Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

(2019) Tessa Dhaeze et al.   Cellular & Molecular Immunology

Claudin-3-deficient C57BL/6J mice display intact brain barriers

(2019) Mariana Castro Dias et al.   Scientific Reports

Optimized cultivation of porcine choroid plexus epithelial cells, a blood–cerebrospinal fluid barrier model, for studying granulocyte transmigration

(2019) Alexa N. Lauer et al.   LABORATORY INVESTIGATION

MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation

(2019) Violaine Hubert et al.   Scientific Reports

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

(2019) Isabella Wimmer et al.   Frontiers in Immunology

Distinct migratory pattern of naive and effector T cells through the blood–CSF barrier following Echovirus 30 infection

(2019) Marie Wiatr et al.   Journal of Neuroinflammation

T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention

(2018) Jamie van Langelaar et al.   BRAIN

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System

(2018) Itai Strominger et al.   Frontiers in Immunology

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

(2018) Ivan Jelcic et al.   CELL

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

(2018) Mitja Mitrovič et al.   CELL

Application of Europium-Doped Very Small Iron Oxide Nanoparticles to Visualize Neuroinflammation with MRI and Fluorescence Microscopy

(2017) Jason M. Millward et al.   NEUROSCIENCE

Sequential transmigration of polymorphonuclear cells and naive CD3 + T lymphocytes across the blood-cerebrospinal-fluid barrier in vitro following infection with Echovirus 30

(2017) Tobias Dahm et al.   VIRUS RESEARCH

A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis

(2017) Neda Haghayegh Jahromi et al.   Frontiers in Immunology

Heterogeneity of Human CD4+T Cells Against Microbes

(2016) Federica Sallusto   Annual Review of Immunology

Postarrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro

(2016) Henriette Rudolph et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

(2016) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration

(2016) Elodie Vandenhaute et al.   LABORATORY INVESTIGATION

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing

(2016) R Sumagin et al.   Mucosal Immunology

T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium

(2016) Nathalie Strazielle et al.   PLoS One

Immunological treatment of multiple sclerosis

(2016) Martin Diebold et al.   SEMINARS IN HEMATOLOGY

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier

(2015) Alexandra Bernd et al.   PHARMACEUTICAL RESEARCH

Rapid Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the Blood–Brain Barrier

(2014) Ryan C. Winger et al.   JOURNAL OF IMMUNOLOGY

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

The Oral Commensal Streptococcus mitis Shows a Mixed Memory Th Cell Signature That Is Similar to and Cross-Reactive with Streptococcus pneumoniae

(2014) Stian André Engen et al.   PLoS One

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

(2014) S. Becattini et al.   SCIENCE

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood–cerebrospinal fluid barrier

(2013) Tim Gründler et al.   MICROBES AND INFECTION

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

TCR Bias and HLA Cross-Restriction Are Strategies of Human Brain-Infiltrating JC Virus-Specific CD4+ T Cells during Viral Infection

(2012) S. Yousef et al.   JOURNAL OF IMMUNOLOGY

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Fatal PML associated with efalizumab therapy: Insights into integrin  L 2 in JC virus control

(2012) N. Schwab et al.   NEUROLOGY

Polar Invasion and Translocation of Neisseria meningitidis and Streptococcus suis in a Novel Human Model of the Blood-Cerebrospinal Fluid Barrier

(2012) Christian Schwerk et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood–cerebrospinal fluid barrier

(2012) Henriette Schneider et al.   VIRUS RESEARCH

Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

(2012) Fernanda Marques et al.   Frontiers in Cellular Neuroscience

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome

(2011) Lilian Aly et al.   BRAIN

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Loss of  4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells

(2011) S. Glatigny et al.   JOURNAL OF IMMUNOLOGY

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

(2011) Ziv Shulman et al.   NATURE IMMUNOLOGY

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

(2009) Kenneth R Carson et al.   LANCET ONCOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis

(2008) Jason R. Lees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE