GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice
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Title
GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice
Authors
Keywords
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Journal
Cells
Volume 8, Issue 12, Pages 1596
Publisher
MDPI AG
Online
2019-12-09
DOI
10.3390/cells8121596
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- Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents
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- Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1
- (2016) Pooja Singhmar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CREB pathway links PGE2 signaling with macrophage polarization
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- Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile
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- G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration
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- Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis
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