Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody

Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

(2019) Netanel Tzarum et al.   Science Advances

Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals

(2018) Julia Dietz et al.   GASTROENTEROLOGY

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

(2018) Peter D. Kwong et al.   IMMUNITY

Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?

(2018) Valerie J. Kinchen et al.   TRENDS IN MICROBIOLOGY

Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection

(2018) Valerie J. Kinchen et al.   Cell Host & Microbe

HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design

(2018) Andrew I. Flyak et al.   Cell Host & Microbe

Hepatitis C virus escape studies for human antibody AR3A reveals a high barrier to resistance and novel insights on viral antibody evasion mechanisms

(2018) Rodrigo Velázquez-Moctezuma et al.   JOURNAL OF VIROLOGY

A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey

(2017) Xuesong Wang et al.   GUT

Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms

(2017) Madeleine C. Mankowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

(2017) Radhika Gopal et al.   PLoS Pathogens

Why highly effective drugs are not enough: the need for an affordable solution to eliminating HCV

(2017) C. Nelson Hayes et al.   Expert Review of Clinical Pharmacology

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

(2016) Catherine Fauvelle et al.   Expert Review of Vaccines

IFN-λ4 desensitizes the response to IFN-α treatment in chronic hepatitis C through long-term induction of USP18

(2016) Weiguo Fan et al.   JOURNAL OF GENERAL VIROLOGY

Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice

(2016) Dapeng Li et al.   JOURNAL OF VIROLOGY

Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design

(2016) Brian G. Pierce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

(2015) Yousef Alhammad et al.   JOURNAL OF VIROLOGY

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

(2015) Tianlei Ying et al.   Nature Communications

Targeting B-cell germlines and focusing affinity maturation: the next hurdles in HIV-1-vaccine development?

(2014) Max Medina-Ramírez et al.   Expert Review of Vaccines

Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

(2014) William O. Osburn et al.   HEPATOLOGY

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

(2014) E-Chiang Lee et al.   NATURE BIOTECHNOLOGY

CD81 and Hepatitis C Virus (HCV) Infection

(2014) Lucie Fénéant et al.   Viruses-Basel

Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents

(2014) Fei Xiao et al.   PLoS Pathogens

Reshaping Antibody Diversity

(2013) Feng Wang et al.   CELL

Ever closer to a prophylactic vaccine for HCV

(2013) Leo Swadling et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A Novel Strategy To Develop a Robust Infectious Hepatitis C Virus Cell Culture System Directly from a Clinical Isolate

(2013) J. Lu et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

(2013) L. Kong et al.   SCIENCE

Construction and characterization of infectious hepatitis C virus chimera containing structural proteins directly from genotype 1b clinical isolates

(2013) Jie Lu et al.   VIROLOGY

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

(2013) Thomas Krey et al.   PLoS Pathogens

Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33

(2012) L. Kong et al.   JOURNAL OF VIROLOGY

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient

(2012) Weibin Hu et al.   VIROLOGY

Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles

(2011) Gang Long et al.   GASTROENTEROLOGY

Naturally Occurring Antibodies That Recognize Linear Epitopes in the Amino Terminus of the Hepatitis C Virus E2 Protein Confer Noninterfering, Additive Neutralization

(2011) A. W. Tarr et al.   JOURNAL OF VIROLOGY

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

(2010) Jun Liu et al.   Cellular & Molecular Immunology

Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus

(2009) T. J. Broering et al.   JOURNAL OF VIROLOGY

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment

(2009) T. MacCarthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA