Review
Chemistry, Multidisciplinary
Bei Ran, Lei Ran, Zuokai Wang, Jinfeng Liao, Dandan Li, Keda Chen, Wenlin Cai, Jungang Hou, Xiaojun Peng
Summary: Phototherapy strategies, particularly photocatalytic antimicrobial therapy (PCAT), have emerged as effective methods for inactivating pathogenic microorganisms. This review summarizes the latest progress in the field of PCAT, including the development of various photocatalytic antimicrobials, their antimicrobial mechanisms, design strategies, and practical applications in various fields.
Review
Chemistry, Inorganic & Nuclear
Zhen-Yu Chen, Ning-Yu Huang, Qiang Xu
Summary: Metal halide perovskites (MHPs) have shown great potential as a new generation of photocatalysts due to their tunable band gap, wide visible light absorption range, and fast carrier transfer. However, their poor stability under water, oxygen, and high temperatures, as well as the recombination of photogenerated charges and weak oxidation activity, pose challenges for their development.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Applied
Kunkun Tu, Yong Ding, Tobias Keplinger
Summary: Metal-organic frameworks (MOFs) combined with cellulose substrates to fabricate engineered materials provide excellent mechanical properties, tunable porosity, and accessible active sites. Current state-of-the-art fabrication routes focusing on three-dimensional bio-based cellulosic scaffolds show unique potential for MOF/cellulose composites. These composites have broad applications in gas and liquid adsorption, antibacterial and protein immobilization, chemical sensors, and electrical energy storage.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Analytical
Jiamu Cao, Rongji Zhang, Liang Chen, Dongbo Wang, Weiqi Wang, Endong Tan, Xianghe Meng, Huaxin Xiu, Lin Wang, Xinglian Yang, Zhoumin Yang, Qijun Yang, Liancheng Zhao
Summary: Responsive metal-based luminescence probes, with advantages of large Stokes shifts, long lifetimes, high photostabilities, and easy ligand addition, are considered better alternatives to organic ones. This paper reviews critical strategies of achieving response by different stimulus sources and presents the current challenges and future opportunities of responsive metal-based luminescence probes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Haneesh Saini, Nikitha Srinivasan, Veronika Sedajova, Mandira Majumder, Deepak P. Dubal, Michal Otyepka, Radek Zboril, Narendra Kurra, Roland A. Fischer, Kolleboyina Jayaramulu
Summary: The rapid progress in smart materials and hybrid design is driven by energy crisis and environmental challenges. The excitement lies in the tunable properties of hybrid materials, especially the combination of metal-organic frameworks (MOFs) and MXenes for improved performance in various applications. Efforts are focused on enhancing stability, conductivity, and properties of hybrid materials to meet the demands of emerging technologies.
Review
Chemistry, Medicinal
Swarnagowri Nayak, Santosh L. Gaonkar
Summary: The discovery of cisplatin has spurred the search for new metal complexes for fighting cancer. Metal-N-heterocyclic carbene (NHC) complexes have emerged as promising candidates for drug design, particularly with enhanced applications in coinage metals like copper, silver, and gold. This review focuses on recent advancements in synthetic strategies and medicinal applications of these NHC-supported metal complexes.
Review
Chemistry, Multidisciplinary
Tingting Li, Haifeng Zhu, Zhennan Wu
Summary: Aggregation-induced emission (AIE)-type metal nanoclusters (NCs) are a novel type of luminescent metal NCs whose aggregates have shown superior performance compared to individual NCs, and have gained significant attention over the past decade. This article provides a concise overview of the progress made in this field, covering design strategies and applications. The design strategies discussed include solvent-induction, cation-induction, crystallization-induction, pH-induction, ligand inheritance, surface constraint, and minerals- and MOF-confinement. The article also highlights the practical applications of AIE-type metal NCs in areas such as bioimaging, biological diagnosis and therapy, LEDs, detection assays, and circularly polarized luminescence (CPL). The article concludes with viewpoints on the promises and challenges of AIE-type metal NCs and their potential to stimulate new vitality in the field of metal NCs in the future.
Review
Chemistry, Inorganic & Nuclear
Hui-Min Yang, Chen-Chen Weng, Hao-Yu Wang, Zhong-Yong Yuan
Summary: This review systematically discusses the recent advances in energy-related electrocatalysis using transition metal nitride (TMN)-based materials, focusing on the critical role of nitrogen in TMN-based materials in electrocatalytic processes. It explains the strategies for enhancing performance, from active sites to electrochemical interfaces, and the corresponding catalytic behavior. The practical applications in water splitting, metal-air batteries, fuel cells, and artificial nitrogen fixation are described, and the scientific challenges, possible opportunities, and future perspectives of TMN-based electrocatalytic materials are proposed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Niklas Hauptstein, Lorenz Meinel, Tessa Luehmann
Summary: Interferons (IFN) are a class of immunomodulating agents used to treat various diseases, including cancer, hepatitis, and autoimmune diseases. This article reviews the applications and routes of administration for available IFN drugs, and outlines strategies for optimizing their pharmaceutical and clinical performances.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Xianglong Lyu, Jingyuan Chen, Ruitong Zhu, Jiayu Liu, Lingshan Fu, Jeffrey Lawrence Moran, Wei Wang
Summary: Microrotors are microscopic objects that convert energy stored in the environment into spontaneous rotation. They have various applications, including drug delivery, minimally invasive surgery, fluid mixing, and sensing. They are also useful as model systems to study collective behaviors among rotating micro-objects.
Review
Chemistry, Multidisciplinary
Jie Li, Pengyu Li, Mingyu Fan, Xian Zheng, Jun Guan, Meizhen Yin
Summary: This Minireview summarizes recent progress in the synthesis and properties of chiral perylene diimides (PDIs) and discusses the various approaches to generate chirality, including the twisted planes of PDIs, the chiral substituents of PDIs, and the co-assembly of achiral PDIs and chiral guests.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Biomaterials
Narsimha Mamidi, Ramiro Manuel Velasco Delgadillo, Aldo Gonzalez-Ortiz
Summary: Stimuli-responsive drug delivery strategies utilizing engineered polymeric nanocomposite fibers show promising potential for biomedical applications. These fibers exhibit thermosensitive drug release, enhanced mechanical strength, prolonged drug release, and improved cytotoxicity against human fibroblast cells, suggesting their potential in biomedical research.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Yiping Liu, Pengyao Xing
Summary: This review systematically summarizes and discusses the application-guided design strategies of circularly polarized light (CPL)-responsive materials. CPL illumination enables the direct synthesis of helical polymers and chiral inorganic nanostructures, and their intramolecular folding and self-assembly are modulated by light. In the aggregated state and liquid crystal phase, the helical sense of molecular packing is sensitive to the enantiomeric bias brought by CPL, achieving chiral amplification. Furthermore, applications of CPL detection and biomedical applications are discussed.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Darren M. Griffith, Hongyan Li, Melissa Werrett, Philip C. Andrews, Hongzhe Sun
Summary: Bismuth, a relatively non-toxic and inexpensive metal with exceptional properties, has diverse biomedical applications ranging from treating gastrointestinal disorders to potential treatments for viral infections, multidrug resistant microbial infections, and cancer. Researchers are also exploring its applications in imaging, drug delivery, biosensing, and targeted alpha therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Haoxiang Yu, Zhen Wang, Runtian Zheng, Lei Yan, Liyuan Zhang, Jie Shu
Summary: Due to the natural abundance and cost-effectiveness of iodine, metal-iodine batteries are competitive for high energy density and large power density energy storage systems. However, the inherent properties of iodine and issues like dendrite growth and metal corrosion pose challenges for rate performance, cyclability, and safety of metal-iodine batteries. This review summarizes the research progress of metal-iodine batteries, including the classification and design strategies of iodine electrodes, development and protection strategies for metal anodes, and comparison of key electrochemical parameters.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Dina Baier, Beatrix Schoenhacker-Alte, Mate Rusz, Christine Pirker, Thomas Mohr, Theresa Mendrina, Dominik Kirchhofer, Samuel M. Meier-Menches, Katharina Hohenwallner, Martin Schaier, Evelyn Rampler, Gunda Koellensperger, Petra Heffeter, Bernhard Keppler, Walter Berger
Summary: Cellular energy metabolism is reprogrammed in cancer cells, leading to resistance against ruthenium-based chemotherapy drug BOLD-100 through enhanced glycolytic activity, increased lysosomal compartment, and defective downstream autophagy execution. Combining 2-deoxy-D-glucose with BOLD-100 reverses this resistance by inducing synergistic cell death and disrupting autophagy, suggesting glycolysis as a potential target to enhance BOLD-100 anticancer activity.
Article
Chemistry, Multidisciplinary
Benjamin Neuditschko, A. Paden King, Zhouyang Huang, Lukas Janker, Andrea Bileck, Yasmin Borutzki, Sierra C. Marker, Christopher Gerner, Justin J. Wilson, Samuel M. Meier-Menches
Summary: This study presents an improved approach for prioritizing candidate protein targets in inorganic drug discovery. It identifies TRIP as a first-in-class modulator of the scaffold protein NUBP2, disrupting Fe-S cluster biogenesis at sub-cytotoxic concentrations in ovarian cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Valentin Fuchs, Klaudia Cseh, Michaela Hejl, Petra Vician, Benjamin Neuditschko, Samuel M. Meier-Menches, Lukas Janker, Andrea Bileck, Natalie Gajic, Julia Kronberger, Martin Schaier, Sophie Neumayer, Gunda Koellensperger, Christopher Gerner, Walter Berger, Michael A. Jakupec, Michael S. Malarek, Bernhard K. Keppler
Summary: A series of highly lipophilic Cp-substituted molybdenocenes with different bioactive chelating ligands were synthesized and characterized. They showed significantly increased cytotoxic potency compared to non-Cp-substituted counterparts. In vivo experiments demonstrated tumor growth inhibition for the most active complex containing the thioflavone ligand, along with significant regulation of tubulin-associated and mitochondrial inner membrane proteins.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhofer, Mariann Gyongyosi, Klaus G. Schmetterer, Christopher Gerner
Summary: In order to understand the pathophysiology of long COVID-19 syndrome (LCS), an exploratory study was conducted using blood plasma samples from three groups: healthy vaccinated individuals without SARS-CoV-2 exposure, asymptomatic recovered patients at least three months after SARS-CoV-2 infection, and symptomatic patients at least three months after SARS-CoV-2 infection with LCS. The study found that recovered individuals had slightly elevated pro-inflammatory cytokine levels compared to patients with LCS. Additionally, LCS patients showed low levels of acute phase proteins and macrophage-derived secreted proteins, but high levels of anti-inflammatory oxylipins and osmolytes. The study proposes that alternatively polarized macrophages may be a major contributor to these molecular alterations.
Review
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Pierre Picchetti, Angela Casini
Summary: The discovery of medicinal properties of gold complexes has led to the development of new anticancer drugs, which are unique in their modes of action. Current research focuses on designing drug leads with enhanced pharmacological activities and improving physicochemical properties of gold compounds. Encapsulation of gold compounds in nanocarriers or their grafting onto targeted delivery vectors may lead to new nanomedicines for clinical applications. This article provides an overview of gold anticancer compounds and a detailed review of nanoparticle-based delivery systems for gold chemotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Yasmin Borutzki, Lukas Skos, Christopher Gerner, Samuel M. Meier-Menches
Summary: In recent years, metal-based candidate drugs have shown promise as modulators of cytoskeletal and cytoskeleton-associated proteins. Actin, vimentin, and plectin have been identified as targets of ruthenium(II) and platinum(II)-based modulators. However, there is limited structural information available on molecular interactions. This article compiles scattered reports on metal-based candidate molecules influencing the cytoskeleton and its associated proteins, exploring their potential in cancer-related processes.
Review
Biochemistry & Molecular Biology
Lukas Skos, Yasmin Borutzki, Christopher Gerner, Samuel M. Meier-Menches
Summary: Metal-based anticancer agents occupy a unique chemical space and can be tuned to target proteins as well as DNA. Tailored proteomics strategies are crucial for identifying and validating protein targets of metal-based drugs. Experimental approaches discussed in this article have shown that metals such as ruthenium, gold, rhenium, and platinum can selectively target proteins with downstream effects. Target identification strategies are expected to greatly support the clinical translation of metal-based drugs.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A. Abu el Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, Stefan Woelfl
Summary: Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option for the treatment of triple-negative breast cancer (TNBC). In this study, a multimodal anticancer platinum(II) complex, Pt(II)caffeine, was developed, which simultaneously damages mitochondria, inhibits metabolic pathways, and promotes autophagy, resulting in strong suppression of TNBC cell proliferation both in vitro and in vivo. These findings highlight the potential of Pt(II)caffeine as a metallodrug to overcome the metabolic heterogeneity of TNBC.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nilima Manoj Kumar, Patrick Gruhs, Angela Casini, Frank Biedermann, Guillermo Moreno-Alcantar, Pierre Picchetti
Summary: In this article, a cucurbit[7]uril-based chemosensor with electrochemical signal readout for the detection of pancuronium bromide is presented. The design avoids the need for immobilization on electrode surfaces and can be used with commercially available screen-printed electrodes.
Article
Chemistry, Multidisciplinary
Salma Mansi, Sarah V. Dummert, Geoffrey J. Topping, Mian Zahid Hussain, Carolin Rickert, Kilian M. A. Mueller, Tim Kratky, Martin Elsner, Angela Casini, Franz Schilling, Roland A. Fischer, Oliver Lieleg, Petra Mela
Summary: The study proposes a method to fabricate scaffolds using melt electrowriting, combining metal-organic frameworks and polycaprolactone to create highly ordered constructs with antibacterial properties and MRI visibility.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Gohar Ali Siddiqui, Julia A. Stebani, Darren Wragg, Phaedon-Stelios Koutsourelakis, Angela Casini, Alessio Gagliardi
Summary: In the context of drug discovery, computational methods have been utilized to accelerate the design and optimization of new drug candidates. This study applied machine learning algorithms to automatically identify the collective variables that describe the binding free energy and solvation effects of a drug and DNA complex.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Sandra Deiser, Marike Drexler, Guillermo Moreno-Alcantar, Maximilian Irl, Claudia Schmidt, Thomas Guenther, Angela Casini
Summary: In this study, a self-assembled [Pd2L2]4+ metallacycle was synthesized and functionalized with the radionuclide lutetium-177 for targeted cancer therapy. The resulting compound showed good stability and in vitro properties. Additionally, a new type of metal assembly was explored, providing new insights into the field of nuclear medicine for small molecule coordination polymers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Valeria Scalcon, Riccardo Bonsignore, Jana Aupic, Sophie R. Thomas, Alessandra Folda, Alexandra A. Heidecker, Alexander Pothig, Alessandra Magistrato, Angela Casini, Maria Pia Rigobello
Summary: Two new hybrid metallodrugs of Au(III)(AuTAML)and Cu(II) (CuTAML) were designed to synergize the anticancer activity of both the metal centerand the organic ligand. These drugs showed antiproliferative effects against breast cancer cells and retained binding activity to estrogen receptor (ERα). Furthermore, they exhibited different reactivities and cytotoxic potencies, but displayed a capacity to induce mitochondrial damage.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Mihyun Park, Angela Casini, Nicole Strittmatter
Summary: Mass Spectrometry Imaging (MSI) is a powerful tool for visualizing and analyzing multiple molecules in complex biological samples. Despite some molecules being difficult to access through MSI, sophisticated (bio)chemical sample treatments have been developed to overcome this. This review discusses advancements made in On-Tissue Chemical Derivatisation (OTCD), On-Tissue Enzymatic Digestion (OTED), and On-Tissue Mass Tag Labelling (OTMT) strategies, highlighting their strengths and weaknesses.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mihyun Park, Claudia Schmidt, Sebastian Tuerck, Franziska Hanusch, Simone V. Hirmer, Ingo Ott, Angela Casini, Shigeyoshi Inoue
Summary: A dinuclear gold(I) complex with a strongly donating bis-N-heterocyclic imine ligand was synthesized and characterized. It showed highly selective anticancer effects against non-small cell lung cancer cells, particularly A549 cells. The anticancer effects were not correlated with the amount of gold uptake by the cells but correlated with its selective inhibition of cancer cells overexpressing a specific enzyme.