Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus

A double‐blind, randomized, placebo‐controlled, phase II trial of baricitinib for systemic lupus erythematosus: how to optimize lupus trials to examine effects on cutaneous lupus erythematosus

(2019) V.P. Werth et al.   BRITISH JOURNAL OF DERMATOLOGY

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

(2019) Dyah Ika Krisnawati et al.   Scientific Reports

Functional Analysis of Anti-cytokine Autoantibodies Using Flow Cytometry

(2019) Patricia A. Merkel et al.   Frontiers in Immunology

Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

(2019) Alessia Alunno et al.   Cells

Signaling Pathways of Type I and Type III Interferons and Targeted Therapies in Systemic Lupus Erythematosus

(2019) I-Tsu Chyuan et al.   Cells

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis

(2019) Angelika Rose et al.   Cells

A pivotal phase III, randomised, placebo-controlled study of belimumab in patients with systemic lupus erythematosus located in China, Japan and South Korea

(2018) Fengchun Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical Relevance of Autoantibodies against Interleukin-2 in Patients with Systemic Lupus Erythematosus

(2018) Zhan-Guo Li et al.   CHINESE MEDICAL JOURNAL

Principal component analysis reveals disconnect between regulatory cytokines and disease activity in Systemic Lupus Erythematosus

(2018) Warren David Raymond et al.   CYTOKINE

Intravenous Cyclophosphamide Therapy for Anti-IFN-Gamma Autoantibody-Associated Mycobacterium abscessus Infection

(2018) Ploenchan Chetchotisakd et al.   Journal of Immunology Research

Rituximab Restores IFN-γ-STAT1 Function and Ameliorates Disseminated Mycobacterium avium Infection in a Patient with Anti-Interferon-γ Autoantibody

(2017) Yusuke Koizumi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Immune complexes containing serum B-cell activating factor and immunoglobulin G correlate with disease activity in systemic lupus erythematosus

(2017) Justa Friebus-Kardash et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies

(2016) Rufei Lu et al.   JOURNAL OF AUTOIMMUNITY

Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease

(2016) Chia-Hao Lin et al.   NATURE MEDICINE

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

(2016) Julie Ducreux et al.   RHEUMATOLOGY

Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases

(2016) Sarthak Gupta et al.   Arthritis & Rheumatology

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis

(2016) Brad H. Rovin et al.   Arthritis & Rheumatology

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

(2015) Caroline von Spee-Mayer et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE

(2015) Jens Y Humrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Emerging clinical phenotypes associated with anti-cytokine autoantibodies

(2015) Thierry Vincent et al.   AUTOIMMUNITY REVIEWS

The Expression of BAFF Is Controlled by IRF Transcription Factors

(2015) Maria Sjöstrand et al.   JOURNAL OF IMMUNOLOGY

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

(2015) A. J. Steiman et al.   JOURNAL OF RHEUMATOLOGY

Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab

(2015) D A Roth et al.   LUPUS

Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus

(2015) D. James Haddon et al.   ARTHRITIS RESEARCH & THERAPY

Sirukumab: a novel therapy for lupus nephritis?

(2014) Uma Thanarajasingam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Detection of anti-cytokine antibodies and their clinical relevance

(2014) Anthony Meager et al.   Expert Review of Clinical Immunology

Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections

(2013) Toshihiro Nanki et al.   ANNALS OF THE RHEUMATIC DISEASES

Recurrent Burkholderia gladioli Suppurative Lymphadenitis associated with Neutralizing Anti-IL-12p70 Autoantibodies

(2013) Bich-Thuy T. Sim et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus

(2013) Jordan V. Price et al.   JOURNAL OF CLINICAL INVESTIGATION

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

Adult-Onset Immunodeficiency in Thailand and Taiwan

(2012) Sarah K. Browne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus

(2011) Alyssa M. Morimoto et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Inflammatory Cytokines in Systemic Lupus Erythematosus

(2011) Kim Ohl et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Cytokine disturbances in systemic lupus erythematosus

(2011) Noam Jacob et al.   ARTHRITIS RESEARCH & THERAPY

Anti-IL-lα autoantibodies in patients with rheumatic diseases and in healthy subjects

(2010) H. SUZUKI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

(2009) Jason W. Bauer et al.   ARTHRITIS AND RHEUMATISM

Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus

(2009) K. O. Kong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization and potential clinical applications of autoantibodies against cytokines

(2009) Carina de Lemos Rieper et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Chemokine Autoantibody:Chemokine Immune Complexes Activate Endothelial Cells via IgG Receptors

(2008) Agnieszka Krupa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome

(2008) Rafal Fudala et al.   CLINICAL SCIENCE