Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer

Micromanaging aerobic respiration and glycolysis in cancer cells

(2019) Ayla V. Orang et al.   Molecular Metabolism

Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens

(2019) Barbara Koch et al.   CURRENT GENETICS

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

(2019) Katherine Sellers et al.   BRITISH JOURNAL OF CANCER

Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer

(2019) Wenting Dai et al.   Frontiers in Endocrinology

Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells

(2018) Qin Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

(2018) Maria Peiris-Pagès et al.   Oncotarget

Dynamin-Related Protein 1 at the Crossroads of Cancer

(2018) Ana Rita Lima et al.   Genes

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

(2018) H. Furkan Alkan et al.   Cell Metabolism

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dynamic alterations regulate melanoma cell progression

(2018) Fulya Dal Yontem et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Possible Roles of Mitochondrial Dynamics and the Effects of Pharmacological Interventions in Chemoresistant Ovarian Cancer

(2018) Chalita Kingnate et al.   EBioMedicine

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

(2018) Barbara Koch et al.   Cell Reports

Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing

(2018) Lucie Desmoulins et al.   Molecular Metabolism

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

(2017) Lei Jiang et al.   METABOLIC ENGINEERING

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

(2017) Abdel Aouacheria et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

(2017) J Li et al.   ONCOGENE

Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1

(2016) Giampaolo Morciano et al.   BIOLOGY OF THE CELL

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells

(2016) C.-T. Cheng et al.   CANCER RESEARCH

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients

(2016) Deepak Kumar Tanwar et al.   Oncotarget

Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells

(2015) Jingnan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs

(2015) Ji-Yeong YEON et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration

(2015) André Ferreira-da-Silva et al.   PLoS One

Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

(2015) Wei Qian et al.   Oncotarget

Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells

(2015) Giulia Guzzo et al.   Oncotarget

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

(2014) L Zeng et al.   ONCOGENE

Role of Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus

(2013) Zhigang Hong et al.   CIRCULATION RESEARCH

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

(2013) Ryan J. Mailloux et al.   Redox Biology

Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells

(2012) Akane Inoue-Yamauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Transgenic Control of Mitochondrial Fission Induces Mitochondrial Uncoupling and Relieves Diabetic Oxidative Stress

(2012) C. A. Galloway et al.   DIABETES

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

When more is less

(2012) Lei Jiang et al.   NATURE

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Bax- or Bak-Induced Mitochondrial Fission Can Be Uncoupled from Cytochrome c Release

(2008) Clare Sheridan et al.   MOLECULAR CELL