Review
Plant Sciences
Jie Liu, Meng Ke, Yuhan Sun, Shihui Niu, Wenli Zhang, Yun Li
Summary: Plant rejuvenation involves resetting gene expression patterns, chromatin remodeling, and histone modifications, resulting in the restoration of juvenile characteristics. The epigenetic mechanisms underlying this process are still in the early stages of study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Horticulture
Sadaruddin Chachar, Muzafaruddin Chachar, Adeel Riaz, Aamir Ali Shaikh, Xiulan Li, Xiaoxue Li, Changfei Guan, Pingxian Zhang
Summary: Our era has witnessed significant advancements in plant epigenetics, with recent discoveries of RNA chemical modifications playing a role in gene translation efficiency. The application of epigenetic modifications in horticultural plants has shown promise in studying processes like fruit development, grafting, and bud dormancy. This review highlights the importance of understanding epigenetic regulation mechanisms in plants and the potential for future innovations in computational techniques for research in this field.
SCIENTIA HORTICULTURAE
(2022)
Article
Chemistry, Multidisciplinary
Neng-Bin Xie, Min Wang, Tong-Tong Ji, Xia Guo, Jiang-Hui Ding, Bi-Feng Yuan, Yu-Qi Feng
Summary: The study presents an engineered deaminase-mediated sequencing (EDM-seq) method for the quantitative detection of 5hmC in DNA at single-nucleotide resolution. The method uses an engineered A3A protein to deaminate C and 5mC, while leaving 5hmC unaffected, allowing for the direct and quantitative detection of 5hmC in DNA.
Article
Biochemistry & Molecular Biology
Kelly L. Irving, Jessica J. King, Zoe A. E. Waller, Cameron W. Evans, Nicole M. Smith
Summary: DNA is capable of forming alternative secondary structures, including the i-motif, which was previously believed to be unstable in cellular environments. Recent studies have shown the existence of i-motifs in the human genome and their role in gene regulation. This review discusses the effects of epigenetic modifications on i-motif structure, factors influencing i-motif formation in cells, and highlights the recent progress in targeting i-motifs for biotechnology and therapeutic purposes.
Article
Cell Biology
Dan Liu, Hong Li, Hui Dong, Mincheng Qu, Liguang Yang, Lina Chen, Yixue Li, Hongyang Wang, Yufei He
Summary: This study found that human liver cancer stem-like cells have similar DNA cytosine modification levels to paratumor liver cells. Using a novel method, research showed that liver cancer stem-like cells have strong spatial heterogeneity in genetic and DNA methylation, but have fewer changes compared to other tumor parenchymal cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Jake Harris, Anna Amtmann, Jurriaan Ton
Summary: Priming is a plant's ability to remember environmental stress and improve their response to recurring stress. Epigenetic modifications in DNA and histone proteins may carry short-term and long-term memory or mediate transgenerational effects in plants. New experimental tools allow scientists to manipulate epigenetic modifications in specific locations of the genome, enabling them to study the causality between these modifications and gene expression under stress. Combining site-directed epigenetic manipulation with specific promoters creates opportunities for studying and engineering spatiotemporal patterns of priming.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Spectroscopy
R. Gargallo, A. Avino, R. Eritja, P. Jarosova, S. Mazzini, L. Scaglioni, P. Taborsky
Summary: Berberine interacts weakly with the i-motif formed by the human telomere, mainly through electrostatic interactions. The ligand is not selective for i-motif structures, binding equally to folded and unfolded strands without stabilizing the i-motif structure. The development of analytical methods involving fluorescent ligands should consider thermodynamic aspects and selectivity towards different DNA structures.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Oncology
Judy S. Crabtree
Summary: Gastroenteropancreatic neuroendocrine neoplasms are rare and diverse tumors associated with genetic disorders and epigenetic regulation. Epigenetic signatures can be used as biomarkers for diagnosis and as targets for the development of new treatment approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Jiaxin Zhang, Leaf Huang, Guangbo Ge, Kaili Hu
Summary: Dysregulated epigenetic modifications drive tumor progression, drug resistance, and metastasis by affecting the tumor microenvironment. Therapies targeting epigenetic dysregulation show promise, but clinical results of combination therapies are disappointing due to toxicities and limited effectiveness. This article discusses the role of epigenetic processes, the regulation of the tumor microenvironment, and the use of advanced drug delivery system for targeted therapy.
Article
Biochemical Research Methods
Bin Wang, Eric Chatterton
Summary: This study investigates the feasibility of using capillary electrophoresis as an alternative method for i-motif related research, with results showing that capillary electrophoresis can identify and differentiate different states of DNA and RNA i-motifs through changes in peak shape and migration time.
Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Marta Pogribna, George Hammons
Summary: This review summarizes the current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures, highlighting existing knowledge gaps regarding the role of epigenetic alterations in their toxicity. Additionally, it discusses the potential role of epigenetic changes as translational biomarkers for detecting adverse effects of nanomaterials and nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Luo, Anton Granzhan, Julien Marquevielle, Anne Cucchiarini, Laurent Lacroix, Samir Amrane, Daniela Verga, Jean-Louis Mergny
Summary: Besides the DNA double-helix, G-quadruplexes are non-canonical nucleic acid structures that regulate crucial biological activities. This article provides an overview of G-quadruplexes and a detailed description of the biophysical and biochemical methods used to study them in vitro. The aim is to establish guidelines for standardized research on G-quadruplexes.
Article
Biochemistry & Molecular Biology
Petr Fajkus, Matej Adamik, Andrew D. L. Nelson, Agata M. Kilar, Michal Franek, Michal Bubenik, Radmila Capkova Frydrychova, Alena Votavova, Eva Sykorova, Jiri Fajkus, Vratislav Peska
Summary: Unlike the catalytic subunit of telomerase, the RNA subunit (TR) shows significant differences in size, sequence and biogenesis across eukaryotes. Previous views assumed a common origin of TRs transcribed with RNA polymerase II in Opisthokonta and Trypanosomida, and TRs transcribed with RNA polymerase III in TSAR and Archaeplastida. However, new findings from studying Hymenoptera TRs challenge this assumption and suggest an evolutionary switch in TR type and biogenesis that is associated with the divergence of Arthropods.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Genetics & Heredity
Soujanya Vinayagamurthy, Sulochana Bagri, Jean-Louis Mergny, Shantanu Chowdhury
Summary: Although the impact of telomeres on physiology is well established, the molecular mechanisms by which telomeres affect cellular functions remain unclear. Recent studies have identified telomere-binding factors with non-telomeric functions and discovered the prevalence of locally induced DNA secondary structures called G-quadruplexes in telomeres and gene regulatory regions. These findings suggest that telomeres may impact the non-telomeric genome through associations with factors that influence cell-intrinsic functions and have implications for aging, cancer, and pluripotency.
TRENDS IN GENETICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Jan Chyba, Anna Hruzikova, Michal Knor, Petra Pikulova, Katerina Markova, Jan Novotny, Radek Marek
Summary: In recent years, there has been extensive research on the antitumor and antimetastatic activities of transition-metal coordination compounds. This study focused on synthesizing and investigating the structure, stability, and NMR properties of Ru(III) and Rh(III) coordination compounds. By analyzing NMR spectra and using relativistic density functional theory (DFT), the effects of various factors on the hyperfine NMR shifts of para-magnetic Ru(III) compounds were examined. The study also highlighted the significant influence of solvents on hyperfine NMR shifts and discussed the broader implications for paramagnetic NMR spectroscopy of transition-metal complexes.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Petra Pikulova, Debora Misenkova, Radek Marek, Stanislav Komorovsky, Jan Novotny
Summary: Understanding the relationship between the electronic g-tensor and the electronic structure is crucial for interpreting electron paramagnetic resonance spectra correctly. In this study, we investigated the quadratic spin-orbit (SO) contributions to the g-shift in heavy transition metal complexes. We found that the dominant quadratic SO term, spin-Zeeman (SO2/SZ), generally leads to a negative contribution to the g-shift. Moreover, we analyzed how the SO2/SZ contribution affects the individual principal components of the g-tensor in combination with the linear orbital-Zeeman (SO/OZ) contribution.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Engineering, Environmental
Martin Lycka, Milos Bartak, Ondrej Helia, Stanislav Kopriva, Dana Moravcova, Josef Hajek, Lukas Fojt, Richard Cmelik, Jiri Fajkus, Miloslava Fojtova
Summary: Hydroponic experiments were conducted to investigate the effects of prolonged sulfate limitation and Cd exposure on Arabidopsis thaliana and Nicotiana tabacum. Both species showed adverse effects on morphology, photosynthetic and biochemical parameters, and nutritional status under low sulfate treatments and Cd stress. The responses to low sulfate supply, Cd exposure, or a combination of both factors were species-specific, and Cd exposure had opposing effects on the levels of certain elements in the roots.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Petra Skolakova, Martin Gajarsky, Jan Palacky, Denis Subert, Daniel Renciuk, Lukas Trantirek, Jean-Louis Mergny, Michaela Vorlickova
Summary: Based on various techniques, this study demonstrates that Cytosine-rich DNA regions can form four-stranded structures called i-motifs (iMs) under neutral or slightly alkaline conditions. These iMs exhibit long-lasting kinetics and melt with significant hysteresis. Furthermore, the presence of different iM species, the proportion of which is dependent on temperature and incubation time, is observed in sequences with a length greater than 6.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Plant Sciences
Eva Dvorak Tomastikova, Fen Yang, Kristina Mlynarova, Said Hafidh, Sarka Schorova, Alzbeta Kusova, Marketa Pernisova, Tereza Prerovska, Bozena Klodova, David Honys, Jiri Fajkus, Ales Pecinka, Petra Prochazkova Schrumpfova
Summary: RUVBL1 and RUVBL2 are crucial for the proper development of male and female gametophytes in Arabidopsis. Mutations in these genes result in abnormal embryo sac structure and nuclear numbers. The expression of these proteins is observed in pollen grains, embryo sac, and tapetum cells, playing important roles in reproductive development.
Article
Biochemistry & Molecular Biology
Remi Coulon, Barbora Papouskova, Elmira Mohammadi, Michal Otyepka, Sreekar Wunnava, Jiri Sponer, Judit E. Sponer
Summary: 3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and may have played a central role in the origin of early terrestrial life. A formamide-based systems chemistry could explain their availability on early Earth, as demonstrated by the formation of 3',5'-cyclic nucleotides in liquid formamide environments at elevated temperatures.
Article
Chemistry, Medicinal
Petr Stadlbauer, Vojtech Mlynsky, Miroslav Krepl, Jiri Sponer
Summary: In this study, steered molecular dynamics simulations were performed to investigate the unfolding mechanism of human telomeric GQs. The results showed that the direction of force, pulling velocity, and pulling force all affected the unfolding process. Additionally, it was found that a GQ could continue to unfold after a force drop. Furthermore, the study revealed that different unfolding intermediates could have similar chain end-to-end distances, suggesting limitations in structural interpretations of single-molecule spectroscopic data.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Plant Sciences
Michal Zavodnik, Petr Fajkus, Michal Franek, David Kopecky, Sonia Garcia, Steven Dodsworth, Andres Orejuela, Agata Kilar, Jiri Ptacek, Martin Matl, Anna Hyskova, Jiri Fajkus, Vratislav Peska
Summary: Telomerase, telomeric DNA, and associated proteins form a complex and conserved mechanism that maintains genome integrity by protecting chromosome ends. Evolutionary changes in telomere maintenance have given rise to species with unusual telomeric DNA sequences and telomerase components. Telomerase RNA (TR) plays a central role in telomere maintenance, and mutations in TR can disrupt telomere DNA synthesis and recognition by telomere proteins. Through bioinformatic and experimental analyses, this study investigates the evolutionary changes in TR that underlie telomere transitions in plants, and identifies telomere transitions corresponding to TR paralogs with diverse template regions.
Article
Biochemistry & Molecular Biology
Vaclav Brazda, Michaela Dobrovolna, Natalia Bohalova, Jean-Louis Mergny
Summary: Hepatitis B virus (HBV) is a dangerous human pathogenic virus that has existed alongside humanity for thousands of years. Through analyzing modern and ancient HBV genomes, it was found that G-quadruplex-forming sequences (PQS) were present in all tested HBV genomes. The frequency of PQS in modern HBV genomes has increased over time and is approaching the frequency in the human genome. These results suggest a convergent evolution of PQS frequencies in chronic viral infections to mimic the host and avoid recognition as foreign material.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Physical
Dehui Qiu, Mingpan Cheng, Petr Stadlbauer, Jielin Chen, Michal Langer, Xiaobo Zhang, Qiang Gao, Huangxian Ju, Jiri Sponer, Jean-Louis Mergny, David Monchaud, Jun Zhou
Summary: The active sites of natural and artificial enzymes play a crucial role in their catalytic performance. This study focuses on G-quadruplex (GQ)/hemin DNAzymes and investigates how their active sites can be controlled and manipulated. Experimental and molecular dynamics simulation results reveal that the topology of the GQ and the flanking nucleotides influence the activation of hemin, providing valuable insights into the biocatalytic activity of GQs.
Article
Cell Biology
Gianluca Teano, Lorenzo Concia, Lea Wolff, Leopold Carron, Ivona Biocanin, Katerina Adamusova, Miloslava Fojtova, Michael Bourge, Amira Kramdi, Vincent Colot, Ueli Grossniklaus, Chris Bowler, Celia Baroux, Alessandra Carbone, Aline Probst, Petra Prochazkova Schrumpfova, Jiri Fajkus, Simon Amiard, Stefan Grob, Clara Bourbousse, Fredy Barneche
Summary: A study in Arabidopsis reveals the role of linker histone H1 in nucleosome organization and its functional interactions with chromatin factors. It shows that H1 contributes to chromatin condensation and H3K27me3 deposition at Polycomb Repressive Complex 2 (PRC2) target genes, while selectively preventing H3K27me3 accumulation at telomeres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins. This study provides insights into the mechanistic framework of how H1 safeguards nucleus architecture.
Article
Chemistry, Physical
Vojtech Mlynsky, Petra Kuhrova, Petr Stadlbauer, Miroslav Krepl, Michal Otyepka, Pavel Banas, Jiri Sponer
Summary: Molecular dynamics simulations are commonly used to study RNA molecules. By adjusting the nonbonded parameters, the widely used AMBER OL3 ff in RNA simulations can be improved. The modified simulations show better agreement with experimental results.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)