Ex vivo pulsed dendritic cell vaccination against cancer

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Cord-Blood-Stem-Cell-Derived Conventional Dendritic Cells Specifically Originate from CD115-Expressing Precursors

(2019) Maud Plantinga et al.   Cancers

CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications

(2019) Kutubuddin A. Molla et al.   TRENDS IN BIOTECHNOLOGY

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

(2019) Kalijn F. Bol et al.   Journal for ImmunoTherapy of Cancer

Autologous Hematopoietic Stem Cells Are a Preferred Source to Generate Dendritic Cells for Immunotherapy in Multiple Myeloma Patients

(2019) Prajakta Shinde et al.   Frontiers in Immunology

Personalized Dendritic Cell Vaccines—Recent Breakthroughs and Encouraging Clinical Results

(2019) Beatris Mastelic-Gavillet et al.   Frontiers in Immunology

iPS cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy

(2019) Christopher Horton et al.   STEM CELLS

Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses

(2019) Min-Nung Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

(2018) M E Rodríguez-Ruiz et al.   ANNALS OF ONCOLOGY

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Dendritic cells and routing cargo into exosomes

(2018) Dario A Leone et al.   IMMUNOLOGY AND CELL BIOLOGY

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Arginase I mRNA therapy – A novel approach to rescue arginase 1 enzyme deficiency

(2018) Kirtika H. Asrani et al.   RNA Biology

A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer

(2018) Hatem Soliman et al.   Oncotarget

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells

(2018) Margaret E. Kirkling et al.   Cell Reports

Interleukin-15-Cultured Dendritic Cells Enhance Anti-Tumor Gamma Delta T Cell Functions through IL-15 Secretion

(2018) Heleen H. Van Acker et al.   Frontiers in Immunology

Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma

(2018) Manh-Cuong Vo et al.   Frontiers in Immunology

A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission

(2018) Jennifer L. Hsu et al.   OncoImmunology

An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA–loaded dendritic cells for cancer vaccination

(2018) E. BRABANTS et al.   CYTOTHERAPY

A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination With or Without Ipilimumab

(2018) Theodore S Nowicki et al.   CLINICAL CANCER RESEARCH

Mechanism of action of mRNA-based vaccines

(2017) Carlo Iavarone et al.   Expert Review of Vaccines

RNA metabolism: The short tail that wags the mRNA

(2017) Eytan Zlotorynski   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

(2017) Abhishek D. Garg et al.   TRENDS IN IMMUNOLOGY

Comprehensive immunotherapy combined with intratumoral injection of zoledronate-pulsed dendritic cells, intravenous adoptive activated T lymphocyte and gemcitabine in unresectable locally advanced pancreatic carcinoma: a phase I/II trial

(2017) Yoshiki Hirooka et al.   Oncotarget

Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors

(2017) Julie Helft et al.   Cell Reports

Human Blood CD1c+ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4+ T Cells

(2017) Ingrid M. Leal Rojas et al.   Frontiers in Immunology

Langerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial

(2017) David J. Chung et al.   OncoImmunology

A phase I clinical trial on the combined intravenous (IV) and intradermal (ID) administration of autologous TriMix-DC cellular therapy in patients with pretreated melanoma (TriMixIDIV).

(2017) B. Neyns et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

(2016) Sofie Wilgenhof et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

NK-DC Crosstalk in Immunity to Microbial Infection

(2016) Rony Thomas et al.   Journal of Immunology Research

Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells

(2015) G. Schreibelt et al.   CLINICAL CANCER RESEARCH

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

(2015) Kevin V. Chow et al.   JOURNAL OF IMMUNOLOGY

Different maturation cocktails provide dendritic cells with different chemoattractive properties

(2015) Chiara Massa et al.   Journal of Translational Medicine

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

(2015) Duane A. Mitchell et al.   NATURE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice

(2014) Xiaoyu Gu et al.   INTERNATIONAL JOURNAL OF CANCER

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

(2014) Heleen Dewitte et al.   JOURNAL OF CONTROLLED RELEASE

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling

(2014) H. Zhang et al.   Cancer Immunology Research

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

(2014) Kenneth C McCullough et al.   Molecular Therapy-Nucleic Acids

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

(2013) S. Wilgenhof et al.   ANNALS OF ONCOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

mRNA

(2013) Sandra Van Lint et al.   Human Vaccines & Immunotherapeutics

How many dendritic cells are required to initiate a T-cell response?

(2012) S. Celli et al.   BLOOD

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

(2012) E. H. J. G. Aarntzen et al.   CLINICAL CANCER RESEARCH

Role of inflammatory dendritic cells in innate and adaptive immunity

(2012) Cindy Hespel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy

(2012) Katerina Vopenkova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Monocyte-derived dendritic cells from breast cancer patients are biased to induce CD4+CD25+Foxp3+ regulatory T cells

(2012) R. N. Ramos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy

(2011) S Senju et al.   GENE THERAPY

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

(2010) Karolina Palucka et al.   IMMUNITY

Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient

(2009) J. W. J. van Heijst et al.   SCIENCE

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

(2008) Aude Bonehill et al.   MOLECULAR THERAPY