Article
Biochemistry & Molecular Biology
Shuhei Yamada, Shuji Mizumoto
Summary: This study characterized the properties of HYAL4 and found that it is a specific CS endoglycosidase. It is ubiquitously expressed in various organs in mice and is involved in the intracellular catabolism of CS.
Article
Biochemistry & Molecular Biology
Ayumu Mubuchi, Shoo Katsumoto, Makoto Tsuboi, Hideaki Ishikawa, Yoshihiro Nomura, Kyohei Higashi, Shinji Miyata
Summary: Chondroitin sulfate and heparan sulfate are sulfated glycosaminoglycan chains with different levels of sulfation and disaccharide compositions. The sulfated glycosaminoglycans from Perna canaliculus show potential as biomaterials for studying the structure-function relationships.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Carla Martin, Helena Ordiales, Francisco Vazquez, Marta Pevida, David Rodriguez, Jesus Merayo, Fernando Vazquez, Beatriz Garcia, Luis M. Quiros
Summary: This study found that cell surface glycosaminoglycans (GAGs) are involved in the adhesion of acne-related bacteria to skin cells, with different bacteria affecting different cell types. Bacterial adherence also led to changes in gene expression in skin cells, affecting the structure of GAG chains.
Review
Polymer Science
Qingchi Wang, Lianli Chi
Summary: This review investigates the structural alterations and roles of GAGs/PGs in various diseases, and discusses their potential in disease diagnosis, monitoring, prognosis, and drug development.
Article
Biochemical Research Methods
Gabor Toth, Domonkos Pal, Simon Sugar, Ilona Kovalszky, Katalin Dezso, Gitta Schlosser, Laszlo Drahos, Lilla Turiak
Summary: This study investigated the content and sulfation pattern of chondroitin sulfate (CS) and heparan sulfate (HS) in human hepatocellular carcinoma and cirrhotic liver tissues, considering the etiology of the diseases. Major differences were observed in the total abundance and sulfation pattern of CS and HS chains, providing important insights into the molecular mechanisms of chronic liver diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Htoo Zarni Oo, Zoltan Lohinai, Nastaran Khazamipour, Joey Lo, Gunjan Kumar, Jessica Pihl, Hans Adomat, Noushin Nabavi, Hakhamanesh Behmanesh, Beibei Zhai, Robert Dagil, Swati Choudhary, Tobias Gustavsson, Thomas M. Clausen, Jeffrey D. Esko, Jeffrey W. Allen, Michael A. Thompson, Nhan L. Tran, Judit Moldvay, Balazs Dome, Ali Salanti, Nader Al-Nakouzi, Glen J. Weiss, Mads Daugaard
Summary: Targeting oncofetal chondroitin sulfate (CS) chains can serve as a prognostic and therapeutic strategy for non-small cell lung cancer (NSCLC), with high expression associated with poorer outcomes. Both clinical and preclinical studies demonstrate the potential of oncofetal CS as a actionable prognostic marker and therapeutic target in NSCLC.
Review
Biochemistry & Molecular Biology
Weijiao Zhang, Ruirui Xu, Jiamin Chen, Haibo Xiong, Yang Wang, Bo Pang, Guocheng Du, Zhen Kang
Summary: This review summarizes the advances in biosynthesis of chondroitin sulfate (CS) and its oligosaccharides. The use of cell-free enzyme catalyzed systems and de novo biosynthesis strategies allows for the regulation of CS sulfonated pattern and molecular weight, addressing the limitations of animal-derived CS and enabling the production of CS oligosaccharides with defined structures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Anastasia V. Strokotova, Elvira V. Grigorieva
Summary: Glucocorticoids are commonly used to treat various diseases but can cause side effects. Recent studies suggest that the toxic effects of glucocorticoids on key extracellular components in the brain may be an underlying mechanism for these side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Karina Biskup, Caroline Stellmach, Elena Ioana Braicu, Jalid Sehouli, Veronique Blanchard
Summary: The modification of glycosaminoglycans in tissues surrounding malignant cells may contribute to tumor progression and metastasis in various types of cancers. A novel GAG-based score, CS-bio, was proposed as a potential biomarker for primary epithelial ovarian cancer, showing better sensitivity and specificity than the clinically used CA125 in identifying early-stage patients.
Article
Microbiology
Lin Wei, Qingdong Zhang, Danrong Lu, Min Du, Xiangyu Xu, Wenshuang Wang, Yu-Zhong Zhang, Xunyi Yuan, Fuchuan Li
Summary: This study identified two novel chondroitin sulfate/dematan sulfate sulfatases that can hydrolyze sulfate groups, providing insights for the structural and functional studies of chondroitin sulfate/dermatan sulfate.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhiwei Zhang, Lixin Ma, Jingwen Luo
Summary: The development of chondroitin sulfate liposomes (CSLs) for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) shows promising results in suppressing lung metastasis of breast cancer. CSLs efficiently encapsulate both RA and DOX and demonstrate better anticancer and anti-metastatic activity compared to other drug carriers.
Article
Chemistry, Analytical
Maria Sokol, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, Elena Nikolskaya
Summary: The combinatorial administration of vorinostat and genotoxic agents enhances their antitumoral action against tumors. To support this, a high-performance liquid chromatography method was developed for the simultaneous determination of doxorubicin and vorinostat in polymeric nanoparticles. The method was precise and accurate, and could be adopted for routine analysis of the drugs in nanoparticles.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Mitra Amani, Nedasadat Saadati Ardestani, Navid Yeganeh Majd
Summary: Nanoparticles of Capecitabine (CPT) were successfully produced using the GAS process with optimized conditions, leading to significant size reduction, uniform structure, and improved solubility. The physical analysis confirmed the purity of CPT structure with higher solubility and no changes during the process.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Biochemistry & Molecular Biology
Tomoko Watanabe, Ko Takeda, Keiko Hiemori, Toshikazu Minamisawa, Hiroaki Tateno
Summary: This study revealed that the SARS-CoV-2 spike protein binds to both heparin/HS and chondroitin sulfate E, and analyzed the specificity of each subunit of the S protein. Moreover, chondroitin sulfate E may serve as an alternative attachment factor for HS in SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Melanie Bilong, Parisa Bayat, Matthieu Bourderioux, Murielle Jerome, Alexandre Giuliani, Regis Daniel
Summary: Mammalian hyaluronidases play a role in the catabolism of chondroitin sulfate, producing a wide range of oligosaccharides from CS-A and CS-C. Structural investigation using mass spectrometry reveals selective glycosidic bond cleavage catalyzed by mammalian hyaluronidase, supporting its role in CS metabolism. Additionally, differences in oligosaccharide distribution between CS-A and CS-C digestion mixtures have been observed.
Article
Plant Sciences
Farhan Ahmad, Aisha Kamal, Ananya Singh, Farha Ashfaque, Saud Alamri, Manzer H. Siddiqui
Summary: This study evaluated the effect of seed priming with salicylic acid (SA) on reducing the adverse effects of salt stress in pea seedlings. The results showed that seed priming with SA alleviated the negative impact of salinity on overall plant performance, including growth and photosynthetic attributes. SA achieved this by inducing enzymatic and non-enzymatic antioxidant systems, promoting soluble sugar and proline accumulation, and regulating ion homeostasis. Seed priming with SA could be a promising approach for cultivating salt-tolerant plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Chemistry, Analytical
Nazeer Hasan, Mohammad Imran, Dhara Jain, Athar Shamim, Sarwar Beg, Prashant Kesharwani, Gaurav Jain, Farhan J. Ahmad
Summary: The paper describes the development and validation of a simple and reliable HPLC method for simultaneous estimation of 5-FU and CBD. The method showed good linearity, precision, specificity, and robustness. It could be effectively used for quantification of these drugs in various in vitro and in vivo studies.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Education, Scientific Disciplines
Tej Pratap Singh, Navneet Verma, Farhan Jalees Ahmad, Phool Chandra, Gaurav Kumar Jain
Summary: This study evaluated the wound healing potential of raloxifene nanoemulsion gel in a rat model. The results showed that the raloxifene nanoemulsion gel can enhance breaking strength, tensile strength, and wound contraction in incision wounds, as well as promote re-epithelialization, neo-vascularization, fibroblast proliferation, and collagen deposition. It demonstrates significant wound healing potential.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nazeer Hasan, Mohammad Imran, Afsana Sheikh, Suma Saad, Gaurav Chaudhary, Gaurav Kumar Jain, Prashant Kesharwani, Farhan J. Ahmad
Summary: This review discusses the potential of cannabis in treating cancer, its safety profile, and the advancements in using nanotechnology to improve its therapeutic efficacy. It also explores the role of cannabinoids in different cancers and provides information on completed and ongoing clinical trials.
JOURNAL OF DRUG TARGETING
(2022)
Article
Multidisciplinary Sciences
Bharti Vyas, Ratul Bhowmik, Mymoona Akhter, Farhan Jalees Ahmad
Summary: This study used computational analysis to identify potential mutations associated with hereditary glutathione reductase deficiency and other diseases. Structural and evolutionary analyses suggested that the mutations may alter the structure and function of the GSR protein. Additionally, genetic studies found that certain variations were associated with obstructive heart defects and hereditary anemia.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Syed Mohammad Danish, Anshul Gupta, Urooj Ahmad Khan, Nazeer Hasan, Farhan Jalees Ahmad, Musarrat Husain Warsi, Ahmed M. Abdelhaleem Ali, Ameeduzzafar Zafar, Gaurav Kumar Jain
Summary: Intranasal cerium oxide nanoparticles (CNPs) have the potential to improve cognitive function in Alzheimer's disease (AD) through their antioxidant effect.
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Review
Biochemistry & Molecular Biology
Syed M. Kawish, Shwetakshi Sharma, Waleed H. Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik S. A. Altamimi, Fahad A. Al-Abbasi, Sarwar Beg, Farhan J. Ahmad
Summary: The pharmaceutical industry is advancing towards personalized medicine through innovation in drug development. Three-dimensional printing technology has enabled the manufacturing of personalized dosage forms, opening up new possibilities for discovering compounds and technologies.
CURRENT DRUG METABOLISM
(2022)
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, Farhan Jalees Ahmad
Summary: A colorimetric method was developed for visual detection of oxytocin in bottle gourd. The method showed high sensitivity and a quick reaction time, allowing for accurate screening of oxytocin.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Rehan A. Rub, Sagar Suman Panda, Sunil K. Panda, Waleed H. Almalki, Majed Alrobaian, Abdul Hafeez, Mahfoozur Rahman, Sarwar Beg, Asgar Ali, Farhan J. Ahmed
Summary: The research focuses on developing an analytical method for estimating aripiprazole in rat plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Propranolol was chosen as the internal standard for maximum recovery of the drug from rat plasma during pharmacokinetic evaluation.
SEPARATION SCIENCE PLUS
(2022)
Article
Engineering, Biomedical
Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M. Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad
Summary: The study reported the use of nanoparticles to enhance the targeting and bioavailability of ropinirole hydrochloride for the treatment of ischemic stroke. The nanoparticles showed improved therapeutic effects and reduced unwanted toxicities. Additionally, they were able to attenuate ischemic injury and restore neurological and behavioral deficits.
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Analytical
Musarrat Husain Warsi, Sharmistha Mohapatra, Mohammed Asfer, Mohammad Yusuf, Abuzer Ali, Mohammad Akhlaquer Rahman, Amena Ali, Abdul Qadir, Gaurav K. Jain
Summary: This study investigated the release and antibacterial effects of LNZ-loaded SPIONs on Staphylococcus aureus and Streptococcus pneumoniae. The results showed that the reduced dose of LNZ incorporated in SPIONs was able to show similar activity as the marketed product.
JOURNAL OF AOAC INTERNATIONAL
(2023)
Article
Oncology
Farhan Ahmad, Shalini Singh, Niraj Kumari
Summary: Spontaneous regression (SR) is relatively rare in non-small-cell lung cancer, especially with adenocarcinoma histology. Various mechanisms have been postulated, but the exact underlying mechanism is still uncertain.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Arif Nadaf, Akash Gupta, Nazeer Hasan, Fauziya, Shadaan Ahmad, Prashant Kesharwani, Farhan J. Ahmad
Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
