Article
Oncology
Jian Wan, Shizhen Chen, Anqin Zhang, Yiting Liu, Yangyang Zhang, Qinghua Li, Ziqi Yu, Yuwei Wan, Lei Yang, Qi Wang
Summary: This study identified an ATIRE signature associated with the overall survival and disease-free survival of breast cancer patients. A risk score based on these ATIRE sites was established and a nomogram was generated to predict patient outcomes. Experimental confirmation showed that high risk scores were associated with increased risk of death. The nomogram showed good predictive accuracy for breast cancer patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lang Xiong, Haolin Chen, Xiaofeng Tang, Biyun Chen, Xinhua Jiang, Lizhi Liu, Yanqiu Feng, Longzhong Liu, Li Li
Summary: In this study, a radiomics signature based on preoperative ultrasound was developed to predict disease-free survival in invasive breast cancer patients. The study showed that the radiomics signature had additional value for individualized prediction of disease-free survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Huang, Lei Zhang, Jinming Fu, Tian Tian, Xinyan Liu, Yupeng Liu, Hongru Sun, Dapeng Li, Lin Zhu, Jing Xu, Ting Zheng, Chenyang Jia, Yashuang Zhao
Summary: This study aimed to develop and validate novel methylation prognostic models correlated with different survival indicators for individualized prognosis prediction for CRC patients. The prognostic models were successfully developed and validated in TCGA CRC dataset and an independent CRC dataset, utilizing a combination of selected 3-CpG methylation sites in three genes.
MOLECULAR CARCINOGENESIS
(2021)
Article
Oncology
Annelie Johansson, Nancy Y. Yu, Adina Iftimi, Nicholas P. Tobin, Laura 't Veer, Bo Nordenskjold, Christopher C. Benz, Tommy Fornander, Gizeh Perez-Tenorio, Olle Stal, Laura J. Esserman, Christina Yau, Linda S. Lindstrom
Summary: ER-positive ultralow risk breast cancers have distinct clinical and molecular characteristics compared to other ER-positive tumors, including smaller tumor size, lower grade, positive expression of progesterone receptor, negative expression of HER2, and low Ki-67 levels. The gene expression patterns in ultralow risk tumors also differ, with lower expression of genes involved in immune response and proliferation, and higher expression of genes associated with PIK3CA mutation.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou, Qiang Sun
Summary: This study aimed to establish easy-to-use nomogram models to predict the individualized binary and quartile categorized risk classification of 70-GS test. The models showed fair performance and could provide information for treatment choice for patients who have no access to the 70-GS testing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Zhuowei Tang, Yuzhu Ji, Yu Min, Xiaohong Zhang, Weiyun Xu, Lijuan Zhao, Jing Zhang, Li Long, Jing Feng, Yixue Wen
Summary: This study aimed to investigate the clinicopathological features and prognostic factors of elderly primary operable TNBC patients. The results showed that radiation therapy and adjuvant chemotherapy were associated with better long-term survival rates, and predictive models for survival were successfully developed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Hongxu Sheng, Zhexue Hao, Linhai Zhu, Yuan Zeng, Jianxing He
Summary: A two-gene signature was constructed and validated to predict the overall survival of NSCLC patients. The study found that SUMOylation regulatory genes were highly expressed in various tumors. The two-gene signature, constructed using LASSO regression analysis, was able to predict patient survival in both the training and validation cohorts. Functional enrichment analysis revealed that high-risk patients were associated with malignant phenomena. Experimental results demonstrated that the two risk genes promoted proliferation and migration in NSCLC cells.
Article
Multidisciplinary Sciences
Xiangyang Yu, Feng Wang, Longjun Yang, Kai Ma, Xiaotong Guo, Lixu Wang, Longde Du, Xin Yu, Shengcheng Lin, Hua Xiao, Zhilin Sui, Lanjun Zhang, Zhentao Yu
Summary: In this study, nomograms were developed to predict disease-free survival (DFS) and overall survival (OS) for patients who underwent pneumonectomy for primary lung cancer. The nomograms showed good discrimination accuracy and clinical utility. They can assist in identifying high-risk patients and developing personalized treatment strategies to improve survival.
Article
Oncology
Meizhen Zhu, Chenlu Liang, Fanrong Zhang, Liang Zhu, Daobao Chen
Summary: Neoadjuvant chemotherapy is important for locally advanced TNBC. Predicting disease-free survival is crucial. Factors such as response to treatment, residual tumor size, and lymphatic vessel invasion can impact prognosis. The constructed nomogram showed superior predictive performance for TNBC patients compared to current staging systems.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jeongmin Lee, Sung Hun Kim, Yelin Kim, Jaewoo Park, Ga Eun Park, Bong Joo Kang
Summary: This study aimed to predict early breast cancer recurrence in women under 40 years of age using radiomics signature and clinicopathological information. The results showed that the radiomics-based nomogram had a reasonably high disease-free survival predictive ability, especially within 2 years of surgery.
Article
Genetics & Heredity
Bingqing Xia, He Wang, Zhe Wang, Zhaoxia Qian, Qin Xiao, Yin Liu, Zhimin Shao, Shuling Zhou, Weimin Chai, Chao You, Yajia Gu
Summary: The radiomics signature from preoperative MRI images is associated with disease-free survival in triple-negative breast cancer patients. A nomogram based on radiomics signatures, MRI findings, and clinicopathological variables was developed to predict DFS, improving individualized estimation.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Xuan Wang, Neng Wang, Linda L. D. Zhong, Kexin Su, Shengqi Wang, Yifeng Zheng, Bowen Yang, Juping Zhang, Bo Pan, Wei Yang, Zhiyu Wang
Summary: The study established a depression-related gene signature to predict overall survival in breast cancer patients, indicating its correlation with pathological parameters and sensitivity to therapy. The high-risk group had higher levels of immunosuppressive cells and low-risk patients responded better to chemotherapy and endocrine therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Lu, Pinbo Liu, Ran Zhang
Summary: In this study, a predictive model combining metabolic enzyme genes and clinicopathological characteristics was developed to predict the overall survival in patients with breast cancer. The model showed high accuracy in classifying patients into high- and low-risk groups and predicting their prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Fangxu Yin, Song Wang, Chong Hou, Yiyuan Zhang, Zhenlin Yang, Xiaohong Wang
Summary: This study developed two accurate prediction models for survival outcomes in locally advanced breast cancer patients, which were more accurate than conventional TNM staging. These models can guide clinical decision-making and treatment planning for these patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Carlos A. Barron-Gallardo, Mariel Garcia-Chagollan, Andres J. Moran-Mendoza, Raul Delgadillo-Cristerna, Maria G. Martinez-Silva, Maria M. Villasenor-Garcia, Adriana Aguilar-Lemarroy, Luis F. Jave-Suarez
Summary: Breast cancer is the leading cause of death and incidence among women worldwide, and the HER2+ subtype is known for its aggressiveness. This study aimed to identify prognostic markers for treatment and survival in HER2+ patients. Through RNA-seq analysis, 94 differentially expressed genes related to treatment resistance were identified. Survival analysis revealed that 12 genes were good predictors of disease-free survival, while 8 genes were good predictors of overall survival.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Kyumin Kim, Harin Kim, Joohee Lee, Inn-Kyu Cho, Myung Hee Ahn, Ki Young Son, Jeong Eun Kim, Hee Jeong Kim, Sang Min Yoon, So Hee Kim, Moon Jung Kwon, Hwa Jung Kim, Su-Jin Koh, Seyoung Seo, Seockhoon Chung
Summary: This study investigated the mental health and healthcare service utilization of cancer patients during the COVID-19 pandemic. The results showed that cancer patients in this era experienced depression, anxiety regarding the viral epidemic, and disruptions in healthcare service utilization, which may affect their mental health functioning.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
Hee Seung Hong, Jiwon Jung, Sang Hyoung Park, Hwa Jung Kim, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Summary: This study investigated the seropositivity rates for common viral infectious diseases in Korean patients with IBD, and found that they were similar to those of the general population. It was noted that younger age groups may require protective immunity against measles, VZV, and HAV through proper vaccination.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Oncology
Jwa Hoon Kim, Seyoung Seo, Jee Hyun Kim, Su-Jin Koh, Yongchel Ahn, Kyung Hae Jung, Jin-Hee Ahn, Sung-Bae Kim, Tae Won Kim, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Sang-We Kim, Dae Ho Lee, Jae Cheol Lee, Chang-Min Choi, Shinkyo Yoon, Jae Ho Jeong, Hwa Jung Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Young Joo Min, Jin Ho Baek, Sook Ryun Park
Summary: The study showed that after the introduction of healthcare reimbursement for AE evaluation, patients had lower rates of ER visits and hospitalizations compared to the pre-reimbursement period, especially after the second chemotherapy cycle. The post-reimbursement group had higher rates of completing chemotherapy as planned and reported more AEs during cycle 1, which decreased significantly after cycle 2.
Article
Hematology
Boram Han, Hyo Jung Kim, Ho-Young Yhim, Doyeun Oh, Sung Hwa Bae, Ho-Jin Shin, Won-Sik Lee, JiHyun Kwon, Jeong-Ok Lee, Hwa Jung Kim, Soo-Mee Bang
Summary: According to the study, H. pylori eradication is an effective treatment for patients with moderate immune thrombocytopenia (ITP). The sequential eradication regimen not only achieves a high eradication rate of H. pylori, but also significantly improves platelet response in ITP patients.
ANNALS OF HEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hee Kyong Na, Kee Don Choi, Young Soo Park, Hwa Jung Kim, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: The study aimed to develop an endoscopic scoring system to evaluate gastric atrophy and intestinal metaplasia. The results showed that the endoscopic scoring using NBI-NFM correlated with histologic staging in Korea, a high-risk region for gastric cancer.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Yura Ahn, Se Jin Choi, Soyeoun Lim, Joon Bum Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song, Hwa Jung Kim, Joon-Won Kang, Dong Hyun Yang, Dae-Hee Kim, Hyun Jung Koo
Summary: This study examined the preoperative clinical and cardiac CT findings of different subtypes of AS in patients with surgical AVR and evaluated the subtype classification as a factor affecting post-surgical outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Bora Yoon, Hwa-Jung Kim
Summary: This study evaluated the incidence and treatment patterns of dementia in elderly patients with Parkinson's disease (PD) in Korea. The results showed a high incidence of dementia in PD patients, with a significant proportion of women and the use of anticholinergic medication in PD patients with dementia. Dementia was observed to occur relatively soon after the diagnosis of PD, and donepezil was the most commonly prescribed medication for dementia treatment.
Article
Gastroenterology & Hepatology
Woohyung Lee, Dae Wook Hwang, Ho-Seong Han, In Woong Han, Jin Seok Heo, Michiaki Unno, Masaharu Ishida, Hiroshi Tajima, Nobuyuki Nishizawa, Kohei Nakata, Yasuji Seyama, Yoshiya Isikawa, Ho Kyoung Hwang, Jin-Young Jang, Taeho Hong, Joon Seong Park, Hee Joon Kim, Chi-Young Jeong, Ippei Matsumoto, Hiroki Yamaue, Manabu Kawai, Masayuki Ohtsuka, Shugo Mizuno, Mitsuhiro Asakuma, Yuji Soejima, Teijiro Hirashita, Masayuki Sho, Yutaka Takeda, Jeong-Ik Park, Yong Hoon Kim, Hwa Jung Kim, Masakazu Yamamoto, Itaru Endo, Masafumi Nakamura, Yoo-Seok Yoon
Summary: The study aimed to evaluate the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. By comparing the data of postoperative infectious complications in different groups, the study found that spleen preservation could lower the risk of infectious complications, but the risk may vary according to the surgeon's experience.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jimin Kim, Seul Ki Lee, Donguk Kim, Eunyoung Lee, Chan Yoon Park, Han Choe, Min-Ji Kang, Hwa Jung Kim, Jong-Hyeok Kim, Joon Pio Hong, Yeon Ji Lee, Hye Soon Park, Yoonseok Heo, Yeon Jin Jang
Summary: This study found that the expression of LECT2 is elevated in adipose tissue of obese women and is associated with insulin resistance. Additionally, the study suggests that adipocyte-derived LECT2 may contribute to adipose tissue dysfunction.
Article
Multidisciplinary Sciences
Sungjin Yoon, Kwai Han Yoo, So Hyun Park, Hawk Kim, Jae Hoon Lee, Jinny Park, Seong Ho Park, Hwa Jung Kim
Summary: This study evaluated the image quality, detection rate of enlarged lymph nodes, and radiation dose exposure of ultralow-dose and low-dose CT in lymphoma patients. The results showed that even with reduced radiation doses, ultralow-dose and low-dose CT maintained adequate image quality and can be used for follow-up evaluation of lymphoma.
Article
Gastroenterology & Hepatology
Boram Cha, Kyungmin Choi, Kee Wook Jung, Hwa Jung Kim, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Segyeong Joo
Summary: This study compared two diagnostic tools for non-obstructive dysphagia (NOD) and found that the volume of inverted impedance (VII) ratio is more reliable than the esophageal impedance integral (EII) ratio.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Oncology
Sungchan Gwark, Hwa Jung Kim, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Sae Byul Lee
Summary: In breast cancer patients treated with neoadjuvant chemotherapy, breast-conserving surgery plus radiotherapy improves 5-year disease-free survival, distant metastasis-free survival, and overall survival compared to mastectomy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hoonsub So, Sung Woo Ko, Seung Hwan Shin, Eun Ha Kim, Jimin Son, SuHyun Ha, Ki Byung Song, Hwa Jung Kim, Myung-Hwan Kim, Do Hyun Park
Summary: Compared with surgery, EUS-EA is a safer and less invasive treatment option for small nonfunctioning PNETs, with a shorter length of hospital stay.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Environmental Sciences
Ho Young Lee, Hyeon-Ju Kim, Hwa Jung Kim, Geunjoo Na, Youngwon Jang, Soo Han Kim, Na Hyun Kim, Ho Cheol Kim, Young-Jun Park, Hwan Cheol Kim, Young-Kil Yun, Sei Won Lee
Summary: This study investigated the association between lung function, respiratory symptoms, and air pollutant concentration with meteorological factors in elite sports athletes. The findings suggest that air pollutants and meteorological factors have significant effects on lung function and respiratory symptoms in elite athletes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Min Joo Choi, Jung Yeon Heo, Yu Bin Seo, Young Kyung Yoon, Jang Wook Sohn, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Ju-yeon Choi, Hwa Jung Kim, Young Jae Lee, Hye Won Lee, Sung Soon Kim, Byoungguk Kim, Joon Young Song
Summary: This study aimed to investigate the humoral and cellular immune response to the mRNA-1273 vaccine through a prospective longitudinal cohort. The results showed that the two-dose mRNA-1273 vaccination induced a strong antibody response that remained elevated over time. A higher peak antibody titer was associated with better cross-reactive immunity against Delta and Omicron variants and longer-lasting humoral immunity. Overall, the cellular immune response was not correlated with antibody titers.
FRONTIERS IN IMMUNOLOGY
(2023)