βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells

Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis

(2015) Jian Wen et al.   BREAST CANCER RESEARCH AND TREATMENT

The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis

(2015) P.S. Kolb et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

(2015) Sophie Vasseur et al.   SEMINARS IN CANCER BIOLOGY

Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells

(2015) Sivan M. Bokobza et al.   Oncotarget

TUBB3/ III-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non-Small Cell Lung Cancer

(2014) J. A. McCarroll et al.   CANCER RESEARCH

Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: A meta-analysis

(2014) Yang Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation

(2014) Nancy Mokbel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Microtubules and Their Role in Cellular Stress in Cancer

(2014) Amelia L. Parker et al.   Frontiers in Oncology

The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets

(2013) Steven L. Wood et al.   CANCER TREATMENT REVIEWS

Correlation between [18F]FDG PET/CT and volume perfusion CT in primary tumours and mediastinal lymph nodes of non-small-cell lung cancer

(2013) Alexander W. Sauter et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

(2013) Anne-Laure Huber et al.   MOLECULAR CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Site-specific activation of AKT protects cells from death induced by glucose deprivation

(2013) M Gao et al.   ONCOGENE

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas

(2012) Georgia Karpathiou et al.   APMIS

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

(2012) Shane Deegan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multitargeted anti-angiogenic agents and NSCLC: Clinical update and future directions

(2012) Peter M. Ellis et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Lipid-Induced Endoplasmic Reticulum Stress in Liver Cells Results in Two Distinct Outcomes: Adaptation with Enhanced Insulin Signaling or Insulin Resistance

(2012) Caroline S. Achard et al.   ENDOCRINOLOGY

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Association between class III β-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: A meta-analysis

(2012) Hai-Long Zhang et al.   LUNG CANCER

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis

(2012) R A Veldhoen et al.   ONCOGENE

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials

(2011) T. Reiman et al.   ANNALS OF ONCOLOGY

MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells

(2011) Giampietro Viola et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

Class III  -Tubulin in Advanced NSCLC of Adenocarcinoma Subtype Predicts Superior Outcome in a Randomized Trial

(2011) A. C. Vilmar et al.   CLINICAL CANCER RESEARCH

Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions

(2011) Kyoung Min Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

HuR Regulates  -Tubulin Isotype Expression in Ovarian Cancer

(2010) G. Raspaglio et al.   CANCER RESEARCH

βIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer

(2010) Joshua A. McCarroll et al.   CANCER RESEARCH

Light-Chain 3A Autophagic Activity and Prognostic Significance in Non-small Cell Lung Carcinomas

(2010) Georgia Karpathiou et al.   CHEST

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Monitoring Response to Antiangiogenic Therapy in Non-Small Cell Lung Cancer Using Imaging Markers Derived from PET and Dynamic Contrast-Enhanced MRI

(2010) A. J. de Langen et al.   JOURNAL OF NUCLEAR MEDICINE

Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells

(2010) Yidan Lin et al.   LUNG CANCER

Microtubule Dynamics, Mitotic Arrest, and Apoptosis: Drug-Induced Differential Effects of  III-Tubulin

(2010) P. P. Gan et al.   MOLECULAR CANCER THERAPEUTICS

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response

(2009) Jiao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

Proteomic characterization of cytoskeletal and mitochondrial class III  -tubulin

(2008) L. Cicchillitti et al.   MOLECULAR CANCER THERAPEUTICS