Article
Chemistry, Analytical
Yuanyuan Zhang, Jing Wang, Wanxiang Yi, Aliya Tiemuer, Hui Yu, Yi Liu, Dan Su
Summary: We report an activatable frequency upconversion luminescence (FUCL) MAO-B nano-probe (NIR-MNP) capable of highly specific and real-time MAO-B imaging in biological samples. The turn-on FUCL effect enables high-quality imaging and tissue penetration for in vivo imaging, distinguishing it from existing probes. Furthermore, we used NIR-MNP to confirm the role of MAO-B inhibitor in delaying Parkinson's disease (PD) progression in mouse PD models through in vivo bioimaging technique. Lastly, our study provides a visual way to gain further insight into the involvement of MAO-B in PD onset and progression in animals.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roberta Lattanzi, Rossella Miele
Summary: Prokineticins are a new class of peptides that play a crucial role in neuroinflammatory processes, regulating neuronal-glial interactions and T cell function. PK2 and PKRs are upregulated during inflammation, influencing inflammatory responses and directing T cells towards a pro-inflammatory phenotype.
Article
Plant Sciences
Hairong Zhao, Mei Wang, Xi Huang, Xiumei Wu, Huai Xiao, Fanmao Jin, Jiaming Lv, Jidong Cheng, Yu Zhao, Chenggui Zhang
Summary: Wasp venom exhibits potential neuroprotective effects on acute ischaemic stroke (AIS) in rats, improving neurological impairment, promoting blood flow recovery, reducing infarct volume, and regulating blood-brain barrier permeability. The venom also inhibits inflammation and apoptosis, and modulates angiogenesis factors in the brain.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Immunology
Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter
Summary: In experimental autoimmune encephalomyelitis (EAE), claudin-5 (CLN-5) was found on leukocytes in the blood and central nervous system (CNS), potentially facilitating leukocyte transendothelial migration (TEM) across the blood-brain barrier. Flow cytometry analysis showed CLN-5(+) populations among various leukocyte subtypes, with higher levels in CNS tissue than in blood, suggesting preferential access to the CNS. This novel mechanism may guide leukocytes to sites for diapedesis across the BBB.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Zhengzheng Ruan, Dongdong Zhang, Ruixue Huang, Wei Sun, Liyan Hou, Jie Zhao, Qingshan Wang
Summary: Chronic neuroinflammation damages dopaminergic neurons in a rotenone-induced mouse PD model through blood-brain barrier dysfunction mediated by microglial MMP-2/-9 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yu-Lian Zeng, Yang Du, Xin-Xin Xu, Ya-Jun Wang, Sai-Xi Yu, Ting Liu, Shiyuan Luo, Xiao-Wei Xiang, Wei Liu, Yu-Chen Chen, Hongjun Huang, Hai Gao, Yuhui Shen, Yan Luo, Chengrong Bao, Yan-Jun Liu
Summary: The blood-brain barrier (BBB) is a physical structure that maintains CNS homeostasis and its disruption is involved in neurodegenerative diseases. A microfluidic BBB chip model was developed to mimic the physiological and pathological states. Glial cells in the functional BBB showed activation in response to stimulation, but exhibited blunted responses in a pathological extracellular microenvironment. The BBB-on-a-chip can help study cell-cell interactions in neurodegenerative diseases and evaluate drug efficacy.
Article
Medicine, Research & Experimental
Katarzyna Potyrak, Benita Wiatrak, Edward Krzyzak, L. Lukasz Szczukowski, Piotr Swiatek, Adam Szelag
Summary: Alzheimer's disease remains a serious disorder with no effective therapy. However, certain compounds show potential for beneficial effects on damaged neuronal cells and are capable of crossing the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Scott R. Burks, Cymon N. Kersch, Jaclyn A. Witko, Michael A. Pagel, Maggie Sundby, Leslie L. Muldoon, Edward A. Neuwelt, Joseph A. Frank
Summary: Intracarotid arterial hyperosmolar mannitol (ICAHM) is effective and safe for treating central nervous system malignancies by disrupting the blood-brain barrier, but it can induce a transient neuroinflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Orianne Constant, Ghizlane Maarifi, Fabien P. Blanchet, Philippe van de Perre, Yannick Simonin, Sara Salinas
Summary: This review highlights the important contribution of dendritic cells in the development and consequences of viral brain infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Loescher
Summary: The authors proposed a novel approach involving multiple targets and networks, combining drugs to prevent the onset of epilepsy, and provided initial evidence of its effectiveness.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Engineering, Biomedical
Danny Lam, Anisha Javadekar, Nirav Patil, Marina Yu, Longshun Li, Dhariyat M. Menendez, Anirban Sen Gupta, Jeffrey R. Capadona, Andrew J. Shoffstall
Summary: Intracortical microelectrodes induce vascular injury upon insertion into the cortex, leading to blood-brain barrier damage and increased immune and inflammatory responses. Blood proteins, including fibrinogen and von Willebrand Factor, as well as platelets, persist at the microelectrode interface, promoting neuroinflammation and declining recording performance.
ACTA BIOMATERIALIA
(2023)
Article
Clinical Neurology
Alexis M. Crockett, Sean K. Ryan, Adriana Hernandez Vasquez, Caroline Canning, Nickole Kanyuch, Hania Kebir, Guadalupe Ceja, James Gesualdi, Elaine Zackai, Donna McDonald-McGinn, Angela Viaene, Richa Kapoor, Nail Benallegue, Raquel Gur, Stewart A. Anderson, Jorge Alvarez
Summary: Neuroimmune dysregulation is implicated in neuropsychiatric disorders, including schizophrenia. Research found compromised vascular phenotype in patients with 22q11.2 deletion syndrome, leading to compromised immune privilege and potentially increased risk of neuropsychiatric disease.
Review
Cell Biology
Supriya D. Mahajan, Nigel Smith Ordain, Hilliard Kutscher, Shanta Karki, Jessica L. Reynolds
Summary: Exosomes play a significant role in HIV neuroinflammation and neuropathogenesis, with potential as biomarkers and drug delivery vehicles for the treatment of HIV neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Zhen Yan, Yu-mei Liu, Wei-dong Wu, Yuhan Jiang, Lai-Bao Zhuo
Summary: This study aimed to investigate the role and potential mechanisms of ozone (O-3) in heat stress (HS)-induced cognitive impairment. The results showed that co-exposure to O-3 exacerbated the cognitive impairment induced by high temperature in rats, possibly through glial-mediated neuroinflammation and blood brain barrier disruption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Yuping Han, Lin Shen, Zhen Li, Zhihong Liu
ANALYTICAL METHODS
(2018)
Article
Chemistry, Analytical
Songjiao Li, Dan Song, Weijing Huang, Zhen Li, Zhihong Liu
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Miaomiao Zuo, Qian Duan, Chenchen Li, Juan Ge, Qirong Wang, Zhen Li, Zhihong Liu
Summary: Efficiency of energy transfer and brightness of UCNPs, as well as aggregation-caused quenching of energy accepting dyes, are identified as main factors restricting emission of energy acceptors. By modulating UCNPs structure and assembly of energy donor-acceptor pair, this issue was addressed. A ratiometric upconversion nanoprobe for H2S detection was successfully developed, allowing tracking and visualization of H2S levels in living cells, zebrafish, and mice during physiological processes.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Qirong Wang, Tao Liang, Junjie Wu, Zhen Li, Zhihong Liu
Summary: A new type of dye-sensitized rare earth-doped nanoparticle has been designed for real-time NIR-IIb luminescence imaging with high temporal-spatial resolution and contrast. This method can be used for diagnosing and monitoring the therapeutic effects of blood circulatory system-related diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Meng Zhang, Zijun Wang, Caixia Wang, Yuting Wu, Zhen Li, Zhihong Liu
Summary: A responsive NIR-II nanoprobe was developed for in vivo imaging of oxidative stress levels in ischemic tissue, allowing differentiation between salvageable ischemic tissue and infarcted stroke core. This probe provides a practical tool for timely assessment of IS.
Article
Chemistry, Analytical
Dan Song, Mengting Zhu, Siyu Chi, Lan Xia, Zhen Li, Zhihong Liu
Summary: A new nanomaterial, QDs-LnNCs, was developed for real-time imaging of cerebrovascular structure and hemodynamics related to brain injury, achieving significant imaging results.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dan Song, Mengting Zhu, Chenchen Li, Yan Zhou, Yudan Xie, Zhen Li, Zhihong Liu
Summary: A NIR dye-sensitization strategy was proposed to enhance the luminescence intensity of Ag2Te QDs and construct activatable probes, resulting in the successful fabrication of a ratiometric NIR-IIb nanoprobe for visualizing GSH in vivo.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tao Liang, Zhi Guo, Yifan He, Yanying Wang, Chunya Li, Zhen Li, Zhihong Liu
Summary: A strategy is proposed to prepare MOFs with strong near-infrared II (NIR-II) emission by integrating NIR dye and Ln(3+) into a same framework. The obtained Er-BTC-IR exhibits excellent NIR-II emission efficiency and biocompatibility for bioimaging.
Article
Chemistry, Analytical
Qian Duan, Yifan He, Wenqiang Bi, Tao Liang, Zhihong Liu, Zhen Li
Summary: In this study, a NIR-excitable ratiometric nanoprobe based on upconversion nanoparticles and an organic molecule was developed for the reversible detection of hydrogen polysulfide. The nanoprobe showed high selectivity and fast response, enabling the monitoring of the formation and consumption of endogenous hydrogen polysulfide in living cells.
ANALYTICAL CHEMISTRY
(2022)
Correction
Chemistry, Analytical
Yuying Zhang, Zhen Li, Wei Hu, Zhihong Liu
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Li, Wenqiang Bi, Tao Liang, Zhen Li, Zhihong Liu
Summary: This study developed a novel ratiometric near-infrared-II (NIR-II) nanoprobe for tracking the fluctuations of reactive nitrogen species in vivo. The relationship between reactive nitrogen species and hepatic ischemia-reperfusion injury (HIRI) was revealed, suggesting that reactive nitrogen species may be products of stress reactions during HIRI. This work not only provides a useful tool for visually tracking reactive nitrogen species in vivo but also offers first-hand information about their role in HIRI.
Article
Multidisciplinary Sciences
Zhen Li, Junjie Wu, Qirong Wang, Tao Liang, Juan Ge, Peipei Wang, Zhihong Liu
Article
Chemistry, Multidisciplinary
Tianyu Yu, Dong-Mei Wei, Zhen Li, Liang-Jun Pan, Zhi-Ling Zhang, Zhi-Quan Tian, Zhihong Liu
CHEMICAL COMMUNICATIONS
(2020)
