Article
Environmental Sciences
Fenghua Li, Narcisse T. Tsona, Jianlong Li, Lin Du
Summary: This study systematically reports the photooxidation of syringic acid induced by OH radicals in the aqueous phase, revealing the formation of products that contribute to the generation of HULIS and proposing a possible reaction mechanism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Applied
Youssef Elamine, Badiaa Lyoussi, Maria G. Miguel, Ofelia Anjos, Leticia Estevinho, Manuel Alaiz, Julio Giron-Calle, Jesus Martin, Javier Vioque
Summary: Zantaz honey is a monofloral variety with a high content of polyphenols, especially in methyl syringate, accounting for over 50% of total polyphenols. This honey exhibits antioxidant and antiproliferative activities, mainly correlated with the content of methyl syringate and gallic acid. The recognition of health promoting activities in Zantaz honey is expected to increase its commercial value and positively impact the rural communities in Morocco where it is produced.
Article
Immunology
Maryam Ghasemi-Dehnoo, Hossein Amini-Khoei, Zahra Lorigooini, Maryam AnjomShoa, Elham Bijad, Mahmoud Rafieian-Kopaei
Summary: The study found that syringic acid significantly reduced inflammatory and apoptotic gene expressions in rats with UC, improved colon tissue damage, decreased oxidative stress and inflammation, and increased antioxidant capacity.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biology
Srinivasulu Cheemanapalli, Chandrasekaran Palaniappan, Yeshwanth Mahesh, Yuvaraj Iyyappan, Suresh Yarrappagaari, Sekar Kanagaraj
Summary: A chemically synthesized novel SA analog (SA10) was evaluated for its anticancer activity. The results showed that SA10 exhibited higher inhibition than SA in K562 cells. Molecular docking and simulation revealed that SA10 had stronger binding affinity to NFkB and interfered with its association with DNA. SA10 demonstrated more robust NFkB inhibitory activity and could be a potential therapeutic NFkB inhibitor for treating cancers.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xidong Li, Xuejie Zhang, Ruixian Xing, Fengjiao Qi, Jing Dong, Dan Li, Xue Tian, Bo Yu, Meiyi Huang, Lei Zhang, Xueling Yuan, Yang Yang, Huiru Wu, Lie Zang, Xin Mao, Rubo Sui
Summary: Studies have shown that syringic acid has the ability to control tau protein aggregation by modulating amyloid kinetic parameters, exposure of hydrophobic residues, and structural changes. Additionally, it can regulate the viability of neuron-like cells (SH-SY5Y) by downregulating ATF-6, caspase-8, and caspase-3 mRNA through the endoplasmic reticulum stress signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Cordelia Mano John, Sumathy Arockiasamy
Summary: Dietary free fatty acids, particularly palmitic acid, can induce adipogenesis in adipocytes, while flavonoids and phenolic acids can reduce its negative effects. This study demonstrates that flavonoids and phenolic acids inhibit palmitic acid-induced clonal expansion, lipid accumulation, and oxidative stress in adipocytes.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Food Science & Technology
Md. Mahfuzur Rob, Kawsar Hossen, Kaori Ozaki, Toshiaki Teruya, Hisashi Kato-Noguchi
Summary: The leaves of Calamus tenuis exhibit significant growth inhibitory potential and can exert dominance over surrounding plant communities by affecting neighboring plants. The identified compounds, calamulactone and 3-oxo-alpha-ionone, play a key role in the phytotoxicity of C. tenuis and could be used as templates for the development of ecofriendly bioherbicides.
Article
Biochemistry & Molecular Biology
Lina Yang, Changhong Qu, Jiaxi Jin, Hong Yang, Lipeng Pei
Summary: Syringic acid (SRA) exhibits proapoptotic activities on ovarian cancer cells, suppressing cell proliferation and migration through regulation of cell cycle and apoptosis-related proteins.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hisashi Kato-Noguchi
Summary: Teak is a valuable timber species cultivated in agroforestry systems and home gardens in many countries. Its large amount of litter decomposes quickly in tropical humid conditions, with allelopathic effects that can be potentially useful for weed management. Agroforestry systems with teak can enhance income through crop and wood production, and provide energy efficiency for crop cultivation.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Dan Li, Dongdong Luo, Su Hu, Hailin Zhao, Biao Peng
Summary: This study examined the anticancer effects of syringic acid (SA) on human brain tumor glioblastoma (GBM) cells. The results demonstrated that SA inhibited GBM cell proliferation and invasion, and promoted apoptosis. Therefore, SA may be an ideal neuroprotective agent for controlling brain malignancy.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Agronomy
Ramida Krumsri, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: This study explores the phytotoxic activities of Senna garrettiana leaf extracts and isolated three active substances. The isolated compounds, caffeic acid, methyl caffeate, and (S)-6-hydroxymellein, showed significant inhibitory effects on the germination and growth of weeds. These compounds have the potential to be used as bioherbicides.
Article
Environmental Sciences
Sabiha Mehmood, Noshin Ilyas, Nosheen Akhtar, Wen Yi Chia, Ali A. Shati, Mohammad Y. Alfaifi, R. Z. Sayyed, Yustina M. Pusparizkita, Heli Siti Halimatul Munawaroh, Pham Minh Quan, Pau Loke Show
Summary: Vast amounts of plastic waste are causing serious environmental issues. This study investigated the role of inorganic, organic, and biological soil amendments on the degradation of Polyethylene (PE) and the growth of lettuce plants. The results showed that bacteria and starch could effectively degrade pre-treated PE.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ainaz Mihanfar, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Mohammad Mirza-Aghazadeh-Attari, Bahman Yousefi, Maryam Majidinia
Summary: This study demonstrates the inhibitory effects of syringic acid on proliferation and induction of apoptosis in human colorectal cancer cells, as well as its reduction of tumor volume and incidence in a rat model of colorectal cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Kawsar Hossen, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: Albizia richardiana, a fast-growing deciduous tree, shows phytotoxic effects on weed growth. Dehydrovomifoliol and loliolide, two allelopathic substances found in the leaf extracts, significantly inhibit the growth of cress seedlings. These findings suggest the potential use of these compounds for weed control in a sustainable manner.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Yunke Huang, Min Xu, Junfeng Li, Ken Chen, Liang Xia, Wei Wang, Ping Ren, Xi Huang
Summary: The study revealed that syringic acid and ferulic acid in concord grape juice have vasodilation effects in vivo through regulating pathways like nitric oxide and Src kinase. This could potentially redefine the antioxidant-sensitive vasoprotective pathway associated with resveratrol in the French paradox.
Article
Agronomy
Yuki Matuda, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: Metasequoia glyptostroboides, one of the oldest living conifer species, exhibits allelopathic properties. The fallen leaves of this species contain allelopathic substances that inhibit the growth of nearby competing plant species, giving M. glyptostroboides a competitive advantage.
Article
Agronomy
Ramida Krumsri, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: The extracts of S. garrettiana leaves, containing vanillic acid and ferulic acid, show significant phytotoxicity against L. sativum, indicating their potential as natural herbicides. The compounds were found to have synergistic inhibitory activity when used in combination, suggesting a promising alternative for weed control.
Article
Agronomy
Ei Han Kyaw, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: Research showed that extracts of Dregea volubilis contain two phytotoxic compounds, dehydrovomifoliol and loliolide, which significantly inhibit the seedling growth of Italian ryegrass and cress, and may be key substances responsible for the allelopathy of D. volubilis.
Article
Chemistry, Multidisciplinary
Naoaki Kurisawa, Arihiro Iwasaki, Kazuya Teranuma, Shingo Dan, Chikashi Toyoshima, Masaru Hashimoto, Kiyotake Suenaga
Summary: In this study, a new SERCA inhibitor, iezoside (1), isolated from the marine cyanobacterium Leptochromothrix valpauliae, is reported. Iezoside (1) is the second-strongest SERCA inhibitor known to date, with a structure fundamentally different from any other SERCA inhibitor, and the highest potency among marine natural products (K_i 7.1 nM). The comprehensive analysis of iezoside (1), including its isolation, structural characterization supported by density functional theory (DFT) calculations and statistical analysis, total synthesis, and clarification of the mode of action of its potent antiproliferative activity (IC50 6.7 +/- 0.4 nM against HeLa cells), is described.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Environmental Sciences
Kawsar Hossen, Yuka Asato, Toshiaki Teruya, Hisashi Kato-Noguchi
Summary: Allelopathic compounds derived from plants like Elaeocarpus floribundus can be used as natural herbicides to control weeds and reduce environmental pollution. This study identified four active compounds with strong growth inhibitory potential against cress, suggesting their pivotal role in the allelopathic potential of E. floribundus.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Plant Sciences
Hisashi Kato-Noguchi, Yuri Hamada, Misuzu Kojima, Sanae Kumagai, Arihiro Iwasaki, Kiyotake Suenaga
Summary: Osmanthus fragrans Lour. has been cultivated for more than 2500 years for its fragrance and color. The flowers and roots have multiple uses in various industries. Limited information is available on the allelopathic properties of O. fragrans. This study reveals that the fallen leaves of O. fragrans and its hybrid species O. x fortunei possess allelopathic substances that inhibit the growth of neighboring plants. These findings suggest that the leaves of these Osmanthus species can be utilized for weed management in sustainable agriculture systems.
Article
Biochemistry & Molecular Biology
Fumitaka Kudo, Takuji Chikuma, Mizuki Nambu, Taichi Chisuga, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Akimasa Miyanaga, Tadashi Eguchi
Summary: In this study, we analyzed the genome sequence of Moorena bouillonii, a marine cyanobacterium that produces lyngbyapeptin B, and identified a gene cluster responsible for its biosynthesis. We characterized two unique enzymatic activities: O-methylation by LynB2 and oxidative decarboxylation by LynB7. These findings provide insights into the biosynthetic mechanisms of lyngbyapeptin B.
ACS CHEMICAL BIOLOGY
(2023)
Article
Plant Sciences
Kaori Ozaki, Yuka Asato, Noriyuki Natsume, Shunya Tojo, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from a marine cyanobacterium called Okeania. Their structures were determined using spectroscopic analyses and their absolute configurations were elucidated through a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) were found to dose-dependently promote the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Yuta Miyamoto, Arihiro Iwasaki, Haruka Fujimura, Chihiro Kudo, Naoaki Kurisawa, Osamu Ohno, Kiyotake Suenaga
Summary: Caldorazole, a novel polyketide, was isolated from a marine cyanobacterium in 2022. Despite lacking chiral centers, it exhibits potent inhibitory activity against mitochondrial respiratory chain complex I. To study its structure-activity relationship, we accomplished the first total synthesis of caldorazole using a convergent synthetic route, aiming to establish a method for obtaining caldorazole without relying on biological resources.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hiroki Takahashi, Arihiro Iwasaki, Akira Ebihara, Raimu Taguchi, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: Two new natural products obtained from the marine cyanobacterium Rivularia sp. collected in Japan are described. Hennaminal possesses a rare beta,beta-diamino unsaturated ketone functional group, only previously found in bohemamine-type natural products. Hennamide contains a reactive N-acyl pyrrolinone moiety, which induces self-dimerization. The isolation and structure determination, supported by computational chemistry, total synthesis, and antitrypanosomal activities of hennaminal and hennamide, are discussed.
Article
Plant Sciences
Thang Lam Lun, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: This experiment separated two compounds from the medicinal plant Polygonum chinense that were found to inhibit the growth of cress and lettuce seedlings. These compounds, (-)-3-hydroxy-beta-ionone and (-)-3-hydroxy-7,8-dihydro-beta-ionone, could potentially be used as weed control agents.
Article
Plant Sciences
Seinn Moh Moh, Naoaki Kurisawa, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: A study found that a bioactive substance, steroidal glycoside 3, extracted from Marsdenia tenacissima leaves, has significant inhibitory effects on weed growth, suggesting its potential as a natural alternative for weed control in sustainable agriculture.
Article
Food Science & Technology
Md. Mahfuzur Rob, Kawsar Hossen, Kaori Ozaki, Toshiaki Teruya, Hisashi Kato-Noguchi
Summary: The leaves of Calamus tenuis exhibit significant growth inhibitory potential and can exert dominance over surrounding plant communities by affecting neighboring plants. The identified compounds, calamulactone and 3-oxo-alpha-ionone, play a key role in the phytotoxicity of C. tenuis and could be used as templates for the development of ecofriendly bioherbicides.
Article
Chemistry, Organic
Hiroki Takahashi, Arihiro Iwasaki, Akira Ebihara, Raimu Taguchi, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: Two new natural products were isolated from the marine cyanobacterium Rivularia sp. collected in Japan. Hennaminal contains a rare functional group, beta,beta-diamino unsaturated ketone, which has only been found in bohemamine-type natural products so far. Hennamide possesses a reactive N-acyl pyrrolinone moiety, which induces self-dimerization. The article describes the isolation and structure determination of hennaminal and hennamide, supported by computational chemistry and total synthesis, as well as their antitrypanosomal activities.