Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

(2019) Seok Kim et al.   Cancers

Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells

(2019) Jianfei Zhu et al.   LIFE SCIENCES

Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation

(2019) Xi Chen et al.   CANCER LETTERS

Long noncoding RNA LNC473 inhibits the ubiquitination of survivin via association with USP9X and enhances cell proliferation and invasion in hepatocellular carcinoma cells

(2018) Hui Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway

(2018) Chung-Ching Chio et al.   PHYTOMEDICINE

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells

(2018) Sk Shahriyar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutations in renal cell carcinoma

(2018) Christopher D'Avella et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways

(2018) Chien-Shan Chiu et al.   CANCER LETTERS

Mechanisms of regulation and diversification of deubiquitylating enzyme function

(2017) Pawel Leznicki et al.   JOURNAL OF CELL SCIENCE

YM155 enhances ABT-737-mediated apoptosis through Mcl-1 downregulation in Mcl-1-overexpressed cancer cells

(2017) Seon Min Woo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection

(2017) Rileen Sinha et al.   Nature Communications

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin

(2017) Seung Un Seo et al.   Redox Biology

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction

(2017) Lingmei Sun et al.   PLoS One

Onto better TRAILs for cancer treatment

(2016) D de Miguel et al.   CELL DEATH AND DIFFERENTIATION

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4–CHOP–DR5 Axis in Human Esophageal Cancer Cells

(2016) Ping Chen et al.   CLINICAL CANCER RESEARCH

Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells

(2016) Ning Ji et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Choosing the right cell line for renal cell cancer research

(2016) Klaudia K. Brodaczewska et al.   Molecular Cancer

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

(2016) M Jeong et al.   ONCOGENE

Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft

(2015) Jin Hyoung Cho et al.   BIOMATERIALS

Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression

(2015) Lei Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

(2015) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

(2014) J. Pan et al.   Cancer Prevention Research

Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells

(2014) Ying-Jiun Lai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Landmarks in the diagnosis and treatment of renal cell carcinoma

(2014) Jaimin R. Bhatt et al.   Nature Reviews Urology

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Honokiol Enhances Paclitaxel Efficacy in Multi-Drug Resistant Human Cancer Model through the Induction of Apoptosis

(2014) Xu Wang et al.   PLoS One

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

(2013) X Song et al.   Cell Death & Disease

Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death

(2012) WEI TIAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF- B Activation

(2012) A. Lavorgna et al.   JOURNAL OF VIROLOGY

Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects

(2011) Zhiyun He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA

(2011) Chao Zhao et al.   BIOCHIMIE

Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells

(2010) Yao Wang et al.   TOXICOLOGY MECHANISMS AND METHODS

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRAIL and cancer therapy

(2008) Frank A.E. Kruyt   CANCER LETTERS

TRAIL Resistance of Breast Cancer Cells Is Associated with Constitutive Endocytosis of Death Receptors 4 and 5

(2008) Y. Zhang et al.   MOLECULAR CANCER RESEARCH

The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis

(2008) S. M. Raja et al.   MOLECULAR CANCER THERAPEUTICS