Article
Microbiology
Sandrine Dufourny, Nadine Antoine, Elena Pitchugina, Veronique Delcenserie, Stephane Godbout, Caroline Douny, Marie-Louise Scippo, Eric Froidmont, Pierre Rondia, Jose Wavreille, Nadia Everaert
Summary: The study found that the addition of apple pomace feed has a beneficial effect on the growth performance, intestinal morphology, and microbiota of weaned piglets, with the 4% inclusion level showing the most promising results.
Article
Microbiology
Md Rayhan Mahmud, Ching Jian, Md Karim Uddin, Mirja Huhtinen, Anne Salonen, Olli Peltoniemi, Heli Venhoranta, Claudio Oliviero
Summary: Small-scale studies on pigs' intestinal microbiota and growth performance have yielded inconsistent results. This study found that the gut microbiota during the nursery stage, not the suckling period, was a predictor of piglet growth. Certain SCFA-producing bacterial genera were significantly correlated with high piglet growth, and the gut microbiota of high-ADG piglets matured faster and stabilized sooner after weaning compared to low-ADG piglets. The findings suggest that weaning is a major driver of gut microbiota variation and that specific gut microbiota at weaning may be beneficial for piglet growth.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Hui Han, Shunfen Zhang, Ruqing Zhong, Chaohua Tang, Jie Yin, Junmin Zhang, Hongfu Zhang
Summary: The experiment with CTC showed that the drug did not affect growth performance in piglets, but could adjust intestinal structure. It seems that the colonic microbiota is no longer sensitive to CTC due to long-term use and low bioavailability.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Jing Liang, Shasha Kou, Cheng Chen, Sayed Haidar Abbas Raza, Sihu Wang, Xi Ma, Wen-Ju Zhang, Cunxi Nie
Summary: The study found that feeding piglets with C. butyricum did not significantly affect their growth performance or incidence of diarrhea during the experimental period. Analysis of 16S rRNA gene sequencing results showed that the CB group had significantly increased microbial diversity compared to the NC group. Furthermore, the addition of C. butyricum led to significant changes in fecal metabolites, particularly involving pathways related to citrulline, dicarboxylic acids, branched-chain amino acids, and tryptophan metabolism.
Article
Agriculture, Dairy & Animal Science
Shilong Liu, Xiaoping Zhu, Yueqin Qiu, Li Wang, Xiuguo Shang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang
Summary: The study found that niacin supplementation significantly improved the growth performance of piglets and increased the relative abundance of beneficial bacteria in the colon, while alleviating the inflammatory response in the intestinal mucosa.
Article
Agriculture, Dairy & Animal Science
Taiwo J. Erinle, Samson Oladokun, Janice MacIsaac, Bruce Rathgeber, Deborah Adewole
Summary: This study aimed to investigate the use of grape pomace as an alternative to antibiotics in poultry feed and evaluate its effects on growth, intestinal morphology, microbiota, short-chain fatty acid concentration, blood biochemical parameters, and meat quality in broiler chickens. The results showed that the inclusion of grape pomace in the diet improved gut morphology, modified the cecal bacterial community and blood biochemical profiles, without adverse effects on growth performance and meat quality.
Article
Microbiology
Yusen Wei, Jiangdi Mao, Jingliang Liu, Yu Zhang, Zhaoxi Deng, Jiaqi Lv, Maolong He, Jianxin Liu, Haifeng Wang
Summary: The study demonstrated that supplementing piglets' diet with a mixture of methyl salicylate and tributyrin improved feed intake, average daily gain, blood protein levels, and antioxidant capacity, while reducing specific bacteria in the gut. On the other hand, supplementing with a mixture of oregano oil and tributyrin increased antioxidant capacity and altered the abundance of certain microbes in the ileum.
Article
Agriculture, Dairy & Animal Science
Yuying Wu, Bei Cheng, Longxiang Ji, Xiangyun Lv, Yingying Feng, Liu'an Li, Xin Wu
Summary: This study found that lysozyme could significantly improve the growth performance and intestinal barrier function of weaned piglets. It also improved intestinal morphology and increased the expression of occludin. Additionally, lysozyme regulated the abundance and composition of intestinal flora and had anti-inflammatory effects. These findings provide an important theoretical basis for the application of lysozyme in pig production.
Article
Biochemistry & Molecular Biology
Hao Ding, Xichen Zhao, Md Abul Kalam Azad, Cui Ma, Qiankun Gao, Jianhua He, Xiangfeng Kong
Summary: The study found that feeding XOS can improve piglets' growth performance, while feeding BS or XOS can influence intestinal health by improving intestinal morphology, microbial community, and metabolites. Additionally, there are interactions between BS and XOS in intestinal metabolites.
Article
Agriculture, Dairy & Animal Science
Min Song, Fenglin Zhang, Lin Chen, Qiang Yang, Han Su, Xiaohua Yang, Haiwen He, Mingfa Ling, Jisong Zheng, Chen Duan, Xumin Lai, Mushui Pan, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
Summary: CDCA supplementation improved the growth performance of weaned piglets by enhancing intestinal morphology and barrier function, enhancing lipid digestion, altering serum metabolic profiles, and changing the relative abundance of certain gut bacteria.
Article
Agriculture, Dairy & Animal Science
Mingxing Huang, Jiang Yi, Hua Chen, Yuehui Song, Xinyue Hu, Hua Zhou, Nianhua Zhu
Summary: This experiment investigated the potential of low-dose zinc-loaded montmorillonite (Zn-MMT) as an alternative to high-dose conventional zinc oxide (ZnO) for preventing diarrhea in weaned piglets. The results showed that Zn-MMT and ZnO had similar effects in promoting growth, reducing diarrhea, improving mucosal barrier integrity, and regulating gut microbiota.
Article
Veterinary Sciences
Yongdi Zeng, Zirui Wang, Tiande Zou, Jun Chen, Guanhong Li, Liuzhen Zheng, Shuo Li, Jinming You
Summary: This study found that dietary supplementation of 400mg/kg bacteriophage can improve the growth performance, intestinal morphology, barrier function, and gut microbiota of weaned piglets, serving as an antibiotic alternative. The underlying mechanism involves a positive effect on intestinal inflammation, barrier function, and gut microbiota.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Feize Sun, Huahui Li, Zhiqiang Sun, Ling Liu, Xiujun Zhang, Jinbiao Zhao
Summary: This study aimed to investigate the effects of xylose with different polymerizations on growth performance, intestinal barrier function, and gut microbial composition in weaned piglets. Results showed that dietary supplementation of XOS or AX reduced diarrhea incidence and increased intestinal villus height, antioxidase activity, and sIgA contents. XOS had a faster microbial fermentation and increased the abundance of Lactobacillus and Bifidobacterium in the ileal digesta, while AX increased the abundance of Bifidobacterium in the colonic digesta.
Article
Agriculture, Dairy & Animal Science
Shuaibing Xing, Shuai Chen, Ying Zhao, Yuheng Luo, Bing Yu, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Junqiu Luo, Hui Yan, Jie Yu
Summary: This study investigated the effects of high ambient temperature on growth performance, small intestinal morphology, and colonic microbiota in weaned piglets. The results showed that high ambient temperature had negative effects on piglet growth performance and colonic microbiota.
Article
Microbiology
Zhihua Li, Qian Zhu, Md. Abul Kalam Azad, Huawei Li, Pan Huang, Xiangfeng Kong
Summary: The study showed that 4% FML dietary supplementation can enhance amino acid metabolism, while 2% and 4% FML supplementation can improve growth performance and intestinal health of weaned piglets.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Zhang, JunMei Wang, HengTong Fang, Hao Yu, Yun Zhao, JingLin Shen, ChangHai Zhou, YongCheng Jin
Summary: Studies have shown that pterostilbene (PTE) can effectively reduce the cytotoxicity of tricothecene mycotoxin, deoxynivalenol (DON), in mammary alveolar cells-large T antigen cells (MAC-T) by improving cell viability, proliferation, and antioxidant capacity, as well as regulating the expression of key genes involved in oxidative stress and inflammatory response. PTE shows promising potential as an anti-inflammatory and antioxidant agent to protect cells from mycotoxin-induced damage.
Review
Pharmacology & Pharmacy
Zhang Jing, Wang Rui, Li Ruihua, Yu Hao, Fang Hengtong
Summary: Maslinic acid has been found to promote health and resist various diseases. Research has shown its positive effects on cardiovascular diseases, neuroprotection, diabetes, cancer, inflammation, and pathogens, making it a potential nutritional additive and drug candidate.
CURRENT DRUG TARGETS
(2021)
Article
Food Science & Technology
Yurong Fu, Yongcheng Jin, Anshan Shan, Jing Zhang, Hongyu Tang, Jinglin Shen, Changhai Zhou, Hao Yu, Hengtong Fang, Yun Zhao, Junxiong Wang, Yue Tian
Summary: The study showed that PD can effectively alleviate ZEA-induced damage on bovine mammary epithelial cells by reducing oxidative damage and ER stress, thus reducing cell apoptosis.
Article
Food Science & Technology
Ruihua Li, Hengtong Fang, Jinglin Shen, Yongcheng Jin, Yun Zhao, Rui Wang, Yurong Fu, Yue Tian, Hao Yu, Jing Zhang
Summary: The study demonstrates that curcumin (CUR) can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by endotoxin (LPS), potentially through regulation of antioxidant, anti-inflammatory, and anti-apoptotic pathways.
Article
Biochemistry & Molecular Biology
Jinxin Zong, Jinglin Shen, Xinlu Liu, Jiayi Liu, Jing Zhang, Changhai Zhou, Yating Fan, Yongcheng Jin
Summary: The study found that lithium salts can promote milk protein and fat synthesis while inhibiting the expression of inhibitors in mammary epithelial cells. This finding suggests that lithium salts can be used as potential nutrients to regulate milk synthesis in dairy cows.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Xinlu Liu, Jinglin Shen, Jinxin Zong, Jiayi Liu, Yongcheng Jin
Summary: Beta-sitosterol, at concentrations ranging from 0.1 to 10 µM, has been shown to promote the expression of milk protein and fat synthesis-related genes and proteins in bovine mammary epithelial cells, suggesting its potential use as a feed additive to improve milk quality in dairy cows.
Article
Food Science & Technology
Junxiong Wang, Kexin Zheng, Yongcheng Jin, Yurong Fu, Rui Wang, Jing Zhang
Summary: In this study, it was found that taraxasterol can protect bovine mammary epithelial cells from damage caused by deoxynivalenol (DON), reduce cell apoptosis, alleviate endoplasmic reticulum stress, and reduce reactive oxygen species accumulation.
Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Yingying Jiao, Linlin Hao, Peijun Xia, Yunyun Cheng, Jie Song, Xi Chen, Zhaoguo Wang, Ze Ma, Shuo Zheng, Ting Chen, Ying Zhang, Hao Yu
Summary: This research investigated the differences in growth performance between Bama minipigs and Landrace pigs by detecting differentially expressed miRNA and mRNA in pituitary tissues. By screening growth-related pathways and establishing protein-protein interaction networks, the interaction between differentially expressed miRNAs and mRNAs was predicted. Four regulatory pathways were identified and validated using quantitative real-time PCR. The findings shed light on the molecular mechanisms underlying growth differences in pigs of different body sizes.
Article
Food Science & Technology
Yue Tian, Haoyu Che, Jinsheng Yang, Yongcheng Jin, Hao Yu, Chuanqi Wang, Yurong Fu, Na Li, Jing Zhang
Summary: The study aimed to investigate the protective effects of AST on AFB1-induced impairment in IPEC-J2 cells and elucidate the underlying mechanism. The results showed that AST significantly improved cell viability, attenuated AFB1-induced ROS production and expression of pro-apoptotic proteins, and activated the Nrf2 signaling pathway to enhance antioxidant capacity. In conclusion, AST ameliorates oxidative stress and apoptosis caused by AFB1 through the activation of the Nrf2 pathway.