Article
Environmental Sciences
Shama Mustafa, Haseeb Anwar, Qurat ul Ain, Hussain Ahmed, Shabnoor Iqbal, Muhammad Umar Ijaz
Summary: The study aimed to investigate the ameliorative potential of GPTN against PQ-induced testicular damages. Results showed that PQ exposure caused biochemical abnormalities, decreased spermatogenic indices, altered hormone levels, induced cell apoptosis, and led to histopathological damages. However, GPTN was able to reverse these impairments, indicating its antioxidant, androgenic, and anti-apoptotic potential.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Kuiyu Chen, Limin Wu, Qianzhuo Liu, Fang Tan, Luyao Wang, Dan Zhao, Xinru Fang, Xiang Liu, Jiabo Liu, Hui Han
Summary: This study observed the changes in spermatogenesis, mitochondrial damage, apoptosis, and oxidative stress levels in the testes of Wilson disease mice, and investigated the effect and mechanism of glutathione on testicular spermatogenesis. The results showed that Wilson disease mice exhibited impaired testicular tissue structure, reduced sperm count, increased apoptosis, elevated oxidative stress levels, and abnormal mitochondrial ultrastructure. Glutathione treatment significantly improved testicular tissue structure, sperm count, apoptosis rate, mitochondrial structure, and oxidative stress levels in Wilson disease mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Emad H. M. Hassanein, Basel A. Abdel-Wahab, Fares E. M. Ali, Omnia A. M. Abd El-Ghafar, Magy R. Kozman, Souty M. Z. Sharkawi
Summary: The study demonstrated that TFA has potential protective effects against CDDP-induced testicular injury by reducing oxidative stress and inflammatory response. It also enhanced the cytotoxic effect of CDDP in vitro through induction of apoptosis in both early and late stages. Additionally, TFA modulated various signaling pathways related to inflammation and cytotoxic activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Chih-Wei Tsao, Yuan-Ru Liao, Ting-Chia Chang, Yih-Fong Liew, Chin-Yu Liu
Summary: This study aimed to investigate the effects of iron supplementation on spermatogenesis and testicular functions in iron-deficient rats. The results showed that iron deficiency resulted in poorer spermatogenesis and testis dysfunction, while iron supplementation reversed the impairment and improved antioxidant levels.
Article
Environmental Sciences
Yi Wang, Jie Wu, Mingming Zhang, Huijuan OuYang, Mengyuan Li, Didi Jia, Rong Wang, Weiyi Zhou, Hao Liu, Yuan Hu, Yuyou Yao, Yehao Liu, YanLi Ji
Summary: This study explored the effects and mechanisms of pubertal Cd exposure on testicular development and spermatogenesis. The results showed that Cd exposure during puberty caused pathological damage to testes, reduced sperm counts in adult mice, and induced iron overload and oxidative stress. Furthermore, transcriptomics analysis revealed that Cd disrupted intracellular iron homeostasis and peroxidation signal pathway. In conclusion, Cd exposure during puberty may trigger ferroptosis in spermatogonia, leading to testicular damage and impaired spermatogenesis in adult mice.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Asmaa Elsayed, Ashraf Elkomy, Mohamed Alkafafy, Reda Elkammar, Anwar El-Shafey, Ahmed Soliman, Mohamed Aboubakr
Summary: The study evaluated the protective effects of lycopene and N-acetylcysteine on testicular toxicity induced by cisplatin in rats. Results showed that the administration of lycopene and N-acetylcysteine could improve cisplatin-induced testicular damage and apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chih-Wei Tsao, Pei-Shan Ke, Hsin-Yi Yang, Ting-Chia Chang, Chin-Yu Liu
Summary: This study aimed to investigate the effects of curcumin supplementation on male fertility issues induced by a low-carbohydrate diet. The results showed that replacing the low-carbohydrate diet with a normal diet or a ketogenic diet supplemented with curcumin improved testicular biopsy score and sperm morphology, while reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Samaneh Akbar Gharehbagh, Javad Tolouei Azar, Mazdak Razi
Summary: Exercise training has significant impacts on testicular antioxidant and metabolic potentials. High-intensity training can suppress antioxidant biomarkers while increasing autophagy-inducers expression, while low and moderate intensity training may help maintain metabolic homeostasis and promote spermatogenesis differentiation.
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Ghorbannejad Hadi, Tofighi Asghar, Tolouei Azar Javad, Razi Mazdak
Summary: Long-term consumption of tramadol negatively affects spermatogenesis development, while exercise training protocols (ETPs) can reduce the damage caused by tramadol on antioxidant and endocrine capacities, with low-intensity training showing the best results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Fereshteh Radmanesh, Mazdak Razi, Ali Shalizar-Jalali
Summary: The study revealed that curcumin nano-micelle (NCMN) has an impact on testicular antioxidant status, leading to increased expression of heat shock proteins (Hsp) 70-2a and Hsp90, as well as cell DNA and mRNA damage, reduced sperm count, motility, and DNA integrity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Jing Wu, You Wu, Hui Fan, Chenglin Yang, Mengran Yang, Xiangyi Kong, Can Ning, Siqi Wang, Wenguang Xiao, Naidong Wang, Jine Yi, Zhihang Yuan
Summary: This study investigated the mechanism of Citrinin (CTN) exposure on male infertility. The results showed that CTN exposure caused disorder of androgen, decreased sperm quality, and histopathological damage of testis. The expression of blood-testis barrier (BTB) related proteins were inhibited, and oxidative and ER stress damage were observed in the testis. Additionally, treatment with 4-Phenylbutyric acid blocked the adverse effects of CTN exposure on male reproduction.
Article
Plant Sciences
Lin Li, Beibei Chen, Tian An, Hao Zhang, Bingke Xia, Rui Li, Ruyuan Zhu, Yimiao Tian, Lili Wang, Dandan Zhao, Fangfang Mo, Yu Li, Ge Yang, Alexander N. Orekhov, Marc Prentki, Dongwei Zhang, Guangjian Jiang, Xiaofeng Zhu
Summary: BZBS medication can preserve sperm and testicular morphology in aging mice, increase serum antioxidant capacity, hormone levels, and maintain testicular morphology and sperm quality by improving oxidative stress and regulating signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Amal A. Halawa, Gehad E. Elshopakey, Mohammed A. Elmetwally, Mohamed El-Adl, Samah Lashen, Nancy Shalaby, Ehab Eldomany, Ahmed Farghali, Mohamed Z. Sayed-Ahmed, Nawazish Alam, Nabeel Kashan Syed, Sarfaraz Ahmad, Shaymaa Rezk
Summary: This study investigated the potential reproductive toxic effects of oral TiO2 nanoparticles (NPs) in adult male rats and the potential alleviation of chitosan administration. The results showed that TiO2 NPs had negative effects on the testicles, while chitosan was able to ameliorate this toxicity.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Sailo Lalrinzuali, Maurya Khushboo, Roy Dinata, Baishya Bhanushree, Nisekhoto Nisa, Rema Momin Bidanchi, Saeed-Ahmed Laskar, Bose Manikandan, Giri Abinash, Buragohain Pori, Vikas Kumar Roy, Guruswami Gurusubramanian
Summary: Long-term consumption of fermented pork fat (FPF) food with excessive calories, high fat content, and high FAME levels induces oxidative stress, inflammation, and apoptosis, resulting in metabolic syndrome and hampering male reproductive system and functions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Clinical Neurology
Heng-Wei Chang, Sabri Sudirman, Yu-Wen Yen, Chien-Feng Mao, Alan Darmasaputra Ong, Zwe-Ling Kong
JOURNAL OF PAIN RESEARCH
(2020)
Article
Nanoscience & Nanotechnology
Zwe-Ling Kong, Jia-Ling He, Sabri Sudirman, Mao-Tien Kuo, Song Miao, Ke-Liang B. Chang, David Tsou
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Athira Johnson, Jia-Ling He, Fanbin Kong, Yi-Cheng Huang, Sabu Thomas, Hong-Ting Victor Lin, Zwe-Ling Kong
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Chemistry, Medicinal
Zwe-Ling Kong, Ya-Ting Hsu, Athira Johnson, Tung-Han Tsai, Song Miao, Jia-Ling He, David Tsou
Summary: The study demonstrated that Antrodia camphorata-alcohol extracts (AC-AE) could protect cells from oxidative stress-induced damage and reduce ischemic stroke by regulating reactive oxygen species (ROS) production, indicating its potential therapeutic value.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Athira Johnson, Fanbin Kong, Song Miao, Sabu Thomas, Sabah Ansar, Zwe-Ling Kong
Summary: The study investigated the antibacterial and anti-inflammatory properties of surfactin-loaded nanoparticles, showing that these nanoparticles effectively inhibited the growth and metabolic activity of certain bacteria, as well as reducing biofilm formation. Additionally, the nanoparticles were found to impact oxidative stress and demonstrate anti-inflammatory effects in stimulated cells.
Article
Chemistry, Multidisciplinary
Zwe-Ling Kong, Athira Johnson, Tzu-Ling Ting, Po-Jen Cheng, Chien-Feng Mao
Summary: This study found that Echinacea purpurea ethanol extract can increase antioxidant enzymes levels, decrease lipid peroxidation, blood glucose levels, nitric oxide production, IL-6 levels, and TNF-alpha levels in obese rats, as well as improve sperm parameters and protein expressions related to reproductive health and inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Veterinary Sciences
Chien-Feng Mao, Sabri Sudirman, Chi-Chih Lee, David Tsou, Zwe-Ling Kong
Summary: The study showed that Echinacea purpurea extract improved hyperglycemia and insulin resistance in diabetic rats, enhanced sperm motility, protected sperm morphology and mitochondrial membrane potential, increased protein for testosterone synthesis enzyme, and reduced proinflammatory cytokine levels. Additionally, EPE decreased TLR4 and downstream phospho-NF-kappa B p65 content, suggesting a potential mechanism for reducing inflammation and improving diabetes-induced male infertility.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Sabri Sudirman, Chieh-Yu Su, David Tsou, Meng-Chou Lee, Zwe-Ling Kong
Summary: The study demonstrated that seahorse peptide hydrolysate has ameliorative effects on diabetic-induced male reproductive dysfunction in rat models by inhibiting lipid peroxidation, increasing antioxidant enzyme activity, restoring testis morphology, and improving testosterone levels and sperm count.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Sabri Sudirman, Po-Sheng Tseng, Chun-Kai Chen, David Tsou, Zwe-Ling Kong
Summary: This study investigated the effects of seahorse protein hydrolysate (SH) on posttraumatic osteoarthritis (OA) in obese rats. The results showed that SH reduced the expression of inflammatory factors, attenuated cartilage degradation and pain, and improved the development of OA.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Sabri Sudirman, Chun-Yu Chen, Chun-Kai Chen, Jerrell Felim, Hsiang-Ping Kuo, Zwe-Ling Kong
Summary: This study investigated the effect of collagen fermented from jellyfish on knee osteoarthritis in obese rats. The results showed that collagen reduced fat weight and cholesterol levels in obese rats, while also protecting and attenuating the degradation of articular cartilage. This suggests that collagen may be a promising candidate for the treatment of osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Sabri Sudirman, Aatikah Dewi Ghaisani, Indah Widiastuti, Yohana Novelina Herpandi, Yohana Novelina Sirat, Miftahul Janna
Summary: This study investigated the alpha-glucosidase inhibitory activity of polysaccharides from water lettuce leaf and compared the effects of different extraction methods. The results showed that hot water extraction was more effective in inhibiting the enzyme activity and had potential as an anti-diabetes agent.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
