong Zhang, Lijun Li, Peng Xu, Yifeng Lei, Qianlin Song, Junwei Liu, Yunhe Xiong, Sixing Yang, Yurong Zhang, Longjian Xue
Summary: The friction force measurement is a more advantageous method for characterizing surface wettability compared to contact angle and sliding angle measurements. The friction measurement reveals significant differences in opposite directions and shows strong dependence on periodic parameters.
Article
Materials Science, Biomaterials
Zhaoyang Guo, Haiyang Liu, Zhekun Shi, Lulu Lin, Yinping Li, Miao Wang, Guoqing Pan, Yifeng Lei, Longjian Xue
Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Yujie Zhang, Mingxin Wu, Di Tan, Quan Liu, Re Xia, Min Chen, Yuangang Liu, Longjian Xue, Yifeng Lei
Summary: The study developed a dissolving and glucose-responsive insulin-releasing microneedle patch system for minimally invasive and glucose-responsive insulin delivery for type 1 diabetes therapy. The system effectively regulated blood glucose levels in mice for 1-2 days and alleviated diabetic symptoms in type 1 diabetic mice.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Yujie Zhang, Jingwen Li, Mingxin Wu, Zhaoyang Guo, Di Tan, Xiaohong Zhou, Yinping Li, Sheng Liu, Longjian Xue, Yifeng Lei
ACS APPLIED BIO MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Di Tan, Aoyi Luo, Xin Wang, Zhekun Shi, Yifeng Lei, Martin Steinhart, Alexander E. Kovalev, Stanislav Gorb, Kevin T. Turner, Longjian Xue
ACS APPLIED NANO MATERIALS
(2020)