Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Jia Yang, Qihui Sun, Qingyun Ma, Qinhui Yu, Xiaoyun Liu, Yanliang Liu, Yuxiu Han, Yong Yang, Rong Rong
Summary: The study found that treatment with MXF significantly reduced apoptosis in MCM cells induced by thermal stimulation, possibly through the mitochondrial-mediated signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Jiangyan Li, Xiaoru Chang, Mengting Shang, Shuyan Niu, Wenli Zhang, Bangyong Zhang, Wenyan Huang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: The study showed that the cytotoxicity of silver nanoparticles on A549 cells led to apoptosis and mitochondrial injury, triggering autophagy and mitophagy, and also causing lysosomal damage and oxidative/antioxidant imbalance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yajuan Lu, Hanyu Tang, Xia Wang, Junjie Xu, Fei Sun
Summary: This study reveals the detrimental effects of dibutyltin dichloride (DBTCl) exposure on mouse oocytes, resulting in decreased follicle and oocyte numbers, inhibited meiotic maturation, impaired spindle assembly and chromosome alignment, and mitochondrial dysfunction leading to the accumulation of reactive oxygen species and induction of apoptosis.
Article
Integrative & Complementary Medicine
Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao
Summary: Toosendanin (TSN) extracted from Melia toosendan Sieb et Zucc has been demonstrated to possess antitumor activities on ovarian cancer cells, inhibiting cell proliferation, inducing apoptosis, reducing mitochondrial membrane potential, and suppressing invasion and migration. TSN's effects are associated with modulation of expression levels of key proteins related to the caspase-dependent mitochondrial apoptotic pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang, Xue-Kang Zhang
Summary: Dex demonstrates protective effects against intestinal I/R injury in rats by promoting mitophagy and inhibiting apoptosis of enteric glial cells, involving the SIRT3/PINK1/HDAC3/p53 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Applied
Xueli Tong, Chunqin Lao, Di Li, Jingmian Chen, Weijie Xu, Lu Li, Huiling Ye, Xiaofeng Guo, Jiejing Li
Summary: This study demonstrates that the purified polysaccharide ABPA1 from AVBEC can induce apoptosis in colorectal cancer cells by regulating the Bax and cytochrome-c mediated mitochondrial pathway. In vivo experiments show that ABPA1 significantly suppresses tumor growth in an orthotopic colon cancer model and has distinct impacts on the mitochondrial metabolism of colorectal cancer cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Haixia Du, Yu He, Jiaqi Zhu, Huifen Zhou, Chongyu Shao, Jiehong Yang, Haitong Wan
Summary: This study found that Danhong injection (DHI) can alleviate cerebral ischemia-reperfusion injury in hyperlipidemia rats. This may be achieved by restoring the mitochondrial respiratory chain and changing the balance of mitochondrial fusion and fission proteins to inhibit mitochondria-dependent apoptosis and improve mitochondrial function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Xue-Mei Wan, Chuan Zheng, Xue-Lei Zhou
Summary: Recent investigations have shown that puerarin can alleviate cadmium-induced hepatic damage by inhibiting oxidative stress. This study used mouse hepatocyte AML-12 cell line and found that puerarin prevents mitochondrial damage caused by cadmium exposure and restores mitochondrial network fragmentation through the Sirt1 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Plant Sciences
Hai-Yue Lan, Pei An, Qiu-Ping Liu, Yu-Ying Chen, Yuan-Yuan Yu, Xin Luan, Jian-Yuan Tang, Hong Zhang
Summary: Aidi injection inhibits the growth of liver cancer by regulating the PI3K/Akt and MAPK signal transduction pathways, inducing mitochondrial apoptosis pathway through MMP collapse, and ultimately eliciting apoptosis of hepatocellular carcinoma cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Huan Li, Qinli Zhang, Xingli Xue, Jingsi Zhang, Shanshan Wang, Jing Zhang, Li Lin, Qiao Niu
Summary: This study investigated the mechanisms and signalling pathways involved in aluminium exposure-induced neuronal apoptosis. The results showed that aluminium exposure decreased the number of PC12 cells, changed cell morphology, and increased apoptosis rate. It was found that Lnc001209 interacts with the CD36 protein, and CD36 overexpression likely increased the activation levels of the p-Akt signalling pathway, promoting neuronal apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Jinghua Zhao, Ruxin Zhang, Wei Wang, Sheng Jiang, Huimei Liang, Chen Guo, Jingyi Qi, Huan Zeng, Houhui Song
Summary: Ketamine suppresses neuroinflammation in nerve cells by activating the alpha 7nAChR-mediated cholinergic anti-inflammatory pathway, showing its potential as a therapeutic agent for neuronal apoptosis and neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi, Sujit Kumar Bhutia
Summary: Stress-induced mitochondrial hyperfusion (SIMH) has a protective effect on cell survival, but in the absence of mitochondrial fission, SIMH can induce apoptosis related to oxidative stress. This study found that MTP18, a protein promoting mitochondrial fission, is increased in oral cancer. A novel inhibitor of MTP18 called S28 was identified, which induces SIMH and triggers apoptosis. S28 inhibits MTP18-mediated mitochondrial fission and induces autophagy, resulting in the loss of mitochondrial membrane potential and the generation of mitochondrial superoxide to induce apoptosis. Combining S28 with FDA-approved anticancer drugs enhances apoptotic activity and decreases cell viability.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)