Review
Biochemistry & Molecular Biology
Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hualin Chen, Lin Ma, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: POLR3G is highly expressed in bladder cancer and is associated with poor prognosis. Its deficiency inhibits migration and invasion of bladder cancer cells and reduces the expression of EMT-related markers. Mechanistically, POLR3G can promote EMT in bladder cancer by activating the PI3K/AKT signaling pathway.
Article
Cell Biology
Weipu Mao, Keyi Wang, Si Sun, Jianping Wu, Ming Chen, Jiang Geng, Ming Luo
Summary: The study revealed that ID2 serves as a tumor suppressor in bladder cancer, with high ID2 expression associated with lower tumor staging and better survival rates. Mechanistically, ID2 inhibits the progression and metastasis of BCa through the PI3K/AKT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Guang-Cheng Luo, Lin Chen, Jiang Fang, Zhi-Jian Yan
Summary: This study revealed that hsa_circ_0030586 is significantly upregulated in prostate cancer cells and may promote epithelial-mesenchymal transition (EMT) through the PI3K-AKT signaling pathway. Experiment results showed that interfering with hsa_circ_0030586 could inhibit tumor cell proliferation, migration, and invasion in PCa.
Review
Pathology
Mohsen Karami Fath, Ramtin Akhavan Masouleh, Negin Afifi, Shirin Loghmani, Parham Tamimi, Alireza Fazeli, Seyed Ali Mousavian, Mohammad Mehdi Falsafi, Ghasem Barati
Summary: The PI3K/Akt/mTOR signaling pathway controls various cellular behaviors, and dysregulated circRNAs have been found to upregulate this pathway, promoting breast tumor initiation, growth, and progression. The dysregulation of PI3K/Akt-regulating circRNAs is correlated with clinical features of breast cancer. Targeting these circRNAs may be a promising option for cancer therapy. Understanding the molecular pathogenesis of the circRNA-PI3K/AKT axis may lead to the development of new therapeutic and diagnostic approaches for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Na Li, Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge, Si-Yu Sun
Summary: Scoparone inhibits the proliferation, migration, and invasion of pancreatic cancer cells, induces cell cycle arrest and apoptosis, and acts through the PI3K/Akt signaling pathway, both in vitro and in vivo.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Immunology
LiangDong Chen, DeQiang Zhuo, HongYin Yuan
Summary: Circular RNA circ_100395 plays an anti-oncogenic role in papillary thyroid cancer cells through the inhibition of PI3K/AKT/mTOR signaling pathway.
IMMUNOLOGY LETTERS
(2022)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Medicine, Research & Experimental
Tao Xu, Ting Rao, Wei-Ming Yu, Jin-Zhuo Ning, Xi Yu, Shao-Ming Zhu, Kang Yang, Tao Bai, Fan Cheng
Summary: The study revealed that NFKBIZ has low expression in bladder cancer and inhibits the proliferation of bladder cancer cells through the PTEN/PI3K/Akt signaling pathway. This suggests that NFKBIZ may serve as a novel prognostic biomarker and potential therapeutic target for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Yalan Dai, Liqiong Yang, Abass Sakandar, Duoli Zhang, Fukuan Du, Xinyi Zhang, Linglin Zou, Yueshui Zhao, Jigang Wang, Zhenhua Zhang, Xu Wu, Mingxing Li, Xiao Ling, Lei Yu, Lishu Dong, Jing Shen, Zhangang Xiao, Qinglian Wen
Summary: This study investigates the role of immune escape encoding genes on the prognosis of breast cancer and predicts novel targeting agents. A prognostic model consisting of eleven immune escape related protein-coding genes is established and validated. Vemurafenib is identified as a potential targeted agent for breast cancer treatment by targeting the PI3K/AKT signaling pathway and suppressing the immune escape biomarker BCL2A1.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xuehui Wang, Hongming Song, Lin Fang, Tianqi Wu
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)
Article
Plant Sciences
Fei Chen, Jing-Jing Cui, De-Chun Jiang, Hai-Zheng Wang, Wei Zhuang, Ying-Nan Feng, Xiao-Lan Lin, Sheng-Yan Xi
Summary: The study aimed to investigate the therapeutic mechanism of Kangliu pill (KLP) in the treatment of gliomas. An in situ xenograft model of glioma cells in mice was established to evaluate the therapeutic effect of KLP. The results showed that KLP regulates multiple pathways, including the PI3K/AKT signaling pathway, to treat gliomas.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Plant Sciences
Xiao-chen Li, Shuai Wang, Xin-xin Yang, Tian-jiao Li, Jia-xing Gu, Lin Zhao, Yong-rui Bao, Xian-sheng Meng
Summary: This study aimed to investigate the treatment of colorectal cancer (CRC) using Patrinia villosa Juss. (P.V) and clarify its underlying mechanism. The results from animal models showed that P.V can reduce tumor number and diameter, improve colon cell injury, and decrease levels of CRC biomarkers. Metabolomics analysis revealed changes in endogenous metabolites, indicating that P.V modulates the glycerol phospholipid metabolites closely related to the PI3K target and PI3K/Akt signaling pathway for CRC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Letter
Urology & Nephrology
Wei Liu, Xiaoping Liu, Shen Li
Article
Oncology
Dong-Hu Yu, Jing-Yu Huang, Xiao-Ping Liu, Xiao-Lan Ruan, Chen Chen, Wei-Dong Hu, Sheng Li
Article
Biotechnology & Applied Microbiology
Dong-Hu Yu, Wei Li, Jing-Yu Huang, Xiao-Ping Liu, Chi Zhang, Xiao-Lan Ruan, Sheng Li
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biotechnology & Applied Microbiology
Cong-kuan Song, Zi-xin Guo, Xiao-yan Shen, Yu-jin Wang, Qing-wen Wang, Dong-hu Yu, Chen Chen, Xiao-ping Liu, Jing-yu Huang, Sheng Li, Weidong Hu
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Oncology
Donghu Yu, Xiaolan Ruan, Jingyu Huang, Weidong Hu, Chen Chen, Yu Xu, Jinxuan Hou, Sheng Li
FRONTIERS IN ONCOLOGY
(2020)
Article
Cell Biology
Jiazhi Jiang, Yaqiong Bi, Xiao-Ping Liu, Donghu Yu, Xin Yan, Jie Yao, Tongzu Liu, Sheng Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Genetics & Heredity
Dong Hu Yu, Xiao-Lan Ruan, Jing-Yu Huang, Xiao-Ping Liu, Hao-Li Ma, Chen Chen, Wei-Dong Hu, Sheng Li
FRONTIERS IN GENETICS
(2020)
Article
Genetics & Heredity
Zixin Guo, Jingyu Huang, Yujin Wang, Xiao-Ping Liu, Wei Li, Jie Yao, Sheng Li, Weidong Hu
FRONTIERS IN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Xiao-Ping Liu, Jinxuan Hou, Chen Chen, Li Guan, Han-Kun Hu, Sheng Li
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Review
Clinical Neurology
Chang Xu, Luis Furuya-Kanamori, Joey S. W. Kwong, Sheng Li, Yu Liu, Suhail A. Doi
Summary: An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine, but the methodological validity of these studies is poor, indicating a need for further improvement.
SLEEP MEDICINE REVIEWS
(2021)
Article
Cell Biology
Congkuan Song, Zhiquan Wu, Qingwen Wang, Yujin Wang, Zixin Guo, Sheng Li, Weidong Hu
Summary: A study identified two genes that can predict response to immunotherapy in lung adenocarcinoma patients, developed a signature to distinguish high- and low-risk patients, and constructed a nomogram by combining immune prognostic signature with clinical features.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Dong-Hu Yu, Chen Chen, Xiao-Ping Liu, Jie Yao, Sheng Li, Xiao-Lan Ruan
Summary: The interaction between FLT3-ITD mutation and the CXCL12/CXCR4 axis activates the PI3K-Akt-mTOR pathway, leading to increased expression of RPS6KA1 and AP2M1 in AML. These two genes regulate drug resistance in AML, while miR-138-5p serves as a common regulatory target for both RPS6KA1 and AP2M1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zixin Guo, Xin Yan, Congkuan Song, Qingwen Wang, Yujin Wang, Xiao-Ping Liu, Jingyu Huang, Sheng Li, Weidong Hu
Summary: The study found that FAT3 mutation is related to high TMB and poor prognosis in ESCA patients. FAT3 mutation status may be an independent prognostic factor for ESCA patients. The research also revealed the potential mechanism of FAT3 mutation in the occurrence and development of ESCA.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Xin Yan, Zi-Xin Guo, Dong-Hu Yu, Chen Chen, Xiao-Ping Liu, Zhi-Wei Yang, Tong-Zu Liu, Sheng Li
Summary: This study established and validated a prognostic multi-gene model, identifying six prognostic biomarkers that may be useful for predicting the prognosis of ACC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)