CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

Palbociclib triggers apoptosis in bladder cancer cells by Cdk2-induced Rad9-mediated reorganization of the Bak.Bcl-xl complex

(2019) Guohai Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines

(2019) Felix Bremmer et al.   DISEASE MARKERS

Therapeutic approaches for refractory germ cell cancer

(2018) Christoph Oing et al.   Expert Review of Anticancer Therapy

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

The Role of Salvage High-Dose Chemotherapy in Relapsed Male Germ Cell Tumors

(2018) Christoph Oing et al.   Oncology Research and Treatment

Palliative treatment of germ cell cancer

(2018) Christoph Oing et al.   CANCER TREATMENT REVIEWS

Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors

(2018) Daniel Nettersheim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Testicular cancer

(2018) Liang Cheng et al.   Nature Reviews Disease Primers

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

(2018) Francesco Schettini et al.   Frontiers in Oncology

CDK4/6 Inhibition as a therapeutic strategy in breast cancer: palbociclib, ribociclib, and abemaciclib

(2017) Bahar Laderian et al.   SEMINARS IN ONCOLOGY

The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

(2016) Daniel Nettersheim et al.   BRITISH JOURNAL OF CANCER

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

(2016) Maria Teresa Herrera-Abreu et al.   CANCER RESEARCH

Targeting CDK4/6 in patients with cancer

(2016) Erika Hamilton et al.   CANCER TREATMENT REVIEWS

Cyclin-Dependent Kinase 4/6 Inhibition for the Treatment of Unresectable Mature Teratoma: Long-Term Follow-Up of a Phase II Study

(2016) Vivek Narayan et al.   Clinical Genitourinary Cancer

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Germ cell neoplasiain situ(GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

(2016) Daniel M Berney et al.   HISTOPATHOLOGY

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

(2016) Sina Jostes et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

(2016) Aditya Bagrodia et al.   JOURNAL OF CLINICAL ONCOLOGY

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

(2016) Daniel Nettersheim et al.   Oncotarget

SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate

(2016) Daniel Nettersheim et al.   Oncotarget

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

(2016) Jorge Franco et al.   Cell Reports

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

(2015) Daniel Nettersheim et al.   PLoS Genetics

Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors

(2014) David J. Vaughn et al.   CANCER

The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes

(2014) Sabine Paternot et al.   CELL CYCLE

Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development

(2013) Daniel Nettersheim et al.   PLoS One

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Cisplatin resistance induced in germ cell tumour cells is due to reduced susceptibility towards cell death but not to altered DNA damage induction or repair

(2012) Annabelle E. Fenske et al.   CANCER LETTERS

Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: a Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study

(2011) K. Oechsle et al.   ANNALS OF ONCOLOGY

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

(2010) J L Dean et al.   ONCOGENE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH