Article
Polymer Science
Ning Ren, Chunyang Yu, Xinyuan Zhu
Summary: The larger size of macromonomers compared to regular monomers presents new synthetic challenges and requires a deeper investigation into polymerization mechanisms. The topological effect significantly affects the kinetics and mechanisms of macromonomer polymerization. The formation of a brush segment hinders propagation, resulting in a molecular weight dependence of the propagation rate. Copolymerization with other monomers can make the propagation rate independent of the macromonomers' molecular weight again.
Article
Polymer Science
Zi Li, Xiangzhu Ren, Peng Sun, Hao Ding, Shumu Li, Yilin Zhao, Ke Zhang
Summary: This study developed a protecting-group-free iterative exponential growth method for the formation of sequence-defined polymers, utilizing three orthogonal click reactions to avoid the complexity of traditional protecting-group chemistry. This approach can exponentially grow three different sequence-defined polymers simultaneously with high efficiency, while introducing external side groups to provide molecular variation and side-chain functionalization for the resultant polymers.
Article
Polymer Science
Bo Fan, Jing Wan, Yiyi Liu, Wendy Wenjun Tian, San H. Thang
Summary: By utilizing proper design and selection of RAFT agents, EGaIn nanoparticles can be prepared via ultrasonic treatment, allowing for the controlled growth of polymers and block copolymers with precise molecular weights and low dispersities. The successful incorporation of RAFT polymers on the surface of EGaIn could significantly improve its stability and dispersibility, facilitating applications in biomedicine, additive manufacturing, and other fields.
Review
Biochemistry & Molecular Biology
Gopika Gopan, Jobin Jose, Kartik Bhairu Khot, Akshay Bandiwadekar
Summary: Obesity is a clinical condition with detrimental impacts on human health, and traditional treatment methods have severe side effects and recurrence. Recent studies have shown that utilizing cellulose, chitosan, and hyaluronic acid can enhance the release and efficacy of obesity medications, and transdermal drug delivery through microneedles offers a promising solution to overcome therapy limitations in managing obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Oana-Teodora Afloarea, Catalina Natalia Cheaburu Yilmaz, Liliana Verestiuc, Nela Bibire
Summary: Chitosan-based hydrogels are considered suitable materials for biomedical and pharmaceutical applications due to their biocompatibility and non-toxicity. This study aimed to develop formulations for vaginal administration of progesterone and evaluated their properties. The results showed that the hydrogels had pH- and temperature-dependent swelling and drug release characteristics, and the CS-g-PNIPAAm/PVA 80/20 +PGT hydrogel was recommended as a proper constituent for the vaginal formulation.
Article
Polymer Science
Ami Nishijima, Takashi Uemura
Summary: This paper presents different synthetic approaches to two-dimensional polymeric materials (2DPMs) and classifies them into three categories. Each approach can generate 2DPMs with unique features. Lastly, it discusses current challenges in synthetic design and future development directions.
Article
Multidisciplinary Sciences
Michelle Cutajar, Fabrizio Andriulo, Megan R. Thomsett, Jonathan C. Moore, Benoit Couturaud, Steven M. Howdle, Robert A. Stockman, Stephen E. Harding
Summary: A novel polyhydroxylated monomer was synthesized from sustainable terpene feedstock derived from pine trees and used to prepare a polymer for wood consolidation purposes. Extensive characterization revealed the polymer's elongated shape, hydrogen bonding potential, and suitable molecular weight for further consideration as a potential consolidant.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Quan Xuan Duong, Nguyen Hanh Do, Hien Thanh Pham, Thu Hong Anh Ngo
Summary: This study aims to enhance the antibacterial and anti-biofouling properties of thin-film composite polyamide membranes by modifying them with antibacterial chitosan and silver nanoparticle materials through the UV-induced graft polymerization technique. Various surface assessment methods were used, and the membrane performance was demonstrated through flux and retention tests. The results showed that the chitosan/silver nanoparticle-grafted membranes exhibited superior antibacterial and anti-biofouling abilities, making them a promising option for filtration systems to reduce biofouling and improve overall efficacy.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxiao Lin, Zesheng Liu, Ruipeng Chen, Yue Hou, Ran Lu, Shuang Li, Shuyue Ren, Zhixian Gao
Summary: By preparing a PAAM/CS hydrogel, the problems of noxious dyes and excessive metal ions in water were effectively addressed, ensuring water safety and preventing damage from contaminants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Sumit Kumar, Aditi Arora, Sandeep Kumar, Rajesh Kumar, Jyotirmoy Maity, Brajendra K. Singh
Summary: Passerini reaction is a versatile reaction studied in organic chemistry, and its products have been utilized in various fields such as natural product chemistry, heterocyclic chemistry, biomedical science, pharmaceutical industry, macrocyclic chemistry, polymer science, and carbohydrate chemistry. Over the years, Passerini reaction has become an important approach for the design and synthesis of macromolecules and polymeric materials, allowing for easy modification and the synthesis of multifunctional materials. This review discusses the synthesis and applications of Passerini reaction in polymer chemistry.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Environmental
Li Feng, Kunyu Zhong, Wen Zhou, Jiajun Liu, Bingzhi Liu, Wanying Wang, Huaili Zheng
Summary: Ni2+ rich wastewater is a severe problem causing water contamination, environmental pollution, and threats to aquatic organisms and human health. This study focuses on the efficient removal of Ni2+ using a novel chitosan graft modified flocculant (CS-g-PAAI) prepared by microwave initiation and polymerization. The CS-g-PAAI showed excellent removal efficiency of Ni2+ compared to other materials such as CS, PAA, and CS-g-PAA. The flocculation effect of Ni2+ by CS-g-PAAI was as high as 86.3% under the optimal conditions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Hui Zheng, Shiwen Cui, Bingxin Sun, Baiqing Zhang, Dongbing Tao, Zhiyong Wang, Yunhe Zhang, Fengming Ma
Summary: This study investigated the synergistic degradation of chitosan by discrete ultrasonic and H2O2, and analyzed the changes in its characteristics and antioxidant activity. The results showed that the synergistic degradation process was consistent with a first-order reaction and resulted in a higher antioxidant activity in the degraded chitosan.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Pedro M. S. Ouro, Dora C. S. Costa, Aderito J. R. Amaral, Joao F. Mano
Summary: Printable hydrogels based on a dual-crosslinked system of double functionalized chitosan (CHTMA-Tricine) show promising potential for tissue engineering applications. These hydrogels exhibit enhanced toughness and cytocompatibility, making them suitable for 3D bioprinting. The use of tricine as a hydrogel component is a novel approach, utilizing its supramolecular interactions for reinforced 3D structures.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Yu Kang, Zhi Liu, Yingyun Long, Baolong Wang, Xu Yang, Di Sha, Kai Shi, Xiangling Ji, Bai Li, Yonggang Liu
Summary: A two-step method was used to synthesize N,N,N-trimethyl chitosan (TMC) from chitosan, with molecular weight ranging from 29 to 136 kg/mol and quaternization degree from 70% to 82%. Size exclusion chromatography (SEC) coupled with multiangle laser light scattering was employed to analyze the molecular weight and chain conformation, showing a significant increase in chain flexibility upon N-methylation, possibly due to the breakage of intramolecular hydrogen bonds between chitosan repeating units.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Applied
Haifeng Rong, Pu Li, Hui Zheng, Dongxu Guo, Miao Li, Ying Shi, Wenze Hu, Guoxin Yue, Baiqing Zhang, Bingxin Sun, Yufeng Xu, Tianzhi Liu, Fengming Ma
Summary: In this study, solution plasma process (SPP) was used to degrade chitosan, and the effects of initial pH value and distance between electrodes on properties and antioxidant activity of chitosan were investigated. The results showed that lower initial pH value and narrower electrode distance led to decreased viscosity, increased shear-thinning capacity, decreased crystallinity and molecular aggregation, and enhanced antioxidant activity of chitosan.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
E. V. Salomatina, A. Yu. Sharova, S. A. Chesnokov, E. A. Zakharychev, L. A. Smirnova
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2019)
Article
Polymer Science
E. V. Salomatina, I. R. Lednev, N. E. Silina, E. A. Gracheva, A. S. Koryagin, O. N. Smirnova, M. K. Gorshenin, L. A. Smirnova
Article
Polymer Science
S. Y. Budnikov, A. A. Smirnov, D. L. Vorozhtsov, E. V. Salomatina, A. V. Afanasiev, N. M. Bityurin, L. A. Smirnova
JOURNAL OF POLYMER RESEARCH
(2020)
Article
Chemistry, Medicinal
K. Apryatina, A. S. Koryagin, O. N. Smirnova, L. A. Smirnova
Summary: The production of new effective hemostatic materials based on modified chitosan with a three-dimensional cross-linked structure and coordinated calcium ions was studied. Optimal concentration of calcium ions at 10-20 mM resulted in a blood coagulation time of 40 seconds in vitro. Compositions of chitosan succinate and chloride, along with nicotinic acid, showed effective hemostatic activity. In vivo tests demonstrated the effectiveness of the chitosan-based composition in stopping bleeding of varying severity, both externally and internally.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Thermodynamics
Kristina Victorovna Apryatina, Evgeniia Vladimirovna Salomatina, Semen Sergeevich Sologubov, Alexey Vladimirovich Markin, Larisa Alexandrovna Smirnova
Summary: The thermophysical properties of polymer nanocomposites containing conducting nanoparticles of silver, gold, and fullerene C60 were studied. Nanoparticles were formed in situ in polymer matrices of various natures via UV reduction method, with an average size not exceeding 20 nm. A significant decrease in the glass transition temperatures of all polymer nanocomposites was observed compared to the polymer matrix.
THERMOCHIMICA ACTA
(2021)
Article
Biotechnology & Applied Microbiology
K. Apryatina, E. Murach, S. Amarantov, E. Erlykina, V. S. Veselov, L. A. Smirnova
Summary: A biologically active composition of chitosan-selenium nanoparticles with a bimodal size distribution has been developed. The main active centers for nanoparticle complexation are the amino and hydroxyl groups of chitosan. The composition has shown high biocompatibility and a corrective effect on oxidative processes in the body, making it a promising candidate for antioxidant and adaptogenic drugs.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2022)
Article
Polymer Science
Kristina Apryatina, Irina A. Glazova, Alexander S. Koryagin, Sergey D. Zaitsev, Larisa A. Smirnova
Summary: A method to obtain a multilayer insulin-containing composition in a nanostructured form was developed and its long-lasting hypoglycemic effect was verified through experiments.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Engineering, Environmental
Alyona N. Pochina, Evgeniia V. Salomatina, Alexander V. Knyazev, Anastasia S. Shipilova, Lydia N. Ivashkina, Ekaterina V. Bobrina, Ivan D. Grishin, Kristina V. Apryatina, Alla E. Mochalova
Summary: The copolymerization of N,N-dimethylaminoethyl methacrylate (DMAEMA) on chitosan (CTS) using ultrasonic irradiation was studied, and copolymers with different compositions and properties of CTS-graft-poly(DMAEMA) were obtained.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Kristina V. Apryatina, Dmitry N. Zuev, Sergey V. Amarantov, Sergey A. Gusev, Evgeniy A. Zakharychev, Larisa A. Smirnova
Summary: Platinum nanoparticles were chemically obtained in acetic acid solutions of chitosan using sodium borohydride as a reducing agent with UV irradiation. The size and characteristics of the nanoparticles are affected by the conformation of chitosan macromolecules. The introduction of platinum nanoparticles into chitosan significantly affects its glass transition temperature and tensile strength.
Article
Polymer Science
Evgeniia Salomatina, Aleksander Pikulin, Dmitry Semenov, Ivan Grishin, Natalia Kirillova, Larisa Smirnova
Summary: A new method of block-copolymer synthesis using a multifunctional Si-organic chain transfer agent is presented. The method allows for a wider choice of monomers and is applicable for obtaining block copolymers with wide molecular weight distribution. The synthesis can be completed in a few hours at moderate temperatures and does not involve sulfur-based or metalorganic compounds, making it suitable for various applications. The resulting polymer molecular weight can be controlled by adjusting the concentrations of the initiator and Si-Cl-based agent.
Article
Chemistry, Multidisciplinary
Kristina Apryatina, Ekaterina K. Tkachuk, Larisa A. Smirnova
PERIODICO TCHE QUIMICA
(2020)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
