Article
Multidisciplinary Sciences
Young Joo Lee, Young Sol Hwang, Junetae Kim, Sei-Hyun Ahn, Byung Ho Son, Hee Jeong Kim, Beom Seok Ko, Jisun Kim, Il Yong Chung, Jong Won Lee, Sae Byul Lee
Summary: A prediction nomogram model for MMP genomic risk assessment in HR+/HER2- breast cancer with minimal axillary burden was developed and validated, using clinicopathological factors to accurately predict low-risk MMP results. The nomogram incorporated traditional prognostic factors and showed high accuracy in predicting the need for additional MMP testing in high-risk patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Young Sol Hwang, Hwa Jung Kim, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Sae Byul Lee
Summary: This study aimed to validate a nomogram for predicting low-risk patients and evaluate the difference in survival outcomes between different nomogram scores. The findings showed satisfactory performance of the nomogram in predicting low genomic risk patients and significant differences in survival outcomes based on nomogram scores. Further studies are needed to validate the model in international cohorts and large prospective cohorts from other institutions.
Article
Oncology
Jesus Eduardo Amezcua-Galvez, Carlos A. Lopez-Garcia, Cynthia Villarreal-Garza, Victor Lopez-Rivera, Mauricio Canavati-Marcos, Sandra Santuario-Facio, Antonio Dono, Paloma Del C. Monroig-Bosque, Rocio Ortiz-Lopez, Andrea Leal-Lopez, Gabriela Sofia Gomez-Macias
Summary: This study evaluates the performance of using the proliferation marker Ki-67 to identify patients with hormone receptor-positive early invasive breast cancer (HR+ EIBC) and explores its association with molecular signatures and risk stratification markers. The results show that Ki-67 is concordant with MammaPrint risk stratification, but not with the EndoPredict molecular signature. Cost-effectiveness analysis of these tests in developing countries is needed before making a final decision, but in the meantime, using Ki-67 to aid clinical decisions appears reasonable, along with other established clinicopathological variables.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Mathematical & Computational Biology
Rickard Strandberg, Kamila Czene, Per Hall, Keith Humphreys
Summary: Mammography screening programs aim to reduce breast cancer mortality by detecting tumors early. Moving towards personalized screening based on individual risk factors is of interest. This study develops a novel approach using a continuous growth model to predict breast cancer risk and incorporates individual screening visits in the prediction.
STATISTICS IN MEDICINE
(2023)
Article
Oncology
Mustapha Abubakar, Changyuan Guo, Hela Koka, Bin Zhu, Joseph Deng, Nan Hu, Bin Zhou, Montserrat Garcia-Closas, Ning Lu, Xiaohong R. Yang
Summary: The study found that factors such as age, parity, family history, and body mass index may impact clinically relevant prognostic biomarkers in breast cancer, with implications for surveillance, prognostication, and counseling.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Anesthesiology
Ekaterina Baryshnikova, Umberto Di Dedda, Marco Ranucci
Summary: This study aimed to investigate the performance of different point-of-care devices and platelet aggregometry in predicting postoperative major bleeding in high-risk patients undergoing cardiac surgery. The results showed that QUANTRA PCS, ROTEM A10 PC, and Multiplate ADPtest significantly decreased after cardiopulmonary bypass, while ROTEM PC and Multiplate TRAPtest did not. Postoperative platelet function testing can moderately to well predict major bleeding.
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, Research & Experimental
Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou, Qiang Sun
Summary: This study aimed to establish easy-to-use nomogram models to predict the individualized binary and quartile categorized risk classification of 70-GS test. The models showed fair performance and could provide information for treatment choice for patients who have no access to the 70-GS testing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Panagiotis Baliakas, Arielle R. Munters, Anders Kampe, Bianca Tesi, Marie-Louise Bondeson, Claes Ladenvall, Daniel Eriksson
Summary: Incorporating an established Polygenic Risk Score (PRS313) into clinical sequencing of women with familial breast cancer can potentially change the recommended follow-up in a significant percentage of patients. Women with breast cancer but no pathogenic variants in hereditary breast cancer genes have a higher PRS313 compared with population controls.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Engineering, Biomedical
Xuejun Qian, Jing Pei, Hui Zheng, Xinxin Xie, Lin Yan, Hao Zhang, Chunguang Han, Xiang Gao, Hanqi Zhang, Weiwei Zheng, Qiang Sun, Lu Lu, K. Kirk Shung
Summary: An explainable deep-learning system accurately predicts clinical scores for breast cancer risk from multimodal breast-ultrasound images, as demonstrated through prospective testing. The system's performance is comparable to experienced radiologists, indicating its potential for facilitating the adoption of ultrasound imaging in screening mammography workflows.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Oncology
Paul Jank, Judith Lea Lindner, Annika Lehmann, Berit Maria Pfitzner, Jens-Uwe Blohmer, David Horst, Ralf Kronenwett, Carsten Denkert, Wolfgang Daniel Schmitt
Summary: This study found significant positive associations between the 12-gene MS and EPclin scores with tumor grading and Ki67, but clinically relevant differences were observed between EP test results, Ki67, and tumor grading. The distribution of EP risk scores varied among Ki67 expression groups, especially in Ki67 low and high tumors, indicating that classical pathological parameters and gene expression parameters are not interchangeable and should be used in combination for risk assessment.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Nutrition & Dietetics
Sumaira Mubarik, Rajesh Sharma, Syeda Rija Hussain, Mujahid Iqbal, Nawsherwan, Xiaoxue Liu, Chuanhua Yu
Summary: In East and South Asian countries, breast cancer mortality rate is predicted to increase, especially in low/middle socio-demographic index (SDI) countries. Early detection through screening, raising awareness among females and healthcare workers, and timely and cost-effective treatment for breast cancer patients are crucial in combating the rising burden of breast cancer in the next decade.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Aparna Gunda, Mallikarjuna S. Eshwaraiah, Kiran Gangappa, Taranjot Kaur, Manjiri M. Bakre
Summary: This study compares the recurrence risk predictions of CanAssist Breast (CAB), Nottingham Prognostic Index (NPI), and PREDICT in Indian and European cohorts of breast cancer. The results show fair agreement between CAB and NPI/PREDICT, with a high concordance in the low-risk categories.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Mary Kathryn Abel, Amy M. Shui, A. Jo Chien, Hope S. Rugo, Michelle Melisko, Frederick Baehner, Rita A. Mukhtar
Summary: This study aims to evaluate the discordance between clinical and genomic risk in breast cancer patients using the 21-gene recurrence score (RS), specifically in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) cases. The results showed a higher rate of discordant clinical and genomic risk in ILC patients. For patients with 1-3 positive nodes and RS≤25, chemotherapy did not significantly affect the survival rate of IDC and ILC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Mary Kathryn Abel, Amy M. Shui, Michelle Melisko, A. Jo Chien, Emi J. Yoshida, Elizabeth M. Lancaster, Laura Van T. Veer, Laura J. Esserman, Rita A. Mukhtar
Summary: This study found that patients with invasive lobular carcinoma are more likely to have clinical high/genomic low-risk tumors compared to those with invasive ductal carcinoma. These findings suggest that current tools for stratifying clinical and genomic risk could be improved for those with invasive lobular carcinoma to better tailor treatment selection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joyce Epp, Rasika Rajapakshe
Summary: Birth cohorts have an impact on the risk of breast cancer for different ethnicities in BC. South Asians have a lower risk, First Nations have a higher risk, and East Asians have a similar risk compared to Caucasians.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Review
Medicine, General & Internal
Stephan W. Jahn, Markus Plass, Farid Moinfar
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Christoph Suppan, Ricarda Graf, Stephan Jahn, Qing Zhou, Eva Valentina Klocker, Rupert Bartsch, Angelika Terbuch, Karl Kashofer, Peter Regitnig, Joerg Lindenmann, Florian Posch, Hanno Gerritsmann, Philipp J. Jost, Ellen Heitzer, Nadia Dandachi, Marija Balic
Summary: This study compared the detection of PIK3CA mutations in blood samples and tissue samples, finding that SiMSen-Seq showed advantageous concordance with tissue analyses in detecting PIK3CA mutations in plasma. Combining an untargeted approach for detecting ctDNA fractions may confirm negative PIK3CA results and enhance the performance of the SiMSen-Seq test.
BRITISH JOURNAL OF CANCER
(2022)