Roles of CD38 in the Immune Response to Infection

Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice

(2019) Qi Li et al.   Journal of Immunology Research

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma

(2019) Hareth Nahi et al.   PLoS One

Daratumumab: A Review in Combination Therapy for Transplant-Ineligible Newly Diagnosed Multiple Myeloma

(2019) Yahiya Y. Syed   DRUGS

A Phase Ib study of isatuximab plus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma

(2019) Joseph Mikhael et al.   BLOOD

Preemptive therapy for cytomegalovirus reactivation after daratumumab-containing treatment in patients with relapsed and refractory multiple myeloma

(2019) Ryo Nakagawa et al.   ANNALS OF HEMATOLOGY

Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics

(2019) Bruna A. David et al.   IMMUNOLOGICAL REVIEWS

Subcutaneous Delivery of Daratumumab in Relapsed or Refractory Multiple Myeloma

(2019) Saad Z. Usmani et al.   BLOOD

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

(2019) Kelly A. Hogan et al.   Frontiers in Immunology

Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes

(2019) Kuan Yang et al.   JOURNAL OF IMMUNOLOGY

CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production

(2019) Qianting Yang et al.   mBio

Daratumumab is effective in the relapsed or refractory systemic light‐chain amyloidosis but associated with high infection burden in a frail real‐life population

(2019) Zoe Van de Wyngaert et al.   BRITISH JOURNAL OF HAEMATOLOGY

Exosomes in Sepsis and Inflammatory Tissue Injury.

(2019) Eun Jeong Park et al.   CURRENT PHARMACEUTICAL DESIGN

Daratumumab added to standard of care in patients with newly diagnosed multiple myeloma: A network meta‐analysis

(2019) Wenjun Xu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study

(2019) Michel Attal et al.   LANCET

Overall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial

(2019) Maria-Victoria Mateos et al.   LANCET

Inhibiting the CD38/cADPR pathway protected rats against sepsis associated brain injury

(2018) Qian-Yi Peng et al.   BRAIN RESEARCH

Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression

(2018) Bingyan Shu et al.   CELLULAR SIGNALLING

CD157: From immunoregulatory protein to potential therapeutic target

(2018) Erika Ortolan et al.   IMMUNOLOGY LETTERS

Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis

(2018) Susana Beceiro et al.   MOLECULAR AND CELLULAR BIOLOGY

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

(2018) Stephanie A. Amici et al.   Frontiers in Immunology

Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells

(2018) Karsten Lücke et al.   PLoS One

Cellular traffic through afferent lymphatic vessels

(2018) Philipp Schineis et al.   VASCULAR PHARMACOLOGY

HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?

(2018) Juan C. Rodríguez‐Alba et al.   BIOESSAYS

Results of an early access treatment protocol of daratumumab in United States patients with relapsed or refractory multiple myeloma

(2018) Ajai Chari et al.   CANCER

CD38: A Target for Immunotherapeutic Approaches in Multiple Myeloma

(2018) Fabio Morandi et al.   Frontiers in Immunology

CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells

(2017) Ilaria Schiavoni et al.   IMMUNOLOGY

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD + -Glycohydrolase: Evidence for Extracellular Activity

(2017) Dóra Hancz et al.   mBio

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

(2017) Jonathan Matalonga et al.   Cell Reports

Phagocytosis: A Fundamental Process in Immunity

(2017) Carlos Rosales et al.   Biomed Research International

Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

(2016) J. Krejcik et al.   BLOOD

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production

(2016) Julie G. Burel et al.   PLoS Pathogens

Exosome Biogenesis, Regulation, and Function in Viral Infection

(2015) Marta Alenquer et al.   Viruses-Basel

The Macrophage Paradox

(2014) Jordan V. Price et al.   IMMUNITY

Binding of CD157 Protein to Fibronectin Regulates Cell Adhesion and Spreading

(2014) Simona Morone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38 and CD157: A long journey from activation markers to multifunctional molecules

(2013) Valeria Quarona et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

CD38 Controls the Innate Immune Response against Listeria monocytogenes

(2013) Timo Lischke et al.   INFECTION AND IMMUNITY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

The Role of CD38 in Fcγ Receptor (FcγR)-mediated Phagocytosis in Murine Macrophages

(2012) John Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide induces CD38 expression and solubilization in J774 macrophage cells

(2012) Cha-Uk Lee et al.   MOLECULES AND CELLS

Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8+ T Cells with IFN-γ-Mediated Suppressor Activities

(2012) Rajia Bahri et al.   PLoS One

Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells

(2012) Ming Li et al.   PROTEOMICS

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

Tetrameric Interaction of the Ectoenzyme CD38 on the Cell Surface Enables Its Catalytic and Raft-Association Activities

(2012) Miki Hara-Yokoyama et al.   STRUCTURE

Flavonoids as inhibitors of human CD38

(2011) Esther Kellenberger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CD38 through the life of a murine B lymphocyte

(2011) Felipe Vences-Catalán et al.   IUBMB LIFE

The CD157-Integrin Partnership Controls Transendothelial Migration and Adhesion of Human Monocytes

(2011) Nicola Lo Buono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of CD38 delays arrival of neutrophils to the liver and innate immune response development during hepatic amoebiasis by Entamoeba histolytica

(2011) L. A. ESTRADA-FIGUEROA et al.   PARASITE IMMUNOLOGY

The PI3K p110δ Regulates Expression of CD38 on Regulatory T Cells

(2011) Daniel T. Patton et al.   PLoS One

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn

(2010) Esther Zumaquero et al.   EXPERIMENTAL CELL RESEARCH

Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse

(2008) P. Munoz et al.   BLOOD

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS