Article
Biochemistry & Molecular Biology
Kong-Nan Zhao, Paul Masci, Goce Dimeski, Lambro Johnson, Michael Grant, John de Jersey, Martin F. Lavin
Summary: This study successfully purified and cloned a codon-optimized form of the snake prothrombin activator ecarin, which was expressed in human embryonic kidney cells. The clotting performance of the recombinant ecarin was found to be comparable to the native ecarin, with the recombinant form showing an important advantage of no observed clotting and hemolysis in high doses.
Article
Biochemistry & Molecular Biology
Francisco Romero-Gavilan, Andreia Cerqueira, Eduardo Anitua, Ricardo Tejero, Inaki Garcia-Arnaez, Cristina Martinez-Ramos, Seda Ozturan, Raul Izquierdo, Mikel Azkargorta, Felix Elortza, Marilo Gurruchaga, Isabel Goni, Julio Suay
Summary: This study investigates the dynamics of protein adsorption on surfaces enriched with calcium ions, showing distinct kinetics between materials and revealing increased protein adsorption associated with coagulation and immune responses prior to calcium release. The findings suggest a strong coagulatory effect for calcium surfaces and initial inflammation that disappears once calcium is released, which explains the differential biological responses between titanium and calcium-ion modified implant surfaces.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Lei Wang, Wenjun Li, Yan Qu, Kai Wang, Kangning Lv, Xiaoli He, Song Qin
Summary: This study utilizes tilapia to extract macromolecular type I collagen to prepare a new hemostatic sponge for controlling acute wound bleeding. The extracted fish collagen has high purity, uniform molecular size, and high hydroxyproline content. The developed hemostatic sponge has a uniform honeycomb-shaped porous structure and high water absorption capacity. The sponge cell has good compatibility, can be degraded gradually and completely, and has excellent coagulation performance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Jianxin Fu, Nuan Liu, Yunxi Peng, Guoqing Wang, Xiaokun Wang, Qiaoning Wang, Min Lv, Lingxin Chen
Summary: A crosslinked sponge made of naturally occurring corn starch and gelatin can efficiently degrade micro- and nano-scale plastics with excellent mechanical strength, making it suitable for removing plastics in water and soil.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Polymer Science
Yushan Li, Jie Li, Yiyi Lu, Wentian Shi, Huafeng Tian
Summary: In this study, a durable S@P@PU sponge was developed by immersing polyurethane sponges in a blending solution of starch granules and polydimethylsiloxane (PDMS). The blending of starch granules and PDMS ensured reliable adhesion and secondary structure formation on the sponge surface. The resulting sponge showed excellent hydrophobicity, organic solvent affinity, and separation efficiency. Furthermore, it exhibited outstanding mechanical durability and chemical stability.
Article
Polymer Science
Daniele Bugnotti, Sara Dalle Vacche, Leandro Hernan Esposito, Emanuela Callone, Sara Fernanda Orsini, Riccardo Ceccato, Massimiliano D'Arienzo, Roberta Bongiovanni, Sandra Dire, Alessandra Vitale
Summary: The effect of processing method and sepiolite filler amount on the microstructure of starch-based nanocomposites was investigated. The processing method disrupted the rigid lattice structure of semicrystalline starch, resulting in amorphous flexible films with high transparency and good thermal resistance. The microstructure of the bio-nanocomposites depended on complex interactions among sepiolite, glycerol, and starch chains, which also affected the final properties of the composite materials.
Article
Dentistry, Oral Surgery & Medicine
Sabrina Elise Moecke, Ana Gabriele de Cassia Santos Silva, Adrielle Caroline Moreira Andrade, Alessandra Buhler Borges, Carlos Rocha Gomes Torres
Summary: This study evaluated the effects of varnishes containing different concentrations of S-PRG filler or sodium fluoride on enamel caries remineralization. The results showed that the varnish containing 40% S-PRG filler was the most effective, followed by the one containing 5% sodium fluoride.
JOURNAL OF DENTISTRY
(2022)
Article
Biochemistry & Molecular Biology
Harleen Gujral, Archana Sinhmar, Manju Nehra, Vikash Nain, Rahul Thory, Ashok Kumar Pathera, Prafull Chavan
Summary: The incorporation of starch nanoparticles (SNPs) into film formulation led to improvements in film properties, including increased swelling power and solubility, decreased water vapor transmission rate, enhanced burst strength, increased film thickness, and enhanced biodegradability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Amelie I. S. Sobczak, Kondwani G. H. Katundu, Fladia A. Phoenix, Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz, Claudia A. Blindauer, Samantha J. Pitt, Terry K. Smith, Ramzi A. Ajjan, Alan J. Stewart
Summary: This study reveals that under certain conditions, specific non-esterified fatty acids (NEFAs) can interfere with human serum albumin (HSA) buffering capacity for zinc (Zn2+), impacting the cellular and protein aspects of coagulation.
Article
Chemistry, Multidisciplinary
Dongyu Hao, Xuechuan Wang, Xinhua Liu, Rongrong Su, Zhengjun Duan, Xugang Dang
Summary: A biomass-based chrome-free tanning agent DCST-EGDE was successfully synthesized, verified by various analytical techniques, and shown to effectively replace chromium tanning agents, improving the mechanical properties, whiteness, and overall performance of leather.
Review
Engineering, Multidisciplinary
Alireza Aminoroaya, Rasoul Esmaeely Neisiany, Saied Nouri Khorasani, Parisa Panahi, Oisik Das, Henning Madry, Magali Cucchiarini, Seeram Ramakrishna
Summary: This article provides a comprehensive review of recent developments in resin-based dental composites, discussing the challenges faced in clinical applications, the chemical aspects of the systems, characteristics of fillers used, and suggesting future research directions.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sevki Guler, Burcu Ozkan Cetinkaya, Sevda Kurt Bayrakdar, Bulent Ayas, Gonca Cayir Keles
Summary: The study aimed to compare the effectiveness of Ankaferd Blood Stopper (ABS) and enamel matrix derivatives (EMD) in treating fenestration defects in rats. The results showed that both ABS and EMD significantly increased new bone area and ratio in a certain time frame, along with higher levels of C-III and OPN expression.
Article
Engineering, Biomedical
Jun-ting Gu, Kai Jiao, Jing Li, Jian-fei Yan, Kai-yan Wang, Fu Wang, Yan Liu, Franklin R. Tay, Ji-hua Chen, Li-na Niu
Summary: This study investigated the use of a modified collagen scaffold, covalently bonded with polyphosphate, for the treatment of post-extraction bleeding and alveolar bone loss. The modified scaffold demonstrated improved hemostatic property and promoted bone regeneration, making it a potential effective treatment option for these complications.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Nicoly Donati, Jordana Corralo Spada, Isabel Cristina Tessaro
Summary: This study investigated the effect of rice husk ash on the properties of starch-based foams. It was found that adding 20-50% ash content improved the thermal stability, density, and biodegradability of the foams while reducing water absorption capacity. The filled foams also exhibited smaller pores and better mechanical properties.
Article
Agricultural Engineering
Xiaoxiao Hou, Linglong Chu, Yifei Wang, Xinshan Song, Yingying Liu, Dongpeng Li, Xiaoxiang Zhao
Summary: This study successfully established a microelectrolysis-assisted constructed wetland using sponge iron as filler surrounding the cathode (e-SICW), which reduced ammonia accumulation and intensified the removal of nitrate, total nitrogen, and total phosphorus.
BIORESOURCE TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Claudia Ventura-Lopez, Karla Cervantes-Luevano, Janet S. Aguirre-Sanchez, Juan C. Flores-Caballero, Carolina Alvarez-Delgado, Johanna Bernaldez-Sarabia, Noemi Sanchez-Campos, Laura A. Lugo-Sanchez, Ileana C. Rodriguez-Vazquez, Jose G. Sander-Padilla, Yulia Romero-Antonio, Maria M. Arguedas-Nunez, Jorge Gonzalez-Canudas, Alexei F. Licea-Navarro
Summary: The study evaluated the effects of Metformin Glycinate on SARS-CoV-2 in vitro and in vivo, showing that MG effectively inhibits viral replication and increases cell survival rates. Clinical data also demonstrated that MG treatment significantly reduces viral load and supplementary oxygen requirements for infected patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Materials Science, Multidisciplinary
L. Garcia-Uriostegui, H. Ivan Melendez-Ortiz, T. A. Camacho-Villegas, P. H. Lugo-Fabres, G. Toriz
Summary: Hybrid nanoparticles based on PHEMA grafted onto MSiO2 particles were prepared and showed potential as a drug carrier for cancer therapy. The grafted PHEMA allowed for good dispersion of the hybrid nanoparticles in aqueous solution and efficient loading of the drug 5FU. In vitro cytotoxicity tests demonstrated the effectiveness of the hybrid delivery system against glioblastoma cells.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Immunology
Erendira Villalobos-Sanchez, Mirna Burciaga-Flores, Lorena Zapata-Cuellar, Tanya A. Camacho-Villegas, Darwin E. Elizondo-Quiroga
Summary: This article summarizes the research on the mechanism of prenatal vertical infection of ZIKV, including in vitro, in vivo, and ex vivo experiments, as well as investigations on pregnant women. The study found that ZIKV can be transmitted to the fetus through transplacental, paracellular, transcytosis mediated by extracellular vesicles, and paraplacental routes.
Article
Immunology
Olivia Cabanillas-Bernal, Karla Cervantes-Luevano, Gonzalo Isai Flores-Acosta, Johanna Bernaldez-Sarabia, Alexei F. Licea-Navarro
Summary: This study evaluates the presence of neutralizing antibodies in the breast milk of lactating mothers who received vaccines from Pfizer-BioNtech, Johnson & Johnson (J&J)/Janssen, and CanSino Biologics against SARS-CoV-2. The results demonstrate the strongest neutralizing effect in breast milk from mothers vaccinated with Pfizer, followed by J&J, and the least neutralizing effect in CanSino vaccinations. The findings emphasize the importance of recommending vaccination to lactating mothers and the continuation of breastfeeding for potential health benefits to infants.
Article
Microbiology
Jorge Rojas-Vargas, Ricardo Gonzalez-Sanchez, Alejandro Sanchez-Flores, Alexei Fedorovish Licea-Navarro, Liliana Pardo-Lopez
Summary: This study reports the complete genome sequence of a marine bacteria strain isolated from asphalt sediments in the Gulf of Mexico. Investigating the genomes of atypical environmental bacteria contributes to our understanding of microorganisms metabolizing pollutants and also provides a biotechnological resource for developing bioremediation methods.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Multidisciplinary Sciences
Karla Cervantes-Luevano, Astrid N. Espino-Vazquez, Gonzalo Flores-Acosta, Johanna Bernaldez-Sarabia, Olivia Cabanillas-Bernal, Jahaziel Gasperin-Bulbarela, Ricardo Gonzalez-Sanchez, Andreu Comas-Garcia, Alexei F. Licea-Navarro
Summary: The coordinated efforts to stop the spread of SARS-CoV-2 include massive immunization, which has been shown to induce potent neutralizing antibodies in convalescent patients and patients without previous history of COVID-19. Heterologous prime-boost with Ad5-nCoV vaccine has been found to induce higher levels of neutralizing antibodies compared to a single vaccination scheme.
Article
Multidisciplinary Sciences
David Ramirez-Delgado, Francesco Cicala, Ricardo A. Gonzalez-Sanchez, Rosalia Avalos-Tellez, Elena Solana-Arellano, Alexei Licea-Navarro
Summary: This study employed a multi-locus analysis to comprehensively assess the gastrointestinal bacterial consortium in rectal samples from Zalophus californianus pups. The results showed distinctive bacterial community profiles for each analyzed hypervariable region of the 16S rRNA. The study also identified certain regions that may be suitable for identifying geographic variations and functional capabilities within the microbiome.
Article
Biochemistry & Molecular Biology
Blanca J. Valdovino-Navarro, Salvador Duenas, G. Isai Flores-Acosta, Jahaziel Gasperin-Bulbarela, Johanna Bernaldez-Sarabia, Olivia Cabanillas-Bernal, Karla E. Cervantes-Luevano, Alexei F. Licea-Navarro
Summary: This study characterized a VNAR antibody (SP240) and demonstrated its potential as a neutralizing antibody against emerging SARS-CoV-2 variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jessica Andrea Badillo-Mata, Tanya Amanda Camacho-Villegas, Pavel Hayl Lugo-Fabres
Summary: The researchers discuss the pathophysiology and current treatment strategies of rheumatoid arthritis (RA). They also explore the application of 3D cell culture technology in rheumatological diseases and RA models, and summarize its application in RA treatment.
Article
Virology
Erendira Villalobos-Sanchez, Daniel Garcia-Ruiz, Tanya A. Camacho-Villegas, Alejandro A. Canales-Aguirre, Abel Gutierrez-Ortega, Jose E. Munoz-Medina, Darwin E. Elizondo-Quiroga
Summary: This article evaluates the antiviral activity of NDGA against SARS-CoV-2 in vitro, showing that NDGA has a remarkable inhibitory effect on the virus and could be a promising therapeutic candidate for COVID-19.
Article
Multidisciplinary Sciences
Mirna Burciaga-Flores, Ana Laura Marquez-Aguirre, Salvador Duenas, Jahaziel Gasperin-Bulbarela, Alexei F. Licea-Navarro, Tanya A. Camacho-Villegas
Summary: This study obtained a vNAR T1 that binds to TGF-beta isoforms from a non-immunized Heterodontus francisci shark library. The binding ability of vNAR T1 to TGF-beta was demonstrated through direct ELISA assay and surface plasmon resonance (SPR) analysis. This vNAR T1 has the potential to be used as a therapeutic agent.
SCIENTIFIC REPORTS
(2023)
Review
Environmental Sciences
Juan Carlos Herguera, Edward M. Peters, Julio Sheinbaum, Paula Perez-Brunius, Sharon Z. Herzka, Alexei Licea-Navarro, Francisco Ocampo-Torres, M. Leopoldina Aguirre-Macedo, Victor M. Vidal-Martinez, Hector Garcia-Nava, Tomas Salgado, Rosario Romero-Centeno, Jorge Zavala-Hidalgo, Liliana Pardo-Lopez, Adolfo Gracia
Summary: The 2010 Macondo platform accident by BP resulted in one of the largest oil spills in history, lasting over three months and releasing nearly 500 million liters of oil. This accident exposed technological deficiencies in controlling spills in deep waters. To address the need for understanding and predicting large oil spills in the southern Gulf of Mexico, a consortium of researchers from Mexico and abroad launched an ocean observation project (2015-22) to establish an environmental baseline, enhance monitoring and computational modeling capabilities, and promote scientific understanding of the marine environment.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Polymer Science
G. Tonantzin De Dios-Figueroa, Janette del Rocio Aguilera-Marquez, Lorena Garcia-Uriostegui, Rodolfo Hernandez-Gutierrez, Tanya A. Camacho-Villegas, Pavel H. Lugo-Fabres
Summary: The authors developed a hydrogel using biopolymers to encapsulate HER2-positive breast cancer cells. The hydrogel exhibited suitable physical properties and biocompatibility, maintaining the morphology and viability of the cells. It has potential applications in evaluating new HER2-targeted therapies.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
