Article
Cell Biology
Zetian Shen, Han Zhou, Aomei Li, Tiancong Wu, Xiaoqin Ji, Lei Guo, Xixu Zhu, Dagan Zhang, Xia He
Summary: The study found that Metformin inhibits the development of HCC cells by inducing apoptosis and pyroptosis, partially dependent on FOXO3 activation of NLRP3 transcription.
Article
Virology
Zhenqiao Wei, Rui Gao, Zhen Sun, Wen Yang, Qi He, Chenhui Wang, Jingxiang Zhang, Xiaochang Zhang, Liang Guo, Shengqi Wang
Summary: This study reveals that baicalin, derived from Scutellaria baicalensis, can protect lung alveolar epithelial cells from H1N1-induced pyroptosis, an inflammatory form of programmed cell death, by inhibiting the caspase-3/GSDME pathway. This is the first demonstration of the important role of baicalin in antiviral activity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yixuan Liu, Kai Guo, Min Ding, Bingchen Zhang, Nanyang Xiao, Zonghao Tang, Zhengming Wang, Chengfei Zhang, Quazi T. H. Shubhra
Summary: This study reports the development of a polymer-based nanodrug delivery system for the efficient treatment of breast cancer using a combination of pyroptosis-starvation-chemotherapy. The system demonstrates targeted delivery to tumor sites, pH responsiveness, synergistic effect, and lack of severe side effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Genetics & Heredity
Anyi Zhu, Cheng Cheng, Shuangquan Lin, Zhengdong Hong, Zimin Shi, Huanhuan Deng, Gan Zhang
Summary: The objective of this study was to investigate the role and potential mechanism of linc00023 in the development of pyroptosis in clear cell renal cell carcinoma (ccRCC). The expression of linc00023 was assessed in cells using qRT-PCR, and knockdown of linc00023 resulted in increased cell proliferation and decreased pyroptosis. Furthermore, the inhibition of linc00023 led to changes in the expression of numerous mRNAs, including p53.
Article
Oncology
Gangyin Xie, Linxiao Sun, Yonglin Li, Bicheng Chen, Cheng Wang
Summary: The study demonstrates that periplocin inhibits the proliferation of human pancreatic cancer cells and induces apoptosis by activating the AMPK/mTOR pathway. Additionally, it attenuates cell migration and invasion abilities.
Article
Biochemistry & Molecular Biology
Yusha Xiao, Kang Yang, Pengpeng Liu, Dong Ma, Ping Lei, Quanyan Liu
Summary: The study showed that DNASE1L3 could inhibit the progression of HCC by inducing cell apoptosis and weakening glycolysis, suggesting its potential as a prognostic biomarker and therapeutic target for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Min Zhang, Qinsheng Lu, Huomei Hou, Dingqian Sun, Miaojuan Chen, Fen Ning, Peihuang Wu, Dan Wei, Yaoyun Duan, Yue Pan, Gendie E. Lash
Summary: Garcinol demonstrates significant inhibitory effects on cell proliferation and cell cycle in endometrial cancer cells, making it a promising candidate for endometrial cancer chemotherapy.
Article
Physiology
Milja Arponen, Niki Jalava, Nicko Widjaja, Kaisa K. Ivaska
Summary: Research indicates that different types of glucose transporters play different roles in the proliferation and differentiation of osteoblasts. Expression of GLUT4 is crucial for the proliferation and differentiation of osteoblasts, while GLUT1 is abundant in early precursors and GLUT3 shows stable expression during differentiation. Apart from GLUT1, 3, and 4, osteoblasts also express other types of glucose transporters to regulate glucose uptake.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Yan Peng, Ren-Ping Xiong, Zhuo-Hang Zhang, Ya-Lei Ning, Yan Zhao, Si-Wei Tan, Yuan-Guo Zhou, Ping Li
Summary: This study demonstrated that Ski plays a crucial role in regulating fibroblast proliferation and apoptosis under high-glucose conditions through the FoxO1 pathway. Increasing Ski protein levels alleviated the inhibitory effects of high glucose on proliferation and promoted apoptosis, highlighting the potential therapeutic implications of targeting Ski in diabetic complications.
CELL PROLIFERATION
(2021)
Article
Environmental Sciences
Qiqi Zhu, Shanshan Zhu, Qiyao Li, Yun Wang, Dongxu Zheng, Chunjiang Chen, Naqi Ruan, Haiqiong Chen, Haoni Yan, Han Lin, Ren-Shan Ge
Summary: Exposure to MTBE during late puberty compromises the development of Leydig cells in male rats by inhibiting cell proliferation, inducing mitochondrial autophagy and apoptosis, and indirectly stimulating Sertoli cells to secrete anti-Mullerian hormones, resulting in a reduced number of Leydig cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Lingling Feng, Wei Zhao, Yunshan Fan, Chengcheng Yuan, Xiaohua Zhang
Summary: This study reveals the inhibitory role of RNA N6-methyladenosine (m(6)A) and fat mass and obesity-associated gene (FTO) in the differentiation and function of osteoblasts (OBs) in bone marrow mesenchymal stem cells (BMSCs) under excess glucocorticoids (GCs).
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Yiqing Cai, Liemei Lv, Tiange Lu, Mengfei Ding, Zhuoya Yu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang
Summary: Metabolic reprogramming, specifically dysregulation of glutamine metabolism, plays a crucial role in tumorigenesis, microenvironment remodeling, and therapeutic resistance in DLBCL. High levels of glutamine are associated with poor clinical outcomes, while the derivative of glutamine, a-KG, is negatively correlated with invasiveness features. Treatment with DM-aKG significantly inhibits tumor growth by inducing apoptosis and non-apoptotic cell death. The study highlights the potential use of a-KG as a novel therapeutic strategy for DHL patients.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Guangping Zhang, Xin Zhao, Weixian Liu
Summary: Glycolysis contributes to the cell metabolism and proliferation of oral squamous cell carcinoma (OSCC), the most common type of oral cancer. Understanding the regulatory mechanisms involved in glycolysis of OSCC cells may have important therapeutic implications. The study showed that NEDD4L is downregulated in OSCC tissues and its expression is positively correlated with 5-year patient survival rate. Overexpression of NEDD4L inhibited the proliferation, cell cycle transition, and glycolysis of OSCC cells, and suppressed tumor growth in vivo. ENO1, an enzyme involved in glycolysis, was identified as a substrate of NEDD4L. Overexpression of NEDD4L led to the ubiquitination and degradation of ENO1. The functional effects of NEDD4L overexpression were reversed by overexpression of ENO1. These findings reveal a signaling axis that is important for OSCC cell survival and metabolism and could serve as a potential therapeutic target.
CANCER BIOLOGY & THERAPY
(2022)
Article
Medicine, Research & Experimental
Keliang Song, Jinfeng Ma, Yang Gao, Yan Qu, Chongmin Ren, Peng Yan, Bingxin Zheng, Bin Yue
Summary: This study identified the expression of Siglec-15 in osteosarcoma cells and demonstrated that targeting the Siglec-15/STAT3/Bcl-2 pathway promotes apoptosis and pyroptosis while inhibiting proliferation.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Oncology
Yongqiang Wang, Hewei Zhang, Zusen Ye, Qiang Ye, Xuezhi Yang, Wei Mao, Ruoting Xu, Yanlei Zhang
Summary: This study reveals that maslinic acid significantly inhibits the proliferation, invasion, and migration of glioma cells, promotes cell apoptosis, and acts through suppressing the MAPK signaling pathway. This is the first analysis of the mechanism of maslinic acid against glioma at the transcriptional level.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)