The Role of Pseudomonas aeruginosa Lipopolysaccharide in Bacterial Pathogenesis and Physiology

Microbe-focused glycan array screening platform

(2019) Andreas Geissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LlpB represents a second subclass of lectin-like bacteriocins

(2019) Maarten G. K. Ghequire et al.   Microbial Biotechnology

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

(2019) Austin Hoggarth et al.   Drug Design Development and Therapy

Remodeling of O Antigen in Mucoid Pseudomonas aeruginosa via Transcriptional Repression of wzz2

(2019) Ashley R. Cross et al.   mBio

Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins

(2019) Olubukola Oluyombo et al.   mBio

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold

(2019) Adam J. Salazar et al.   PLoS One

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Pushing the envelope: LPS modifications and their consequences

(2019) Brent W. Simpson et al.   NATURE REVIEWS MICROBIOLOGY

Recent advances in the production of recombinant glycoconjugate vaccines

(2019) Emily Kay et al.   npj Vaccines

Mutations in pmrB confer cross-resistance between the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa

(2019) Keith P Romano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic and Biochemical Mechanisms for Bacterial Lipid A Modifiers Associated with Polymyxin Resistance

(2019) Huimin Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pleiotropic effects of rfa-gene mutations on Escherichia coli envelope properties

(2019) Christophe Pagnout et al.   Scientific Reports

Potent LpxC Inhibitors with In Vitro Activity Against Multi-Drug Resistant Pseudomonas aeruginosa

(2019) Kevin M. Krause et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

(2019) Frederick Cohen et al.   ChemMedChem

Specific blood group antibodies inhibit Shigella flexneri interaction with human cells in the absence of spinoculation

(2019) Elizabeth Ngoc Hoa Tran et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa

(2018) Gloria Andolina et al.   ACS Chemical Biology

Release of large amounts of lipopolysaccharides from Pseudomonas aeruginosa cells reduces their susceptibility to colistin

(2018) Shin-ichi Yokota et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

OUP accepted manuscript

(2018)   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lipopolysaccharides Trigger Two Successive Bursts of Reactive Oxygen Species at Distinct Cellular Locations

(2018) Keke Shang-Guan et al.   PLANT PHYSIOLOGY

Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes

(2018) Ilia Belotserkovsky et al.   mBio

Hitting with a BAM: Selective Killing by Lectin-Like Bacteriocins

(2018) Maarten G. K. Ghequire et al.   mBio

Cell-based glycan arrays for probing glycan–glycan binding protein interactions

(2018) Jennie Grace Briard et al.   Nature Communications

Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa

(2018) Jeannette N. Rapicavoli et al.   Nature Communications

Interaction of Mannose-Binding Lectin With Lipopolysaccharide Outer Core Region and Its Biological Consequences

(2018) Aleksandra Man-Kupisinska et al.   Frontiers in Immunology

Epidemiology of Pseudomonas aeruginosa in agricultural areas*

(2018) Milton N. Schroth et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Targeting mechanisms of tailed bacteriophages

(2018) Franklin L. Nobrega et al.   NATURE REVIEWS MICROBIOLOGY

O-antigen dependent colicin insensitivity of uropathogenic Escherichia coli

(2018) Connor Sharp et al.   JOURNAL OF BACTERIOLOGY

Molecular conformation affects the interaction of the Pseudomonas quinolone signal with the bacterial outer membrane

(2018) Ao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

(2017) Florent Cochet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cystic Fibrosis Airway Microbiome: Overturning the Old, Opening the Way for the New

(2017) George A. O'Toole   JOURNAL OF BACTERIOLOGY

OsCERK1 plays a crucial role in the lipopolysaccharide-induced immune response of rice

(2017) Yoshitake Desaki et al.   NEW PHYTOLOGIST

Pseudomonas aeruginosa cells attached to a surface display a typical proteome early as 20 minutes of incubation

(2017) Marc Crouzet et al.   PLoS One

Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa

(2017) Catalina Florez et al.   mBio

Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells

(2017) Eloise J. O’Donoghue et al.   PLoS Pathogens

The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function

(2017) Anna M. Lasica et al.   Frontiers in Cellular and Infection Microbiology

Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion

(2017) Ronan R. McCarthy et al.   Nature Microbiology

Plant-expressed pyocins for control of Pseudomonas aeruginosa

(2017) Šarūnas Paškevičius et al.   PLoS One

The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence

(2017) Tomasz Olszak et al.   Scientific Reports

The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer

(2016) Jeremy C. Henderson et al.   Annual Review of Microbiology

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

(2016) L. C. McCaughey et al.   BIOCHEMICAL JOURNAL

Characterization ofPseudomonas aeruginosaphage K5 genome and identification of its receptor related genes

(2016) Lingyan Li et al.   JOURNAL OF BASIC MICROBIOLOGY

Application of Whole-Genome Sequencing Data for O-Specific Antigen Analysis andIn SilicoSerotyping of Pseudomonas aeruginosa Isolates

(2016) Sandra Wingaard Thrane et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils

(2016) Shuvasree SenGupta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comparison of O-Antigen Gene Clusters of All O-Serogroups of Escherichia coli and Proposal for Adopting a New Nomenclature for O-Typing

(2016) Chitrita DebRoy et al.   PLoS One

Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis

(2016) Wanatchaporn Arunmanee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS Remodeling Triggers Formation of Outer Membrane Vesicles in Salmonella

(2016) Wael Elhenawy et al.   mBio

Outer Membrane Vesicle Production Facilitates LPS Remodeling and Outer Membrane Maintenance in Salmonella during Environmental Transitions

(2016) Katherine E. Bonnington et al.   mBio

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

(2016) Nicholas Jochumsen et al.   Nature Communications

Arabidopsis LBP/BPI related-1 and -2 bind to LPS directly and regulate PR1 expression

(2016) Sayaka Iizasa et al.   Scientific Reports

Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection

(2016) Laura C. McCaughey et al.   Scientific Reports

Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC

(2016) Alice L. Erwin   Cold Spring Harbor Perspectives in Medicine

Genetic Evidence for O-Specific Antigen as Receptor of Pseudomonas aeruginosa Phage K8 and Its Genomic Analysis

(2016) Xuewei Pan et al.   Frontiers in Microbiology

Small Colony Variants and Single Nucleotide Variations in Pf1 Region of PB1 Phage-Resistant Pseudomonas aeruginosa

(2016) Wee S. Lim et al.   Frontiers in Microbiology

Pseudomonas aeruginosain premise plumbing of large buildings

(2016) Emilie Bédard et al.   MicrobiologyOpen

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

Extracellular DNA Acidifies Biofilms and Induces Aminoglycoside Resistance in Pseudomonas aeruginosa

(2015) Mike Wilton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A multivariate approach to correlate bacterial surface properties to biofilm formation by lipopolysaccharide mutants of Pseudomonas aeruginosa

(2015) Rohit Ruhal et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Complement activation, regulation, and molecular basis for complement-related diseases

(2015) G. Bajic et al.   EMBO JOURNAL

Symbol Nomenclature for Graphical Representations of Glycans

(2015) Ajit Varki et al.   GLYCOBIOLOGY

Interaction of human mannose-binding lectin (MBL) with Yersinia enterocolitica lipopolysaccharide

(2015) Katarzyna Kasperkiewicz et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Effects of the Bradyrhizobium japonicum waaL (rfaL) Gene on Hydrophobicity, Motility, Stress Tolerance, and Symbiotic Relationship with Soybeans

(2015) Jun-Gu Noh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-Nucleotide Polymorphisms Found in themigAandwbpXGlycosyltransferase Genes Account for the Intrinsic Lipopolysaccharide Defects Exhibited by Pseudomonas aeruginosa PA14

(2015) Youai Hao et al.   JOURNAL OF BACTERIOLOGY

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate ofBurkholderia cenocepacia

(2015) Flaviana Di Lorenzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular zinc induces phosphoethanolamine addition toPseudomonas aeruginosalipid A via the ColRS two-component system

(2015) Emily M. Nowicki et al.   MOLECULAR MICROBIOLOGY

A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

(2015) Stefanie Ranf et al.   NATURE IMMUNOLOGY

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Glycan:glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells

(2015) Christopher J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biofilm Formation As a Response to Ecological Competition

(2015) Nuno M. Oliveira et al.   PLOS BIOLOGY

Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa

(2015) Kirill V. Korneev et al.   Frontiers in Immunology

Biosynthesis and Export of Bacterial Lipopolysaccharides

(2014) Chris Whitfield et al.   Annual Review of Biochemistry

Influence of O Polysaccharides on Biofilm Development and Outer Membrane Vesicle Biogenesis in Pseudomonas aeruginosa PAO1

(2014) K. Murphy et al.   JOURNAL OF BACTERIOLOGY

Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing

(2014) Timothy J. Wells et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relationship between O-antigen chain length and resistance to colicin E2 in Shigella flexneri

(2014) E. N. H. Tran et al.   MICROBIOLOGY-SGM

Mutation of a Salmonella Serogroup-C1-Specific Gene Abrogates O7-Antigen Biosynthesis and Triggers NaCl-Dependent Motility Deficiency

(2014) Xiujuan Zhou et al.   PLoS One

The waaL gene is involved in lipopolysaccharide synthesis and plays a role on the bacterial pathogenesis of avian pathogenic Escherichia coli

(2014) Yue Han et al.   VETERINARY MICROBIOLOGY

Rapid Evolution of Culture-Impaired Bacteria during Adaptation to Biofilm Growth

(2014) Jon Penterman et al.   Cell Reports

Lectin-Like Bacteriocins from Pseudomonas spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor

(2014) Laura C. McCaughey et al.   PLoS Pathogens

Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

(2014) Samir Rahman et al.   Frontiers in Immunology

Defects inD-Rhamnosyl Residue Biosynthetic Genes Affect Lipopolysaccharide Structure, Motility, and Cell-Surface Hydrophobicity inPseudomonas syringaePathovarglycineaRace 4

(2013) Kazuhiro CHIKU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The D3 Bacteriophage  -Polymerase Inhibitor (Iap) Peptide Disrupts O-Antigen Biosynthesis through Mimicry of the Chain Length Regulator Wzz in Pseudomonas aeruginosa

(2013) V. L. Taylor et al.   JOURNAL OF BACTERIOLOGY

A deletion in thewapBpromoter in many serotypes ofPseudomonas aeruginosaaccounts for the lack of a terminal glucose residue in the core oligosaccharide and resistance to killing by R3-pyocin

(2013) Dana Kocíncová et al.   MOLECULAR MICROBIOLOGY

A Rhamnose-Rich O-Antigen Mediates Adhesion, Virulence, and Host Colonization for the Xylem-Limited PhytopathogenXylella fastidiosa

(2013) Jennifer C. Clifford et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Role of Bacterial Surface Structures on the Interaction of Klebsiella pneumoniae with Phagocytes

(2013) Catalina March et al.   PLoS One

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

O-antigen and Core Carbohydrate ofVibrio fischeriLipopolysaccharide

(2012) Deborah M. B. Post et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel virulence-related gene nlxA in the lipopolysaccharide cluster of Xanthomonas citri ssp. citri is involved in the production of lipopolysaccharide and extracellular polysaccharide, motility, biofilm formation and stress resistance

(2012) QING YAN et al.   MOLECULAR PLANT PATHOLOGY

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

A Bilayer-Couple Model of Bacterial Outer Membrane Vesicle Biogenesis

(2012) J. W. Schertzer et al.   mBio

Activity of Pyocin S2 against Pseudomonas aeruginosa Biofilms

(2011) Karen Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of bacterial outer membrane vesicles to innate bacterial defense

(2011) Andrew J Manning et al.   BMC MICROBIOLOGY

Genetic analysis of surface motility in Acinetobacter baumannii

(2011) K. M. Clemmer et al.   MICROBIOLOGY-SGM

Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide

(2011) Joseph S. Lam et al.   Frontiers in Microbiology

IgG subclass antibodies to Pseudomonas aeruginosa in sera from patients with chronic Ps. aeruginosa infection investigated by ELISA

(2010) T. PRESSLER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Use of aDictyosteliumModel for Isolation of Genetic Loci Associated with Phagocytosis and Virulence inKlebsiella pneumoniae

(2010) Yi-Jiun Pan et al.   INFECTION AND IMMUNITY

Loss of the WaaL O-Antigen Ligase Prevents Surface Activation of the Flagellar Gene Cascade in Proteus mirabilis

(2010) R. M. Morgenstein et al.   JOURNAL OF BACTERIOLOGY

Lipopolysaccharide as Shield and Receptor for R-Pyocin-Mediated Killing in Pseudomonas aeruginosa

(2010) T. Kohler et al.   JOURNAL OF BACTERIOLOGY

Relating the Physical Properties of Pseudomonas aeruginosa Lipopolysaccharides to Virulence by Atomic Force Microscopy

(2010) I. E. Ivanov et al.   JOURNAL OF BACTERIOLOGY

Selective Sorting of Cargo Proteins into Bacterial Membrane Vesicles

(2010) M. Florencia Haurat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

The role of lipopolysaccharide moieties in macrophage response to Escherichia coli

(2009) Katalin Eder et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Replacement of Lipopolysaccharide with Free Lipid A Molecules inEscherichia coliMutants Lacking All Core Sugars

(2009) C. Michael Reynolds et al.   BIOCHEMISTRY

Absolute Quantitation of Bacterial Biofilm Adhesion and Viscoelasticity by Microbead Force Spectroscopy

(2009) Peter C.Y. Lau et al.   BIOPHYSICAL JOURNAL

Differential Lipopolysaccharide Core Capping Leads to Quantitative and Correlated Modifications of Mechanical and Structural Properties in Pseudomonas aeruginosa Biofilms

(2009) P. C. Y. Lau et al.   JOURNAL OF BACTERIOLOGY

Escherichia coliK-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases

(2009) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Burkholderia cenocepacia O antigen lipopolysaccharide prevents phagocytosis by macrophages and adhesion to epithelial cells

(2009) M. S. Saldias et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Truncation in the core oligosaccharide of lipopolysaccharide affects flagella-mediated motility in Pseudomonas aeruginosa PAO1 via modulation of cell surface attachment

(2009) T. Lindhout et al.   MICROBIOLOGY-SGM

Single amino acid substitutions in either YhjD or MsbA confer viability to 3-deoxy-d-manno-oct-2-ulosonic acid-depletedEscherichia coli

(2009) Uwe Mamat et al.   MOLECULAR MICROBIOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

O-Antigen Delays Lipopolysaccharide Recognition and Impairs Antibacterial Host Defense in Murine Intestinal Epithelial Cells

(2009) Claudia U. Duerr et al.   PLoS Pathogens

Antibacterial Efficacy of R-Type Pyocins towards Pseudomonas aeruginosa in a Murine Peritonitis Model

(2008) D. Scholl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa

(2008) K. N. Schurek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella

(2008) D. Bravo et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation

(2008) Lauren Mashburn-Warren et al.   MOLECULAR MICROBIOLOGY

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens