Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease

Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with End-stage Kidney Disease Receiving Maintenance Hemodialysis

(2019) Jason R. Stubbs et al.   Clinical Journal of the American Society of Nephrology

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

(2019) Sonia Chothani et al.   CIRCULATION

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Isoproterenol Disrupts Intestinal Barriers Activating Gut-Liver-Axis: Effects on Intestinal Mucus and Vascular Barrier as Entry Sites

(2019) Marcel Sorribas et al.   DIGESTION

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)

(2019) Mitchell et al.   Nutrients

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles

(2018) Sahir Kalim et al.   Clinical Journal of the American Society of Nephrology

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

(2018) Zeneng Wang et al.   EUROPEAN HEART JOURNAL

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies

(2017) Jiaqian Qi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury

(2017) Mariana Charleaux de Ponte et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS–based metabolomics approach

(2017) Eikan Mishima et al.   KIDNEY INTERNATIONAL

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function

(2017) Eke G. Gruppen et al.   Scientific Reports

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

TrimethylamineN-Oxide and Cardiovascular Events in Hemodialysis Patients

(2016) Tariq Shafi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events

(2016) Richard B. Kim et al.   KIDNEY INTERNATIONAL

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients

(2016) Cassianne Robinson-Cohen et al.   PLoS One

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Effect of a Symbiotic Gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on Presence and Severity of Gastrointestinal Symptoms in Hemodialysis Patients

(2015) Daniela Viramontes-Hörner et al.   JOURNAL OF RENAL NUTRITION

Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis

(2015) George A. Kaysen et al.   JOURNAL OF RENAL NUTRITION

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Patiromer in Patients with Kidney Disease and Hyperkalemia Receiving RAAS Inhibitors

(2015) Matthew R. Weir et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy

(2015) Qian Liu et al.   Scientific Reports

The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial

(2015) I.-K. Wang et al.   Beneficial Microbes

Gut-Microbiota-Metabolite Axis in Early Renal Function Decline

(2015) Clara Barrios et al.   PLoS One

Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients

(2015) Xin Hai et al.   PLoS One

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

(2014) Zeneng Wang et al.   ANALYTICAL BIOCHEMISTRY

Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible

(2014) Paul J. McMurdie et al.   PLoS Computational Biology

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

(2013) E. P. Rhee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

(2013) Hiroshi Watanabe et al.   KIDNEY INTERNATIONAL

Albuminuria is associated with too few glomeruli and too much testosterone

(2013) David A. Long et al.   KIDNEY INTERNATIONAL

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

(2013) Paul J. McMurdie et al.   PLoS One

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Chronic kidney disease alters intestinal microbial flora

(2012) Nosratola D. Vaziri et al.   KIDNEY INTERNATIONAL

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure

(2011) Guido Grassi et al.   HYPERTENSION

Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves

(2011) Daniel Schock-Kusch et al.   KIDNEY INTERNATIONAL

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

(2010) B. K. I. Meijers et al.   Clinical Journal of the American Society of Nephrology

Discovering the false discovery rate

(2010) Yoav Benjamini   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Removal of uraemic retention solutes in standard bicarbonate haemodialysis and long-hour slow-flow bicarbonate haemodialysis

(2010) C. Basile et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Operons

(2009) Anne E. Osbourn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Analysis of Sensor Domains from the TMAO-Responsive Histidine Kinase Receptor TorS

(2009) Jason O. Moore et al.   STRUCTURE

Sympathetic Activation in Chronic Renal Failure

(2008) M. P. Schlaich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY