Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells

(2019) Tomasz Kowalczyk et al.   CYTOTECHNOLOGY

ADMET modeling approaches in drug discovery

(2019) Leonardo L.G. Ferreira et al.   DRUG DISCOVERY TODAY

Computer-Assisted Drug Virtual Screening Based on the Natural Product Databases

(2019) Baoyu Yang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The evaluation of anti-breast cancer activity and safety pharmacology of the ethanol extract of Aralia elata Seem. leaves

(2019) Fengjin Li et al.   DRUG AND CHEMICAL TOXICOLOGY

Accelerated drug discovery by rapid candidate drug identification

(2019) Fredrik Bergström et al.   DRUG DISCOVERY TODAY

Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown

(2019) Yingtong Lv et al.   MOLECULES

Network Pharmacology Reveals the Molecular Mechanism of Cuyuxunxi Prescription in Promoting Wound Healing in Patients with Anal Fistula

(2019) Yin Qu et al.   Evidence-based Complementary and Alternative Medicine

A drug-likeness toolbox facilitates ADMET study in drug discovery

(2019) Chen-Yang Jia et al.   DRUG DISCOVERY TODAY

Predicting Meridian in Chinese traditional medicine using machine learning approaches

(2019) Yinyin Wang et al.   PLoS Computational Biology

Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells

(2018) Suthasinee Paramee et al.   BMC Complementary and Alternative Medicine

Current and Future Approaches for Effective Cancer Imaging and Treatment

(2018) Merve Karpuz et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

What Factors Guide the Selection of Medicinal Plants in a Local Pharmacopoeia? A Case Study in a Rural Community from a Historically Transformed Atlantic Forest Landscape

(2018) Taline Cristina da Silva et al.   Evidence-based Complementary and Alternative Medicine

Plant toxins and acute medicinal plant poisoning in children: A systematic literature review

(2018) Mahdi Balali-Mood et al.   Journal of Research in Medical Sciences

Antitumoral Potency by Immunomodulation of Chloroform Extract from Leaves of Nitraria retusa, Tunisian Medicinal Plant, via its Major Compounds β-sitosterol and Palmitic Acid in BALB/c Mice Bearing Induced Tumor

(2018) Jihed Boubaker et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Accelerating pharmaceutical structure-guided drug design: a successful model

(2018) Lisa J. Keefe et al.   DRUG DISCOVERY TODAY

In vitro and in vivo studies of 5,7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma

(2018) S. Lakshmi et al.   MEDICINAL CHEMISTRY RESEARCH

SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping

(2018) Yang Wu et al.   NUCLEIC ACIDS RESEARCH

ETCM: an encyclopaedia of traditional Chinese medicine

(2018) Hai-Yu Xu et al.   NUCLEIC ACIDS RESEARCH

CMAUP: a database of collective molecular activities of useful plants

(2018) Xian Zeng et al.   NUCLEIC ACIDS RESEARCH

Production of biomass and useful compounds through elicitation in adventitious root cultures of Fagonia indica

(2017) Tariq Khan et al.   INDUSTRIAL CROPS AND PRODUCTS

TCMID 2.0: a comprehensive resource for TCM

(2017) Lin Huang et al.   NUCLEIC ACIDS RESEARCH

A Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines

(2017) Yan Li et al.   PLoS One

Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells

(2017) Ibrahim Turan et al.   SAUDI PHARMACEUTICAL JOURNAL

Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell

(2017) Xinzheng Wang et al.   Oncology Letters

Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo

(2017) Tao Huang et al.   Scientific Reports

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

(2017) Yulin Zhang et al.   Chinese Medicine

Antioxidant and antimicrobial activities of bitter and sweet apricot (Prunus armeniaca L.) kernels

(2017) D. Yiğit et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Differential Effects of Thidiazuron on Production of Anticancer Phenolic Compounds in Callus Cultures of Fagonia indica

(2016) Tariq Khan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Structure-Activity Relationship Studies on Holy Basil (Ocimum sanctum L.) Based Flavonoid Orientin and its Analogue for Cytotoxic Activity in Liver Cancer Cell Line HepG2

(2016) Pooja Sharma et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia

(2016) Ping Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model

(2016) Yasser M. Tabana et al.   MICROVASCULAR RESEARCH

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

(2016) Fidele Ntie-Kang et al.   Drug Design Development and Therapy

Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis

(2016) Dongqing Zhu et al.   PLoS One

Molecular Modeling Based Synthesis and Evaluation of In vitro Anticancer Activity of Indolyl Chalcones

(2015) Rashmi Gaur et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Platycodon grandiflorus – An Ethnopharmacological, phytochemical and pharmacological review

(2015) Le Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

New cytotoxic and anti-inflammatory compounds isolated fromMorus albaL.

(2015) Jing Qin et al.   NATURAL PRODUCT RESEARCH

Paris polyphylla: Chemical and Biological Prospectives

(2014) Jagmohan Negi et al.   Anti-Cancer Agents in Medicinal Chemistry

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway

(2014) Runfa Bao et al.   BMC CANCER

Characterization of Proapoptotic Compounds from the Bark of Garcinia oblongifolia

(2014) Chao Feng et al.   JOURNAL OF NATURAL PRODUCTS

Anti-tumor Effect of Polysaccharides From Scutellaria Barbata D. Don on the 95-D Xenograft Model via Inhibition of the C-Met Pathway

(2014) Xiaokun Yang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Structural diversity and bioactivities of natural benzophenones

(2014) Shi-Biao Wu et al.   NATURAL PRODUCT REPORTS

Antiradical and antioxidant activity of flavones fromScutellariae baicalensis radix

(2014) Dorota Woźniak et al.   NATURAL PRODUCT RESEARCH

Water Extract fromPleurotus pulmonariuswith Antioxidant Activity Exerts In Vivo Chemoprophylaxis and Chemosensitization for Liver Cancer

(2014) Wen Wen Xu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells

(2014) HYO-JUNG LEE et al.   ONCOLOGY REPORTS

Isolation and biological activity of compounds fromGarcinia preussii

(2014) Bernadette Biloa Messi et al.   PHARMACEUTICAL BIOLOGY

Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway

(2013) Y Wanga et al.   African Journal of Traditional Complementary and Alternative Medicines

Oridonin Induces Apoptosis, Inhibits Migration and Invasion on Highly-Metastatic Human Breast Cancer Cells

(2013) Shengpeng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antioxidant Activity of Essential Oils from Wedelia chinensis (Osbeck) in vitro and in vivo Lung Cancer Bearing C57BL/6 Mice

(2013) A. Manjamalai et al.   Asian Pacific Journal of Cancer Prevention

In vitro antioxidant, antimicrobial, and antitumor activities of bitter almond and sweet apricot (Prunus armeniaca L.) kernels

(2013) Eman Zakaria Gomaa   FOOD SCIENCE AND BIOTECHNOLOGY

Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice

(2013) Bin Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antioxidant and hepatoprotective activity of Fagonia schweinfurthii (Hadidi) Hadidi extract in carbon tetrachloride induced hepatotoxicity in HepG2 cell line and rats

(2013) Anil Pareek et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Anti-Lung Cancer Activities of Steroidal Saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through Enhanced Immunostimulation in Experimental Lewis Tumor-Bearing C57BL/6 Mice and Induction of Apoptosis in the A549 Cell Line

(2013) Yu Li et al.   MOLECULES

Herbal Medicines as Adjuvants for Cancer Therapeutics

(2012) Chong-Zhi Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Paris polyphylla Smith Extract Induces Apoptosis and Activates Cancer Suppressor Gene Connexin26 Expression

(2012) Fu-Rong Li et al.   Asian Pacific Journal of Cancer Prevention

Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content

(2012) Anjaneya S Ravipati et al.   BMC Complementary and Alternative Medicine

Flavones from Root of Scutellaria Baicalensis Georgi: Drugs of the Future in Neurodegeneration?

(2012) Kazimierz Gasiorowski et al.   CNS & Neurological Disorders-Drug Targets

A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells

(2012) Abdul Waheed et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway

(2012) XU-ZHENG CHEN et al.   ONCOLOGY REPORTS

Identification and Analysis of the Active Phytochemicals from the Anti-Cancer Botanical Extract Bezielle

(2012) Vivian Chen et al.   PLoS One

An Aqueous Extract of Fagonia cretica Induces DNA Damage, Cell Cycle Arrest and Apoptosis in Breast Cancer Cells via FOXO3a and p53 Expression

(2012) Matt Lam et al.   PLoS One

Purification and Characterization of a Novel Anti-Proliferative Lectin from Morus alba L. Leaves

(2012) Mundekkad Deepa et al.   PROTEIN AND PEPTIDE LETTERS

Zebrafish Models for Cancer

(2011) Shu Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Isoegomaketone Induces Apoptosis through Caspase-Dependent and Caspase-Independent Pathways in Human DLD1 Cells

(2011) Byoung Ok CHO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo

(2011) Shokoofe Noori et al.   CELLULAR IMMUNOLOGY

Correlation Between Antioxidant Activity of Garlic Extracts and WEHI-164 Fibrosarcoma Tumor Growth in BALB/c Mice

(2011) Hedayatollah Shirzad et al.   JOURNAL OF MEDICINAL FOOD

In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer

(2011) Zhi-Jun Dai et al.   MOLECULES

An overview on genus garcinia: phytochemical and therapeutical aspects

(2011) M. Hemshekhar et al.   PHYTOCHEMISTRY REVIEWS

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

(2011) Weidong Xie et al.   PLoS One

Platycodon grandiflorum Induces Apoptosis in SKOV3 Human Ovarian Cancer Cells Through Mitochondrial-Dependent Pathway

(2010) Qin Hu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

(2010) Albert A Baskar et al.   BMC Complementary and Alternative Medicine

Albanol A from the Root Bark of Morus alba L. Induces Apoptotic Cell Death in HL60 Human Leukemia Cell Line

(2010) Takashi Kikuchi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Two new cytotoxicent-clerodane diterpenoids fromScutellaria barbata

(2010) Gui-Wu Qu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism

(2010) Ning Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The genus Scutellaria an ethnopharmacological and phytochemical review

(2010) Xiaofei Shang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats

(2010) Qing-Qiu Mao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phenolic-Containing Organic Extracts of Mulberry (Morus alba L.) Leaves Inhibit HepG2 Hepatoma Cells Through G2/M Phase Arrest, Induction of Apoptosis, and Inhibition of Topoisomerase IIα Activity

(2010) Wanlaya Naowaratwattana et al.   JOURNAL OF MEDICINAL FOOD

Platycodin D Induces Apoptosis in MCF-7 Human Breast Cancer Cells

(2010) Ji Sun Yu et al.   JOURNAL OF MEDICINAL FOOD

Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells

(2010) Hui Wang et al.   PHYTOMEDICINE

Antioxidant and antiproliferative effects of methanol extracts from raw and fermented parts of mulberry plant (Morus alba L.)

(2009) Sang-Uk Chon et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

(2009) Yueshan Hu et al.   FITOTERAPIA

Effect of calcium treatment on nanostructure of chelate-soluble pectin and physicochemical and textural properties of apricot fruits

(2009) Hui Liu et al.   FOOD RESEARCH INTERNATIONAL

Triptolide functions as a potent angiogenesis inhibitor

(2009) Ming-Fang He et al.   INTERNATIONAL JOURNAL OF CANCER

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

(2009) Jun Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Perilla Leaf, Perilla frutescens, Induces Apoptosis and G1 Phase Arrest in Human Leukemia HL-60 Cells Through the Combinations of Death Receptor-Mediated, Mitochondrial, and Endoplasmic Reticulum Stress-Induced Pathways

(2009) Chung Shil Kwak et al.   JOURNAL OF MEDICINAL FOOD

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH

In vivoInhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal HerbsCoptis chinensisandEvodia rutaecarpa

(2009) Xiao-na Wang et al.   PLANTA MEDICA

Steroidal saponins from the rhizomes of Paris delavayi

(2009) Ting Zhang et al.   STEROIDS

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

(2009) Mara B. Antonoff et al.   SURGERY

CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells

(2009) Vasilis P. Androutsopoulos et al.   TOXICOLOGY

Methylanthraquinone from Hedyotis diffusa WILLD induces Ca2+-mediated apoptosis in human breast cancer cells

(2009) Zheng Liu et al.   TOXICOLOGY IN VITRO

Evolutionary relationships in the showy mistletoe family (Loranthaceae)

(2008) Romina Vidal-Russell et al.   AMERICAN JOURNAL OF BOTANY

Involvement of Mitochondrial Pathway in Triptolide-Induced Cytotoxicity in Human Normal Liver L-02 Cells

(2008) Jincheng Yao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells

(2008) Dong Yeok Shin et al.   BIOMEDICINE & PHARMACOTHERAPY

Saponins derived from the roots of Platycodon grandiflorum inhibit HT-1080 cell invasion and MMPs activities: Regulation of NF-κB activation via ROS signal pathway

(2008) Kyung Jin Lee et al.   CANCER LETTERS

Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells

(2008) Mun-Ock Kim et al.   CANCER LETTERS

Effect of drying temperature on polyphenolic content and antioxidant activity of apricots

(2008) Monica A. Madrau et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Potent protective effect of apricot and β-carotene on methotrexate-induced intestinal oxidative damage in rats

(2008) Nigar Vardi et al.   FOOD AND CHEMICAL TOXICOLOGY

Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice

(2008) Tilak Khanal et al.   FOOD AND CHEMICAL TOXICOLOGY

Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding

(2008) L. Guo et al.   HUMAN REPRODUCTION

Synergistic Tumor-Killing Effect of Radiation and Berberine Combined Treatment in Lung Cancer: The Contribution of Autophagic Cell Death

(2008) Pei-ling Peng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Bioassay-Guided Isolation of Xanthones and Polycyclic Prenylated Acylphloroglucinols fromGarcinia oblongifolia

(2008) Sheng-Xiong Huang et al.   JOURNAL OF NATURAL PRODUCTS

Analysis of iridoid glucosides in Hedyotis diffusa by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

(2008) Cunman Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism

(2008) Y.-L. FU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

p53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo

(2008) Santosh K. Katiyar et al.   MOLECULAR CARCINOGENESIS

Antifungal Saponins fromParis polyphyllaSmith

(2008) Dawei Deng et al.   PLANTA MEDICA

Steroidal Saponins from the Rhizome ofParis polyphyllaand Their Cytotoxic Activities

(2008) Yu Zhao et al.   PLANTA MEDICA

A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum

(2008) Yong Xie et al.   VACCINE

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

(2008) Jun Yin et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

A new kaempferol triglycoside from Fagonia taeckholmiana: cytotoxic activity of its extracts

(2007) Lamyaa F. Ibrahim et al.   CARBOHYDRATE RESEARCH

Plant-derived compounds in clinical trials

(2007) A SAKLANI et al.   DRUG DISCOVERY TODAY