Article
Biochemistry & Molecular Biology
Stephanie T. P. Mezger, Alma M. A. Mingels, Matthieu Soulie, Carine J. Peutz-Kootstra, Otto Bekers, Paul Mulder, Ron M. A. Heeren, Berta Cillero-Pastor
Summary: This study combines MALDI-MSI and label-free proteomics in the research of rat myocardial ischemia/reperfusion (I/R) injury. It provides insights into the protein pathways involved in myocardial damage and offers a new methodology for developing strategies to minimize damage after myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Huanhuan Wang, Zhenkun Li, Guangzhao Cao, Liying Tang, Rui Zhou, Caifeng Li, Jingjing Zhang, Hongwei Wu, Xianyu Li, Hongjun Yang
Summary: LC-QQQ-MS and MALDI-MSI were used to study the effect of cerebral ischemia-reperfusion (I/R) injury and the therapeutic effect of Guhong injection (GHI) on tissue-specific metabolic alterations in the brain. GHI significantly improved infarction rate, neurological deficit, cerebral blood flow, and neuronal damage in I/R rats. LC-QQQ-MS identified 23 altered energy metabolites in the I/R group, while 12 metabolites showed a significant tendency of returning to baseline values after GHI treatment. MALDI-MSI revealed differential expression of metabolites in specific brain regions, which were regulated by GHI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shu-Er Yang, Jin-Cherng Lien, Chia-Wen Tsai, Chi-Rei Wu
Summary: Isoflavones, including simple O-substituted derivatives, have been extensively studied and shown to possess various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Simple O-substituted isoflavones, in particular, have potential therapeutic effects against cerebral ischemia reperfusion through estrogenic receptor modulation and multiple signaling pathways. However, clinical trials are needed to confirm their efficacy in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yi Zhong, Bo Yin, Yingze Ye, Omar Y. A. T. Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan Gu
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Behavioral Sciences
Ying Li, Min Gong
Summary: The treatment of cerebral ischemia-reperfusion injury remains a challenge, with GLP-1 receptor agonist Liraglutide showing promising effects in alleviating this type of injury. This study aimed to clarify the physiological protection role of Liraglutide in MCAO mice, revealing that it significantly reduced infarct volume and induced various effects on protein expression levels and phosphorylation. These findings contribute to identifying novel therapeutic targets for ischemia-reperfusion injury.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Wenya Bai, Siying Huo, Guilin Zhou, Junjie Li, Yuan Yang, Jianlin Shao
Summary: This study investigated the potential of Biliverdin to alleviate cerebral ischemia reperfusion injury (CIRI) by inhibiting pyroptosis. Biliverdin was found to significantly alleviate CIRI both in vivo and in vitro by activating the Nrf2/A20/eEF1A2 axis, which in turn inhibited the NF-KB pathway. The findings of this study provide insights into novel therapeutic targets for the treatment of CIRI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Di Ren, Zhibin He, Julia Fedorova, Jingwen Zhang, Elizabeth Wood, Xiang Zhang, David E. Kang, Ji Li
Summary: Sesn2, a stress-inducible protein, declines with aging in the heart. Lack of Sesn2 results in cardiac aging-like dysfunction and intolerance to ischemia reperfusion stress. Sesn2 deficiency impairs mitochondrial function and affects oxidative phosphorylation complex activity, impacting the maintenance of cardiac mitochondrial integrity.
Review
Medicine, Research & Experimental
Qianghua Yuan, Yan Yuan, Yan Zheng, Rong Sheng, Li Liu, Fan Xie, Jing Tan
Summary: Cerebral ischemia-reperfusion injury can lead to serious brain diseases and polysaccharides may be a potential treatment. Research shows that polysaccharides can improve neural damage through various mechanisms such as anti-oxidation and anti-inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Jie Huang, Lei Chen, Zi-meng Yao, Xiao-rong Sun, Xu-hui Tong, Shu-ying Dong
Summary: Stroke, particularly ischemic stroke, is a major cause of death and disability worldwide. Reperfusion, the restoration of blood supply, is crucial for treatment, but it can also worsen the injury through cerebral ischemia-reperfusion injury (CIRI). Mitochondrial dysfunction is a key characteristic of CIRI, and improving mitochondrial dynamics is considered a potential therapeutic approach to improve outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qian Xu, Guohui Ma, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, Yunchao Kan
Summary: This study elucidated the involvement of C2dat2 in regulating autophagy and apoptosis induced by CIRI, by inhibiting miR-30d-5p through a ceRNA mechanism, affecting the DDIT4/mTOR pathway. This contributes to a better understanding of the mechanisms of CIRI.
Article
Biochemistry & Molecular Biology
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie, Xiao-Ping Pu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Medicine, Legal
Zhilin Zhang, Runzhe Liu, Xiaoping Pu, Yi Sun, Xin Zhao
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2017)
Article
Cell Biology
Yupeng Wang, Yi Sun, Xin Zhao, Renpei Yuan, Hui Jiang, Xiaoping Pu
MEDIATORS OF INFLAMMATION
(2018)
Article
Cell Biology
Ke Zhang, Zhenfeng Dai, Runzhe Liu, Fang Tian, Xi Liu, Yi Sun, Xin Zhao, Xiaoping Pu
MEDIATORS OF INFLAMMATION
(2018)
Article
Plant Sciences
Xi Liu, Runzhe Liu, Zhenfeng Dai, Hao Wu, Ming Lin, Fang Tian, Zeyu Gao, Xin Zhao, Yi Sun, Xiaoping Pu
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Behavioral Sciences
Jiamin Xu, Zhilin Zhang, Runzhe Liu, Yi Sun, Huihui Liu, Zongxiu Nie, Xin Zhao, Xiaoping Pu
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Hao Wu, Xi Liu, Ze-yu Gao, Zhen-feng Dai, Ming Lin, Fang Tian, Xin Zhao, Yi Sun, Xiao-ping Pu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Letter
Neurosciences
Ming Lin, Jiamin Xu, Zhimin Liu, Liang Qin, Xiaodong Wang, Xiaoping Pu
NEUROSCIENCE BULLETIN
(2020)
Article
Biochemistry & Molecular Biology
Hao Wu, Xi Liu, Ze-Yu Gao, Ming Lin, Xin Zhao, Yi Sun, Xiao-Ping Pu
Summary: The study demonstrates that the flavonoid icaritin can simultaneously reduce neuroinflammation, oxidative stress, and improve alterations in neuronal energy metabolism to improve Parkinson's disease. By inhibiting NLRP3 inflammasome activity and stabilizing mitochondrial function, icaritin shows therapeutic potential in PD. The results suggest that icaritin interacts with key proteins and molecules related to inflammation, mitochondrial function, and energy metabolism, providing insights into its promising therapeutic effects.
Article
Biochemistry & Molecular Biology
Hui Lei, Rutong Ren, Yi Sun, Ke Zhang, Xin Zhao, Nuramatjan Ablat, Xiaoping Pu